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1.
A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997 Wulfsohn , M. S. , Tsiatis , A. A. ( 1997 ). A joint model for survival and longitudinal data measured with error . Biometrics 53 ( 1 ): 330339 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) and Song et al. (2002 Song , X. , Davidian , M. , Tsiatis , A. A. ( 2002 ). A Semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data . Biometrics 58 ( 4 ): 742753 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]). In this article, similar to Henderson et al. (2002 Henderson , R. , Diggle , P. J. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 3350 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data.  相似文献   

2.
Extending the bifurcating autoregressive (BAR) process (cf. Cowan and Staudte, 1986 Cowan , R. , Staudte , R. G. ( 1986 ). The bifurcating autoregression model in cell lineage studies . Biometrics 42 : 769783 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) to multi-casting (multi-splitting) data, Hwang and Choi (2009 Hwang , S. Y. , Choi , M. S. ( 2009 ). Modeling and large sample estimation for multi-casting autoregression . Statist. Prob. Lett. 79 : 19431950 .[Crossref], [Web of Science ®] [Google Scholar]) introduced multi-casting autoregression (MCAR, for short) defined on multi-casting tree structured data. This article is concerned with the case when the MCAR model is partially specified only through conditional mean and variance without directly imposing autoregressive (AR) structure. The resulting class of models will be referred to as P-MCAR (partially specified MCAR). The P-MCAR considerably enlarges the class of multi-casting models including (as special cases) MCAR, random coefficient MCAR, conditionally heteroscedastic multi-casting models and binomial-thinning processes. Moment structures for this broad P-MCAR class are investigated. Least squares (LS) estimation method is discussed and asymptotic relative efficiency (ARE) of the generalized-LS over ordinary-LS is obtained in a closed form. A simulation study is conducted to illustrate results.  相似文献   

3.
We develop a series of Bayesian statistical models for estimating survival of a neotropic didelphid marsupial, the Brazilian gracile mouse opossum (Gracilinanus microtarsus). These models are based on the Cormack–Jolly–Seber model (Cormack, 1964 Cormack , R. M. ( 1964 ). Estimates of survival from the sighting of marked animals . Biometrika 51 : 429438 .[Crossref], [Web of Science ®] [Google Scholar]; Jolly 1965 Jolly , G. M. ( 1965 ). Explicit estimates from capture-recapture data with both death and immigration stochastic model . Biometrika 52 : 225247 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]; Seber 1965 Seber , G. A. F. ( 1965 ). A note on the multiple recapture census . Biometrika 52 : 249259 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) with both survival and recapture rates expressed as a function of covariates using a logit link. The proposed models allow taking into account heterogeneity in capture probability caused by the existence of different groups of individuals in the population. The models were applied to two cohorts (Cohort, 2000, 2001) with the first one including 14 and the second one 15 sampling occasions. The best models for each of the cohorts indicate that G. microtarsus is best described as partially semelparous, a condition in which mortality after the first mating is high but graded over time, with a fraction of males surviving for a second breeding season (Boonstra, 2005 Boonstra , R. ( 2005 ). Equipped for life: the adaptive role of the stress axis in male mammals . Journal of Mammalogy 86 : 236247 .[Crossref], [Web of Science ®] [Google Scholar]).  相似文献   

4.
We extend the approach of Walker (2003 Walker , S. ( 2003 ). On sufficient conditions for Bayesian consistency . Biometrika 90 ( 2 ): 482488 .[Crossref], [Web of Science ®] [Google Scholar]); (2004 Walker , S. ( 2004 ). New approaches to Bayesian consistency . Ann. Statist. 32 ( 5 ): 20282043 .[Crossref], [Web of Science ®] [Google Scholar]) to the case of misspecified models. A sufficient condition for establishing rates of convergence is given based on a key identity involving martingales, which does not require construction of tests. We also show roughly that the result obtained by using tests can also be obtained by our approach, which demonstrates the potential wider applicability of this method.  相似文献   

