Some Remarks on Testing Overdispersion in Zero-Inflated Poisson and Binomial Regression Models

This note extends the score test statistics for overdispersion in Poisson and binomial regression models (Dean, 1992 Dean , C. B. ( 1992 ). Testing for overdispersion in Poisson and binomial regression models . J. Amer. Statist. Assoc. 87 : 451 – 457 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) to the zero-inflated models. Some general results are obtained, and examples illustrate the application of the extended results.     

Bayesian Capture-Recapture Analysis: An Application in Modeling Semelparity of a Neotropical Didelphid Marsupial

We develop a series of Bayesian statistical models for estimating survival of a neotropic didelphid marsupial, the Brazilian gracile mouse opossum (Gracilinanus microtarsus). These models are based on the Cormack–Jolly–Seber model (Cormack, 1964 Cormack , R. M. ( 1964 ). Estimates of survival from the sighting of marked animals . Biometrika 51 : 429 – 438 .[Crossref], [Web of Science ®] , [Google Scholar]; Jolly 1965 Jolly , G. M. ( 1965 ). Explicit estimates from capture-recapture data with both death and immigration stochastic model . Biometrika 52 : 225 – 247 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Seber 1965 Seber , G. A. F. ( 1965 ). A note on the multiple recapture census . Biometrika 52 : 249 – 259 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) with both survival and recapture rates expressed as a function of covariates using a logit link. The proposed models allow taking into account heterogeneity in capture probability caused by the existence of different groups of individuals in the population. The models were applied to two cohorts (Cohort, 2000, 2001) with the first one including 14 and the second one 15 sampling occasions. The best models for each of the cohorts indicate that G. microtarsus is best described as partially semelparous, a condition in which mortality after the first mating is high but graded over time, with a fraction of males surviving for a second breeding season (Boonstra, 2005 Boonstra , R. ( 2005 ). Equipped for life: the adaptive role of the stress axis in male mammals . Journal of Mammalogy 86 : 236 – 247 .[Crossref], [Web of Science ®] , [Google Scholar]).     

On Testing Sample Selection Bias Under the Multicollinearity Problem

ABSTRACT

This paper reviews and extends the literature on the finite sample behavior of tests for sample selection bias. Monte Carlo results show that, when the “multicollinearity problem” identified by Nawata (1993 Nawata , K. ( 1993 ). A note on the estimation of models with sample-selection biases . Economics Letters 42 : 15 – 24 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) is severe, (i) the t-test based on the Heckman–Greene variance estimator can be unreliable, (ii) the Likelihood Ratio test remains powerful, and (iii) nonnormality can be interpreted as severe sample selection bias by Maximum Likelihood methods, leading to negative Wald statistics. We also confirm previous findings (Leung and Yu, 1996 Leung , S. F. , Yu , S. ( 1996 ). On the choice between sample selection and two-part models . Journal of Econometrics 72 : 197 – 229 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) that the standard regression-based t-test (Heckman, 1979 Heckman , J. J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153 – 161 . [CSA] [Crossref], [Web of Science ®] , [Google Scholar]) and the asymptotically efficient Lagrange Multiplier test (Melino, 1982 Melino , A. ( 1982 ). Testing for sample selection bias . Review of Economic Studies 49 : 151 – 153 . [CSA] [Crossref], [Web of Science ®] , [Google Scholar]), are robust to nonnormality but have very little power.     

Hazards Regression for Cancer Studies

The complication in analyzing tumor data is that the tumors detected in a screening program tend to be slowly progressive tumors, which is the so-called length-biased sampling that is inherent in screening studies. Under the assumption that all subjects have the same tumor growth function, Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) developed estimation procedures for proportional hazards model. In this article, by modeling growth function as a function of covariates, we demonstrate that Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])'s approach can be extended to the case when each subject has a specific growth function. A simulation study is conducted to demonstrate the potential usefulness of the proposed estimators for the regression parameters in the proportional and additive hazards model.     

