Additive Transformation Models for Clustered Doubly Censored Data

In this article, we propose estimating procedures for additive semiparametric transformation models with clustered doubly-censored data. A simulation study is conducted to investigate the performance of the proposed estimators. We apply the proposed methods to the dataset from the well-known Diabetic Retinopathy Study.     

Regression M-estimators with One Modified Form of Doubly Censored Data

In this article, we consider the M-estimators for the linear regression model when both response and covariate variables are subject to double censoring. The proposed estimators are constructed as some functional of three types of estimators for a bivariate survival distribution. The first two estimators are the generalizations of the Campbell and Földes (1982 Campbell, G. and Földes, A. 1982. “Large sample properties of nonparametric statistical inference”. In Nonparametric Statistical Inference., Edited by: Gnredenko, B. V., Puri, M. L. and Vineze, I. 103–122. Amsterdam: North-Holland.  [Google Scholar]) and Dabrowska (1988 Dabrowska, D. M. 1988. Kaplan-Meier estimate on the plane. Annals of Statistics, 18: 1475–1489. [Crossref], [Web of Science ®] , [Google Scholar]) estimators proposed by Shen (2009 Shen, P. S. 2009. Nonparametric estimation of the bivariate survival function one modified form of doubly censored data. Computational Statistics, 25: 203–313. [Crossref], [Web of Science ®] , [Google Scholar]). The third estimator is the generalization of the Prentice and Cai (1992 Prentice, R. L. and Cai, J. 1992. Covariance and survivor function estimation using censored multivariate failure time data. Biometrika, 79: 495–512. [Crossref], [Web of Science ®] , [Google Scholar]) estimator. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to estimate standard deviations and construct interval estimators.     

A Marginal Additive Rates Model for Recurrent Event Data with a Terminal Event

Recurrent events data with a terminal event often arise in many longitudinal studies. Most of existing models assume multiplicative covariate effects and model the conditional recurrent event rate given survival. In this article, we propose a marginal additive rates model for recurrent events with a terminal event, and develop two procedures for estimating the model parameters. The asymptotic properties of the resulting estimators are established. In addition, some numerical procedures are presented for model checking. The finite-sample behavior of the proposed methods is examined through simulation studies, and an application to a bladder cancer study is also illustrated.     

Additive Transformation Models for Recurrent Events

In this article, we propose a class of additive transformation models for recurrent event data, which includes the additive rates model as a special case. The new models offer great flexibility in formulating the effects of covariates on the mean function of recurrent events. Estimating equation approaches are developed for the model parameters, and asymptotic properties of the resulting estimators are established. In addition, a model checking procedure is presented to assess the adequacy of the model. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a bladder cancer study is presented.     

Additive Transformation Models for Multivariate Interval-Censored Data

ABSTRACT

We present a new estimator of extreme quantiles dedicated to Weibull tail distributions. This estimate is based on a consistent estimator of the Weibull tail coefficient. This parameter is defined as the regular variation coefficient of the inverse cumulative hazard function. We give conditions in order to obtain the weak consistency and the asymptotic distribution of the extreme quantiles estimator. Its asymptotic as well as its finite sample performances are compared to classical ones.     

On Fitting Transformation Model to Survey Data

In this article, we consider fitting a semiparametric linear model to survey data with censored observations. The specific goal of the paper is to extend the methods of Cheng et al. (1995 Cheng, S.C., Wei, L.J., Ying, Z. (1995). Analysis of transformation models with censored data. Biometrika 82(4):835–845.[Crossref], [Web of Science ®] , [Google Scholar]) and Chen et al. (2002 Chen, K., Jin, Z. Ying, Z. (2002). Semiparametric analysis of transformation models with censored data. Biometrika 89:659–668.[Crossref], [Web of Science ®] , [Google Scholar]) to the case when the sample has been drawn from a population using a complex sampling design. Similar to the approach of Lin (2000 Lin, D.Y. (2000). On fitting Cox’s proportional hazards models to survey data. Biometrika 87:37–47.[Crossref], [Web of Science ®] , [Google Scholar]), we regard the survey population as a random sample from an infinite universe and accounts for this randomness in the statistical inference. A simulation study is conducted to investigate the performance of the proposed estimators.     

