Generalized Laplacian approximations in Bayesian inference

This paper presents a new Laplacian approximation to the posterior density of η = g(θ). It has a simpler analytical form than that described by Leonard et al. (1989). The approximation derived by Leonard et al. requires a conditional information matrix R_η to be positive definite for every fixed η. However, in many cases, not all R_η are positive definite. In such cases, the computations of their approximations fail, since the approximation cannot be normalized. However, the new approximation may be modified so that the corresponding conditional information matrix can be made positive definite for every fixed η. In addition, a Bayesian procedure for contingency-table model checking is provided. An example of cross-classification between the educational level of a wife and fertility-planning status of couples is used for explanation. Various Laplacian approximations are computed and compared in this example and in an example of public school expenditures in the context of Bayesian analysis of the multiparameter Fisher-Behrens problem.     

Asymptotic results in canonical discriminant analysis when the dimension is large compared to the sample size

This paper deals with the distributions of test statistics for the number of useful discriminant functions and the characteristic roots in canonical discriminant analysis. These asymptotic distributions have been extensively studied when the number p   of variables is fixed, the number q+1$q+1$ of groups is fixed, and the sample size N tends to infinity. However, these approximations become increasingly inaccurate as the value of p increases for a fixed value of N. On the other hand, we encounter to analyze high-dimensional data such that p is large compared to n. The purpose of the present paper is to derive asymptotic distributions of these statistics in a high-dimensional framework such that q   is fixed, p→∞$p\to \infty$, m=n-p+q→∞$m=n-p+q\to \infty$, and p/n→c∈(0,1)$p/n\to c\in (0,1)$, where n=N-q-1$n=N-q-1$. Numerical simulation revealed that our new asymptotic approximations are more accurate than the classical asymptotic approximations in a considerably wide range of (n,p,q)$(n,p,q)$.     

Minimum phi-divergence estimators for loglinear models with linear constraints and multinomial sampling

In this paper the family ofφ-divergence estimators for loglinear models with linear constraints and multinomial sampling is studied. This family is an extension of the maximum likelihood estimator studied by Haber and Brown (1986). A simulation study is presented and some alternative estimators to the maximum likelihood are obtained. This work was parcially supported by Grant DGES PB2003-892     

On Christensen's conjecture

In this paper we give solution to a conjecture appearing in Christensen (1997, p. 360) in relation to the definitions of standardized residuals in loglinear models. Work done when he was visiting as the Distinguished Lukacs Professor on leave from the Complutense University of Madrid. An erratum to this article is available at .     

Connections of the Poisson weight function to overdispersion and underdispersion

In this paper, we establish several connections of the Poisson weight function to overdispersion and underdispersion. Specifically, we establish that the logconvexity (logconcavity) of the mean weight function is a necessary and sufficient condition for overdispersion (underdispersion) when the Poisson weight function does not depend on the original Poisson parameter. We also discuss some properties of the weighted Poisson distributions (WPD). We then introduce a notion of pointwise duality between two WPDs and discuss some associated properties. Next, we present some illustrative examples and provide a discussion on various Poisson weight functions used in practice. Finally, some concluding remarks are made.     

Waiting time distributions for a run with additional constraints

This paper proposes a method for obtaining the exact probability of occurrence of the first success run of specified length with the additional constraint that at every trial until the occurrence of the first success run the number of successes up to the trial exceeds that of failures. For the sake of the additional constraint, the problem cannot be solved by the usual method of conditional probability generating functions. An idea of a kind of truncation is introduced and studied in order to solve the problem. Concrete methods for obtaining the probability in the cases of Bernoulli trials and time-homogeneous {0,1}$\{0,1\}$-valued Markov dependent trials are given. As an application of the results, a modification of the start-up demonstration test is studied. Numerical examples which illustrate the feasibility of the results are also given.     

