Existence Conditions for Balanced Fractional 2m Factorial Designs of Resolution 2l + 1 Derived from Simple Arrays

We consider a fractional 2^m factorial design derived from a simple array (SA) such that the (? + 1)-factor and higher-order interactions are negligible, where 2? ? m. The purpose of this article is to give a necessary and sufficient condition for an SA to be a balanced fractional 2^m factorial design of resolution 2? + 1. Such a design is concretely characterized by the suffixes of the indices of an SA.     

Balanced Factorial Designs for cDNA Microarray Experiments

Balanced factorial designs are introduced for cDNA microarray experiments. Single replicate designs obtained using the classical method of confounding are shown to be particularly useful for deriving suitable balanced designs for cDNA microarrays. Classical factorial designs obtained using methods other than the method of confounding are also shown to be useful. The paper provides a systematic method of deriving designs for microarray experiments as opposed to algorithmic and ad-hoc methods and generalizes several of the microarray designs given recently in the literature.     

D-Optimal Two-Level Fractional Factorial Designs of Resolution III with Two Dispersion Factors

The problem of finding D-optimal designs, with two dispersion factors, for the estimation of all location main effects is investigated in the class of regular unreplicated two-level fractional factorial designs of resolution III. Designs having length three words involving both of the dispersion factors in the defining relation are shown to be inferior in terms of D-optimality. Tables of factors that are named as the two dispersion factors so that the resulting design is either D-optimal or has the largest determinant of the information matrix are provided. Rank-order of designs is studied when the number of length three words involving either one of the dispersion factors and the number of length four words involving both of the dispersion factors are fixed. Rank-order of designs when the numbers of aforementioned words are less than or equal to ten is given.     

Existence conditions for balanced fractional 3m factorial designs of resolution R({00, 10, 01, 20, 11})

We consider a fractional 3^m factorial design derived from a simple array (SA) such that the non negligible factorial effects are the general mean, the linear and the quadratic components of the main effect, and the linear-by-linear and the linear-by-quadratic components of the two-factor interaction. If these effects are estimable, then a design is said to be of resolution R({00, 10, 01, 20, 11}). In this paper, we give a necessary and sufficient condition for an SA to be a balanced fractional 3^m factorial design of resolution R({00, 10, 01, 20, 11}). Such a design is concretely characterized by the suffixes of the indices of an SA.     

Hyper-Graeco-Latin Squares and Fractional Factorial Designs

A Latin square of order s is an arrangement of the s letters in an s × s square so that every letter appears exactly once in every row and exactly once in every column. Copeland and Nelson (2000) used two examples to show that a Latin square can be chosen such that it corresponds to a fractional factorial design. In this article, we are going to study this topic more precisely. Furthermore, we will explore the relationship between fractional factorial designs and hyper-Graeco-Latin squares in general, where s is a prime or a power of a prime.     

D-optimal Factorial Designs under Generalized Linear Models

Generalized linear models (GLMs) have been used widely for modeling the mean response both for discrete and continuous random variables with an emphasis on categorical response. Recently Yang, Mandal and Majumdar (2013 Yang, J., Mandal, A., Majumdar, D. (2013). Optimal designs for 2^k factorial experiments with binary response. Technical Report, Available at: http://arxiv.org/pdf/1109.5320v4.pdf. [Google Scholar]) considered full factorial and fractional factorial locally D-optimal designs for binary response and two-level experimental factors. In this article, we extend their results to a general setup with response belonging to a single-parameter exponential family and for multilevel predictors.     

Some Results on Fractional Factorial Split-Plot Designs with Multi-Level Factors

Fractional factorial split-plot (FFSP) designs have received much attention in recent years. In this article, the matrix representation for FFSP designs with multi-level factors is first developed, which is an extension of the one proposed by Bingham and Sitter (1999b Bingham , D. , Sitter , R. R. ( 1999b ). Some theoretical results for fractional factorial split-plot designs . Ann. Statist. 27 : 1240 – 1255 . [Google Scholar]) for the two-level case. Based on this representation, periodicity results of maximum resolution and minimum aberration for such designs are derived. Differences between FFSP designs with multi-level factors and those with two-level factors are highlighted.     

Sequential Experimentation Approach for Augmenting of Resolution III Fractions

General augmentation techniques in experimental design, such as the foldover and the semifold, have been a common practice in industrial experimentation for years. Even though these techniques are extremely effective in maintaining balance and near orthogonality, they possess disadvantages, such as the inability to decouple specific terms and inefficiency. This article aims for a sequential experimentation approach capable of overcoming the drawbacks of the general methods while maintaining some of their benefits. We focus on the development of an algorithm for sequential augmentation of fractional factorial designs resolution III. Advantages, limitations, and potential benefits of the new method are provided.     

Catalogue of Group Structures for Three-level Fractional Factorial Designs

Taguchi (1959) introduced the concept of split-unit design to sort the factors into different groups depending upon the difficulties involved in changing the levels of factors. Li et al. (1991) renamed it as split-plot design. Chen et al. (1993) have given a catalogue of small designs for two- and three-level fractional factorial designs pertaining to a single type of factors. Aggarwal et al. (1997) have given a catalogue of group structure for two-level fractional factorial designs developed under the concept of split-plot design. In this paper, an algorithm has been developed for generating group structure and possible allocations for various 3^n-k fractional factorial designs.     

Fractional Factorial Designs for Model-Based Evaluation of Customer Preferences

In this article, we explore the connection between Conjoint Analysis (CA) and a recent theory for minimum size orthogonal fractional factorial design generation (Fontana, 2013 Fontana , R. ( 2013 ). Algebraic generation of minimum size orthogonal fractional factorial designs: an approach based on integer linear programming . Computat. Statist. 28 : 241 – 253 .[Crossref], [Web of Science ®] , [Google Scholar]).