5.
This article presents results concerning the performance of both single equation and system panel cointegration tests and estimators. The study considers the tests developed in Pedroni (1999 Pedroni , P. ( 1999 ). Critical values for cointegration tests in heterogeneous panels with multiple regressors . Oxford Bulletin of Economics and Statistics 61 : 653670 .[Crossref], [Web of Science ®] [Google Scholar], 2004 Pedroni , P. ( 2004 ). Panel cointegration. Asymptotic and finite sample properties of pooled time series tests with an application to the PPP hypothesis . Econometric Theory 20 : 597625 .[Crossref], [Web of Science ®] [Google Scholar]), Westerlund (2005 Westerlund , J. ( 2005 ). New simple tests for panel cointegration . Econometric Reviews 24 : 297316 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]), Larsson et al. (2001 Larsson , R. , Lyhagen , J. , Löthgren , M. ( 2001 ). Likelihood-based cointegration tests in heterogeneous panels . Econometrics Journal 4 : 109142 .[Crossref] [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151173 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]) and the estimators developed in Phillips and Moon (1999 Phillips , P. C. B. , Moon , H. R. ( 1999 ). Linear regression limit theory for nonstationary panel data . Econometrica 67 : 10571111 .[Crossref], [Web of Science ®] [Google Scholar]), Pedroni (2000 Pedroni , P. ( 2000 ). Fully modified OLS for heterogeneous cointegrated panels . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 93130 .[Crossref] [Google Scholar]), Kao and Chiang (2000 Kao , C. , Chiang , M.-H. ( 2000 ). On the estimation and inference of a cointegrated regression in panel data . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 179222 .[Crossref] [Google Scholar]), Mark and Sul (2003 Mark , N. C. , Sul , D. ( 2003 ). Cointegration vector estimation by panel dynamic OLS and long-run money demand . Oxford Bulletin of Economics and Statistics 65 : 655680 .[Crossref], [Web of Science ®] [Google Scholar]), Pedroni (2001 Pedroni , P. ( 2001 ). Purchasing power parity tests in cointegrated panels . Review of Economics and Statistics 83 : 13711375 . [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151173 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]). We study the impact of stable autoregressive roots approaching the unit circle, of I(2) components, of short-run cross-sectional correlation and of cross-unit cointegration on the performance of the tests and estimators. The data are simulated from three-dimensional individual specific VAR systems with cointegrating ranks varying from zero to two for fourteen different panel dimensions. The usual specifications of deterministic components are considered.  相似文献   

6.
We propose a method of including polynomial and interaction terms in Distance-Based Regression (Cuadras and Arenas, 1990 Cuadras , C. M. , Arenas , C. ( 1990 ). A distance based regression model for prediction with mixed data . Commun. Statist. A Theor. Meth. 19 : 22612279 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]), relying on properties of a semi-Hadamard or Khatri-Rao product of matrices. We demonstrate its application to real data examples.  相似文献   

7.
ABSTRACT

This paper reviews and extends the literature on the finite sample behavior of tests for sample selection bias. Monte Carlo results show that, when the “multicollinearity problem” identified by Nawata (1993 Nawata , K. ( 1993 ). A note on the estimation of models with sample-selection biases . Economics Letters 42 : 1524 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] [Google Scholar]) is severe, (i) the t-test based on the Heckman–Greene variance estimator can be unreliable, (ii) the Likelihood Ratio test remains powerful, and (iii) nonnormality can be interpreted as severe sample selection bias by Maximum Likelihood methods, leading to negative Wald statistics. We also confirm previous findings (Leung and Yu, 1996 Leung , S. F. , Yu , S. ( 1996 ). On the choice between sample selection and two-part models . Journal of Econometrics 72 : 197229 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] [Google Scholar]) that the standard regression-based t-test (Heckman, 1979 Heckman , J. J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153161 . [CSA] [Crossref], [Web of Science ®] [Google Scholar]) and the asymptotically efficient Lagrange Multiplier test (Melino, 1982 Melino , A. ( 1982 ). Testing for sample selection bias . Review of Economic Studies 49 : 151153 . [CSA] [Crossref], [Web of Science ®] [Google Scholar]), are robust to nonnormality but have very little power.  相似文献   

8.
In this article, we consider the progressive Type II right censored sample from Pareto distribution. We introduce a new approach for constructing the simultaneous confidence interval of the unknown parameters of this distribution under progressive censoring. A Monte Carlo study is also presented for illustration. It is shown that this confidence region has a smaller area than that introduced by Ku? and Kaya (2007 Ku? , C. , Kaya , M. F. ( 2007 ). Estimation for the parameters of the Pareto distribution under progressive censoring . Commun. Statist. Theor. Meth. 36 : 13591365 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]).  相似文献   

9.
In this article, we consider a new insurance risk model based on the entrance process proposed in Li et al. (2005 Li , Z. , Zhu , J. , Chen , F. ( 2005 ). Study of a risk model based on the entrance process . Statist. Probab. Lett. 72 : 110 .[Crossref], [Web of Science ®] [Google Scholar]), and investigate the finite time ruin probabilities of this model. It is showed that an exponential upper bound for the finite time ruin probability exists, when the distributions of the claim size are light tailed. Furthermore, when the distributions of the claim size are heavy tailed, an asymptotic formula for the finite time ruin probability is obtained.  相似文献   

