A Comparison of Procedures for Controlling the False Discovery Rate in the Presence of Small Variance Genes: A Simulation Study

The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 5116 – 5121 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.     

Some Modifications for Choosing Ridge Parameters

Standard least square regression can produce estimates having a large mean squares error (MSE) when predictor variables are highly correlated or multicollinear. In this article, we propose four modifications to choose the ridge parameter (K) when multicollinearity exists among the columns of the design matrix. The proposed new estimators are extended versions of that suggested by Khalaf and Shukur (2005 Khalaf , G. , Shukur , G. ( 2005 ). Choosing ridge parameter for regression problems . Commun. Statist. A 34 : 1177 – 1182 . [CSA] [Taylor & Francis Online] , [Google Scholar]). The properties of these estimators are compared with those of Hoerl and Kennard (1970a Hoerl , A. E. , Kennard , R. W. ( 1970a ). Ridge regression: biased estimation for non-orthogonal problems . Tech. . 12 : 55 – 67 . [CSA] [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and the OLS using the MSE criterion. All estimators under consideration are evaluated using simulation techniques under certain conditions where a number of factors that may affect their properties have been varied. In addition, it is shown that at least one of the proposed estimators either has a smaller MSE than the others or is the next best otherwise.     

The Restricted and Unrestricted Two-Parameter Estimators

In this article, we introduce a new two-parameter estimator by grafting the contraction estimator into the modified ridge estimator proposed by Swindel (1976 Swindel , B. F. ( 1976 ). Good ridge estimators based on prior information . Commun. Statist. Theor. Meth. A5 : 1065 – 1075 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). This new two-parameter estimator is a general estimator which includes the ordinary least squares, the ridge, the Liu, and the contraction estimators as special cases. Furthermore, by setting restrictions Rβ = r on the parameter values we introduce a new restricted two-parameter estimator which includes the well-known restricted least squares, the restricted ridge proposed by Groß (2003 Groß , J. ( 2003 ). Restricted ridge estimation . Statist. Probab. Lett. 65 : 57 – 64 .[Crossref], [Web of Science ®] , [Google Scholar]), the restricted contraction estimators, and a new restricted Liu estimator which we call the modified restricted Liu estimator different from the restricted Liu estimator proposed by Kaç?ranlar et al. (1999 Kaç?ranlar , S. , Sakall?o?lu , S. , Akdeniz , F. , Styan , G. P. H. , Werner , H. J. ( 1999 ). A new biased estimator in linear regression and a detailed analysis of the widely-analysed dataset on Portland cement . Sankhya Ser. B., Ind. J. Statist. 61 : 443 – 459 . [Google Scholar]). We also obtain necessary and sufficient condition for the superiority of the new two-parameter estimator over the ordinary least squares estimator and the comparison of the new restricted two-parameter estimator to the new two-parameter estimator is done by the criterion of matrix mean square error. The estimators of the biasing parameters are given and a simulation study is done for the comparison as well as the determination of the biasing parameters.     

The Identification of Potential Longitudinal Biomarkers and Measurements of Effectiveness for Biomarkers as Surrogates in Multivariate Survival Data

A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997 Wulfsohn , M. S. , Tsiatis , A. A. ( 1997 ). A joint model for survival and longitudinal data measured with error . Biometrics 53 ( 1 ): 330 – 339 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and Song et al. (2002 Song , X. , Davidian , M. , Tsiatis , A. A. ( 2002 ). A Semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data . Biometrics 58 ( 4 ): 742 – 753 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In this article, similar to Henderson et al. (2002 Henderson , R. , Diggle , P. J. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data.     

Estimating Incidence Rate on Current Status Data with Application to a Phase IV Cancer Trial

New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007 Hudson , M. M. , Rai , S. N. , Nunez , C. , Merchant , T. E. , Marina , N. M. , Zalamea , N. , Cox , C. , Phipps , S. , Pompeu , R. , Rosenthal , D. ( 2007 ). Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors . J. Clin. Oncol. 25 : 3635 – 3643 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings.     

