A unimodal hazard rate function and its failure distribution

A unimodal hazard rate function is suggested to model a failure rate that has a relatively high rate of failure in the middle of expected life time. This unimodal hazard rate function has two shape parameters. One of the parameters indicates the location (time) of the mode and the other controls the height of the mode. In effect, these two parameters index the class of unimodal hazard rate functions. The reliability function and the failure density function of the unimodal hazard rate function are relatively uncomplicated and mathematically tractable. The properties of the unimodal hazard rate function and the failure density function are investigated. The maximum likelihood method is used for the inference concerning the two parameters and an example based on real data is presented. This unimodal hazard rate function is particularly useful when the time of the peak failure rate is of prime interest. The failure distribution provides a practical way of estimating the peak failure time.     

Proportional cause-specific reversed hazards model

The proportional reversed hazards model explains the multiplicative effect of covariates on the baseline reversed hazard rate function of lifetimes. In the present study, we introduce a proportional cause-specific reversed hazards model. The proposed regression model facilitates the analysis of failure time data with multiple causes of failure under left censoring. We estimate the regression parameters using a partial likelihood approach. We provide Breslow's type estimators for the cumulative cause-specific reversed hazard rate functions. Asymptotic properties of the estimators are discussed. Simulation studies are conducted to assess their performance. We illustrate the applicability of the proposed model using a real data set.     

Nonparametric modeling of the gap time in recurrent event data

Recurrent event data arise in many biomedical and engineering studies when failure events can occur repeatedly over time for each study subject. In this article, we are interested in nonparametric estimation of the hazard function for gap time. A penalized likelihood model is proposed to estimate the hazard as a function of both gap time and covariate. Method for smoothing parameter selection is developed from subject-wise cross-validation. Confidence intervals for the hazard function are derived using the Bayes model of the penalized likelihood. An eigenvalue analysis establishes the asymptotic convergence rates of the relevant estimates. Empirical studies are performed to evaluate various aspects of the method. The proposed technique is demonstrated through an application to the well-known bladder tumor cancer data.     

Testing dependence between the failure time and failure modes: An application of enlarged filtration

The model of independent competing risks provides no information for the assessment of competing failure modes if the failure mechanisms underlying these modes are coupled. Models for dependent competing risks in the literature can be distinguished on the basis of the functional behaviour of the conditional probability of failure due to a particular failure mode given that the failure time exceeds a fixed time, as a function of time. There is an interesting link between monotonicity of such conditional probability and dependence between failure time and failure mode, via crude hazard rates. In this paper, we propose tests for testing the dependence between failure time and failure mode using the crude hazards and using the conditional probabilities mentioned above. We establish the equivalence between the two approaches and provide an asymptotically efficient weight function under a sequence of local alternatives. The tests are applied to simulated data and to mortality follow-up data.     

Fitting Cox Models with Doubly Censored Data Using Spline‐Based Sieve Marginal Likelihood

In some applications, the failure time of interest is the time from an originating event to a failure event while both event times are interval censored. We propose fitting Cox proportional hazards models to this type of data using a spline‐based sieve maximum marginal likelihood, where the time to the originating event is integrated out in the empirical likelihood function of the failure time of interest. This greatly reduces the complexity of the objective function compared with the fully semiparametric likelihood. The dependence of the time of interest on time to the originating event is induced by including the latter as a covariate in the proportional hazards model for the failure time of interest. The use of splines results in a higher rate of convergence of the estimator of the baseline hazard function compared with the usual non‐parametric estimator. The computation of the estimator is facilitated by a multiple imputation approach. Asymptotic theory is established and a simulation study is conducted to assess its finite sample performance. It is also applied to analyzing a real data set on AIDS incubation time.     

Detecting multiple change points in piecewise constant hazard functions

The National Cancer Institute (NCI) suggests a sudden reduction in prostate cancer mortality rates, likely due to highly successful treatments and screening methods for early diagnosis. We are interested in understanding the impact of medical breakthroughs, treatments, or interventions, on the survival experience for a population. For this purpose, estimating the underlying hazard function, with possible time change points, would be of substantial interest, as it will provide a general picture of the survival trend and when this trend is disrupted. Increasing attention has been given to testing the assumption of a constant failure rate against a failure rate that changes at a single point in time. We expand the set of alternatives to allow for the consideration of multiple change-points, and propose a model selection algorithm using sequential testing for the piecewise constant hazard model. These methods are data driven and allow us to estimate not only the number of change points in the hazard function but where those changes occur. Such an analysis allows for better understanding of how changing medical practice affects the survival experience for a patient population. We test for change points in prostate cancer mortality rates using the NCI Surveillance, Epidemiology, and End Results dataset.     