We show how searching for a minimum size OFFD that satisfies a set of constraints, expressed in terms of orthogonality between simple and interaction effects, is equivalent to solving an integer linear programming problem. It is worth noting that the methodology puts no restriction either on the number of levels of each factor or on the orthogonality constraints and so it can be applied to a very wide range of designs, including mixed orthogonal arrays. An algorithm, that has been implemented in SAS/IML, is briefly described.

The use of this algorithm during the design stage of a generic CA is shown in two applications.     

Fractional Factorial Designs for the Detection of Interactions between Design and Noise Factors

In industrial experiments on both design (control) factors and noise factors aimed at improving the quality of manufactured products, designs are needed which afford independent estimation of all design×noise interactions in as few runs as possible, while allowing aliasing between those factorial effects of less interest. An algorithm for generating orthogonal fractional factorial designs of this type is described for factors at two levels. The generated designs are appropriate for experimenting on individual factors or for experimentation involving group screening of factors.     

Constructions of Nested Pairwise Efficiency and Variance Balanced Designs

ABSTRACT

Nested pairwise efficiency and variance balanced designs form a new class of block designs. In this article, two methods of constructing such designs from a symmetric balanced incomplete block design are proposed with some illustrations.     

On the Use of Semi-folding in Regular Blocked Two-level Factorial Designs

In this article, we consider experimental situations where a blocked regular two-level fractional factorial initial design is used. We investigate the use of the semi-fold technique as a follow-up strategy for de-aliasing effects that are confounded in the initial design as well as an alternative method for constructing blocked fractional factorial designs. A construction method is suggested based on the full foldover technique and sufficient conditions are obtained when the semi-fold yields as many estimable effects as the full foldover.     

Linear Integer Programming Approach to Construction of Balanced Incomplete Block Designs

This article proposes a linear integer programming-based algorithm to construct balanced incomplete block designs. Working of the algorithm is illustrated with the help of an example. The algorithm is able to generate balanced incomplete block designs very fast in most of the cases. The performance of the proposed algorithm is compared with other algorithms proposed in the literature. It is demonstrated that the proposed algorithm is competitive with the existing algorithms.     

Generalisation of Mood's Test to Factorial Designs to Detect Heterogeneity of Variances

Mood's test, which is a relatively old test (and the oldest non‐parametric test among those tests in its class) for determining heterogeneity of variance, is still being widely used in different areas such as biometry, biostatistics and medicine. Although it is a popular test, it is not suitable for use on a two‐way factorial design. In this paper, Mood's test is generalised to the 2 × 2 factorial design setting and its performance is compared with that of Klotz's test. The power and robustness of these tests are examined in detail by means of a simulation study with 10,000 replications. Based on the simulation results, the generalised Mood's and Klotz's tests can especially be recommended in settings in which the parent distribution is symmetric. As an example application we analyse data from a multi‐factor agricultural system that involves chilli peppers, nematodes and yellow nutsedge. This example dataset suggests that the performance of the generalised Mood test is in agreement with that of the generalised Klotz's test.     

Balanced e-optimal designs of resolution III for the 2×3 series

We consider the problem of constructing designs which are E-optimal in the class of all balanced resolution III designs for the 2^m×3ⁿ series. The inverse of the information matrix for general resolution III balanced 2^m×3ⁿ designs is obtained. Optimal designs are constructed for the cases (m,n)=(3, 1), (4, 1), (2, 2) and (3, 2) for various numbers of runs in the practical range.     

On Universal Optimality of Circular Weakly Neighbor Balanced Designs Under an Interference Model

In this article, the optimal design problem in a fixed effects interference model with left-neighbor effects is studied. It is known (Druilhet, 1999 Druilhet , P. ( 1999 ). Optimality of circular neighbor balanced designs . J. Statist. Plann. Infer. 81 : 141 – 152 .[Crossref], [Web of Science ®] , [Google Scholar]) that circular neighbor balanced designs (CNBDs) are universally optimal in such a model. We prove the universal optimality of circular weakly neighbor balanced designs (CWNBDs), which require a smaller number of blocks than CNBDs. CWNBDs with the number of blocks smaller than the number of treatments belong to the class of partially neighbor balanced designs (PNBDs) defined by Wilkinson et al. (1983 Wilkinson , G. N. , Eckert , R. , Hancock , T. W. , Mayo , O. ( 1983 ). Nearest neighbour (NN) analysis of field experiments . J. Roy. Statist. Soc. Ser. B 45 : 151 – 210 . [Google Scholar]). We give a construction method for some CWNBDs, with examples.     

Minimum Aberration Regular Two-Level Designs in the Presence of Dispersion Factors

In practice, the variance of the response variable may change as some specific factors change from one setting to another in a factorial experiment. These factors affecting the variation of the response are called dispersion factors, which can violate the usual assumption of variance homogeneity. In this study, we modify the conventional minimum aberration criterion to take the impact of dispersion factors into account. The situations of one or two dispersion factors are investigated. As a result, we present regular 2^{n ? p} designs with run sizes equal to 16 and 32 using the modified minimum aberration criterion.     

The Use of Balanced Incomplete Block Designs in Designing Randomized Response Surveys

This paper investigates the block total response method proposed by Raghavarao and Federer for providing accurate estimates of the base rates of sensitive characteristics during surveys. It determines the best balanced incomplete block design to use to estimate the base rates for three, four, five and six sensitive attributes respectively, given a maximum total number of 13 questions. The estimates obtained from this method have smaller variance than estimates obtained using the similar, but more popular, unmatched count technique.