Simultaneous Inferences on the Cumulative Distribution Function of a Normal Distribution

This paper addresses the problem of constructing simultaneous confidence intervals for the cumulative distribution function of a normal distribution at several specified points. The procedure is based upon the observation of a random sample of independent observations from a normal distribution with an unknown mean and variance. A new methodology is proposed for obtaining confidence intervals with a specified overall simultaneous confidence level through the inversion of acceptance sets. Both one-sided and two-sided confidence intervals are considered. Some illustrations of the new method are provided, and comparisons are made with other approaches to the problem.     

Multiple comparisons with a control for exponential location parameters under heteroscedasticity

In this paper, a new design-oriented two-stage two-sided simultaneous confidence intervals, for comparing several exponential populations with control population in terms of location parameters under heteroscedasticity, are proposed. If there is a prior information that the location parameter of k exponential populations are not less than the location parameter of control population, one-sided simultaneous confidence intervals provide more inferential sensitivity than two-sided simultaneous confidence intervals. But the two-sided simultaneous confidence intervals have advantages over the one-sided simultaneous confidence intervals as they provide both lower and upper bounds for the parameters of interest. The proposed design-oriented two-stage two-sided simultaneous confidence intervals provide the benefits of both the two-stage one-sided and two-sided simultaneous confidence intervals. When the additional sample at the second stage may not be available due to the experimental budget shortage or other factors in an experiment, one-stage two-sided confidence intervals are proposed, which combine the advantages of one-stage one-sided and two-sided simultaneous confidence intervals. The critical constants are obtained using the techniques given in Lam [9,10]. These critical constant are compared with the critical constants obtained by Bonferroni inequality techniques and found that critical constant obtained by Lam [9,10] are less conservative than critical constants computed from the Bonferroni inequality technique. Implementation of the proposed simultaneous confidence intervals is demonstrated by a numerical example.     

Simultaneous Small Sample Inference for Linear Combinations of Generalized Linear Model Parameters

A method is proposed to construct simultaneous confidence intervals for multiple linear combinations of generalized linear model parameters, that uses a multivariate normal- or t-distribution together with the signed likelihood root statistic. In an application to a case study simultaneous confidence bands for logistic regression are calculated. A simulation study based on the example evaluation suggests superior performance compared to the common Wald-type approaches. The proposed methods are readily implemented in the R extension package mcprofile.     

Simultaneous Confidence Intervals for the Population Cell Means,for Two-by-Two Factorial Data,that Utilize Uncertain Prior Information

Consider a two-by-two factorial experiment with more than one replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the four population cell means, with simultaneous confidence coefficient 1 ? α, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukey’s method, with simultaneous confidence coefficient 1 ? α, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.     

Tolerance intervals for symmetric location-scale families based on uncensored or censored samples

Exact methods for constructing two-sided tolerance intervals (TIs) and tolerance intervals that control percentages in both tails for a location-scale family of distributions are proposed. The proposed methods are illustrated by constructing TIs for a normal, logistic, and Laplace (double exponential) distributions based on type II singly censored samples. Factors for constructing one-sided and two-sided TIs for a logistic distribution are tabulated for the case of uncensored samples. Factors for constructing TIs based on censored samples for all three distributions are also tabulated. The factors for all cases are estimated by Monte Carlo simulation. An adjustment to the tolerance factors based on type II censored samples is proposed so that they can be used to find approximate TIs based on type I censored samples. Coverage studies of the approximate TIs based on type I censored samples indicate that the approximation is satisfactory as long as the proportion of censored observations is no more than 0.70. The methods are illustrated using some practical examples.     

Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout

A bootstrap based method to construct 1−α simultaneous confidence intervals for relative effects in the one-way layout is presented. This procedure takes the stochastic correlation between the test statistics into account and results in narrower simultaneous confidence intervals than the application of the Bonferroni correction. Instead of using the bootstrap distribution of a maximum statistic, the coverage of the confidence intervals for the individual comparisons are adjusted iteratively until the overall confidence level is reached. Empirical coverage and power estimates of the introduced procedure for many-to-one comparisons are presented and compared with asymptotic procedures based on the multivariate normal distribution.     

