A New Estimator for Cox Proportional Hazard Regression Model in Presence of Collinearity

We propose a new approach to estimate the parameters of the Cox proportional hazards model in the presence of collinearity. Generally, a maximum partial likelihood estimator is used to estimate parameters for the Cox proportional hazards model. However, the maximum partial likelihood estimators can be seriously affected by the presence of collinearity since the parameter estimates result in large variances.

In this study, we develop a Liu-type estimator for Cox proportional hazards model parameters and compare it with a ridge regression estimator based on the scalar mean squared error (MSE). Finally, we evaluate its performance through a simulation study.     

Comments on “On the weighted mixed Liu-type estimator under unbiased stochastic restrictions”

We make some comments about the paper of Yildiz (2017 Yildiz, N. 2017. On the weighted mixed Liu-type estimator under unbiased stochastic restrictions. Communications in Statistics Simulation and Computation 46 (9):7238–48. do?:10.1080/03610918.2016.1235189.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and correct the theorems in that paper.     

A new stochastic mixed Liu estimator in linear regression model

Abstract

To overcome multicollinearity, a new stochastic mixed Liu estimator is presented and its efficiency is considered. We also compare the proposed estimators in the sense of matrix mean squared error criteria. Finally a numerical example and a simulation study are given to show the performance of the estimators.     

Partial Partial Likelihood

The maximum likelihood and maximum partial likelihood approaches to the proportional hazards model are unified. The purpose is to give a general approach to the analysis of the proportional hazards model, whether the baseline distribution is absolutely continuous, discrete, or a mixture. The advantage is that heavily tied data will be analyzed with a discrete time model, while data with no ties is analyzed with ordinary Cox regression. Data sets in between are treated by a compromise between the discrete time model and Efron's approach to tied data in survival analysis, and the transitions between modes are automatic. A simulation study is conducted comparing the proposed approach to standard methods of handling ties. A recent suggestion, that revives Breslow's approach to tied data, is finally discussed.     

On the weighted mixed Liu-type estimator under unbiased stochastic restrictions

In this article, we introduce the weighted mixed Liu-type estimator (WMLTE) based on the weighted mixed and Liu-type estimator (LTE) in linear regression model. We will also present necessary and sufficient conditions for superiority of the weighted mixed Liu-type estimator over the weighted mixed estimator (WME) and Liu type estimator (LTE) in terms of mean square error matrix (MSEM) criterion. Finally, a numerical example and a Monte Carlo simulation is also given to show the theoretical results.     

A Note on the Estimate of Treatment Effect from a Cox Regression Model When the Proportionality Assumption Is Violated

ABSTRACT

Cox proportional hazards regression model has been widely used to estimate the effect of a prognostic factor on a time-to-event outcome. In a survey of survival analyses in cancer journals, it was found that only 5% of studies using Cox proportional hazards model attempted to verify the underlying assumption. Usually an estimate of the treatment effect from fitting a Cox model was reported without validation of the proportionality assumption. It is not clear how such an estimate should be interpreted if the proportionality assumption is violated. In this article, we show that the estimate of treatment effect from a Cox regression model can be interpreted as a weighted average of the log-scaled hazard ratio over the duration of study. A hypothetic example is used to explain the weights.     

Using Liu estimator for detection of influential observations in linear measurement error models

Abstract

In this paper, we introduce Liu estimator for the vector of parameters in linear measurement error models and discuss its asymptotic properties. Based on the Liu estimator, diagnostic measures are developed to identify influential observations. Additionally, the analogs of Cook’s distance and likelihood distance are proposed to determine influential observations using case deletion approach. A parametric bootstrap procedure is used to obtain empirical distributions of the test statistics. Finally, the performance of the influence measures have been illustrated through simulation study and analyzing a real data set.     

Inference on proportional hazard rate model parameter under Type-I progressively hybrid censoring scheme

ABSTRACT

In this paper, under Type-I progressive hybrid censoring sample, we obtain maximum likelihood estimator of unknown parameter when the parent distribution belongs to proportional hazard rate family. We derive the conditional probability density function of the maximum likelihood estimator using moment-generating function technique. The exact confidence interval is obtained and compared by conducting a Monte Carlo simulation study for burr Type XII distribution. Finally, we obtain the Bayes and posterior regret gamma minimax estimates of the parameter under a precautionary loss function with precautionary index k = 2 and compare their behavior via a Monte Carlo simulation study.     