Hazard-based nonparametric survivor function estimation

Summary.  A representation is developed that expresses the bivariate survivor function as a function of the hazard function for truncated failure time variables. This leads to a class of nonparametric survivor function estimators that avoid negative mass. The transformation from hazard function to survivor function is weakly continuous and compact differentiable, so that such properties as strong consistency, weak convergence to a Gaussian process and bootstrap applicability for a hazard function estimator are inherited by the corresponding survivor function estimator. The set of point mass assignments for a survivor function estimator is readily obtained by using a simple matrix calculation on the set of hazard rate estimators. Special cases arise from a simple empirical hazard rate estimator, and from an empirical hazard rate estimator following the redistribution of singly censored observations within strips. The latter is shown to equal van der Laan's repaired nonparametric maximum likelihood estimator, for which a Greenwood-like variance estimator is given. Simulation studies are presented to compare the moderate sample performance of various nonparametric survivor function estimators.     

The Weibull–Pareto Composite Family with Applications to the Analysis of Unimodal Failure Rate Data

The Weibull distribution is composited with Pareto model to obtain a flexible, reliable long-tailed parametric distribution for modeling unimodal failure rate data. The hazard function of the composite family accommodates decreasing and unimodal failure rates, which are separated by the boundary line of the space of shape parameter, gamma, when it equals to a known constant. The least square and maximum likelihood parameter estimation techniques are discussed. The advantages of using the proposed family are demonstrated and compared by illustrating well-known examples: guinea pigs survival time data, head and neck cancer data, and nasopharynx cancer survival data.     

Sensitivity analysis of reliability functions of the exponential power series lifetime distribution

ABSTRACT

Hazard rate functions are often used in modeling of lifetime data. The Exponential Power Series (EPS) family has a monotone hazard rate function. In this article, the influence of input factors such as time and parameters on the variability of hazard rate function is assessed by local and global sensitivity analysis. Two different indices based on local and global sensitivity indices are presented. The simulation results for two datasets show that the hazard rate functions of the EPS family are sensitive to input parameters. The results also show that the hazard rate function of the EPS family is more sensitive to the exponential distribution than power series distributions.     

On computing estimates of a change-point in the Weibull regression hazard model

The hazard function describes the instantaneous rate of failure at a time t, given that the individual survives up to t. In applications, the effect of covariates produce changes in the hazard function. When dealing with survival analysis, it is of interest to identify where a change point in time has occurred. In this work, covariates and censored variables are considered in order to estimate a change-point in the Weibull regression hazard model, which is a generalization of the exponential model. For this more general model, it is possible to obtain maximum likelihood estimators for the change-point and for the parameters involved. A Monte Carlo simulation study shows that indeed, it is possible to implement this model in practice. An application with clinical trial data coming from a treatment of chronic granulomatous disease is also included.     

Progressively Type-II censored competing risks data for exponential distributions based on sequential order statistics

We consider the progressively Type-II censored competing risks model based on sequential order statistics. It is assumed that the latent failure times are independent and the failure of each unit influences the lifetime distributions of the latent failure times of surviving units. We provide explicit expressions for the likelihood function of the available data under the conditional proportional hazard rate (CPHR) and the power trend conditional proportional hazard rate (PTCPHR) models. Under CPHR and PTCPHR models and assumption that the baseline distributions of the latent failure times are exponential, classical and Bayesian estimates of the unknown parameters are provided. Monte Carlo simulations are then performed for illustrative purposes. Finally, two datasets are analyzed.     

Missing genetic information in case-control family data with general semi-parametric shared frailty model

Case-control family data are now widely used to examine the role of gene-environment interactions in the etiology of complex diseases. In these types of studies, exposure levels are obtained retrospectively and, frequently, information on most risk factors of interest is available on the probands but not on their relatives. In this work we consider correlated failure time data arising from population-based case-control family studies with missing genotypes of relatives. We present a new method for estimating the age-dependent marginalized hazard function. The proposed technique has two major advantages: (1) it is based on the pseudo full likelihood function rather than a pseudo composite likelihood function, which usually suffers from substantial efficiency loss; (2) the cumulative baseline hazard function is estimated using a two-stage estimator instead of an iterative process. We assess the performance of the proposed methodology with simulation studies, and illustrate its utility on a real data example.     

Marker processes in survival analysis

In the development of many diseases there are often associated variables which continuously measure the progress of an individual towards the final expression of the disease (failure). Such variables are stochastic processes, here called marker processes, and, at a given point in time, they may provide information about the current hazard and subsequently on the remaining time to failure. Here we consider a simple additive model for the relationship between the hazard function at time t and the history of the marker process up until time t. We develop some basic calculations based on this model. Interest is focused on statistical applications for markers related to estimation of the survival distribution of time to failure, including (i) the use of markers as surrogate responses for failure with censored data, and (ii) the use of markers as predictors of the time elapsed since onset of a survival process in prevalent individuals. Particular attention is directed to potential gains in efficiency incurred by using marker process information.     

