A comparative study of tests for paired lifetime data

In this paper, we investigate different procedures for testing the equality of two mean survival times in paired lifetime studies. We consider Owen’s M-test and Q-test, a likelihood ratio test, the paired t-test, the Wilcoxon signed rank test and a permutation test based on log-transformed survival times in the comparative study. We also consider the paired t-test, the Wilcoxon signed rank test and a permutation test based on original survival times for the sake of comparison. The size and power characteristics of these tests are studied by means of Monte Carlo simulations under a frailty Weibull model. For less skewed marginal distributions, the Wilcoxon signed rank test based on original survival times is found to be desirable. Otherwise, the M-test and the likelihood ratio test are the best choices in terms of power. In general, one can choose a test procedure based on information about the correlation between the two survival times and the skewness of the marginal survival distributions.     

Efficiency of t-Test and Hotelling's T 2-Test After Box-Cox Transformation

Early investigations of the effects of non-normality indicated that skewness has a greater effect on the distribution of t-statistic than does kurtosis. When the distribution is skewed, the actual p-values can be larger than the values calculated from the t-tables. Transformation of data to normality has shown good results in the case of univariate t-test. In order to reduce the effect of skewness of the distribution on normal-based t-test, one can transform the data and perform the t-test on the transformed scale. This method is not only a remedy for satisfying the distributional assumption, but it also turns out that one can achieve greater efficiency of the test. We investigate the efficiency of tests after a Box-Cox transformation. In particular, we consider the one sample test of location and study the gains in efficiency for one-sample t-test following a Box-Cox transformation. Under some conditions, we prove that the asymptotic relative efficiency of transformed t-test and Hotelling's T ²-test of multivariate location with respect to the same statistic based on untransformed data is at least one.     

A DISTRIBUTION-FREE TEST FOR TWO-WAY LAYOUT1

Many nonparametric tests have been proposed for the hypothesis of no row (treatment) effect in a one-way layout design. Examples of such tests are Kruskal-Wallis H-test, Bhapkar's (1961) V-test and Deshpande's (1965) L-test. However not many tests are available for testing the same hypothesis in a two-way layout design without interaction. Perhaps the only “established” test is the one due to Friedman (1937). However, it applies to the case of one observation per cell only. In this paper, a new distribution-free test is proposed for the hypothesis of row effect in a two-way layout design. It applies to the case of several observations per cell, not necessarily equal. The asymptotic efficiency of the proposed test relative to other tests is studied.     

Extended tests for non-zero between-study variance

The ANOVA F-test, James tests and generalized F-test are extended to test hypotheses on the between-study variance for values greater than zero. Using simulations, we compare the performance of extended test procedures with respect to the actual attained type I error rate. Examples are provided to demonstrate the application of the procedures in ANOVA models and meta-analysis.     

An adaptive test for the one-way layout

An adaptive test is proposed for the one-way layout. This test procedure uses the order statistics of the combined data to obtain estimates of percentiles, which are used to select an appropriate set of rank scores for the one-way test statistic. This test is designed to have reasonably high power over a range of distributions. The adaptive procedure proposed for a one-way layout is a generalization of an existing two-sample adaptive test procedure. In this Monte Carlo study, the power and significance level of the F-test, the Kruskal-Wallis test, the normal scores test, and the adaptive test were evaluated for the one-way layout. All tests maintained their significance level for data sets having at least 24 observations. The simulation results show that the adaptive test is more powerful than the other tests for skewed distributions if the total number of observations equals or exceeds 24. For data sets having at least 60 observations the adaptive test is also more powerful than the F-test for some symmetric distributions.     

Heterogeneity of variance and biased hypothesis tests

This study examined the influence of heterogeneity of variance on Type I error rates and power of the independent-samples Student's t-test of equality of means on samples of scores from normal and 10 non-normal distributions. The same test of equality of means was performed on corresponding rank-transformed scores. For many non-normal distributions, both versions produced anomalous power functions, resulting partly from the fact that the hypothesis test was biased, so that under some conditions, the probability of rejecting H ₀ decreased as the difference between means increased. In all cases where bias occurred, the t-test on ranks exhibited substantially greater bias than the t-test on scores. This anomalous result was independent of the more familiar changes in Type I error rates and power attributable to unequal sample sizes combined with unequal variances.     