On Complete Convergence for Arrays of Dependent Random Variables

A complete convergence theorem for an array of rowwise independent random variables was established by Sung et al. (2005 Sung , S. H. , Volodin , A. I. , Hu , T.-C. ( 2005 ). More on complete convergence for arrays . Statist. Probab. Lett. 71 : 303 – 311 .[Crossref], [Web of Science ®] , [Google Scholar]). This result has been generalized and extended by Kruglov et al. (2006 Kruglov , V. M. , Volodin , A. I. , Hu , T.-C. ( 2006 ). On complete convergence for arrays . Statist. Probab. Lett. 76 : 1631 – 1640 .[Crossref], [Web of Science ®] , [Google Scholar]) and Chen et al. (2007 Chen , P. , Hu , T.-C. , Liu , X. , Volodin , A. ( 2007 ). On complete convergence for arrays of rowwise negatively associated random variables . Theor. Probab. Appl. 52 : 393 – 397 . [Google Scholar]). In this article, we extend the results of Sung et al. (2005 Sung , S. H. , Volodin , A. I. , Hu , T.-C. ( 2005 ). More on complete convergence for arrays . Statist. Probab. Lett. 71 : 303 – 311 .[Crossref], [Web of Science ®] , [Google Scholar]), Kruglov et al. (2006 Kruglov , V. M. , Volodin , A. I. , Hu , T.-C. ( 2006 ). On complete convergence for arrays . Statist. Probab. Lett. 76 : 1631 – 1640 .[Crossref], [Web of Science ®] , [Google Scholar]), and Chen et al. (2007 Chen , P. , Hu , T.-C. , Liu , X. , Volodin , A. ( 2007 ). On complete convergence for arrays of rowwise negatively associated random variables . Theor. Probab. Appl. 52 : 393 – 397 . [Google Scholar]) to an array of dependent random variables satisfying Hoffmann-Jørgensen type inequalities.     

An Asymmetric Kernel Estimator of Density Function for Stationary Associated Sequences

Here, we apply the smoothing technique proposed by Chaubey et al. (2007 Chaubey , Y. P. , Sen , A. , Sen , P. K. ( 2007 ). A new smooth density estimator for non-negative random variables. Technical Report No. 1/07. Department of Mathematics and Statistics, Concordia University, Montreal, Canada . [Google Scholar]) for the empirical survival function studied in Bagai and Prakasa Rao (1991 Bagai , I. , Prakasa Rao , B. L. S. ( 1991 ). Estimation of the survival function for stationary associated processes . Statist. Probab. Lett. 12 : 385 – 391 .[Crossref], [Web of Science ®] , [Google Scholar]) for a sequence of stationary non-negative associated random variables.The derivative of this estimator in turn is used to propose a nonparametric density estimator. The asymptotic properties of the resulting estimators are studied and contrasted with some other competing estimators. A simulation study is carried out comparing the recent estimator based on the Poisson weights (Chaubey et al., 2011 Chaubey , Y. P. , Dewan , I. , Li , J. ( 2011 ). Smooth estimation of survival and density functions for a stationary associated process using poisson weights . Statist. Probab. Lett. 81 : 267 – 276 .[Crossref], [Web of Science ®] , [Google Scholar]) showing that the two estimators have comparable finite sample global as well as local behavior.     

Marginal correlation from an extended random-effects model for repeated and overdispersed counts

Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]] derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models (GLMM). Their focus was on binary sequences, as well as on a combination of binary and Gaussian sequences. Here, we focus on the specific case of repeated count data, important in two respects. First, we employ the model proposed by Molenberghs et al. [13 Molenberghs, G., Verbeke, G. and Demétrio, C. G.B. 2007. An extended random-effects approach to modeling repeated, overdispersed count data. Lifetime Data Anal., 13: 513–531. [Crossref], [PubMed], [Web of Science ®] [Google Scholar]], which generalizes at the same time the Poisson-normal GLMM and the conventional overdispersion models, in particular the negative-binomial model. The model flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. Second, means, variances, and joint probabilities can be expressed in closed form, allowing for exact intra-sequence correlation expressions. Next to the general situation, some important special cases such as exchangeable clustered outcomes are considered, producing insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]]. Data from an epileptic-seizures trial are analyzed and correlation functions derived. It is shown that the proposed extension strongly outperforms the classical GLMM.     