Dynamic proportional hazard rate and reversed hazard rate models

Cox (1972) proportional hazard (PH) model has been used to model failure time data in Reliability and Survival Analysis. Recently, proportional reversed hazard model has been analyzed in the literature. Sometimes, the hazard rate (or the reversed hazard rate) may not be proportional over the whole time interval, but may be proportional differently in different intervals. In order to take care of this kind of problems, in this paper, we introduce the dynamic proportional hazard rate model, and the dynamic proportional reversed hazard rate model, and study their properties for different aging classes. The closure of the models under different stochastic orders has also been studied. Examples are presented to illustrate different properties of the models.     

Testing equality of cause-specific hazard rates corresponding to m competing risks among K groups

In this paper, a class of tests is developed for comparing the cause-specific hazard rates of m competing risks simultaneously in K ( 2) groups. The data available for a unit are the failure time of the unit along with the identifier of the risk claiming the failure. In practice, the failure time data are generally right censored. The tests are based on the difference between the weighted averages of the cause-specific hazard rates corresponding to each risk. No assumption regarding the dependence of the competing risks is made. It is shown that the proposed test statistic has asymptotically chi-squared distribution. The proposed test is shown to be optimal for a specific type of local alternatives. The choice of weight function is also discussed. A simulation study is carried out using multivariate Gumbel distribution to compare the optimal weight function with a proposed weight function which is to be used in practice. Also, the proposed test is applied to real data on the termination of an intrauterine device.An erratum to this article can be found at     

Accelerated failure time models for the analysis of competing risks

Competing risks are common in clinical cancer research, as patients are subject to multiple potential failure outcomes, such as death from the cancer itself or from complications arising from the disease. In the analysis of competing risks, several regression methods are available for the evaluation of the relationship between covariates and cause-specific failures, many of which are based on Cox’s proportional hazards model. Although a great deal of research has been conducted on estimating competing risks, less attention has been devoted to linear regression modeling, which is often referred to as the accelerated failure time (AFT) model in survival literature. In this article, we address the use and interpretation of linear regression analysis with regard to the competing risks problem. We introduce two types of AFT modeling framework, where the influence of a covariate can be evaluated in relation to either a cause-specific hazard function, referred to as cause-specific AFT (CS-AFT) modeling in this study, or the cumulative incidence function of a particular failure type, referred to as crude-risk AFT (CR-AFT) modeling. Simulation studies illustrate that, as in hazard-based competing risks analysis, these two models can produce substantially different effects, depending on the relationship between the covariates and both the failure type of principal interest and competing failure types. We apply the AFT methods to data from non-Hodgkin lymphoma patients, where the dataset is characterized by two competing events, disease relapse and death without relapse, and non-proportionality. We demonstrate how the data can be analyzed and interpreted, using linear competing risks regression models.     

Statistical analysis of right-censored failure-time data with partially specified hazard rates

This paper discusses the analysis of right-censored failure-time data in which the failure rate may have different forms in different time intervals. Such data occur naturally, for example, in demography studies and leukemia research, and a number of methods for the analysis have been proposed in the literature. However, most methods are purely parametric or nonparametric. Matthews and Farewell (1982), for example, discussed this problem and proposed a method for testing a constant failure rate against a failure rate involving a change point. To estimate an absolute limit on the attainable human life span, Zelterman (1992) discussed a hazard function that has different parametric forms over different time intervals. We consider a different situation in which the hazard function may follow a parametric form before a change point and is completely unknown after the change point. To test the existence of the change point, a modified maximal-censored-likelihood-ratio test is proposed and its asymptotic properties are studied. A bootstrap method is described for finding critical values of the proposed test. Simulation results indicate that the test performs well.     

The Kumaraswamy generalized gamma distribution with application in survival analysis

We introduce and study the so-called Kumaraswamy generalized gamma distribution that is capable of modeling bathtub-shaped hazard rate functions. The beauty and importance of this distribution lies in its ability to model monotone and non-monotone failure rate functions, which are quite common in lifetime data analysis and reliability. The new distribution has a large number of well-known lifetime special sub-models such as the exponentiated generalized gamma, exponentiated Weibull, exponentiated generalized half-normal, exponentiated gamma, generalized Rayleigh, among others. Some structural properties of the new distribution are studied. We obtain two infinite sum representations for the moments and an expansion for the generating function. We calculate the density function of the order statistics and an expansion for their moments. The method of maximum likelihood and a Bayesian procedure are adopted for estimating the model parameters. The usefulness of the new distribution is illustrated in two real data sets.     

Multivariate discrete reversed hazard rates

In the present paper, we define and study four versions of multivariate discrete reversed hazard rates, namely scalar reversed hazard rate, vector reversed hazard rate, alternative reversed hazard rate, and conditional reversed hazard rate. Various properties of these functions are studied. Interrelationships between these reversed hazard rates are explored. We also present characterization of discrete distributions using these reversed hazard rates.     

System reliability under δ-shock model

δ-shock model is one of the widely studied shock models in reliability. Under this model, the system fails when the time between two consecutive shocks falls below a fixed threshold δ. In this paper, the survival function and the mean time to failure of the system are obtained when the times between successive shocks follow proportional hazard rate model.