A change-point estimator with the hazard ratio

The problem of estimation of parameters in hazard rate change models with a change-point is considered. A change-point estimator using the hazard ratio is suggested and compared with the previously developed change-point estimators. The proposed estimator is shown to be consistent. The performance of the proposed estimator is checked and compared with other change-point estimators via simulation.     

Non parametric hazard estimation with dependent censoring using penalized likelihood and an assumed copula

This article introduces a novel non parametric penalized likelihood hazard estimation when the censoring time is dependent on the failure time for each subject under observation. More specifically, we model this dependence using a copula, and the method of maximum penalized likelihood (MPL) is adopted to estimate the hazard function. We do not consider covariates in this article. The non negatively constrained MPL hazard estimation is obtained using a multiplicative iterative algorithm. The consistency results and the asymptotic properties of the proposed hazard estimator are derived. The simulation studies show that our MPL estimator under dependent censoring with an assumed copula model provides a better accuracy than the MPL estimator under independent censoring if the sign of dependence is correctly specified in the copula function. The proposed method is applied to a real dataset, with a sensitivity analysis performed over various values of correlation between failure and censoring times.     

Estimation of a Change Point in a Hazard Function Based on Censored Data

The hazard function plays an important role in reliability or survival studies since it describes the instantaneous risk of failure of items at a time point, given that they have not failed before. In some real life applications, abrupt changes in the hazard function are observed due to overhauls, major operations or specific maintenance activities. In such situations it is of interest to detect the location where such a change occurs and estimate the size of the change. In this paper we consider the problem of estimating a single change point in a piecewise constant hazard function when the observed variables are subject to random censoring. We suggest an estimation procedure that is based on certain structural properties and on least squares ideas. A simulation study is carried out to compare the performance of this estimator with two estimators available in the literature: an estimator based on a functional of the Nelson-Aalen estimator and a maximum likelihood estimator. The proposed least squares estimator tums out to be less biased than the other two estimators, but has a larger variance. We illustrate the estimation method on some real data sets.     

Estimation Of A Survival Function With Doubly Censored Data And Dirichlet Process Prior Knowledge On The Observable Variable

This article presents a nonparametric Bayesian procedure for estimating a survival curve in a proportional hazard model when some of the data are censored on the left and some are censored on the right. The method works under the assumption that there is a Dirichlet process prior knowledge on the observable variable. Strong consistency of the estimator is proved and an example is given. To finish some simulation is presented to analyze the estimator.     

Cox regression with missing covariate data using a modified partial likelihood method

Missing covariate values is a common problem in survival analysis. In this paper we propose a novel method for the Cox regression model that is close to maximum likelihood but avoids the use of the EM-algorithm. It exploits that the observed hazard function is multiplicative in the baseline hazard function with the idea being to profile out this function before carrying out the estimation of the parameter of interest. In this step one uses a Breslow type estimator to estimate the cumulative baseline hazard function. We focus on the situation where the observed covariates are categorical which allows us to calculate estimators without having to assume anything about the distribution of the covariates. We show that the proposed estimator is consistent and asymptotically normal, and derive a consistent estimator of the variance–covariance matrix that does not involve any choice of a perturbation parameter. Moderate sample size performance of the estimators is investigated via simulation and by application to a real data example.     

Improved estimation under random censorship

In this article we propose a variant of the Kaplan-Meier estimator which aims at reducing the bias by adding a bootstrap based correction term to the pertaining cumulative hazard function. For the mean lifetime it is demonstrated in a simulation study that the new estimator also has a smaller variance.     

Hazard-based nonparametric survivor function estimation

Summary.  A representation is developed that expresses the bivariate survivor function as a function of the hazard function for truncated failure time variables. This leads to a class of nonparametric survivor function estimators that avoid negative mass. The transformation from hazard function to survivor function is weakly continuous and compact differentiable, so that such properties as strong consistency, weak convergence to a Gaussian process and bootstrap applicability for a hazard function estimator are inherited by the corresponding survivor function estimator. The set of point mass assignments for a survivor function estimator is readily obtained by using a simple matrix calculation on the set of hazard rate estimators. Special cases arise from a simple empirical hazard rate estimator, and from an empirical hazard rate estimator following the redistribution of singly censored observations within strips. The latter is shown to equal van der Laan's repaired nonparametric maximum likelihood estimator, for which a Greenwood-like variance estimator is given. Simulation studies are presented to compare the moderate sample performance of various nonparametric survivor function estimators.     

