贝叶斯非线性混合效应模型及其应用研究

由于常用的线性混合效应模型对具有非线性关系的纵向数据建模具有一定的局限性,因此对线性混合效应模型进行扩展,根据变量间的非线性关系建立不同的非线性混合效应模型,并根据因变量的分布特征建立混合分布模型。基于一组实际的保险损失数据,建立多项式混合效应模型、截断多项式混合效应模型和B样条混合效应模型。研究结果表明,非线性混合效应模型能够显著改进对保险损失数据的建模效果,对非寿险费率厘定具有重要参考价值。     

Comparison of Mixed-Effects Models for Skew-Normal Responses with an Application to AIDS Data: A Bayesian Approach

The potency of antiretroviral agents in AIDS clinical trials can be assessed on the basis of a viral response such as viral decay rate or change in viral load (number of HIV RNA copies in plasma). Linear, nonlinear, and nonparametric mixed-effects models have been proposed to estimate such parameters in viral dynamic models. However, there are two critical questions that stand out: whether these models achieve consistent estimates for viral decay rates, and which model is more appropriate for use in practice. Moreover, one often assumes that a model random error is normally distributed, but this assumption may be unrealistic, obscuring important features of within- and among-subject variations. In this article, we develop a skew-normal (SN) Bayesian linear mixed-effects (SN-BLME) model, an SN Bayesian nonlinear mixed-effects (SN-BNLME) model, and an SN Bayesian semiparametric nonlinear mixed-effects (SN-BSNLME) model that relax the normality assumption by considering model random error to have an SN distribution. We compare the performance of these SN models, and also compare their performance with the corresponding normal models. An AIDS dataset is used to test the proposed models and methods. It was found that there is a significant incongruity in the estimated viral decay rates. The results indicate that SN-BSNLME model is preferred to the other models, implying that an arbitrary data truncation is not necessary. The findings also suggest that it is important to assume a model with an SN distribution in order to achieve reasonable results when the data exhibit skewness.     

Estimation of Some Nonlinear Panel Data Models With Both Time-Varying and Time-Invariant Explanatory Variables

The so-called “fixed effects” approach to the estimation of panel data models suffers from the limitation that it is not possible to estimate the coefficients on explanatory variables that are time-invariant. This is in contrast to a “random effects” approach, which achieves this by making much stronger assumptions on the relationship between the explanatory variables and the individual-specific effect. In a linear model, it is possible to obtain the best of both worlds by making random effects-type assumptions on the time-invariant explanatory variables while maintaining the flexibility of a fixed effects approach when it comes to the time-varying covariates. This article attempts to do the same for some popular nonlinear models.     

Evidence of Convergence Clubs Using Mixture Models

Cross-country economic convergence has been increasingly investigated by finite mixture models. Multiple components in a mixture reflect groups of countries that converge locally. Testing for the number of components is crucial for detecting “convergence clubs.” To assess the number of components of the mixture, we propose a sequential procedure that compares the shape of the hypothesized mixture distribution with the true unknown density, consistently estimated through a kernel estimator. The novelty of our approach is its capability to select the number of components along with a satisfactory fitting of the model. Simulation studies and an empirical application to per capita income distribution across countries testify for the good performance of our approach. A three-clubs convergence seems to emerge.     

On the Performance of Popular Unit-Root Tests Against Various Nonlinear Dynamic Models: A Simulation Study

ABSTRACT

There is a widespread perception that standard unit-root tests have poor discriminatory power when they are applied to time series with nonlinear dynamics. Via Monte Carlo simulations this study re-examines the finite sample properties of selected univariate tests for unit-root and stationarity under a broad class of nonlinear dynamic models. Our simulation experiments produce a couple of interesting findings. First, performance of tests is driven by the degree of underlying persistence rather than the nonlinear dynamics per se. Tests under study exhibit reasonable performance for nonlinear models with mild persistence, while the accuracy of inference deteriorates substantially when the models are highly persistent regardless of the linearity. Second, when it comes to deciding which one to identify first between linearity and stationarity, our results suggest to conduct linearity test first to enhance the reliability of test inference.     

Nonparametric Independence Screening in Sparse Ultra-High Dimensional Additive Models

A variable screening procedure via correlation learning was proposed in Fan and Lv (2008) to reduce dimensionality in sparse ultra-high dimensional models. Even when the true model is linear, the marginal regression can be highly nonlinear. To address this issue, we further extend the correlation learning to marginal nonparametric learning. Our nonparametric independence screening is called NIS, a specific member of the sure independence screening. Several closely related variable screening procedures are proposed. Under general nonparametric models, it is shown that under some mild technical conditions, the proposed independence screening methods enjoy a sure screening property. The extent to which the dimensionality can be reduced by independence screening is also explicitly quantified. As a methodological extension, a data-driven thresholding and an iterative nonparametric independence screening (INIS) are also proposed to enhance the finite sample performance for fitting sparse additive models. The simulation results and a real data analysis demonstrate that the proposed procedure works well with moderate sample size and large dimension and performs better than competing methods.     