Generalized Method of Moments for Additive Hazards Model with Clustered Dental Survival Data

For multivariate survival data, we study the generalized method of moments (GMM) approach to estimation and inference based on the marginal additive hazards model. We propose an efficient iterative algorithm using closed‐form solutions, which dramatically reduces the computational burden. Asymptotic normality of the proposed estimators is established, and the corresponding variance–covariance matrix can be consistently estimated. Inference procedures are derived based on the asymptotic chi‐squared distribution of the GMM objective function. Simulation studies are conducted to empirically examine the finite sample performance of the proposed method, and a real data example from a dental study is used for illustration.     

Empirical Likelihood Ratio for Linear Transformation Models with Doubly Censored Data

Double censoring arises when T represents an outcome variable that can only be accurately measured within a certain range, [L, U], where L and U are the left- and right-censoring variables, respectively. When L is always observed, we consider the empirical likelihood inference for linear transformation models, based on the martingale-type estimating equation proposed by Chen et al. (2002 Chen , K. , Jin , Z. , Ying , Z. ( 2002 ). Semiparametric analysis of transformation models with censored data . Biometrika 89 : 659 – 668 .[Crossref], [Web of Science ®] , [Google Scholar]). It is demonstrated that both the approach of Lu and Liang (2006 Lu , W. , Liang , Y. ( 2006 ). Empirical likelihood inference for linear transformation models . Journal of Multivariate Analysis 97 : 1586 – 1599 .[Crossref], [Web of Science ®] , [Google Scholar]) and that of Yu et al. (2011 Yu , W. , Sun , Y. , Zheng , M. ( 2011 ). Empirical likelihood method for linear transformation models . Annals of the Institute of Statistical Mathematics 63 : 331 – 346 .[Crossref], [Web of Science ®] , [Google Scholar]) can be extended to doubly censored data. Simulation studies are conducted to investigate the performance of the empirical likelihood ratio methods.     

包含加法模型和混合模型的指数分析体系

统计指数体系分析方法的一个较大不足就是局限于乘法形式的经济方程式,然而经济现象之间的相互联系是多种多样的,目前的统计指数体系分析方法难以应用于形式多样的复杂经济现象的因素分析。本文把基于乘法方式的指数体系称之为指数体系的“乘法模型”,并以此为基础,将传统的只包含乘法关系的经济方程式加以扩展,将其推广到可以应用于加减运算的“加法模型”和包含全部四则运算的“混合模型”,建立了“广义指数分析模型”。该模型不仅保留了传统统计指数体系的基本结构和基本分析方法,还可以较大地提高统计指数分析的深度和广度,由此可以基本解决统计指数体系分析方法的局限性问题。     

The NPMLE for Doubly Censored Current Status Data

In biostatistical applications interest often focuses on the estimation of the distribution of time T between two consecutive events. If the initial event time is observed and the subsequent event time is only known to be larger or smaller than an observed point in time, then the data is described by the well understood singly censored current status model, also known as interval censored data, case I. Jewell et al. (1994) extended this current status model by allowing the initial time to be unobserved, but with its distribution over an observed interval ' A, B ' known to be uniformly distributed; the data is referred to as doubly censored current status data. These authors used this model to handle application in AIDS partner studies focusing on the NPMLE of the distribution G of T . The model is a submodel of the current status model, but the distribution G is essentially the derivative of the distribution of interest F in the current status model. In this paper we establish that the NPMLE of G is uniformly consistent and that the resulting estimators for the n ^1/2-estimable parameters are efficient. We propose an iterative weighted pool-adjacent-violator-algorithm to compute the estimator. It is also shown that, without smoothness assumptions, the NPMLE of F converges at rate n ^−2/5 in L ²-norm while the NPMLE of F in the non-parametric current status data model converges at rate n ^−1/3 in L ²-norm, which shows that there is a substantial gain in using the submodel information.     

Empirical Likelihood for the Additive Hazards Model with Current Status Data

We investigate empirical likelihood for the additive hazards model with current status data. An empirical log-likelihood ratio for a vector or subvector of regression parameters is defined and its limiting distribution is shown to be a standard chi-squared distribution. The proposed inference procedure enables us to make empirical likelihood-based inference for the regression parameters. Finite sample performance of the proposed method is assessed in simulation studies to compare with that of a normal approximation method, it shows that the empirical likelihood method provides more accurate inference than the normal approximation method. A real data example is used for illustration.     

Methods of Statistical Inference for Median Regression Models with Doubly Censored Data

Recently, least absolute deviations (LAD) estimator for median regression models with doubly censored data was proposed and the asymptotic normality of the estimator was established. However, it is invalid to make inference on the regression parameter vectors, because the asymptotic covariance matrices are difficult to estimate reliably since they involve conditional densities of error terms. In this article, three methods, which are based on bootstrap, random weighting, and empirical likelihood, respectively, and do not require density estimation, are proposed for making inference for the doubly censored median regression models. Simulations are also done to assess the performance of the proposed methods.     