The Performance of Panel Cointegration Methods: Results from a Large Scale Simulation Study

This article presents results concerning the performance of both single equation and system panel cointegration tests and estimators. The study considers the tests developed in Pedroni (1999 Pedroni , P. ( 1999 ). Critical values for cointegration tests in heterogeneous panels with multiple regressors . Oxford Bulletin of Economics and Statistics 61 : 653 – 670 .[Crossref], [Web of Science ®] , [Google Scholar], 2004 Pedroni , P. ( 2004 ). Panel cointegration. Asymptotic and finite sample properties of pooled time series tests with an application to the PPP hypothesis . Econometric Theory 20 : 597 – 625 .[Crossref], [Web of Science ®] , [Google Scholar]), Westerlund (2005 Westerlund , J. ( 2005 ). New simple tests for panel cointegration . Econometric Reviews 24 : 297 – 316 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Larsson et al. (2001 Larsson , R. , Lyhagen , J. , Löthgren , M. ( 2001 ). Likelihood-based cointegration tests in heterogeneous panels . Econometrics Journal 4 : 109 – 142 .[Crossref] , [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151 – 173 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and the estimators developed in Phillips and Moon (1999 Phillips , P. C. B. , Moon , H. R. ( 1999 ). Linear regression limit theory for nonstationary panel data . Econometrica 67 : 1057 – 1111 .[Crossref], [Web of Science ®] , [Google Scholar]), Pedroni (2000 Pedroni , P. ( 2000 ). Fully modified OLS for heterogeneous cointegrated panels . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 93 – 130 .[Crossref] , [Google Scholar]), Kao and Chiang (2000 Kao , C. , Chiang , M.-H. ( 2000 ). On the estimation and inference of a cointegrated regression in panel data . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 179 – 222 .[Crossref] , [Google Scholar]), Mark and Sul (2003 Mark , N. C. , Sul , D. ( 2003 ). Cointegration vector estimation by panel dynamic OLS and long-run money demand . Oxford Bulletin of Economics and Statistics 65 : 655 – 680 .[Crossref], [Web of Science ®] , [Google Scholar]), Pedroni (2001 Pedroni , P. ( 2001 ). Purchasing power parity tests in cointegrated panels . Review of Economics and Statistics 83 : 1371 – 1375 . [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151 – 173 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). We study the impact of stable autoregressive roots approaching the unit circle, of I(2) components, of short-run cross-sectional correlation and of cross-unit cointegration on the performance of the tests and estimators. The data are simulated from three-dimensional individual specific VAR systems with cointegrating ranks varying from zero to two for fourteen different panel dimensions. The usual specifications of deterministic components are considered.     

A Broad Class of Partially Specified Autoregressions on Multi-Casting Data

Extending the bifurcating autoregressive (BAR) process (cf. Cowan and Staudte, 1986 Cowan , R. , Staudte , R. G. ( 1986 ). The bifurcating autoregression model in cell lineage studies . Biometrics 42 : 769 – 783 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) to multi-casting (multi-splitting) data, Hwang and Choi (2009 Hwang , S. Y. , Choi , M. S. ( 2009 ). Modeling and large sample estimation for multi-casting autoregression . Statist. Prob. Lett. 79 : 1943 – 1950 .[Crossref], [Web of Science ®] , [Google Scholar]) introduced multi-casting autoregression (MCAR, for short) defined on multi-casting tree structured data. This article is concerned with the case when the MCAR model is partially specified only through conditional mean and variance without directly imposing autoregressive (AR) structure. The resulting class of models will be referred to as P-MCAR (partially specified MCAR). The P-MCAR considerably enlarges the class of multi-casting models including (as special cases) MCAR, random coefficient MCAR, conditionally heteroscedastic multi-casting models and binomial-thinning processes. Moment structures for this broad P-MCAR class are investigated. Least squares (LS) estimation method is discussed and asymptotic relative efficiency (ARE) of the generalized-LS over ordinary-LS is obtained in a closed form. A simulation study is conducted to illustrate results.     