One-way ANOVA with Unequal Variances

We consider the one-way ANOVA problem of testing the equality of several normal means when the variances are not assumed to be equal. This is a generalization of the Behrens-Fisher problem, but even in this special case there is no exact test and the actual size of any test depends on the values of the nuisance parameters. Therefore, controlling the actual size of the test is of main concern. In this article, we first consider a test using the concept of generalized p-value. Extensive simulation studies show that the actual size of this test does not exceed the nominal level, for practically all values of the nuisance parameters, but the test is not too conservative either, in the sense that the actual size of the test can be very close to the nominal level for some values of the nuisance parameters. We then use this test to propose a simple F-test, which has similar properties but avoids the computations associated with generalized p-values. Because of its simplicity, both conceptually as well as computationally, this F-test may be more useful in practice, since one-way ANOVA is widely used by practitioners who may not be familiar with the generalized p-value and its computational aspects.     

A comparison of several adaptive tests for paired data

In the last few years, two adaptive tests for paired data have been proposed. One test proposed by Freidlin et al. [On the use of the Shapiro–Wilk test in two-stage adaptive inference for paired data from moderate to very heavy tailed distributions, Biom. J. 45 (2003), pp. 887–900] is a two-stage procedure that uses a selection statistic to determine which of three rank scores to use in the computation of the test statistic. Another statistic, proposed by O'Gorman [Applied Adaptive Statistical Methods: Tests of Significance and Confidence Intervals, Society for Industrial and Applied Mathematics, Philadelphia, 2004], uses a weighted t-test with the weights determined by the data. These two methods, and an earlier rank-based adaptive test proposed by Randles and Hogg [Adaptive Distribution-free Tests, Commun. Stat. 2 (1973), pp. 337–356], are compared with the t-test and to Wilcoxon's signed-rank test. For sample sizes between 15 and 50, the results show that the adaptive test proposed by Freidlin et al. and the adaptive test proposed by O'Gorman have higher power than the other tests over a range of moderate to long-tailed symmetric distributions. The results also show that the test proposed by O'Gorman has greater power than the other tests for short-tailed distributions. For sample sizes greater than 50 and for small sample sizes the adaptive test proposed by O'Gorman has the highest power for most distributions.     

Some tests with specified size for the behrens-fisher problem

For a given significance level α, Welch's approximate t-test for the Behrens-Fisher Problem is modified to get a test with size α. A useful result for carrying out the Berger and Boos test is provided. Simulation results give power comparisons of several size α tests.     

A Revised Version of McNemar's Test for Paired Binary Data

In the formula of the McNemar test, a test on 2 × 2 classification tables with pairs of data, only the two categories A and D, which represent changes, are included; the retained parts B and C, which represent concordant responses, are not considered. Generally, it would be more reasonable for the significance of the changes to depend not only on A and D, but also on B and C, or on the sample size, n. To develop the test, two formulae, based on A, D, and n, and on A, D, B, C, and n, respectively, are proposed.     