DISTRIBUTION FREE MULTIPLE COMPARISONS FOR MONOTONICALLY ORDERED TREATMENT EFFECTS

A method of calculating simultaneous one-sided confidence intervals for all ordered pairwise differences of the treatment effects_j–_i, 1 i < j k, in a one-way model without any distributional assumptions is discussed. When it is known a priori that the treatment effects satisfy the simple ordering_1k, these simultaneous confidence intervals offer the experimenter a simple way of determining which treatment effects may be declared to be unequal, and is more powerful than the usual two-sided Steel-Dwass procedure. Some exact critical points required by the confidence intervals are presented for k= 3 and small sample sizes, and other methods of critical point determination such as asymptotic approximation and simulation are discussed.     

Confidence bands for the laplace distribution

Based on a random sample from the Laplace population with unknown shape and scale parameters, one- and two-sided confidence bands on the entire cumulative distribution function and simultaneous confidence intervals for the interval probabilities under the distribution are constructed using Kolmogorov–Smirnov type statistics. Small sample and asymptotic percentiles of the relevant statistics are provided.     

A Graphical Representation for Non-Parametric Inference

A method is described for determining the sample size required for a specified precision simultaneous confidence statement about the parameters of a multinomial population. The method is based on a simultaneous confidence interval procedure due to Goodman, and the results are compared with those obtained by separately considering each cell of the multinomial population as a binomial.     

Relative Potency Estimation in Parallel-Line Assays – Method Comparison and Some Extensions

Relative potency estimations in both multiple parallel-line and slope-ratio assays involve construction of simultaneous confidence intervals for ratios of linear combinations of general linear model parameters. The key problem here is that of determining multiplicity adjusted percentage points of a multivariate t-distribution, the correlation matrix R of which depends on the unknown relative potency parameters. Several methods have been proposed in the literature on how to deal with R . In this article, we introduce a method based on an estimate of R (also called the plug-in approach) and compare it with various methods including conservative procedures based on probability inequalities. Attention is restricted to parallel-line assays though the theory is applicable for any ratios of coefficients in the general linear model. Extension of the plug-in method to linear mixed effect models is also discussed. The methods will be compared with respect to their simultaneous coverage probabilities via Monte Carlo simulations. We also evaluate the methods in terms of confidence interval width through application to data on multiple parallel-line assay.     

Distribution‐free statistical intervals via ranked‐set sampling

The author shows how to construct distribution‐free statistical intervals from ranked‐set sampling. He considers the cases of confidence, tolerance, and prediction intervals. He shows how to compute their coverage probabilities and he compares their performance to that of intervals based on simple random sampling. He finds that the ranked‐set sampling‐based intervals are at least as good as their classical counterpart in most settings of interest, although the nature of the advantage depends on the type of interval considered.     

Simultaneous tolerance intervals in the random one-way model with covariates

Simultaneous tolerance intervals developed by Limam and Thomas (19881, for the normal regression model, are generalized to the random one-way model with covariates. Simultaneous tolerance intervals for unit means are developed for the balanced model. A simulation study is used to estimate the exact confidence of the tolerance intervals for models with one covariate.     

On Ranges of Confidence Coefficients for Confidence Intervals on Variance Components

The among variance component in the balanced one-factor nested components-of-variance model is of interest in many fields of application. Except for an artificial method that uses a set of random numbers which is of no use in practical situations, an exact-size confidence interval on the among variance has not yet been derived. This paper provides a detailed comparison of three approximate confidence intervals which possess certain desired properties and have been shown to be the better methods among many available approximate procedures. Specifically, the minimum and the maximum of the confidence coefficients for the one- and two-sided intervals of each method are obtained. The expected lengths of the intervals are also compared.     

Low dose risk estimation via simultaneous statistical inferences

Summary.  The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose.     

Percentile bounds and tolerance limits for the birnbaum-saunders distribution

In this paper, a confidence interval for the lOOpth percentile of the Birnbaum-Saunders distribution is constructed. Conservative two-sided tolerance limits are then obtained from the confidence limits. These results are useful for reliability evaluation when using the Birnbaum-Saunders model. A simple scheme for generating Birnbaum-Saunders random variates is derived. This is used for a simulation study on investigating the effectiveness of the proposed confidence interval in terms of its coverage probability.     