Hierarchical-Likelihood Approach for Mixed Linear Models with Censored Data

Mixed linear models describe the dependence via random effects in multivariate normal survival data. Recently they have received considerable attention in the biomedical literature. They model the conditional survival times, whereas the alternative frailty model uses the conditional hazard rate. We develop an inferential method for the mixed linear model via Lee and Nelder's (1996) hierarchical-likelihood (h-likelihood). Simulation and a practical example are presented to illustrate the new method.     

A Multiple Imputation Approach to Linear Regression with Clustered Censored Data

Weextend Wei and Tanner's (1991) multiple imputation approach insemi-parametric linear regression for univariate censored datato clustered censored data. The main idea is to iterate the followingtwo steps: 1) using the data augmentation to impute for censoredfailure times; 2) fitting a linear model with imputed completedata, which takes into consideration of clustering among failuretimes. In particular, we propose using the generalized estimatingequations (GEE) or a linear mixed-effects model to implementthe second step. Through simulation studies our proposal comparesfavorably to the independence approach (Lee et al., 1993), whichignores the within-cluster correlation in estimating the regressioncoefficient. Our proposal is easy to implement by using existingsoftwares.     

A Nonparametric Frailty Model for Clustered Survival Data

Clayton-type counting process formulations for survival data and parametric gamma models for cluster-specific frailty quantities are now routinely applied in analyses of clustered survival data. On the other hand, although nonparametric frailty models have been studied, they are not used much in practice. In this article, the distribution of the frailty terms is assumed to be an unknown random variable. The unknown frailty distribution is then modelled completely with a Dirichlet process prior. This prior assigns cluster units into sub-classes whose members have the same random frailty effect. The Gibbs sampler algorithm is used for computing posterior parameter estimates of the fixed effect hazards regression and the frailty distribution. The methodology is used to analyze community-clustered child survival in sub-Saharan Africa. The results show that the communities could be separated into fewer distinct classes of risk of childhood mortality; the fewer classes could be studied easily in order to provide useful guidance on the more effective use of resources for child health intervention programmes.     

Kernel Survival Function Estimation Based on Doubly Censored Data

This work concerns the estimation of a smooth survival function based on doubly censored data. We establish strong consistency and asymptotic normality for a kernel estimator. Moreover, we also obtain an asymptotic expression for the mean integrated squared error, which yields an optimum bandwidth in terms of readily estimable quantities.     

Regression Analysis of Left-truncated and Case I Interval-censored Data with the Additive Hazards Model

In recent years the analysis of interval-censored failure time data has attracted a great deal of attention and such data arise in many fields including demographical studies, economic and financial studies, epidemiological studies, social sciences, and tumorigenicity experiments. This is especially the case in medical studies such as clinical trials. In this article, we discuss regression analysis of one type of such data, Case I interval-censored data, in the presence of left-truncation. For the problem, the additive hazards model is employed and the maximum likelihood method is applied for estimations of unknown parameters. In particular, we adopt the sieve estimation approach that approximates the baseline cumulative hazard function by linear functions. The resulting estimates of regression parameters are shown to be consistent and efficient and have an asymptotic normal distribution. An illustrative example is provided.     

Testing for the Presence of a Cure Fraction in Clustered Interval‐Censored Survival Data

Clustered interval‐censored survival data are often encountered in clinical and epidemiological studies due to geographic exposures and periodic visits of patients. When a nonnegligible cured proportion exists in the population, several authors in recent years have proposed to use mixture cure models incorporating random effects or frailties to analyze such complex data. However, the implementation of the mixture cure modeling approaches may be cumbersome. Interest then lies in determining whether or not it is necessary to adjust the cured proportion prior to the mixture cure analysis. This paper mainly focuses on the development of a score for testing the presence of cured subjects in clustered and interval‐censored survival data. Through simulation, we evaluate the sampling distribution and power behaviour of the score test. A bootstrap approach is further developed, leading to more accurate significance levels and greater power in small sample situations. We illustrate applications of the test using data sets from a smoking cessation study and a retrospective study of early breast cancer patients.     

Estimation of Multiple Linear Regression Model with Twice-Censored Data

In this article, we propose three M-estimators for multiple regression model when response variable is subject to twice censoring. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to construct interval estimators.