Issues in Fitting Inverse Gaussian First Hitting Time Regression Models for Lifetime Data

Inverse Gaussian first hitting time regression models sometimes provide an attractive representation of lifetime data. Various authors comment that dependence of both parameters on the same covariate may imply multicollinearity. The frequent appearance of conflicting signs for the two coefficients of the same covariate may be related to this. We carry out simulation studies to examine the reality of this possible multicollinearity. Although there is some dependence between estimates, multicollinearity does not seem to be a major problem. Fitting this model to data generated by a Weibull regression suggests that conflicting signs of estimates may be due to model misspecification.     

The First Exit Time Theory Applied to Life Table Data: The Health State Function of a Population and Other Characteristics

In this article, we summarize the main parts of the first exit time theory developed in connection to the life table data and the resulting theoretical and applied issues. New tools arise from the development of this theory and especially the Health State Function and some important characteristics of this function.

We provide both simple and complex models and propose a methodology for reconstructing the health state function from the provided first exit time density distribution (for the appropriate computer program, see http://www.cmsim.net). In the simpler case, this theory is applied for the reconstruction of the so-called Inverse-Gaussian function.