Combining Unbiased Ridge and Principal Component Regression Estimators

In the presence of multicollinearity problem, ordinary least squares (OLS) estimation is inadequate. To circumvent this problem, two well-known estimation procedures often suggested are the unbiased ridge regression (URR) estimator given by Crouse et al. (1995 Crouse , R. , Jin , C. , Hanumara , R. ( 1995 ). Unbiased ridge estimation with prior information and ridge trace . Commun. Statist. Theor. Meth. 24 : 2341 – 2354 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and the (r, k) class estimator given by Baye and Parker (1984 Baye , M. , Parker , D. ( 1984 ). Combining ridge and principal component regression: a money demand illustration . Commun. Statist. Theor. Meth. 13 : 197 – 205 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). In this article, we proposed a new class of estimators, namely modified (r, k) class ridge regression (MCRR) which includes the OLS, the URR, the (r, k) class, and the principal components regression (PCR) estimators. It is based on a criterion that combines the ideas underlying the URR and the PCR estimators. The standard properties of this new class estimator have been investigated and a numerical illustration is done. The conditions under which the MCRR estimator is better than the other two estimators have been investigated.     

Modified Ridge Parameters for Seemingly Unrelated Regression Model

In this article, we modify a number of new biased estimators of seemingly unrelated regression (SUR) parameters which are developed by Alkhamisi and Shukur (2008 Alkhamisi , M. A. , Shukur , G. ( 2008 ). Developing ridge parameters for SUR model . Commun. Statist. Theor. Meth. 37 ( 4 ): 544 – 564 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), AS, when the explanatory variables are affected by multicollinearity. Nine estimators of the ridge parameters have been modified and compared in terms of the trace mean squared error (TMSE) and (PR) criterion. The results from this extended study are the also compared with those founded by AS. A simulation study has been conducted to compare the performance of the modified estimators of the ridge parameters. The results showed that under certain conditions the performance of the multivariate ridge regression estimators based on SUR ridge R _MSmax is superior to other estimators in terms of TMSE and PR criterion. In large samples and when the collinearity between the explanatory variables is not high, the unbiased SUR, estimator produces a smaller TMSEs.     

Improved Predictive Inference for Responses Based on Location Parameter Median from the Rayleigh Model Given a Doubly Censored Sample

The purpose of this article is to investigate the predictive inference for responses from the location parameter mean as well as from the median given a doubly censored sample from the two-parameter Rayleigh model. The predictive results by Khan et al. (2010 Khan , H. M. R. , Provost , S. B. , Ashima , S. ( 2010 ). Predictive Inference from a Two-Parameter Rayleigh Life Model Given a Doubly Censored Sample . Commun. Statist. Theor. Meth. 39 ( 7 ): 1237 – 1246 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) are used to obtain the predictive inference for responses from the median, where Khan et al. (2010 Khan , H. M. R. , Provost , S. B. , Ashima , S. ( 2010 ). Predictive Inference from a Two-Parameter Rayleigh Life Model Given a Doubly Censored Sample . Commun. Statist. Theor. Meth. 39 ( 7 ): 1237 – 1246 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) obtained the future estimates from the mean. A numerical example representing 66 liver cancer patients is used for predictive analysis. It is concluded that the predictive inference from the median gives precise results as compared with the location parameter mean.     

Regression M-estimators with One Modified Form of Doubly Censored Data

In this article, we consider the M-estimators for the linear regression model when both response and covariate variables are subject to double censoring. The proposed estimators are constructed as some functional of three types of estimators for a bivariate survival distribution. The first two estimators are the generalizations of the Campbell and Földes (1982 Campbell, G. and Földes, A. 1982. “Large sample properties of nonparametric statistical inference”. In Nonparametric Statistical Inference., Edited by: Gnredenko, B. V., Puri, M. L. and Vineze, I. 103–122. Amsterdam: North-Holland.  [Google Scholar]) and Dabrowska (1988 Dabrowska, D. M. 1988. Kaplan-Meier estimate on the plane. Annals of Statistics, 18: 1475–1489. [Crossref], [Web of Science ®] , [Google Scholar]) estimators proposed by Shen (2009 Shen, P. S. 2009. Nonparametric estimation of the bivariate survival function one modified form of doubly censored data. Computational Statistics, 25: 203–313. [Crossref], [Web of Science ®] , [Google Scholar]). The third estimator is the generalization of the Prentice and Cai (1992 Prentice, R. L. and Cai, J. 1992. Covariance and survivor function estimation using censored multivariate failure time data. Biometrika, 79: 495–512. [Crossref], [Web of Science ®] , [Google Scholar]) estimator. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to estimate standard deviations and construct interval estimators.     

