A Double Multivariate Exponentially Weighted Moving Average (dMEWMA) Control Chart for a Process Location Monitoring

A new control scheme, dMEWMA, for detecting shifts in the mean vector of multivariately normally distributed quality characteristics is presented. It is shown that the ARL performance of dMEWMA depends on the mean and variance-covariance matricies only through the non-centrality parameter value. Through Monte Carlo simulations, the performance of dMEWMA for detecting various shifts is compared to the competing control schemes, MEWMA and Hotelling's χ². It is concluded that dMEWMA outperforms MEWMA and Hotelling's χ² control schemes for small and larger shifts. In comparison to MEWMA control schemes, dMEWMA schemes are optimal for larger values of the smoothing parameter λ and perform much better for very small shifts in the process mean. Finally, an example to illustrate the construction of the dMEWMA control scheme is introduced.     

Optimal Variable Sample Size and Sampling Interval MSE Chart Based on Improved Square Root Transformation

In the field of statistical process control (SPC), control charts for attributes are widely used to detect the out-of-control condition by checking the number of nondefective units or nondefective in a sample. In this article, we use the average time to signal (ATS) and the average number of observations to signal (ANOS) to evaluate the performance of the optimal variable sample size and sampling interval (VSSI) improved square root transformation (ISRT) mean square error (MSE) (VSSI_ ISRT_ MSE) control chart for attribute data. In addition, this control chart will be used to monitor: (1) the difference between the process mean and the target value, and (2) the process variance shifts. We found that the optimal VSSI_ ISRT_ MSE chart performs better than the specific VSSI, the optimal variable sampling interval (VSI), and the fixed parameters (FP) ISRT_MSE charts. An example is given to illustrate this new proposed approach.     

A minimum asymptotic mean squared error controller for an IMA(1,1) noise process with a starting offset, and its resetting design

In a discrete-part manufacturing process, the noise is often described by an IMA(1,1) process and the pure unit delay transfer function is used as the feedback controller to adjust it. The optimal controller for this process is the well-known minimum mean square error (MMSE) controller. The starting level of the IMA(1,1) model is assumed to be on target when it starts. Considering such an impractical assumption, we adopt the starting offset. Since the starting offset is not observable, the MMSE controller does not exist. An alternative to the MMSE controller is the minimum asymptotic mean square error controller, which makes the long-run mean square error minimum.Another concern in this article is the un-stability of the controller, which may produce high adjustment costs and/or may exceed the physical bounds of the process adjustment. These practical barriers will prevent the controller to adjust the process properly. To avoid this dilemma, a resetting design is proposed. That is, the resetting procedure in use of the controller is to adjust the process according to the controller when it remains within the reset limit, and to reset the process, otherwise.The total cost for the manufacturing process is affected by the off-target cost, the adjustment cost, and the reset cost. Proper values for the reset limit are selected to minimize the average cost per reset interval (ACR) considering various process parameters and cost parameters. A time non-homogeneous Markov chain approach is used for calculating the ACR. The effect of adopting the starting offset is also studied here.     

Determining the Optimum Process Mean of a One-sided Specification Limit with the Linear Quality Loss Function of Product

Wen & Mergen (1999) proposed a method for setting the optimal process mean when a process was not capable of meeting specifications in the short term. However, they neglected to consider the quality loss for a product within specifications in the model. Chen & Chou (2002) presented a modified Wen & Mergen's (1999) model, including the quadratic quality loss function for a one-sided specification limit. In this paper, we propose the modified Wen & Mergen (1999) cost model including the linear quality loss function of a product for determining the optimal process mean of a one-sided specification limit.     

Optimal design of the adaptive exponentially weighted moving average control chart over a range of mean shifts

The adaptive exponentially weighted moving average (AEWMA) control chart is a smooth combination of the Shewhart and exponentially weighted moving average (EWMA) control charts. This chart was proposed by Cappizzi and Masarotto (2003) to achieve a reasonable performance for both small and large shifts. Cappizzi and Masarotto (2003) used a pair of shifts in designing their control chart. In this study, however, the process mean shift is considered as a random variable with a certain probability distribution and the AEWMA control chart is optimized for a wide range of mean shifts according to that probability distribution and not just for a pair of shifts. Using the Markov chain technique, the results show that the new optimization design can improve the performance of the AEWMA control chart from an overall point of view relative to the various designs presented by Cappizzi and Masarotto (2003). Optimal design parameters that achieve the desired in-control average run length (ARL) are computed in several cases and formulas used to find approximately their values are given. Using these formulas, the practitioner can compute the optimal design parameters corresponding to any desired in-control ARL without the need to apply the optimization procedure. The results obtained by these formulas are very promising and would particularly facilitate the design of the AEWMA control chart for any in-control ARL value.     