Nonparametric Estimation and Hypothesis Testing on the Partial Area Under Receiver Operating Characteristic Curves

ABSTRACT

The area under a receiver operating characteristic curve is a useful index of the accuracy of a diagnostic test. When the diagnostic ability of a new biomarker is of interest only in a certain range of specificity, the partial area under the curve becomes desirable. In this article, we extend Bamber's (1975 Bamber , D. ( 1975 ). The area above the ordinal dominance graph and the area below the receiver operating characteristics graph. J. Math. Psychol. 12 : 387 – 415 . [CSA] [Crossref], [Web of Science ®] , [Google Scholar]) results and show that the partial area under a receiver operating characteristic curve is the probability of a constrained stochastic ordering. We then construct a ‘weighted’ Mann-Whitney statistic as an estimator of the partial area and investigate its statistical properties. A testing procedure is also developed to compare partial area under two receiver operating characteristic curves. The methods are exemplified with data from biomarkers associated with coronary heart disease.     

Parametric Nonlinear Regression with Endogenous Switching

Based on the insightful work of Olsen (1980 Olsen , R. J. ( 1980 ). A least squares correction for selectivity bias . Econometrica 48 : 1815 – 1820 .[Crossref], [Web of Science ®] , [Google Scholar]) for the linear context, a generic and unifying framework is developed that affords a simple extension of the classical method of Heckman (1974 Heckman , J. ( 1974 ). Shadow prices, market wages, and labor supply . Econometrica 42 : 679 – 694 .[Crossref], [Web of Science ®] , [Google Scholar], 1976 Heckman , J. ( 1976 ). The common structure of statistical models of truncation sample selection and limited dependent variables and a simple estimator for such models . Annals of Economic and Social Measurement 5 : 475 – 492 . [Google Scholar], 1978 Heckman , J. ( 1978 ). Dummy endogenous variables in a simultaneous equation system . Econometrica 46 : 931 – 959 .[Crossref], [Web of Science ®] , [Google Scholar], 1979 Heckman , J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153 – 161 .[Crossref], [Web of Science ®] , [Google Scholar]) to a broad class of nonlinear regression models involving endogenous switching and its two most common incarnations, endogenous sample selection and endogenous treatment effects. The approach should be appealing to applied researchers for three reasons. First, econometric applications involving endogenous switching abound. Secondly, the approach requires neither linearity of the regression function nor full parametric specification of the model. It can, in fact, be applied under the minimal parametric assumptions—i.e., specification of only the conditional means of the outcome and switching variables. Finally, it is amenable to relatively straightforward estimation methods. Examples of applications of the method are discussed.     

Estimators for the Population Mean in the Case of Missing Data

We propose a class of estimators for the population mean when there are missing data in the data set. Obtaining the mean square error equations of the proposed estimators, we show the conditions where the proposed estimators are more efficient than the sample mean, ratio-type estimators, and the estimators in Singh and Horn (2000 Singh , S. , Horn , S. ( 2000 ). Compromised imputation in survey sampling . Metrika 51 : 267 – 276 .[Crossref], [Web of Science ®] , [Google Scholar]) and Singh and Deo (2003 Singh , S. , Deo , B. (2003). Imputation by power transformation. Statist. Pap. 44:555–579.[Crossref], [Web of Science ®] , [Google Scholar]) in the case of missing data. These conditions are also supported by a numerical example.     

A Nonparametric Test for Symmetry Based on Freeman and Halton's Ideas on Contingency Tables

In this article, we propose a nonparametric method to test for symmetry in bivariate data. By using the extension of Fisher's exact treatment for 2 × 2 contingency tables proposed by Freeman and Halton (1951 Freeman , G. H. , Halton , J. H. ( 1951 ). Note on an exact treatment of contingency tables, goodness of fit and other problems of significance . Biometrika 38 : 141 – 149 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), we can test the hypothesis of equal distribution for two samples of integer valued variables. Then, by counting the number of observations belonging to each cell of a symmetric, appropriately built grid, we can produce the two samples of integers required to use this test for equal distribution. The resulting test for symmetry is potentially extendible to higher dimensions. A simulation study is performed to compare with some known tests (Bowker, 1948 Bowker , A. H. ( 1948 ). A test for symmetry in contingency tables . Journal of the American Statistical Association 43 : 572 – 574 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]; Hollander, 1971 Hollander , M. ( 1971 ). A nonparametric test for bivariate symmetry . Biometrika 58-1 : 203 – 212 .[Crossref], [Web of Science ®] , [Google Scholar]; and its improvement given in Krampe and Kuhnt, 2007 Krampe , A. , Kuhnt , S. ( 2007 ). Bowker's test for symmetry and modifications within the algebraic framework . Computational Statistics and Data Analysis 51 : 4124 – 4142 .[Crossref], [Web of Science ®] , [Google Scholar]). Our proposal represents a competitive option as a test for symmetry.     