Second-Order Covariance Matrix Formula for Heteroskedastic Generalized Linear Models

For the first time, we provide a matrix formula for second-order covariances of maximum likelihood estimates in heteroskedastic generalized linear models, thus generalizing the results of Cordeiro (2004 Cordeiro , G. M. ( 2004 ). Second-order covariance matrix of maximum likelihood estimates in generalized linear models . Statist. Probab. Lett. 66 : 153 – 160 .[Crossref], [Web of Science ®] , [Google Scholar]) and Cordeiro et al. (2006 Cordeiro , G. M. , Barroso , L. P. , Botter , D. A. (2006). Covariance matrix formula for generalized linear models with unknown dispersion. Commun. Statist. Theor. Meth. 35:113–120.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) related to the generalized linear models with known and unknown dispersion parameter, respectively. The covariance matrix formula does not involve cumulants of log-likelihood derivatives and can be easily obtained using simple matrix operations. We apply our main result to a simple model. Some simulations show that the second-order covariances can be quite pronounced in small to moderate samples. The usual covariances of the maximum likelihood estimates can be corrected by these second-order covariances.     

Improved strategy to collect sensitive data by using geometric distribution as a randomization device

Abstract

In this article, we improvise Singh and Grewal (2013 Singh, S., and I. S. Grewal. 2013. Geometric distribution as a randomization device implemented in the Kuk’s model. International Journal of Contemporary Mathematical Sciences 8:243–8.[Crossref] , [Google Scholar]) and Hussain et al. (2016 Hussain, Z., J. Shabbir, Z. Pervez, S. F. Shah, and M. Khan. 2016. Generalized geometric distribution of order k: A flexible choice to randomize the response. Communications in Statistics: Simulation and Computation 46:4708–21.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) techniques by introducing a new two-stage randomization response process. Using the proposed new technique, we achieve better efficiency and increasing protection of privacy of respondents than the Kuk (1990 Kuk, A. Y. C. 1990. Asking sensitive questions indirectly. Biometrika 77 (2):436–8.[Crossref], [Web of Science ®] , [Google Scholar]), Singh and Grewal (2013 Singh, S., and I. S. Grewal. 2013. Geometric distribution as a randomization device implemented in the Kuk’s model. International Journal of Contemporary Mathematical Sciences 8:243–8.[Crossref] , [Google Scholar]) and Hussain et al. (2016 Hussain, Z., J. Shabbir, Z. Pervez, S. F. Shah, and M. Khan. 2016. Generalized geometric distribution of order k: A flexible choice to randomize the response. Communications in Statistics: Simulation and Computation 46:4708–21.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) models. The relative efficiency and protection of the respondents of the proposed two-stage randomization device have been investigated through simulation study, and the situations are reported where the proposed estimator performs better than its competitors. The SAS code used to investigate the performance of the proposed strategy are also provided.     

Semiparametric Efficient Distribution Free Estimation of Panel Models

This article generalizes results from Park et al. (1998 Park , B. U. , Sickles , R. C. , Simar , L. ( 1998 ). Stochastic frontiers: a semiparametric approach . J. Econometrics 84 : 273 – 301 .[Crossref], [Web of Science ®] , [Google Scholar]) and Adams et al. (1999 Adams , R. M. , Berger , A. N. , Sickles , R. C. ( 1999 ). Semiparametric approaches to stochastic panel frontiers with applications in the banking industry . J. Bus. Econ. Statist. 17 : 349 – 358 .[Taylor & Francis Online] , [Google Scholar]) on semiparametric efficient estimation of panel models. The form of semiparametric efficient estimators depends on the statistical assumptions imposed. Normality assumptions on the transitory error are sometimes inappropriate. We relax the normality assumption used in the articles above to derive more general semiparametric efficient estimators. These estimators are illustrated in a Monte Carlo simulation and an analysis of banking productivity.     

A Generalization of the Skew-Normal Distribution: The Beta Skew-Normal

We consider a new generalization of the skew-normal distribution introduced by Azzalini (1985 Azzalini , A. ( 1985 ). A class of distributions which includes the normal ones . Scand. J. Statis. 12 ( 2 ): 171 – 178 .[Web of Science ®] , [Google Scholar]). We denote this distribution Beta skew-normal (BSN) since it is a special case of the Beta generated distribution (Jones, 2004 Jones , M. C. ( 2004 ). Families of distributions of order statistics . Test 13 ( 1 ): 1 – 43 .[Crossref], [Web of Science ®] , [Google Scholar]). Some properties of the BSN are studied. We pay attention to some generalizations of the skew-normal distribution (Bahrami et al., 2009 Bahrami , W. , Agahi , H. , Rangin , H. ( 2009 ). A two-parameter Balakrishnan skew-normal distribution . J. Statist. Res. Iran 6 : 231 – 242 . [Google Scholar]; Sharafi and Behboodian, 2008 Sharafi , M. , Behboodian , J. ( 2008 ). The Balakrishnan skew-normal density . Statist. Pap. 49 : 769 – 778 .[Crossref], [Web of Science ®] , [Google Scholar]; Yadegari et al., 2008 Yadegari , I. , Gerami , A. , Khaledi , M. J. ( 2008 ). A generalization of the Balakrishnan skew-normal distribution . Statist. Probab. Lett. 78 : 1165 – 1167 .[Crossref], [Web of Science ®] , [Google Scholar]) and to their relations with the BSN.     