Improved simultaneous intervals for linear combinations of parameters from generalized linear models

When employing generalized linear models, interest often focuses on estimation of odds ratios or relative risks. Additionally, researchers often make overall conclusions, requiring accurate estimation of a set of these quantities. Consequently, simultaneous estimation is warranted. Current simultaneous estimation methods only perform well in this setting when there are a very small number of comparisons and/or the sample size is relatively large. Additionally, the estimated quantities can have significant bias especially at small sample sizes. The proposed bounds: (1) perform well for a small or large number of comparisons, (2) exhibit improved performance over current methods for small to moderate sample sizes, (3) provide bias adjustment not reliant on asymptotics, and (4) avoid the infinite parameter estimates that can occur with maximum-likelihood estimators. Simulations demonstrate that the proposed bounds achieve the desired level of confidence at smaller sample sizes than previous methods.     

Monitoring exponential data using two-sided control charts with runs rules

In this article, new two-sided control charts with runs rules, suitable for the monitoring of exponential data, are proposed and studied. The proposed schemes are suitable to identify changes (upward or downward) in the mean of an exponential distribution. Also, they have the desired in-control performance as well as unbiased performance. Guidelines for the most effective scheme in practice are provided, along with comparisons with other competitive schemes. Finally, the practical application of the proposed schemes is also discussed.     

OPTIMAL CONTROL OF A DETERIORATING PRODUCTION PROCESS

We study the optimal control of a production process subject to a deterministicdrift and to random shocks. The process mean is observable at discrete points of time after producing a batch and, at each such point, a decision is made whether to reset the process mean to some initial value or to continue with the production. The objective is to find the initial setting of the process mean and the resetting time that minimizes the expected average cost per unit time. It is shown that the optimal control policy is of a control limit type. An algorithm for finding the optimal control parameters is presented.     

A plug-in the number of knots selector for polynomial spline regression

A plug-in the number of interior knots (NIKs) selector is proposed for polynomial spline estimation in nonparametric regression. The existence and properties of the optimal NIKs for spline regression are established by minimising the weighted mean integrated squared error. We obtain plug-in formulae for the optimal NIKs based on the theoretical results of asymptotic optimality, and develop strategies for choosing the NIKs of the spline estimator. The proposed NIKs selection method is tested on our simulated data with quite satisfactory performance, and is illustrated by analysing a fossil data set.     

A mixed control chart for monitoring failure times under accelerated hybrid censoring

In an accelerated hybrid censoring scheme several stress factors can be accelerated to make the products to respond to fail more quickly than under normal operating conditions. In such situations, the control charts available in the literature cover the attribute characteristics only to monitor the performance of the process over time. This study extends the idea by proposing an optimal mixed attribute-variable control chart for Weibull distribution under an accelerated hybrid censoring scheme keeping the advantages of both attribute and variable control charts. It first monitors the number of defectives under accelerated conditions and switches to the variable control chart to investigate the mean failure times when the process stability is dubious. The performance of the proposed chart is evaluated by using run-length characteristics, and the optimality of the design parameter is achieved by minimizing the out-of-control average run length. The simulation study depicted better performance of the proposed control chart than the traditional charts in detecting shifts in the process. A real-life application is also included.KEYWORDS: Mixed control chart, attribute chart, variable chart, Weibull distribution, accelerated hybrid censoring     

Using a Single Average Loss Control Chart to Monitor Process Mean and Variability

A single chart, instead of X-bar and R charts or X-bar and S charts, to monitor simultaneously the process mean and the variability if found would cut down the time and effort. Some researches have been done in finding such charts. In reality, process target is more important than process mean. A much easier average loss chart is first proposed here to detect the increases in the difference of the process mean and the target and the variability simultaneously. An example of the customer complaint processing time of the customer service center of an IT company shows the application and the performance of the proposed average loss control chart. Furthermore, a more efficient optimal average loss chart with variable sampling intervals is proposed and performs better than the average loss chart with fixed sampling intervals and the Shewhart joint X-bar and S charts. Some numerical analyses demonstrated the findings.     

A Mixed Model-assisted Regression Estimator that Uses Variables Employed at the Design Stage

The Generalized regression estimator (GREG) of a finite population mean or total has been shown to be asymptotically optimal when the working linear regression model upon which it is based includes variables related to the sampling design. In this paper a regression estimator assisted by a linear mixed superpopulation model is proposed. It accounts for the extra information coming from the design in the random component of the model and saves degrees of freedom in finite sample estimation. This procedure combines the larger asymptotic efficiency of the optimal estimator and the greater finite sample stability of the GREG. Design based properties of the proposed estimator are discussed and a small simulation study is conducted to explore its finite sample performance.     