Characterizations based on record values and order statistics

Consider a sequence of independent and identically distributed random variables {_Xi,i?1}$\{X_i,i?1\}$ with a common absolutely continuous distribution function F  . Let _X1:n?_X2:n???_Xn:n$X_{1:n}?X_{2:n}???X_{n:n}$ be the order statistics of {_X1,_X2,…,_Xn}$\{X_1,X_2,\dots ,X_n\}$ and {_Yl,l?1}$\{Y_l,l?1\}$ be the sequence of record values generated by {_Xi,i?1}$\{X_i,i?1\}$. In this work, the conditional distribution of _Yl$Y_l$ given _Xn:n$X_{n:n}$ is established. Some characterizations of F   based on record values and _Xn:n$X_{n:n}$ are then given.     

Statistical aspects of linkage analysis in interlaboratory studies

This paper investigates statistical issues that arise in interlaboratory studies known as Key Comparisons when one has to link several comparisons to or through existing studies. An approach to the analysis of such a data is proposed using Gaussian distributions with heterogeneous variances. We develop conditions for the set of sufficient statistics to be complete and for the uniqueness of uniformly minimum variance unbiased estimators (UMVUE) of the contrast parametric functions. New procedures are derived for estimating these functions with estimates of their uncertainty. These estimates lead to associated confidence intervals for the laboratories (or studies) contrasts. Several examples demonstrate statistical inference for contrasts based on linkage through the pilot laboratories. Monte Carlo simulation results on performance of approximate confidence intervals are also reported.     

A construction for generalized hadamard matrices

We prove that if p^r and p^r ? 1 are both prime powers then there is a generalized Hadamard matrix of order p^r(p^r ? 1) with elements from the elementary abelian group Z_p x?x Z_p. This result was motivated by results of Rajkundia on BIBD's. This result is then used to produce p^r ? 1 mutually orthogonal F-squares F(p^r(p^r ? 1); p^r ? 1).     

Burden of bioinformatics in medical research: Statistical perspectives and controversies

The ongoing evolution of genomics and bioinformatics has an overwhelming impact on medical and clinical research, albeit this development is often marked by genuine controversies as well as lack of scientific clarities and acumen. The search for disease genes and the gene–environment interaction has drawn considerable interdisciplinary scientific attention: environmental health, clinical and medical sciences, biological as well as computational and statistical sciences are most noteworthy. Statistical reasoning (quantitative modeling and analysis perspectives) has a focal stand in this respect while data mining resolutions are far from being statistically fully understood or interpretable. The use of human subjects, though unavoidable, under various extraneous restraints, medical ethics perspectives, and human rights undercurrents, has raised concern all over the world, especially in the developing countries. In the genomics context, clinical trials may be designed on chips and yet there are greater challenges due to the curse of dimensionality perspectives. Some of these challenging statistical issues in medical and clinical research (with emphasis on clinical trials) are appraised in the light of existing statistical tools, which are available for less complex clinical research problems.     

The superharmonic condition for simultaneous estimation of means in exponential familles

The mean vector associated with several independent variates from the exponential subclass of Hudson (1978) is estimated under weighted squared error loss. In particular, the formal Bayes and “Stein-like” estimators of the mean vector are given. Conditions are also given under which these estimators dominate any of the “natural estimators”. Our conditions for dominance are motivated by a result of Stein (1981), who treated the N_p (θ, I) case with p ≥ 3. Stein showed that formal Bayes estimators dominate the usual estimator if the marginal density of the data is superharmonic. Our present exponential class generalization entails an elliptic differential inequality in some natural variables. Actually, we assume that each component of the data vector has a probability density function which satisfies a certain differential equation. While the densities of Hudson (1978) are particular solutions of this equation, other solutions are not of the exponential class if certain parameters are unknown. Our approach allows for the possibility of extending the parametric Stein-theory to useful nonexponential cases, but the problem of nuisance parameters is not treated here.     

Bayesian variable window scan statistics

In this article two-stage hierarchical Bayesian models are used for the observed occurrences of events in a rectangular region. Two Bayesian variable window scan statistics are introduced to test the null hypothesis that the observed events follow a specified two-stage hierarchical model vs an alternative that indicates a local increase in the average number of observed events in a subregion (clustering). Both procedures are based on a sequence of Bayes factors and their p$p$-values that have been generated via simulation of posterior samples of the parameters, under the null and alternative hypotheses. The posterior samples of the parameters have been generated by employing Gibbs sampling via introduction of auxiliary variables. Numerical results are presented to evaluate the performance of these variable window scan statistics.     

