On the Choice of a Prior for Bayesian D-Optimal Designs for the Logistic Regression Model with a Single Predictor

The Bayesian design approach accounts for uncertainty of the parameter values on which optimal design depends, but Bayesian designs themselves depend on the choice of a prior distribution for the parameter values. This article investigates Bayesian D-optimal designs for two-parameter logistic models, using numerical search. We show three things: (1) a prior with large variance leads to a design that remains highly efficient under other priors, (2) uniform and normal priors lead to equally efficient designs, and (3) designs with four or five equidistant equally weighted design points are highly efficient relative to the Bayesian D-optimal designs.     

Bayesian D-Optimal Designs for Poisson Regression Models

By incorporating informative and/or historical knowledge of the unknown parameters, Bayesian experimental design under the decision-theory framework can combine all the information available to the experimenter so that a better design may be achieved. Bayesian optimal designs for generalized linear regression models, especially for the Poisson regression model, is of interest in this article. In addition, lack of an efficient computational method in dealing with the Bayesian design leads to development of a hybrid computational method that consists of the combination of a rough global optima search and a more precise local optima search. This approach can efficiently search for the optimal design for multi-variable generalized linear models. Furthermore, the equivalence theorem is used to verify whether the design is optimal or not.     

Double Sampling Designs in Multivariate Linear Models with Missing Variables

We provide a method for finding the optimal double sampling plan for estimating the mean value of a continuous outcome. It is assumed that the fallible and true outcome data are related by a multivariate linear regression model where only some of the explanatory variables are sampled. Conditions under which double sampling is preferred over standard sampling plans are determined. An application of the method to a well-known data set on air pollution is presented.     

On the Functional Approach to Bayesian Efficient Designs for Nonlinear Regression Models

The present article is devoted to an extension of the functional approach elaborated in the book Melas (2006 Melas , V. B. ( 2006 ). Functional Approach to Optimal Experimental Design . Lecture Notes in Statistics , Vol. 184. Heidelberg : Springer . [Google Scholar]) for studying optimal designs in linear and nonlinear regression models. Here we consider Bayesian efficient designs for nonlinear models under the standard assumptions on the observational errors. Sufficient conditions for uniqueness of locally optimal and Bayesian efficient designs for common optimality criteria are given. L-efficient Bayesian designs are constructed and investigated for a special nonlinear regression model of a rational form as an illustration of our main results. This model is interesting in both a practical and a theoretical sense.     

Modified Wynn's Sequential Algorithm for Constructing D-Optimal Designs: Adding Two Points at a Time

Partial least squares (PLS) is a class of methods for modeling relations between sets of observed variables by using the latent components where the predictors are highly collinear. SIMPLS is a commonly used PLS algorithm that calculates the latent components directly as linear combinations of the original variables. However, SIMPLS is known to be very sensible to outliers since it is based on the empirical cross-covariance matrix. RoPLS is a recently proposed iterative method for robust SIMPLS. In this article, the influence function for the RoPLS coefficient estimator is derived. It is demonstrated that under certain conditions, the RoPLS estimator has infinitesimal robustness.     

Optimal Designs for Random Coefficient Regression Models with Heteroscedastic Errors

The purpose of this article is to present the optimal designs based on D-, G-, A-, I-, and D _β-optimality criteria for random coefficient regression (RCR) models with heteroscedastic errors. A sufficient condition for the heteroscedastic structure is given to make sure that the search of optimal designs can be confined at extreme settings of the design region when the criteria satisfy the assumption of the real valued monotone design criteria. Analytical solutions of D-, G-, A-, I-, and D _β-optimal designs for the RCR models are derived. Two examples are presented for random slope models with specific heteroscedastic errors.     

D-Optimal Axial Designs for Quadratic and Cubic Additive Mixture Models

The paper discusses D-optimal axial designs for the additive quadratic and cubic mixture models σ_1≤i≤q(β_ix_i + β_iix²_i) and σ_1≤i≤q(β_ix_i + β_iix²_i + β_iiix³_i), where x_i≥ 0, x₁ + . . . + x_q = 1. For the quadratic model, a saturated symmetric axial design is used, in which support points are of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2 and 0 ≤δ₂ <_{δ1 ≤} 1/(q ?1). It is proved that when 3 ≤q≤ 6, the above design is D-optimal if δ₂ = 0 and δ₁ = 1/(q?1), and when q≥ 7 it is D-optimal if δ₂ = 0 and δ₁ = [5q?1 ? (9q²?10q + 1)^1/2]/(4q²). Similar results exist for the cubic model, with support points of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2, 3 and 0 = δ₃ <_δ2 < δ_{1 ≤}1/(q?1). The saturated D-optimal axial design and D-optimal design for the quadratic model are compared in terms of their efficiency and uniformity.     