A EWMA control chart based on an auxiliary variable and repetitive sampling for monitoring process location

ABSTRACT

This article develops an exponentially weighted moving average (EWMA) control chart using an auxiliary variable and repetitive sampling for efficient detection of small to moderate shifts in location. A EWMA statistic of a product estimator of the average (which utilities the information of auxiliary variables as well as repetitive sampling) is plotted on the proposed chart. The control chart coefficients of the proposed EWMA chart are determined for two strategic limits known as outer and inner control limits for the target in-control average run length. The performance of the proposed EWMA chart is studied using average run length when a shift occurs in the process average. The efficiency of the developed chart is compared with the competitive existing control charts. The results of the study revealed that proposed EWMA chart is more efficient than others to detect small changes in process mean.     

Most stable sample size determination in clinical trials

This paper is devoted to robust Bayes sample size determination under the quadratic loss function. The idea behind the proposed approach is that the smaller a chosen posterior functional, the more robust the posterior inference. Such desired posterior functional has been taken, in the literature, as the range of posterior mean over a class of priors but we show that dealing with the posterior mean is not the only method leading to an optimal sample size. To provide an alternative approach, we propose implementing most stable rules into the context of sample size determination. We discuss properties of the desired most stable estimate and provide some examples in the normal model. We then compare the proposed approach with that of a recent global robustness study from both numerical and theoretical aspects. We illustrate the practical utility of our proposed method by analyzing a real data set.     

An efficient algorithm for constructing optimal design of computer experiments

The long computational time required in constructing optimal designs for computer experiments has limited their uses in practice. In this paper, a new algorithm for constructing optimal experimental designs is developed. There are two major developments involved in this work. One is on developing an efficient global optimal search algorithm, named as enhanced stochastic evolutionary (ESE) algorithm. The other is on developing efficient methods for evaluating optimality criteria. The proposed algorithm is compared to existing techniques and found to be much more efficient in terms of the computation time, the number of exchanges needed for generating new designs, and the achieved optimality criteria. The algorithm is also very flexible to construct various classes of optimal designs to retain certain desired structural properties.     

Weighted Estimating Equations for Linear Regression Analysis of Clustered Failure Time Data

Estimation of regression parameters in linear survival models is considered in the clustered data setting. One step updates from an initial consistent estimator are proposed. The updates are based on scores that are functions of ranks of the residuals, and that incorporate weight matrices to improve efficiency. Optimal weights are approximated as the solution to a quadratic programming problem, and asymptotic relative efficiencies to various other weights computed. Except under strong dependence, simpler methods are found to be nearly as efficient as the optimal weights. The performance of several practical estimators based on exchangeable and independence working models is explored in simulations.     

Ewma control chart under linear drift

An accurate numerical procedure is presented for computing the average run length (ARL) of an exponentially weighted moving average (EWMA) chart under a linear drift in the process mean. The performance of an EWMA chart is then evaluated under a linear drift in the mean. In processes where gradual linear drifts rather than abrupt changes in the mean model the shifts in the mean more accurately, an evaluation of the performance of an EWMA chart under a linear drift is more appropriate. Tables of optimal smoothing parameters and control chart limits are given which make the design of EWMA charts easy.     

A pragmatic adaptive enrichment design for selecting the right target population for cancer immunotherapies

One of the challenges in the design of confirmatory trials is to deal with uncertainties regarding the optimal target population for a novel drug. Adaptive enrichment designs (AED) which allow for a data-driven selection of one or more prespecified biomarker subpopulations at an interim analysis have been proposed in this setting but practical case studies of AEDs are still relatively rare. We present the design of an AED with a binary endpoint in the highly dynamic setting of cancer immunotherapy. The trial was initiated as a conventional trial in early triple-negative breast cancer but amended to an AED based on emerging data external to the trial suggesting that PD-L1 status could be a predictive biomarker. Operating characteristics are discussed including the concept of a minimal detectable difference, that is, the smallest observed treatment effect that would lead to a statistically significant result in at least one of the target populations at the interim or the final analysis, respectively, in the setting of AED.     

New bivariate gamma types with MIMO application

In this paper a bivariate gamma type distribution emanating from the diagonal elements of an inverse Wishart type distribution is developed; which in turn originates from the complex matrix variate elliptical class. From this, a bivariate Weibullised gamma type distribution is also presented, of which the bivariate Nakagami-m type is a special case. The derived results may be applied as decision statistics for a MIMO (multiple input multiple output) system with two transmit antennas. It is proposed that under this elliptical umbrella some performance measures such as the outage probability of MIMO systems can be analyzed in broad generality.     

Multivariate Change Point Control Chart Based on Data Depth for Phase I Analysis

A multivariate change point control chart based on data depth (CPDP) is considered for detecting shifts in either the mean vector, the covariance matrix, or both of the processes for Phase I. The proposed chart is preferable from a robustness point of view, has attractive detection performance, and can be especially useful in Phase I analysis setting, where there is limited information about the underlying process. Comparison results and an illustrative example show that our CPDP chart has great potential for Phase I analysis of multivariate individual observations. The application of CPDP chart is illustrated in a real data example.