Generalized Scrambling in Quantitative Optional Randomized Response Models

Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed an optional randomized response model using a linear combination scrambling which is a generalization of the multiplicative scrambling of Eichhorn and Hayre (1983 Eichhorn , B. H. , Hayre , L. S. ( 1983 ). Scrambled randomized response methods for obtaining sensitive quantitative data . J. Statist. Plann. Infer. 7 : 307 – 316 .[Crossref], [Web of Science ®] , [Google Scholar]) and the additive scrambling of Gupta et al. (2006, 2010). In this article, we discuss two main issues. (1) Can the Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) model be improved further by using a two-stage approach?; (2) Does the linear combination scrambling provide any benefit over the additive scrambling of Gupta et al. (2010 Gupta , S. N. , Shabbir , J. , Sehra , S. ( 2010 ). Mean and sensitivity estimation in optional randomized response models . J. Statist. Plann. Infer. 140 : 2870 – 2874 .[Crossref], [Web of Science ®] , [Google Scholar])? We will note that the answer to the first question is “yes” but the answer to the second question is “no.”     

A Bayes Factor for Replications of ANOVA Results

ABSTRACT

With an increasing number of replication studies performed in psychological science, the question of how to evaluate the outcome of a replication attempt deserves careful consideration. Bayesian approaches allow to incorporate uncertainty and prior information into the analysis of the replication attempt by their design. The Replication Bayes factor, introduced by Verhagen and Wagenmakers (2014 Verhagen, J., and Wagenmakers, E.-J. (2014), “Bayesian Tests to Quantify the Result of a Replication Attempt,” Journal of Experimental Psychology: General, 143, 1457–1475. DOI: 10.1037/a0036731.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), provides quantitative, relative evidence in favor or against a successful replication. In previous work by Verhagen and Wagenmakers (2014 Verhagen, J., and Wagenmakers, E.-J. (2014), “Bayesian Tests to Quantify the Result of a Replication Attempt,” Journal of Experimental Psychology: General, 143, 1457–1475. DOI: 10.1037/a0036731.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), it was limited to the case of t-tests. In this article, the Replication Bayes factor is extended to F-tests in multigroup, fixed-effect ANOVA designs. Simulations and examples are presented to facilitate the understanding and to demonstrate the usefulness of this approach. Finally, the Replication Bayes factor is compared to other Bayesian and frequentist approaches and discussed in the context of replication attempts. R code to calculate Replication Bayes factors and to reproduce the examples in the article is available at https://osf.io/jv39h/.     

Testing for Upper Outliers in Gamma Sample

The problem of multiple upper outlier detection in gamma sample is considered. Balasooriya and Gadag (1994 Balasooriya , U. , Gadag , V. ( 1994 ). Tests for upper outliers in the two-parameter exponential distribution . J. Statist. Computat. Simul. 50 : 249 – 259 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) proposed a location and scale invariant test based on the test statistic Z _k for testing the k upper outliers in two-parameter exponential sample. In this article, the test statistic is extended for gamma sample and the null distribution of the statistic is obtained. A simulation study is carried out to compare the performance of the tests and is found that the test based on Z _k is more powerful than the test based on the test statistic proposed by Jabbari Nooghabi et al. (2010 Jabbari Nooghabi , M. , Jabbari Nooghabi , H. , Nasiri , P. ( 2010 ). Detecting outliers in gamma distribution . Commun. Statist. Theor. Meth. 39 : 698 – 706 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]).     