10.
Multivariate skew-normal (SN) distributions (Azzalini and Dalla Valle, 1996 Azzalini , A. , Dalla Valle , A. ( 1996 ). The multivariate skew-normal distribution . Biometrika 83 : 715726 .[Crossref], [Web of Science ®] [Google Scholar]) enjoy some of the useful properties of normal distributions, have nonlinear heteroscedastic predictors but lack the closure property of normal distributions (the sum of independent SN random variables is not SN). Recently, there has been a proliferation of classes of SN distributions with certain closure properties, one of the most promising being the closed skew-normal (CSN) distributions of González-Farías et al. (2004 González-Farías , G. , Dominguez-Molina , J. A. , Gupta , A. K. ( 2004 ). Additive properties of skew-normal random vectors . J. Statist. Plann. Infer. 126 : 521534 .[Crossref], [Web of Science ®] [Google Scholar]). We study the construction of stationary SN ARMA models for colored SN noise and show that their finite-dimensional distributions are skew-normal, seldom strictly stationary and their covariance functions differ from their normal ARMA counterparts in that they do not converge to zero for large lags. The situation is better for ARMA models driven by CSN noise, but at the additional cost of considerable computational complexity and a less explicit skewness parameter. In view of these results, the widespread use of such classes of SN distributions in the framework of ARMA models seem doubtful.  相似文献   

11.
Li et al. (2005 Li , Z. , Zhu , J. , Chen , F. ( 2005 ). Study of a risk model based on the entrance process . Statist. Probab. Lett. 72 ( 1 ): 110 .[Crossref], [Web of Science ®] [Google Scholar]) proposed a risk model based on the entrance process and studied the asymptotic behavior of the surplus when time goes to infinity. This article considers the ruin problem in that model. Some simple characteristics (stochastic intensity, compensator, mean process, etc.) of the risk process and other related processes are also considered. Under small claim condition, exponential upper bounds for the ruin probability are obtained.  相似文献   

12.
We reinvestigate the empirical problem of lag length selection in unit root tests when using the augmented Dickey–Fuller test based on GLS-detrending. We extend the Ng and Perron (1995 Ng , S. , Perron , P. ( 1995 ). Unit root tests in ARMA models with data-dependent methods for the selection of the truncation lag . Journal of American Statistical Association 90 : 268281 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]) work on this issue by applying the finite sample critical values calculated using the formulae proposed by Cheung and Lai (1995 Cheung , Y. W. , Lai , K. S. ( 1995 ). Lag order and critical values of a modified Dickey–Fuller test . Oxford Bulletin of Business and Economics 57 : 411418 .[Crossref] [Google Scholar]). Unlike Ng and Perron (2001 Ng , S. , Perron , P. (2001). Lag length selection and the construction of unit root tests with good size and power. Econometrica 69:15191554.[Crossref], [Web of Science ®] [Google Scholar]) we find through simulation studies that the method of selecting lag length using the sequential t-test in the ADF regression of GLS-detrended series performs the best in most cases.  相似文献   

13.
In this article, we propose a nonparametric method to test for symmetry in bivariate data. By using the extension of Fisher's exact treatment for 2 × 2 contingency tables proposed by Freeman and Halton (1951 Freeman , G. H. , Halton , J. H. ( 1951 ). Note on an exact treatment of contingency tables, goodness of fit and other problems of significance . Biometrika 38 : 141149 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]), we can test the hypothesis of equal distribution for two samples of integer valued variables. Then, by counting the number of observations belonging to each cell of a symmetric, appropriately built grid, we can produce the two samples of integers required to use this test for equal distribution. The resulting test for symmetry is potentially extendible to higher dimensions. A simulation study is performed to compare with some known tests (Bowker, 1948 Bowker , A. H. ( 1948 ). A test for symmetry in contingency tables . Journal of the American Statistical Association 43 : 572574 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]; Hollander, 1971 Hollander , M. ( 1971 ). A nonparametric test for bivariate symmetry . Biometrika 58-1 : 203212 .[Crossref], [Web of Science ®] [Google Scholar]; and its improvement given in Krampe and Kuhnt, 2007 Krampe , A. , Kuhnt , S. ( 2007 ). Bowker's test for symmetry and modifications within the algebraic framework . Computational Statistics and Data Analysis 51 : 41244142 .[Crossref], [Web of Science ®] [Google Scholar]). Our proposal represents a competitive option as a test for symmetry.  相似文献   

14.
By applying the recursion of Huffer (1988 Huffer, F. 1988. Divided differences and the joint distribution of linear combinations of spacings. Journal of Applied Probability, 25: 346354. [Crossref], [Web of Science ®] [Google Scholar]) repeatedly, we propose an algorithm for evaluating the null joint distribution of Dixon-type test statistics for testing discordancy of k upper outliers in exponential samples. By using the critical values of Dixon-type test statistics determined from the proposed algorithm and those of Cochran-type test statistics presented earlier by Lin and Balakrishnan (2009 Lin, C. T. and Balakrishnan, N. 2009. Exact computation of the null distribution of a test for multiple outliers in an exponential sample. Computational Statistics & Data Analysis, 53: 32813290. [Crossref], [Web of Science ®] [Google Scholar]), we carry out an extensive Monte Carlo study to investigate the powers and the error probabilities for the effects of masking and swamping when the number of outliers k = 2 and 3. Based on our empirical findings, we recommend Rosner’s (1975 Rosner, B. 1975. On the detection of many outliers. Technometrics, 17: 221227. [Taylor & Francis Online], [Web of Science ®] [Google Scholar]) sequential test procedure based on Dixon-type test statistics for testing multiple outliers from an exponential distribution.  相似文献   