On Local Polynomial Modelling of the Additive Risk Model

The additive risk model provides an alternative modelling technique for failure time data to the proportional hazards model. In this article, we consider the additive risk model with a nonparametric risk effect. We study estimation of the risk function and its derivatives with a parametric and an unspecified baseline hazard function respectively. The resulting estimators are the local likelihood and the local score estimators. We establish the asymptotic normality of the estimators and show that both methods have the same formula for asymptotic bias but different formula for variance. It is found that, in some special cases, the local score estimator is of the same efficiency as the local likelihood estimator though it does not use the information about the baseline hazard function. Another advantage of the local score estimator is that it has a closed form and is easy to implement. Some simulation studies are conducted to evaluate and compare the performance of the two estimators. A numerical example is used for illustration.     

Estimating the turning point of a bathtub-shaped failure distribution

The turning point of a hazard rate function is useful in assessing the hazard in the useful life phase and helps to determine and plan appropriate burn-in, maintenance, and repair policies and strategies. For many bathtub-shaped distributions, the turning point is unique, and the hazard varies little in the useful life phase. We investigate the performance of an empirical estimator for the turning point in the case of the modified Weibull distribution, a bathtub-shaped generalization of the Weibull distribution, that has been found to be useful in reliability engineering and other areas concerned with life-time data. We illustrate the theory by means of an example, and also conduct a simulation study to assess the performance of the estimator in practice.     

A Simple Estimator for the Shape Parameter of the Pareto Distribution with Economics and Medical Applications

In the present paper, an estimator of the shape parameter of the Pareto failure model is presented using grouped data. This estimator is based on obtaining the parameter in terms of the hazard rate, then replacing the unknown hazard rate by a grouped data estimator available in the literature. Death records are given as a numerical illustration in the medical context. The relation between the hazard rate and the income elasticity is derived. This relation allows the presentation of the same estimator in terms of the income elasticity so that it could be used in an economic context. Two illustrations are presented using income data. Simulated data are generated to compare the estimator with the maximum likelihood estimator.     

Nonparametric hazard rate estimation by orthogonal wavelet methods

We propose linear and nonlinear wavelet-based hazard rate estimators where the linear estimator is equivalent to a generalized kernel estimator. An asymptotic formula for the mean integrated squared error (MISE) of the nonlinear wavelet-based hazard rate estimator is provided. It is shown that the MISE formula for the nonlinear estimator is available for hazard rates which are smooth only in a piecewise sense, a feature not available for the kernel estimators.     

Lifetime estimation from doubly censored data and dirichlet process prior knowledge on the observable random vector

The purpose of this paper is to present a nonparametric Bayesian procedure for estimating a survival curve in a double censoring situation. Assuming a proportional hazard rates model, we propose a consistent estimation of lifetime, based on a Dirichlet process prior knowledge on the observable random vector. Some large sample properties of this estimator are also derived, We prove strong consistency and asymptotic weak convergence to a Gaussian pro cess. Finally, a simulation study is presented in order to analyze the behavior of the proposed estimator, and establish some comparisons to other estimators.     

Boundary and Bias Correction in Kernel Hazard Estimation

A new class of local linear hazard estimators based on weighted least square kernel estimation is considered. The class includes the kernel hazard estimator of Ramlau-Hansen (1983), which has the same boundary correction property as the local linear regression estimator (see Fan & Gijbels, 1996). It is shown that all the local linear estimators in the class have the same pointwise asymptotic properties. We derive the multiplicative bias correction of the local linear estimator. In addition we propose a new bias correction technique based on bootstrap estimation of additive bias. This latter method has excellent theoretical properties. Based on an extensive simulation study where we compare the performance of competing estimators, we also recommend the use of the additive bias correction in applied work.     

Proportional Hazards Model for Multivariate Failure Time Data

Multivariate failure time data also referred to as correlated or clustered failure time data, often arise in survival studies when each study subject may experience multiple events. Statistical analysis of such data needs to account for intracluster dependence. In this article, we consider a bivariate proportional hazards model using vector hazard rate, in which the covariates under study have different effect on two components of the vector hazard rate function. Estimation of the parameters as well as base line hazard function are discussed. Properties of the estimators are investigated. We illustrated the method using two real life data. A simulation study is reported to assess the performance of the estimator.     

Tests for Comparing Mark-Specific Hazards and Cumulative Incidence Functions

It is of interest in some applications to determine whether there is a relationship between a hazard rate function (or a cumulative incidence function) and a mark variable which is only observed at uncensored failure times. We develop nonparametric tests for this problem when the mark variable is continuous. Tests are developed for the null hypothesis that the mark-specific hazard rate is independent of the mark versus ordered and two-sided alternatives expressed in terms of mark-specific hazard functions and mark-specific cumulative incidence functions. The test statistics are based on functionals of a bivariate test process equal to a weighted average of differences between a Nelson-Aalen-type estimator of the mark-specific cumulative hazard function and a nonparametric estimator of this function under the null hypothesis. The weight function in the test process can be chosen so that the test statistics are asymptotically distribution-free. Asymptotically correct critical values are obtained through a simple simulation procedure. The testing procedures are shown to perform well in numerical studies, and are illustrated with an AIDS clinical trial example. Specifically, the tests are used to assess if the instantaneous or absolute risk of treatment failure depends on the amount of accumulation of drug resistance mutations in a subject's HIV virus. This assessment helps guide development of anti-HIV therapies that surmount the problem of drug resistance.     