Composite Estimating Equation Method for the Accelerated Failure Time Model with Length‐biased Sampling Data

Length‐biased sampling data are often encountered in the studies of economics, industrial reliability, epidemiology, genetics and cancer screening. The complication of this type of data is due to the fact that the observed lifetimes suffer from left truncation and right censoring, where the left truncation variable has a uniform distribution. In the Cox proportional hazards model, Huang & Qin (Journal of the American Statistical Association, 107, 2012, p. 107) proposed a composite partial likelihood method which not only has the simplicity of the popular partial likelihood estimator, but also can be easily performed by the standard statistical software. The accelerated failure time model has become a useful alternative to the Cox proportional hazards model. In this paper, by using the composite partial likelihood technique, we study this model with length‐biased sampling data. The proposed method has a very simple form and is robust when the assumption that the censoring time is independent of the covariate is violated. To ease the difficulty of calculations when solving the non‐smooth estimating equation, we use a kernel smoothed estimation method (Heller; Journal of the American Statistical Association, 102, 2007, p. 552). Large sample results and a re‐sampling method for the variance estimation are discussed. Some simulation studies are conducted to compare the performance of the proposed method with other existing methods. A real data set is used for illustration.     

Case-cohort analysis with semiparametric transformation models

Semiparametric transformation models provide flexible regression models for survival analysis, including the Cox proportional hazards and the proportional odds models as special cases. We consider the application of semiparametric transformation models in case-cohort studies, where the covariate data are observed only on cases and on a subcohort randomly sampled from the full cohort. We first propose an approximate profile likelihood approach with full-cohort data, which amounts to the pseudo-partial likelihood approach of Zucker [2005. A pseudo-partial likelihood method for semiparametric survival regression with covariate errors. J. Amer. Statist. Assoc. 100, 1264–1277]. Simulation results show that our proposal is almost as efficient as the nonparametric maximum likelihood estimator. We then extend this approach to the case-cohort design, applying the Horvitz–Thompson weighting method to the estimating equations from the approximated profile likelihood. Two levels of weights can be utilized to achieve unbiasedness and to gain efficiency. The resulting estimator has a closed-form asymptotic covariance matrix, and is found in simulations to be substantially more efficient than the estimator based on martingale estimating equations. The extension to left-truncated data will be discussed. We illustrate the proposed method on data from a cardiovascular risk factor study conducted in Taiwan.     

Comparison Between Two Partial Likelihood Approaches for the Competing Risks Model with Missing Cause of Failure

In many clinical studies where time to failure is of primary interest, patients may fail or die from one of many causes where failure time can be right censored. In some circumstances, it might also be the case that patients are known to die but the cause of death information is not available for some patients. Under the assumption that cause of death is missing at random, we compare the Goetghebeur and Ryan (1995, Biometrika, 82, 821–833) partial likelihood approach with the Dewanji (1992, Biometrika, 79, 855–857)partial likelihood approach. We show that the estimator for the regression coefficients based on the Dewanji partial likelihood is not only consistent and asymptotically normal, but also semiparametric efficient. While the Goetghebeur and Ryan estimator is more robust than the Dewanji partial likelihood estimator against misspecification of proportional baseline hazards, the Dewanji partial likelihood estimator allows the probability of missing cause of failure to depend on covariate information without the need to model the missingness mechanism. Tests for proportional baseline hazards are also suggested and a robust variance estimator is derived.     

Liu estimation approach to the measurement error models

ABSTRACT

In this paper, we consider the estimation of the parameters of measurement error (ME) models when the multicollinearity exists. To remedy the problem of multicollinearity in ME models, we consider the Liu estimation approach. We define Liu and restricted Liu estimators and also examine the asymptotic properties of proposed estimators in ME models. Moreover, we conduct a Monte Carlo simulation study and a numerical example to investigate the performances of the proposed estimators by the scalar mean squared error criterion.     