15.
In incident cohort studies, survival data often include subjects who have had an initiate event at recruitment and may potentially experience two successive events (first and second) during the follow-up period. Since the second duration process becomes observable only if the first event has occurred, left-truncation and dependent censoring arise if the two duration times are correlated. To confront the two potential sampling biases, Chang and Tzeng (2006 Chang , S.-H. , Tzeng , S.-J. (2006). Noparametric estimation of sojourn time distributions for truncated serial event data- a weight-adjusted approach. Lifetime Data Anal. 5367.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) provided an inverse-probability-weighted (IPW) approach for estimating the joint probability function of successive duration times. In this note, an alternative IPW approach is proposed. A simulation study is conducted to compare the two IPW approaches.  相似文献   

16.
The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 51165121 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801823 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801823 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.  相似文献   

17.
We carried out a simulation study based on the methodology of Newcombe (1998 Newcombe , R. G. ( 1998 ). Interval estimation for the difference between independent proportions: comparison of eleven methods . Statist. Med. 17 : 873890 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) to compare tests for the difference of two binomial proportions by applying different continuity corrections on saddlepoint approximation to tail probabilities. In this article, we proposed a new continuity correction based on the least common multiple of two sample sizes. We evaluated that the best test should have the actual Type I error rates that are, on the whole, closest to α, but not exceeding α, where α is nominal level of significance.  相似文献   

18.
We introduce a score test to identify longitudinal biomarkers or surrogates for a time to event outcome. This method is an extension of Henderson et al. (2000 Henderson , R. , Diggle , P. , Dobson , A. ( 2000 ). Joint modelling of longitudinal measurements and event time data . Biostatistics 1 ( 4 ): 465480 .[Crossref], [PubMed] [Google Scholar], 2002 Henderson , R. , Diggle , P. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 3350 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]). In this article, a score test is based on a joint likelihood function which combines the likelihood functions of the longitudinal biomarkers and the survival times. Henderson et al. (2000 Henderson , R. , Diggle , P. , Dobson , A. ( 2000 ). Joint modelling of longitudinal measurements and event time data . Biostatistics 1 ( 4 ): 465480 .[Crossref], [PubMed] [Google Scholar], 2002 Henderson , R. , Diggle , P. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 3350 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) assumed that the same random effect exists in the longitudinal component and in the Cox model and then they can derive a score test to determine if a longitudinal biomarker is associated with time to an event. We extend this work and our score test is based on a joint likelihood function which allows other random effects to be present in the survival function.

Considering heterogeneous baseline hazards in individuals, we use simulations to explore how the factors can influence the power of a score test to detect the association of a longitudinal biomarker and the survival time. These factors include the functional form of the random effects from the longitudinal biomarkers, in the different number of individuals, and time points per individual. We illustrate our method using a prothrombin index as a predictor of survival in liver cirrhosis patients.  相似文献   

19.
We propose a class of estimators for the population mean when there are missing data in the data set. Obtaining the mean square error equations of the proposed estimators, we show the conditions where the proposed estimators are more efficient than the sample mean, ratio-type estimators, and the estimators in Singh and Horn (2000 Singh , S. , Horn , S. ( 2000 ). Compromised imputation in survey sampling . Metrika 51 : 267276 .[Crossref], [Web of Science ®] [Google Scholar]) and Singh and Deo (2003 Singh , S. , Deo , B. (2003). Imputation by power transformation. Statist. Pap. 44:555579.[Crossref], [Web of Science ®] [Google Scholar]) in the case of missing data. These conditions are also supported by a numerical example.  相似文献   

20.
A number of strong laws of large numbers for sequences of pairwise negative quadrant dependent (NQD) random variables have been established by using the generalized three series theorem. In this article, we obtain a strong law of large numbers by using the truncation technique and method of subsequences instead of the generalized three series theorem. Our result generalizes and improves on the corresponding one in Li and Yang (2008 Li , R. , Yang , W. ( 2008 ). Strong convergence of pairwise NQD random sequences . J. Math. Anal. Appl. 344 : 741747 .[Crossref], [Web of Science ®] [Google Scholar]). We also obtain a complete convergence result for an array of rowwise pairwise NQD random variables.  相似文献   

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