Comment on Ridge Estimation to the Restricted Linear Model

In this note, we show that the estimator and the following results given by Zhong and Yang (2007 Zhong , Z. , Yang , H. ( 2007 ). Ridge estimation to the restricted linear model . Commun. Statist. Theor. Meth. 36 : 2099 – 2115 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) are the same with that of Groß (2003 Groß , J. ( 2003 ). Restricted ridge estimation . Statist. Probab. Lett. 65 : 57 – 64 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Use of Two Decks of Cards in Randomized Response Techniques for Complex Survey Designs

The randomized response (RR) technique with two decks of cards proposed by Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can always be made more efficient than the RR techniques proposed by Warner (1965 Warner , S. L. ( 1965 ). Randomize response: A survey technique for eliminating evasive answer bias . J. Amer. Statist. Assoc. 60 : 63 – 69 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Mangat and Singh (1990 Mangat , N. S. , Singh , R. ( 1990 ). An alternative randomized response procedure . Biometrika 77 : 349 – 442 .[Crossref], [Web of Science ®] , [Google Scholar]), and Mangat (1994 Mangat , N. S. ( 1994 ). An improved randomized response strategy . J. Roy. Statist. Soc. B 56 : 93 – 95 . [Google Scholar]) by adjusting the proportion of cards in the decks. The proposed method of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) is limited to simple random sampling with replacement (SRSWR) sampling only. In this article, generalization of Odumade and Singh strategy is provided for complex survey designs and a wider class of estimators. The results of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can be derived from the proposed method as a special case.     

On Rates of Convergence for Posterior Distributions Under Misspecification

We extend the approach of Walker (2003 Walker , S. ( 2003 ). On sufficient conditions for Bayesian consistency . Biometrika 90 ( 2 ): 482 – 488 .[Crossref], [Web of Science ®] , [Google Scholar]); (2004 Walker , S. ( 2004 ). New approaches to Bayesian consistency . Ann. Statist. 32 ( 5 ): 2028 – 2043 .[Crossref], [Web of Science ®] , [Google Scholar]) to the case of misspecified models. A sufficient condition for establishing rates of convergence is given based on a key identity involving martingales, which does not require construction of tests. We also show roughly that the result obtained by using tests can also be obtained by our approach, which demonstrates the potential wider applicability of this method.     

An Inverse-Probability-Weighted Approach to the Estimation of Successive Duration Times under Left-Truncation and Right-Censoring

In incident cohort studies, survival data often include subjects who have had an initiate event at recruitment and may potentially experience two successive events (first and second) during the follow-up period. Since the second duration process becomes observable only if the first event has occurred, left-truncation and dependent censoring arise if the two duration times are correlated. To confront the two potential sampling biases, Chang and Tzeng (2006 Chang , S.-H. , Tzeng , S.-J. (2006). Noparametric estimation of sojourn time distributions for truncated serial event data- a weight-adjusted approach. Lifetime Data Anal. 53–67.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) provided an inverse-probability-weighted (IPW) approach for estimating the joint probability function of successive duration times. In this note, an alternative IPW approach is proposed. A simulation study is conducted to compare the two IPW approaches.     

The Asymptotic Estimate of Ruin Probability Under a Class of Risk Model in the Presence of Heavy Tails