Restricted Estimation in Partially Linear Errors-in-Variables Models

As a compromise between parametric regression and nonparametric regression, partially linear models are frequently used in statistical modelling. This article considers statistical inference for this semiparametric model when the linear covariate is measured with additive error and some additional linear restrictions on the parametric component are assumed to hold. We propose a restricted corrected profile least-squares estimator for the parametric component, and study the asymptotic normality of the estimator. To test hypothesis on the parametric component, we construct a Wald test statistic and obtain its limiting distribution. Some simulation studies are conducted to illustrate our approaches.     

Variable Selection in Linear Mixed Models Using an Extended Class of Penalties

There is an emerging need to advance linear mixed model technology to include variable selection methods that can simultaneously choose and estimate important effects from a potentially large number of covariates. However, the complex nature of variable selection has made it difficult for it to be incorporated into mixed models. In this paper we extend the well known class of penalties and show that they can be integrated succinctly into a linear mixed model setting. Under mild conditions, the estimator obtained from this mixed model penalised likelihood is shown to be consistent and asymptotically normally distributed. A simulation study reveals that the extended family of penalties achieves varying degrees of estimator shrinkage depending on the value of one of its parameters. The simulation study also shows there is a link between the number of false positives detected and the number of true coefficients when using the same penalty. This new mixed model variable selection (MMVS) technology was applied to a complex wheat quality data set to determine significant quantitative trait loci (QTL).     

Robust Inference in Conditionally Linear Nonlinear Regression Models

Abstract.  We consider robust methods of likelihood and frequentist inference for the nonlinear parameter, say α , in conditionally linear nonlinear regression models. We derive closed-form expressions for robust conditional, marginal, profile and modified profile likelihood functions for α under elliptically contoured data distributions. Next, we develop robust exact-F confidence intervals for α and consider robust Fieller intervals for ratios of regression parameters in linear models. Several well-known examples are considered and Monte Carlo simulation results are presented.     

Threshold Vector Arma Models

In this article, we propose the threshold vector autoregressive moving average model (TVARMA). It is a multivariate nonlinear time series model characterized by two or more regimes that follow a vector ARMA structure and where the switching among them is regulated by a latent variable. The TVARMA model represents a generalization of some nonlinear models proposed in the literature and shows interesting features that are explored. The condition for the strong and weak stationarity of the TVARMA model are presented and the moments up to order two of the process are derived.     

Heterogeneity in Consumer Price Stickiness

We examine heterogeneity in price stickiness using a large, original, set of individual price data collected at the retail level for the computation of the French consumer price index. For that purpose, we estimate at a very high level of disaggregation, a piecewise-constant hazard model, as well as competing-risks duration models that distinguish between price increases, price decreases, and product replacements. The main findings are the following: (a) at the product–outlet-type level, the baseline hazard function of a price spell is nondecreasing; (b) cross-product and cross-outlet-type heterogeneity is pervasive, both in the shape and the level of the hazard function as well as in the impact of covariates; (c) there is strong evidence of state dependence, especially for price increases; (d) there is an asymmetry because determinants of price increases differ from those of price decreases.     

The Use of Working Variables in the Bayesian Modeling of Mean and Dispersion Parameters in Generalized Nonlinear Models with Random Effects

This article is aimed at reviewing a novel Bayesian approach to handle inference and estimation in the class of generalized nonlinear models. These models include some of the main techniques of statistical methodology, namely generalized linear models and parametric nonlinear regression. In addition, this proposal extends to methods for the systematic treatment of variation that is not explicitly predicted within the model, through the inclusion of random effects, and takes into account the modeling of dispersion parameters in the class of two-parameter exponential family. The methodology is based on the implementation of a two-stage algorithm that induces a hybrid approach based on numerical methods for approximating the likelihood to a normal density using a Taylor linearization around the values of current parameters in an MCMC routine.     

A generalisation of T‐optimality for discriminating between competing models with an application to pharmacokinetic studies

The T‐optimality criterion is used in optimal design to derive designs for model selection. To set up the method, it is required that one of the models is considered to be true. We term this local T‐optimality. In this work, we propose a generalisation of T‐optimality (termed robust T‐optimality) that relaxes the requirement that one of the candidate models is set as true. We then show an application to a nonlinear mixed effects model with two candidate non‐nested models and combine robust T‐optimality with robust D‐optimality. Optimal design under local T‐optimality was found to provide adequate power when the a priori assumed true model was the true model but poor power if the a priori assumed true model was not the true model. The robust T‐optimality method provided adequate power irrespective of which model was true. The robust T‐optimality method appears to have useful properties for nonlinear models, where both the parameter values and model structure are required to be known a priori, and the most likely model that would be applied to any new experiment is not known with certainty. Copyright © 2012 John Wiley & Sons, Ltd.     