Statistical inference for a semiparametric measurement error regression model with heteroscedastic errors

Efficient inference for regression models requires that the heteroscedasticity be taken into account. We consider statistical inference under heteroscedasticity in a semiparametric measurement error regression model, in which some covariates are measured with errors. This paper has multiple components. First, we propose a new method for testing the heteroscedasticity. The advantages of the proposed method over the existing ones are that it does not need any nonparametric estimation and does not involve any mismeasured variables. Second, we propose a new two-step estimator for the error variances if there is heteroscedasticity. Finally, we propose a weighted estimating equation-based estimator (WEEBE) for the regression coefficients and establish its asymptotic properties. Compared with existing estimators, the proposed WEEBE is asymptotically more efficient, avoids undersmoothing the regressor functions and requires less restrictions on the observed regressors. Simulation studies show that the proposed test procedure and estimators have nice finite sample performance. A real data set is used to illustrate the utility of our proposed methods.     

Multivariate inverse Gaussian distribution as a limit of multivariate waiting time distributions

Multivariate inverse Gaussian distribution proposed by Minami [2003. A multivariate extension of inverse Gaussian distribution derived from inverse relationship. Commun. Statist. Theory Methods 32(12), 2285–2304] was derived through multivariate inverse relationship with multivariate Gaussian distributions and characterized as the distribution of the location at a certain stopping time of a multivariate Brownian motion. In this paper, we show that the multivariate inverse Gaussian distribution is also a limiting distribution of multivariate Lagrange distributions, which is a family of waiting time distributions, under certain conditions.     

Limit theory of generalized order statistics

Generalized order statistics (gos) were introduced by Kamps [1995. A Concept of Generalized Order Statistics. Teubner, Stuttgart] to unify several models of ordered random variables (rv's), e.g., (ordinary) order statistics (oos), records, sequential order statistics (sos). In a wide subclass of gos that includes oos and sos, the possible limit distribution functions (df's) of the maximum gos are obtained in Nasri-Roudsari [1996. Extreme value theory of generalized order statistics. J. Statist. Plann. Inference 55, 281–297]. In this paper, for this subclass, necessary and sufficient conditions of weak convergence, as well as the form of the possible limit df's of extreme, intermediate and central gos are derived. These results are extended to a wider subclass.     

A comparison of the independent-samples t-test and the paired-samples t-test when the observations are nonnegatively correlated pairs

An account of the behavior of the independent-samples t-test when applied to homoschedastic bivariate normal data is presented, and a comparison is made with the paired-samples t-test. Since the significance level is not violated when applying the independent-samples t-test to data which consist of positively correlated pairs and since the estimate of the variance is based on a larger number of ‘degrees of freedom’, the results suggest that when the sample size is small, one should not worry much about the possible existence of weak positive correlation. One may do better, powerwise, to ignore such correlation and use the independent-samples t-test, as though the samples were independent.     

Star-shaped distributions and their generalizations

Elliptically contoured distributions can be considered to be the distributions for which the contours of the density functions are proportional ellipsoids. We generalize elliptically contoured densities to “star-shaped distributions” with concentric star-shaped contours and show that many results in the former case continue to hold in the more general case. We develop a general theory in the framework of abstract group invariance so that the results can be applied to other cases as well, especially those involving random matrices.     

Methods for calculating stationary distribution in linear models of time series

The article deals with methods for computing the stationary marginal distribution in linear models of time series. Two approaches are described. First, an algorithm based on approximation of solution of the corresponding integral equation is briefly reviewed. Then, we study the limit behaviour of the partial sums c ₁ η₁+c ₂ η₂+···+c _n η _n where η _i are i.i.d. random variables and c _i real constants. We generalize procedure of Haiman (1998) [Haiman, G., 1998, Upper and lower bounds for the tail of the invariant distribution of some AR(1) processes. Asymptotic Methods in Probability and Statistics, 45, 723–730.] to an arbitrary causal linear process and relax the assumptions of his result significantly. This is achieved by investigating the properties of convolution of densities.