In contrast with the classical Cramér–Lundberg model where the premium process is a linear function of time, we consider the ruin probability under the risk model where the aggregate premium consists of both a compound Poisson process and a linear process of time. Moreover, a constant interest force is also taken into account in our model. We restrict ourselves to the case where the claim size is heavy-tailed, i.e., the equilibrium distribution function of the claim size belongs to a wide subclass of the subexponential distribution. An asymptotic formula for the ruin probability is obtained by using the similar method of Kalashnikov and Konstantinides (2000 Kalashnikov , V. , Konstantinides , D. ( 2000 ). Ruin under interest force and subexponential claims: a simple treament . Insur. Math. Econ. 27 : 145 – 149 .[Crossref], [Web of Science ®] , [Google Scholar]). The asymptotic formula we get here is the same as the one in Asmussen (1998 Asmussen , S. ( 1998 ). Subexponential asymptotics for stochastic processes: extremal behaviour, stationary distribution and first passage probabilities . Ann. Appl. Probab. 8 : 354 – 374 .[Crossref], [Web of Science ®] , [Google Scholar]), Klüppelberg and Stadtmüller (1998 Klüppelberg , C. , Stadtmüller , U. ( 1998 ). Ruin probabilities in the presence of heavy-tails and interest rates . Scand. Actuarial J. 1 : 49 – 58 .[Taylor & Francis Online] , [Google Scholar]), and Kalashnikov and Konstantinides (2000 Kalashnikov , V. , Konstantinides , D. ( 2000 ). Ruin under interest force and subexponential claims: a simple treament . Insur. Math. Econ. 27 : 145 – 149 .[Crossref], [Web of Science ®] , [Google Scholar]) which did not consider the stochastic premium.     

Designs Robust Against the Presence of an Aberration in a Diallel Cross Design Setup

In this article, we find designs insensitive to the presence of an outlier in a diallel cross design setup for estimating a complete set of orthonormal contrasts among the effects of the general combining abilities of a set of parental lines. The criterion of robustness, suggested by Mandal (1989 Mandal , N. K. ( 1989 ). On robust designs . Cal. Stat. Assoc. Bull. 38 : 115 – 119 . [Google Scholar]) in block design setup and used by Biswas (2012 Biswas , A. ( 2012 ). Block designs robust against the presence of an aberration in a treatment-control setup . Commun. Statist. Theor. Meth. 41 : 920 – 933 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) in treatment-control setup, is adapted here. Complete diallel cross designs, suggested by Gupta and Kageyama (1994 Gupta , S. , Kageyama , S. ( 1994 ). Optimal complete diallel crosses . Biometrika 81 : 420 – 424 .[Crossref], [Web of Science ®] , [Google Scholar]), and partial diallel cross designs, suggested by Gupta et al. (1995 Gupta , S. , Das , A. , Kageyama , S. ( 1995 ). Single replicate orthogonal block designs for circulant partial diallel crosses . Commun. Statist. A 24 : 2601 – 2607 .[Taylor & Francis Online] , [Google Scholar]) and Mukerjee (1997 Mukerjee , R. ( 1997 ). Optimal partial diallel crosses . Biometrika 84 : 939 – 948 .[Crossref], [Web of Science ®] , [Google Scholar]), are found to be robust under certain conditions.     

Using Frailty Models to Identify the Longitudinal Biomarkers in Survival Analysis

We introduce a score test to identify longitudinal biomarkers or surrogates for a time to event outcome. This method is an extension of Henderson et al. (2000 Henderson , R. , Diggle , P. , Dobson , A. ( 2000 ). Joint modelling of longitudinal measurements and event time data . Biostatistics 1 ( 4 ): 465 – 480 .[Crossref], [PubMed] , [Google Scholar], 2002 Henderson , R. , Diggle , P. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In this article, a score test is based on a joint likelihood function which combines the likelihood functions of the longitudinal biomarkers and the survival times. Henderson et al. (2000 Henderson , R. , Diggle , P. , Dobson , A. ( 2000 ). Joint modelling of longitudinal measurements and event time data . Biostatistics 1 ( 4 ): 465 – 480 .[Crossref], [PubMed] , [Google Scholar], 2002 Henderson , R. , Diggle , P. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) assumed that the same random effect exists in the longitudinal component and in the Cox model and then they can derive a score test to determine if a longitudinal biomarker is associated with time to an event. We extend this work and our score test is based on a joint likelihood function which allows other random effects to be present in the survival function.

Considering heterogeneous baseline hazards in individuals, we use simulations to explore how the factors can influence the power of a score test to detect the association of a longitudinal biomarker and the survival time. These factors include the functional form of the random effects from the longitudinal biomarkers, in the different number of individuals, and time points per individual. We illustrate our method using a prothrombin index as a predictor of survival in liver cirrhosis patients.