Levene type tests for the ratio of two scales

Tests for the equality of variances are of interest in many areas such as quality control, agricultural production systems, experimental education, pharmacology, biology, as well as a preliminary to the analysis of variance, dose–response modelling or discriminant analysis. The literature is vast. Traditional non-parametric tests are due to Mood, Miller and Ansari–Bradley. A test which usually stands out in terms of power and robustness against non-normality is the W50 Brown and Forsythe [Robust tests for the equality of variances, J. Am. Stat. Assoc. 69 (1974), pp. 364–367] modification of the Levene test [Robust tests for equality of variances, in Contributions to Probability and Statistics, I. Olkin, ed., Stanford University Press, Stanford, 1960, pp. 278–292]. This paper deals with the two-sample scale problem and in particular with Levene type tests. We consider 10 Levene type tests: the W50, the M50 and L50 tests [G. Pan, On a Levene type test for equality of two variances, J. Stat. Comput. Simul. 63 (1999), pp. 59–71], the R-test [R.G. O'Brien, A general ANOVA method for robust tests of additive models for variances, J. Am. Stat. Assoc. 74 (1979), pp. 877–880], as well as the bootstrap and permutation versions of the W50, L50 and R tests. We consider also the F-test, the modified Fligner and Killeen [Distribution-free two-sample tests for scale, J. Am. Stat. Assoc. 71 (1976), pp. 210–213] test, an adaptive test due to Hall and Padmanabhan [Adaptive inference for the two-sample scale problem, Technometrics 23 (1997), pp. 351–361] and the two tests due to Shoemaker [Tests for differences in dispersion based on quantiles, Am. Stat. 49(2) (1995), pp. 179–182; Interquantile tests for dispersion in skewed distributions, Commun. Stat. Simul. Comput. 28 (1999), pp. 189–205]. The aim is to identify the effective methods for detecting scale differences. Our study is different with respect to the other ones since it is focused on resampling versions of the Levene type tests, and many tests considered here have not ever been proposed and/or compared. The computationally simplest test found robust is W50. Higher power, while preserving robustness, is achieved by considering the resampling version of Levene type tests like the permutation R-test (recommended for normal- and light-tailed distributions) and the bootstrap L50 test (recommended for heavy-tailed and skewed distributions). Among non-Levene type tests, the best one is the adaptive test due to Hall and Padmanabhan.     

One-Sample One-Sided Student T-Test Under Contaminants

A paradoxical behavior of the t-test under ε-contamination is presented. The paradox consists in that under a fixed distribution of contaminants an increasing of the probability of the appearance of a contaminant may decrease the violation of the size of the test! A simple explanation of the phenomenon is given. It is revealed which contaminants make the test conservative and which make it liberal: it appears that, in spite of the established opinion, conservatism or liberalism of the test depends not so much on the tails of the contaminating distribution as on where its support is located.     

A NOTE ON A SEQUENTIAL GROUP t-TEST

A sequential probability ratio test (SPET) of the mean of a normal distribution with unknown variance, based on an independent sequence of groups of observations, is investigated and its efficiency compared with that of the WAGE sequential t-test, which is based on an invariantly sufficient sequence of test statistics.     

Comparison of the estimators of the intra-cluster correlation for the nested error regression model

The intra-cluster correlation is insisted on nested error regression model that, in practice, is rarely known. This article demonstrates the size in generalized least squares (GLS) F-test using Fuller–Battese transformation and modification F-test. For the balanced case, the former using strictly positive, analysis of covariance (ANCOVA) and analysis of variance (ANOVA) estimators of intra-cluster correlation can control the size for moderate intra-cluster correlations. For small intra-cluster correlation, they perform well when the numbers of cluster are large. The latter using the ANOVA estimator performs well except for small numbers of cluster. When intra-cluster correlation is large, it cannot control the size. For the unbalanced case, the GLS F-test using the Fuller–Battese transformation and the modification F-test using the strictly positive, the ANCOVA and the ANOVA estimators maintain the significance level for small total sample size and small intra-cluster correlations when there is a large variation in cluster sizes, but they perform well in controlling the size for large total sample size and small different variation in cluster sizes. Besides, Henderson’s method 3 estimator maintains the significance level for a few situations.     

Inferences for a Partially Varying Coefficient Model With Endogenous Regressors

In this article, we propose a new class of semiparametric instrumental variable models with partially varying coefficients, in which the structural function has a partially linear form and the impact of endogenous structural variables can vary over different levels of some exogenous variables. We propose a three-step estimation procedure to estimate both functional and constant coefficients. The consistency and asymptotic normality of these proposed estimators are established. Moreover, a generalized F-test is developed to test whether the functional coefficients are of particular parametric forms with some underlying economic intuitions, and furthermore, the limiting distribution of the proposed generalized F-test statistic under the null hypothesis is established. Finally, we illustrate the finite sample performance of our approach with simulations and two real data examples in economics.     