Use of Two Decks of Cards in Randomized Response Techniques for Complex Survey Designs

The randomized response (RR) technique with two decks of cards proposed by Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can always be made more efficient than the RR techniques proposed by Warner (1965 Warner , S. L. ( 1965 ). Randomize response: A survey technique for eliminating evasive answer bias . J. Amer. Statist. Assoc. 60 : 63 – 69 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Mangat and Singh (1990 Mangat , N. S. , Singh , R. ( 1990 ). An alternative randomized response procedure . Biometrika 77 : 349 – 442 .[Crossref], [Web of Science ®] , [Google Scholar]), and Mangat (1994 Mangat , N. S. ( 1994 ). An improved randomized response strategy . J. Roy. Statist. Soc. B 56 : 93 – 95 . [Google Scholar]) by adjusting the proportion of cards in the decks. The proposed method of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) is limited to simple random sampling with replacement (SRSWR) sampling only. In this article, generalization of Odumade and Singh strategy is provided for complex survey designs and a wider class of estimators. The results of Odumade and Singh (2009 Odumade , O. , Singh , S. ( 2009 ). Efficient use of two deck of cards in randomized response sampling . Commun. Statist. Theor. Meth. 38 : 439 – 446 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) can be derived from the proposed method as a special case.     

D-Optimum Designs for Optimum Mixture in a Quadratic Log Contrast Model

Optimal designs for estimating the optimum mixing proportions in a quadratic mixture model was first investigated by Pal and Mandal (2006). In this article, similar investigation is carried out when mean response in a mixture experiment is described by a quadratic log contrast model. It is found that in a symmetric subspace of the finite dimensional simplex, there exists a D-optimal design that puts weights at the centroid of the sub-space and the vertices of the experimental domain. The optimality is checked by numerical computation using Equivalence Theorem.     

Optimum Designs for Estimation of Parameters in a Quadratic Mixture-Amount Model

The authors propose a mixture-amount model, which is quadratic both in the proportions of mixing components and the amount of mixture. They attempt to find the A- and D-optimal designs for the estimation of the model parameters within a subclass of designs. The optimality of the derived designs in the entire class of competing designs has been investigated through equivalence theorem.     

Constructing Efficient Experimental Designs for Generalized Linear Models

Exchange algorithms are popular for finding optimal or efficient designs for linear models, but there are few discussions of this type of algorithm for generalized linear models (GLMs) in literature. A new algorithm, generalized Coordinate Exchange Algorithm (gCEA), is developed in this article to construct efficient designs for GLMs. We compare the performance of the proposed algorithm with other optimization algorithms, including point exchange algorithm, columnwise-pairwise algorithm, simulated annealing and generic algorithm, and demonstrate the superior performance of this new algorithm.     

Optimal two-point designs for the michaelis-menten model with heteroscedastic errors

We construct D-optimal designs for the Michaelis-Menten model when the variance of the response depends on the independent variable. However, this dependence is only partially known. A Bayesian approacn is used to find an optimal design by incorporating the prior lnformation about the variance structure. We demonstrate the method for a class of error variance structures and present efficiencies of these optimal designs under prior mis-specifications. In particular, we show that an erroneous assumption on the variance structure for the Michaelis-Menten model can have serious consequences.     

Flexible Covariance Structures for Categorical Dependent Variables Through Finite Mixtures of Generalized Extreme Value Models

A new class of finite mixture discrete choice models, denoted FinMix (fīn m?ks), is introduced. These arise from the combination of a finite number of core Generalized Extreme Value (GEV) models to achieve more flexible functional forms, particularly in terms of error covariance structures. Example members of the class include combinations of (1) Multinomial Logit (MNL) models with differing scales, (2) multinomial logit with nested MNL models, (3) tree extreme value models with differing preference trees, and so on. Compatibility of FinMix models with utility maximization is easily determined, which permits empirical investigation of the suitability of specific model forms for economic evaluation exercises.     

D-optimal Designs for a Combined Simple Linear and Haar-Wavelet Regression Model

A combined simple linear and Haar-wavelet regression model is the combination of a simple linear model and a Haar-wavelet regression model. In this article we show how to construct D-optimal designs for a combined simple linear and Haar-wavelet regression model. An example is also given.     