Simultaneous inferences for ordered exponential location parameters under unbalanced data and heteroscedasticity of scale parameters

A test procedure for testing homogeneity of location parameters against simple ordered alternative is proposed for k(k ≥ 2) members of two parameter exponential distribution under unbalanced data and heteroscedasticity of the scale parameters. The relevant one-sided and two-sided simultaneous confidence intervals (SCIs) for all k(k ? 1)/2 ordered pairwise differences of location parameters are also proposed. Simulation-based study revealed that the proposed procedure is better than the recently proposed procedure in terms of power, coverage probability, and average volume of SCIs. The implementation of proposed procedure is demonstrated through real life data.     

A Monte Carlo simulation study of two-sided tolerance intervals in balanced one-way random effects model for non-normal errors

Recently, Ong and Mukerjee [Probability matching priors for two-sided tolerance intervals in balanced one-way and two-way nested random effects models. Statistics. 2011;45:403–411] developed two-sided Bayesian tolerance intervals, with approximate frequentist validity, for a future observation in balanced one-way and two-way nested random effects models. These were obtained using probability matching priors (PMP). On the other hand, Krishnamoorthy and Lian [Closed-form approximate tolerance intervals for some general linear models and comparison studies. J Stat Comput Simul. 2012;82:547–563] studied closed-form approximate tolerance intervals by the modified large-sample (MLS) approach. We compare the performances of these two approaches for normal as well as non-normal error distributions. Monte Carlo simulation methods are used to evaluate the resulting tolerance intervals with regard to achieved confidence levels and expected widths. It turns out that PMP tolerance intervals are less conservative for data with large number of classes and small number of observations per class and the MLS procedure is preferable for smaller sample sizes.     

A revision of the tukey multiple comparisons procedure to control the probability of committing at most one type i error

Halperin et al. (1988) suggested an approach which allows for k Type I errors while using Scheffe's method of multiple comparisons for linear combinations of p means. In this paper we apply the same type of error control to Tukey's method of multiple pairwise comparisons. In fact, the variant of the Tukey (1953) approach discussed here defines the error control objective as assuring with a specified probability that at most one out of the p(p-l)/2 comparisons between all pairs of the treatment means is significant in two-sided tests when an overall null hypothesis (all p means are equal) is true or, from a confidence interval point of view, that at most one of a set of simultaneous confidence intervals for all of the pairwise differences of the treatment means is incorrect. The formulae which yield the critical values needed to carry out this new procedure are derived and the critical values are tabulated. A Monte Carlo study was conducted and several tables are presented to demonstrate the experimentwise Type I error rates and the gains in power furnished by the proposed procedure     

On simultaneous confidence intervals based on rank-estimates with application to analysis of gene expression data

Abstract

Inferential methods based on ranks present robust and powerful alternative methodology for testing and estimation. In this article, two objectives are followed. First, develop a general method of simultaneous confidence intervals based on the rank estimates of the parameters of a general linear model and derive the asymptotic distribution of the pivotal quantity. Second, extend the method to high dimensional data such as gene expression data for which the usual large sample approximation does not apply. It is common in practice to use the asymptotic distribution to make inference for small samples. The empirical investigation in this article shows that for methods based on the rank-estimates, this approach does not produce a viable inference and should be avoided. A method based on the bootstrap is outlined and it is shown to provide a reliable and accurate method of constructing simultaneous confidence intervals based on rank estimates. In particular it is shown that commonly applied methods of normal or t-approximation are not satisfactory, particularly for large-scale inferences. Methods based on ranks are uniquely suitable for analysis of microarray gene expression data since they often involve large scale inferences based on small samples containing a large number of outliers and violate the assumption of normality. A real microarray data is analyzed using the rank-estimate simultaneous confidence intervals. Viability of the proposed method is assessed through a Monte Carlo simulation study under varied assumptions.     

Smallest confidence intervals for one binomial proportion

We specify three classes of one-sided and two-sided $1-\alpha$ confidence intervals with certain monotonicity and symmetry on the confidence limits for the probability of success, the parameter in a binomial distribution. For each class of one-sided confidence intervals the smallest interval, in the sense of the set inclusion, is obtained based on the direct analysis of coverage probability functions. A simple sufficient and necessary condition for the existence of the smallest two-sided confidence interval is provided and the smallest interval is derived if it exists. Thus the proposed intervals are uniformly most accurate, and have the uniformly minimum expected length as well.