Linear hypothesis testing for weighted functional data with applications

In socioeconomic areas, functional observations may be collected with weights, called weighted functional data. In this paper, we deal with a general linear hypothesis testing (GLHT) problem in the framework of functional analysis of variance with weighted functional data. With weights taken into account, we obtain unbiased and consistent estimators of the group mean and covariance functions. For the GLHT problem, we obtain a pointwise F-test statistic and build two global tests, respectively, via integrating the pointwise F-test statistic or taking its supremum over an interval of interest. The asymptotic distributions of test statistics under the null and some local alternatives are derived. Methods for approximating their null distributions are discussed. An application of the proposed methods to density function data is also presented. Intensive simulation studies and two real data examples show that the proposed tests outperform the existing competitors substantially in terms of size control and power.     

On the relevance of weaker instruments

ABSTRACT

We study the asymptotic properties of the standard GMM estimator when additional moment restrictions, weaker than the original ones, are available. We provide conditions under which these additional weaker restrictions improve the efficiency of the GMM estimator. To detect “spurious” identification that may come from invalid moments, we rely on the Hansen J-test that assesses the compatibility between existing restrictions and additional ones. Our simulations reveal that the J-test has good power properties and that its power increases with the weakness of the additional restrictions. Our theoretical characterization of the J-test provides some intuition for why that is.     

The robustness of the two—sample t—test over the Pearson system

The present paper has as its objective an accurate quantification of the robustness of the two–sample t-test over an extensive practical range of distributions. The method is that of a major Monte Carlo study over the Pearson system of distributions and the details indicate that the results are quite accurate. The study was conducted over the range β ₁ =0.0(0.4)2.0 (negative and positive skewness) and β ₂ =1.4 (0.4)7.8 with equal sample sizes and for both the one-and two-tail t-tests. The significance level and power levels (for nominal values of 0.05, 0.50, and 0.95, respectively) were evaluated for each underlying distribution and for each sample size, with each probability evaluated from 100,000 generated values of the test-statistic. The results precisely quantify the degree of robustness inherent in the two-sample t-test and indicate to a user the degree of confidence one can have in this procedure over various regions of the Pearson system. The results indicate that the equal-sample size two-sample t-test is quite robust with respect to departures from normality, perhaps even more so than most people realize.     

Approximate testing in two-stage nonlinear mixed models

We investigate here small sample properties of approximate F-tests about fixed effects parameters in nonlinear mixed models. For estimation of population fixed effects parameters as well as variance components, we apply the two-stage approach. This method is useful and popular when the number of observations per sampling unit is large enough. The approximate F-test is constructed based on large-sample approximation to the distribution of nonlinear least-squares estimates of subject-specific parameters. We recommend a modified test statistic that takes into consideration approximation to the large-sample Fisher information matrix (See [Volaufova J, Burton JH. Note on hypothesis testing in mixed models. Oral presentation at: LINSTAT 2012/21st IWMS; 2012; Bedlewo, Poland]). Our main focus is on comparing finite sample properties of broadly used approximate tests (Wald test and likelihood ratio test) and the modified F-test under the null hypothesis, especially accuracy of p-values (See [Volaufova J, LaMotte L. Comparison of approximate tests of fixed effects in linear repeated measures design models with covariates. Tatra Mountains. 2008;39:17–25]). For that purpose two extensive simulation studies are conducted based on pharmacokinetic models (See [Hartford A, Davidian M. Consequences of misspecifying assumptions in nonlinear mixed effects models. Comput Stat and Data Anal. 2000;34:139–164; Pinheiro J, Bates D. Approximations to the log-likelihood function in the non-linear mixed-effects model. J Comput Graph Stat. 1995;4(1):12–35]).