Phi-Divergence Statistics for Testing Linear Hypotheses in Logistic Regression Models

In this paper we introduce and study two new families of statistics for the problem of testing linear combinations of the parameters in logistic regression models. These families are based on the phi-divergence measures. One of them includes the classical likelihood ratio statistic and the other the classical Pearson's statistic for this problem. It is interesting to note that the vector of unknown parameters, in the two new families of phi-divergence statistics considered in this paper, is estimated using the minimum phi-divergence estimator instead of the maximum likelihood estimator. Minimum phi-divergence estimators are a natural extension of the maximum likelihood estimator.     

Optimal designs for multivariate logistic mixed models with longitudinal data

This paper considers the optimal design problem for multivariate mixed-effects logistic models with longitudinal data. A decomposition method of the binary outcome and the penalized quasi-likelihood are used to obtain the information matrix. The D-optimality criterion based on the approximate information matrix is minimized under different cost constraints. The results show that the autocorrelation coefficient plays a significant role in the design. To overcome the dependence of the D-optimal designs on the unknown fixed-effects parameters, the Bayesian D-optimality criterion is proposed. The relative efficiencies of designs reveal that both the cost ratio and autocorrelation coefficient play an important role in the optimal designs.     

Conditions for D A -Maximin Marginal Designs for Generalized Linear Mixed Models to be Uniform

Optimal design theory deals with the assessment of the optimal joint distribution of all independent variables prior to data collection. In many practical situations, however, covariates are involved for which the distribution is not previously determined. The optimal design problem may then be reformulated in terms of finding the optimal marginal distribution for a specific set of variables. In general, the optimal solution may depend on the unknown (conditional) distribution of the covariates. This article discusses the D _A -maximin procedure to account for the uncertain distribution of the covariates. Sufficient conditions will be given under which the uniform design of a subset of independent discrete variables is D _A -maximin. The sufficient conditions are formulated for Generalized Linear Mixed Models with an arbitrary number of quantitative and qualitative independent variables and random effects.     

Efficient Mixture Design Fitting Quadratic Surface with Quantile Responses Using First-degree Polynomial

This study considers efficient mixture designs for the approximation of the response surface of a quantile regression model, which is a second degree polynomial, by a first degree polynomial in the proportions of q components. Instead of least squares estimation in the traditional regression analysis, the objective function in quantile regression models is a weighted sum of absolute deviations and the least absolute deviations (LAD) estimation technique should be used (Bassett and Koenker, 1982 Bassett, G., Koenker, R. (1982). An empirical quantile function for linear models with i.i.d. errors. Journal of the American Statistical Association 77:407–415.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]; Koenker and Bassett, 1978 Koenker, R., Bassett, G. (1978). Regression quantiles. Econometrica 46(1):33–50.[Crossref], [Web of Science ®] , [Google Scholar]). Therefore, the standard optimal mixture designs like the D-optimal or A-optimal mixture designs for the least squared estimation are not appropriate. This study explores mixture designs that minimize the bias between the approximated 1st-degree polynomial and a 2nd-degree polynomial response surfaces by the LAD estimation. In contrast to the standard optimal mixture designs for the least squared estimation, the efficient designs might contain elementary centroid design points of degrees higher than two. An example of a portfolio with five assets is given to illustrate the proposed efficient mixture designs in determining the marginal contribution of risks by individual assets in the portfolio.     

On Exact K-optimal Designs Minimizing the Condition Number

A new design criterion based on the condition number of an information matrix is proposed to construct optimal designs for linear models, and the resulting designs are called K-optimal designs. The relationship between exact and asymptotic K-optimal designs is derived. Since it is usually hard to find exact optimal designs analytically, we apply a simulated annealing algorithm to compute K-optimal design points on continuous design spaces. Specific issues are addressed to make the algorithm effective. Through exact designs, we can examine some properties of the K-optimal designs such as symmetry and the number of support points. Examples and results are given for polynomial regression models and linear models for fractional factorial experiments. In addition, K-optimal designs are compared with A-optimal and D-optimal designs for polynomial regression models, showing that K-optimal designs are quite similar to A-optimal designs.     

Testing Inference from Logistic Regression Models in Data with Unobserved Heterogeneity at Cluster Levels

Clustering due to unobserved heterogeneity may seriously impact on inference from binary regression models. We examined the performance of the logistic, and the logistic-normal models for data with such clustering. The total variance of unobserved heterogeneity rather than the level of clustering determines the size of bias of the maximum likelihood (ML) estimator, for the logistic model. Incorrect specification of clustering as level 2, using the logistic-normal model, provides biased estimates of the structural and random parameters, while specifying level 1, provides unbiased estimates for the former, and adequately estimates the latter. The proposed procedure appeals to many research areas.