Graphical Network Models for International Financial Flows

The late-2000s financial crisis stressed the need to understand the world financial system as a network of countries, where cross-border financial linkages play a fundamental role in the spread of systemic risks. Financial network models, which take into account the complex interrelationships between countries, seem to be an appropriate tool in this context. To improve the statistical performance of financial network models, we propose to generate them by means of multivariate graphical models. We then introduce Bayesian graphical models, which can take model uncertainty into account, and dynamic Bayesian graphical models, which provide a convenient framework to model temporal cross-border data, decomposing the model into autoregressive and contemporaneous networks. The article shows how the application of the proposed models to the Bank of International Settlements locational banking statistics allows the identification of four distinct groups of countries, that can be considered central in systemic risk contagion.     

Influence Diagnostics of Semiparametric Nonlinear Reproductive Dispersion Models

This article proposes a semiparametric nonlinear reproductive dispersion model (SNRDM) which is an extension of nonlinear reproductive dispersion model and semiparametric regression model. Maximum penalized likelihood estimators (MPLEs) of unknown parameters and nonparametric functions in SNRDMs are presented. Some novel diagnostic statistics such as Cook distance and difference deviance for parametric and nonparametric parts are developed to identify influence observations in SNRDMs on the basis of case-deletion method, and some formulae readily computed with the MPLEs algorithm for diagnostic measures are given. The equivalency of case-deletion models and mean-shift outlier models in SNRDM is investigated. A simulation study and a real example are used to illustrate the proposed diagnostic measures.     

Outlier Resistant Estimation in Difference-Based Semiparametric Partially Linear Models

Partially linear models are extensions of linear models that include a nonparametric function of some covariate allowing an adequate and more flexible handling of explanatory variables than in linear models. The difference-based estimation in partially linear models is an approach designed to estimate parametric component by using the ordinary least squares estimator after removing the nonparametric component from the model by differencing. However, it is known that least squares estimates do not provide useful information for the majority of data when the error distribution is not normal, particularly when the errors are heavy-tailed and when outliers are present in the dataset. This paper aims to find an outlier-resistant fit that represents the information in the majority of the data by robustly estimating the parametric and the nonparametric components of the partially linear model. Simulations and a real data example are used to illustrate the feasibility of the proposed methodology and to compare it with the classical difference-based estimator when outliers exist.     

模糊线性回归模型的最小二乘方法

针对自变量和因变量皆模糊的数据系统中的回归分析问题,为避免自变量退化成数值变量时可能引致的估计误差增大而带来的问题,提出系统中引入模糊调整项的回归模型的一般结构,并运用基于模糊数间完备距离的最小二乘法研究模型解析表达式;利用水平截集概念将模糊多元回归模型转化成两个传统回归模型,根据模糊数间距离采用最小二乘法得到参数估计,给出员工工作绩效评估的算例说明方法的有效性,并结合Bootstrap方法的应用,研究回归参数所具有的随机不确定性动态变化。     

Linear Transformations of Linear Mixed-Effects Models

A number of articles have discussed the way lower order polynomial and interaction terms should be handled in linear regression models. Only if all lower order terms are included in the model will the regression model be invariant with respect to coding transformations of the variables. If lower order terms are omitted, the regression model will not be well formulated. In this paper, we extend this work to examine the implications of the ordering of variables in the linear mixed-effects model. We demonstrate how linear transformations of the variables affect the model and tests of significance of fixed effects in the model. We show how the transformations modify the random effects in the model, as well as their covariance matrix and the value of the restricted log-likelihood. We suggest a variable selection strategy for the linear mixed-effects model.     

Linear or Nonlinear? Automatic Structure Discovery for Partially Linear Models

Partially linear models provide a useful class of tools for modeling complex data by naturally incorporating a combination of linear and nonlinear effects within one framework. One key question in partially linear models is the choice of model structure, that is, how to decide which covariates are linear and which are nonlinear. This is a fundamental, yet largely unsolved problem for partially linear models. In practice, one often assumes that the model structure is given or known and then makes estimation and inference based on that structure. Alternatively, there are two methods in common use for tackling the problem: hypotheses testing and visual screening based on the marginal fits. Both methods are quite useful in practice but have their drawbacks. First, it is difficult to construct a powerful procedure for testing multiple hypotheses of linear against nonlinear fits. Second, the screening procedure based on the scatterplots of individual covariate fits may provide an educated guess on the regression function form, but the procedure is ad hoc and lacks theoretical justifications. In this article, we propose a new approach to structure selection for partially linear models, called the LAND (Linear And Nonlinear Discoverer). The procedure is developed in an elegant mathematical framework and possesses desired theoretical and computational properties. Under certain regularity conditions, we show that the LAND estimator is able to identify the underlying true model structure correctly and at the same time estimate the multivariate regression function consistently. The convergence rate of the new estimator is established as well. We further propose an iterative algorithm to implement the procedure and illustrate its performance by simulated and real examples. Supplementary materials for this article are available online.     

Labelled Graphical Models

A class of log‐linear models, referred to as labelled graphical models (LGMs), is introduced for multinomial distributions. These models generalize graphical models (GMs) by employing partial conditional independence restrictions which are valid only in subsets of an outcome space. Theoretical results concerning model identifiability, decomposability and estimation are derived. A decision theoretical framework and a search algorithm for the identification of plausible models are described. Real data sets are used to illustrate that LGMs may provide a simpler interpretation of a dependence structure than GMs.