Shape Constrained Non‐parametric Estimators of the Baseline Distribution in Cox Proportional Hazards Model

Abstract. We investigate non‐parametric estimation of a monotone baseline hazard and a decreasing baseline density within the Cox model. Two estimators of a non‐decreasing baseline hazard function are proposed. We derive the non‐parametric maximum likelihood estimator and consider a Grenander type estimator, defined as the left‐hand slope of the greatest convex minorant of the Breslow estimator. We demonstrate that the two estimators are strongly consistent and asymptotically equivalent and derive their common limit distribution at a fixed point. Both estimators of a non‐increasing baseline hazard and their asymptotic properties are obtained in a similar manner. Furthermore, we introduce a Grenander type estimator for a non‐increasing baseline density, defined as the left‐hand slope of the least concave majorant of an estimator of the baseline cumulative distribution function, derived from the Breslow estimator. We show that this estimator is strongly consistent and derive its asymptotic distribution at a fixed point.     

Mixed Discrete and Continuous Cox Regression Model

The Cox (1972) regression model is extended to include discrete and mixed continuous/discrete failure time data by retaining the multiplicative hazard rate form of the absolutely continuous model. Application of martingale arguments to the regression parameter estimating function show the Breslow (1974) estimator to be consistent and asymptotically Gaussian under this model. A computationally convenient estimator of the variance of the score function can be developed, again using martingale arguments. This estimator reduces to the usual hypergeometric form in the special case of testing equality of several survival curves, and it leads more generally to a convenient consistent variance estimator for the regression parameter. A small simulation study is carried out to study the regression parameter estimator and its variance estimator under the discrete Cox model special case and an application to a bladder cancer recurrence dataset is provided.     

Estimating stage occupation probabilities in non-Markov models

We study non-Markov multistage models under dependent censoring regarding estimation of stage occupation probabilities. The individual transition and censoring mechanisms are linked together through covariate processes that affect both the transition intensities and the censoring hazard for the corresponding subjects. In order to adjust for the dependent censoring, an additive hazard regression model is applied to the censoring times, and all observed counting and “at risk” processes are subsequently given an inverse probability of censoring weighted form. We examine the bias of the Datta–Satten and Aalen–Johansen estimators of stage occupation probability, and also consider the variability of these estimators by studying their estimated standard errors and mean squared errors. Results from different simulation studies of frailty models indicate that the Datta–Satten estimator is approximately unbiased, whereas the Aalen–Johansen estimator either under- or overestimates the stage occupation probability due to the dependent nature of the censoring process. However, in our simulations, the mean squared error of the latter estimator tends to be slightly smaller than that of the former estimator. Studies on development of nephropathy among diabetics and on blood platelet recovery among bone marrow transplant patients are used as demonstrations on how the two estimation methods work in practice. Our analyses show that the Datta–Satten estimator performs well in estimating stage occupation probability, but that the censoring mechanism has to be quite selective before a deviation from the Aalen-Johansen estimator is of practical importance. N. Gunnes—Supported by a grant from the Norwegian Cancer Society.     

On estimation of stress–strength parameter using record values from proportional hazard rate models

ABSTRACT

Based on record values, this article deals with inference for stress–strength reliability, R = P(X < Y), where the distributions of X and Y follow proportional hazard rate models but having different parameters. Maximum likelihood estimator, uniformly minimum variance unbiased estimator, Bayes estimator, and different confidence intervals for R are obtained. Numerical computations and simulation study are presented for illustrative purposes.     

Smoothed bootstrap bandwidth selection for nonparametric hazard rate estimation

A smoothed bootstrap method is presented for the purpose of bandwidth selection in nonparametric hazard rate estimation for iid data. In this context, two new bootstrap bandwidth selectors are established based on the exact expression of the bootstrap version of the mean integrated squared error of some approximations of the kernel hazard rate estimator. This is very useful since Monte Carlo approximation is no longer needed for the implementation of the two bootstrap selectors. A simulation study is carried out in order to show the empirical performance of the new bootstrap bandwidths and to compare them with other existing selectors. The methods are illustrated by applying them to a diabetes data set.