Bias-Corrected Maximum Likelihood Estimators in Nonlinear Heteroscedastic Models

Nonlinear heteroscedastic models are widely used in econometrics and statistical applications. We derive matrix formulae for the second-order biases of the maximum likelihood estimators of the parameters in the mean and variance response which generalize previous results by Cook et al. (1986 Cook , D. R. , Tsai , C. L. , Wei , B. C. ( 1986 ). Bias in nonlinear regression . Biometrika 73 : 615 – 623 .[Crossref], [Web of Science ®] , [Google Scholar]) and Cordeiro (1993 Cordeiro , G. M. ( 1993 ). Bartlett corrections and bias correction for two heteroscedastic regression models . Commun. Statist. Theor. Meth. 22 : 169 – 188 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). The biases of the estimators are easily obtained as vectors of regression coefficients from suitable weighted linear regressions. The practical use of such biases is illustrated in a simulation study and in an application to a real data set.     

A Broad Class of Partially Specified Autoregressions on Multi-Casting Data

Extending the bifurcating autoregressive (BAR) process (cf. Cowan and Staudte, 1986 Cowan , R. , Staudte , R. G. ( 1986 ). The bifurcating autoregression model in cell lineage studies . Biometrics 42 : 769 – 783 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) to multi-casting (multi-splitting) data, Hwang and Choi (2009 Hwang , S. Y. , Choi , M. S. ( 2009 ). Modeling and large sample estimation for multi-casting autoregression . Statist. Prob. Lett. 79 : 1943 – 1950 .[Crossref], [Web of Science ®] , [Google Scholar]) introduced multi-casting autoregression (MCAR, for short) defined on multi-casting tree structured data. This article is concerned with the case when the MCAR model is partially specified only through conditional mean and variance without directly imposing autoregressive (AR) structure. The resulting class of models will be referred to as P-MCAR (partially specified MCAR). The P-MCAR considerably enlarges the class of multi-casting models including (as special cases) MCAR, random coefficient MCAR, conditionally heteroscedastic multi-casting models and binomial-thinning processes. Moment structures for this broad P-MCAR class are investigated. Least squares (LS) estimation method is discussed and asymptotic relative efficiency (ARE) of the generalized-LS over ordinary-LS is obtained in a closed form. A simulation study is conducted to illustrate results.     

Skew-Normal ARMA Models with Nonlinear Heteroscedastic Predictors

Multivariate skew-normal (SN) distributions (Azzalini and Dalla Valle, 1996 Azzalini , A. , Dalla Valle , A. ( 1996 ). The multivariate skew-normal distribution . Biometrika 83 : 715 – 726 .[Crossref], [Web of Science ®] , [Google Scholar]) enjoy some of the useful properties of normal distributions, have nonlinear heteroscedastic predictors but lack the closure property of normal distributions (the sum of independent SN random variables is not SN). Recently, there has been a proliferation of classes of SN distributions with certain closure properties, one of the most promising being the closed skew-normal (CSN) distributions of González-Farías et al. (2004 González-Farías , G. , Dominguez-Molina , J. A. , Gupta , A. K. ( 2004 ). Additive properties of skew-normal random vectors . J. Statist. Plann. Infer. 126 : 521 – 534 .[Crossref], [Web of Science ®] , [Google Scholar]). We study the construction of stationary SN ARMA models for colored SN noise and show that their finite-dimensional distributions are skew-normal, seldom strictly stationary and their covariance functions differ from their normal ARMA counterparts in that they do not converge to zero for large lags. The situation is better for ARMA models driven by CSN noise, but at the additional cost of considerable computational complexity and a less explicit skewness parameter. In view of these results, the widespread use of such classes of SN distributions in the framework of ARMA models seem doubtful.