LIKELIHOOD APPROXIMATIONS AND DISCRETE MODELS FOR TIED SURVIVAL DATA

ABSTRACT

Ties among event times are often recorded in survival studies. For example, in a two week laboratory study where event times are measured in days, ties are very likely to occur. The proportional hazards model might be used in this setting using an approximated partial likelihood function. This approximation works well when the number of ties is small. On the other hand, discrete regression models are suggested when the data are heavily tied. However, in many situations it is not clear which approach should be used in practice. In this work, empirical guidelines based on Monte Carlo simulations are provided. These recommendations are based on a measure of the amount of tied data present and the mean square error. An example illustrates the proposed criterion.     

On the restricted almost unbiased Liu estimator in the logistic regression model

It is known that when the multicollinearity exists in the logistic regression model, variance of maximum likelihood estimator is unstable. As a remedy, in the context of biased shrinkage Liu estimation, Chang introduced an almost unbiased Liu estimator in the logistic regression model. Making use of his approach, when some prior knowledge in the form of linear restrictions are also available, we introduce a restricted almost unbiased Liu estimator in the logistic regression model. Statistical properties of this newly defined estimator are derived and some comparison results are also provided in the form of theorems. A Monte Carlo simulation study along with a real data example are given to investigate the performance of this estimator.     

Deficiency of the mle of a smooth survival function under the proportional hazard model

The problem of estimating a smooth distribution function F at a point t is treated under the proportional hazard model of random censorship. It is shown that a certain class of properly chosen kernel type estimator of F asymptotically perform better than the maximum likelihood estimator. It is shown that the relative deficiency of the maximum likelihood estimator of F under the proportional hazard model with respect to the properly chosen kernel type estimator tends to infinity as the sample size tends to infinity.     

Penalized Empirical Likelihood via Bridge Estimator in Cox's Proportional Hazard Model

We propose the penalized empirical likelihood method via bridge estimator in Cox's proportional hazard model for parameter estimation and variable selection. Under reasonable conditions, we show that penalized empirical likelihood in Cox's proportional hazard model has oracle property. A penalized empirical likelihood ratio for the vector of regression coefficients is defined and its limiting distribution is a chi-square distributions. The advantage of penalized empirical likelihood as a nonparametric likelihood approach is illustrated in testing hypothesis and constructing confidence sets. The method is illustrated by extensive simulation studies and a real example.     

Maximum likelihood estimation in the proportional hazards model of random censorship

The maximum likelihood estimator (MLE) for the survival function S_Tunder the proportional hazards model of censorship is derived and shown to differ from the Abdushukurov-Cheng-Lin estimator when the class of allowable distributions includes all continuous and discrete distributions. The estimators are compared via an example. The MLE is calculated using a Newton-Raphson iterative procedure and implemented via a FORTRAN algorithm.     

Improvement of the Liu estimator in linear regression model

In the presence of stochastic prior information, in addition to the sample, Theil and Goldberger (1961) introduced a Mixed Estimator for the parameter vector β in the standard multiple linear regression model (T,Xβ,σ² I). Recently, the Liu estimator which is an alternative biased estimator for β has been proposed by Liu (1993). In this paper we introduce another new Liu type biased estimator called Stochastic restricted Liu estimator for β, and discuss its efficiency. The necessary and sufficient conditions for mean squared error matrix of the Stochastic restricted Liu estimator to exceed the mean squared error matrix of the mixed estimator will be derived for the two cases in which the parametric restrictions are correct and are not correct. In particular we show that this new biased estimator is superior in the mean squared error matrix sense to both the Mixed estimator and to the biased estimator introduced by Liu (1993).     

Statistical inference for generalized case-cohort design under the proportional hazards model with parameter constraints

ABSTRACT

The generalized case-cohort design is widely used in large cohort studies to reduce the cost and improve the efficiency. Taking prior information of parameters into consideration in modeling process can further raise the inference efficiency. In this paper, we consider fitting proportional hazards model with constraints for generalized case-cohort studies. We establish a working likelihood function for the estimation of model parameters. The asymptotic properties of the proposed estimator are derived via the Karush-Kuhn-Tucker conditions, and their finite properties are assessed by simulation studies. A modified minorization-maximization algorithm is developed for the numerical calculation of the constrained estimator. An application to a Wilms tumor study demonstrates the utility of the proposed method in practice.