Bivariate zero-inflated negative binomial regression model with applications

Count data often display excessive number of zero outcomes than are expected in the Poisson regression model. The zero-inflated Poisson regression model has been suggested to handle zero-inflated data, whereas the zero-inflated negative binomial (ZINB) regression model has been fitted for zero-inflated data with additional overdispersion. For bivariate and zero-inflated cases, several regression models such as the bivariate zero-inflated Poisson (BZIP) and bivariate zero-inflated negative binomial (BZINB) have been considered. This paper introduces several forms of nested BZINB regression model which can be fitted to bivariate and zero-inflated count data. The mean–variance approach is used for comparing the BZIP and our forms of BZINB regression model in this study. A similar approach was also used by past researchers for defining several negative binomial and zero-inflated negative binomial regression models based on the appearance of linear and quadratic terms of the variance function. The nested BZINB regression models proposed in this study have several advantages; the likelihood ratio tests can be performed for choosing the best model, the models have flexible forms of marginal mean–variance relationship, the models can be fitted to bivariate zero-inflated count data with positive or negative correlations, and the models allow additional overdispersion of the two dependent variables.     

GEE-based zero-inflated generalized Poisson model for clustered over or under-dispersed count data

The zero-inflated regression models such as zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB) or zero-inflated generalized Poisson (ZIGP) regression models can model the count data with excess zeros. The ZINB model can handle over-dispersed and the ZIGP model can handle the over or under-dispersed count data with excess zeros as well. Moreover, the count data may be correlated because of data collection procedure or special study design. The clustered sampling approach is one of the examples in which the correlation among subjects could be defined. In such situations, a marginal model using generalized estimating equation (GEE) approach can incorporate these correlations and lead up to the relationships at the population level. In this study, the GEE-based zero-inflated generalized Poisson regression model was proposed to fit over and under-dispersed clustered count data with excess zeros.     

Score test for testing zero-inflated Poisson regression against zero-inflated generalized Poisson alternatives

In several cases, count data often have excessive number of zero outcomes. This zero-inflated phenomenon is a specific cause of overdispersion, and zero-inflated Poisson regression model (ZIP) has been proposed for accommodating zero-inflated data. However, if the data continue to suggest additional overdispersion, zero-inflated negative binomial (ZINB) and zero-inflated generalized Poisson (ZIGP) regression models have been considered as alternatives. This study proposes the score test for testing ZIP regression model against ZIGP alternatives and proves that it is equal to the score test for testing ZIP regression model against ZINB alternatives. The advantage of using the score test over other alternative tests such as likelihood ratio and Wald is that the score test can be used to determine whether a more complex model is appropriate without fitting the more complex model. Applications of the proposed score test on several datasets are also illustrated.     

A Bayesian Approach for Zero-Inflated Count Regression Models by Using the Reversible Jump Markov Chain Monte Carlo Method and an Application

In this study, estimation of the parameters of the zero-inflated count regression models and computations of posterior model probabilities of the log-linear models defined for each zero-inflated count regression models are investigated from the Bayesian point of view. In addition, determinations of the most suitable log-linear and regression models are investigated. It is known that zero-inflated count regression models cover zero-inflated Poisson, zero-inflated negative binomial, and zero-inflated generalized Poisson regression models. The classical approach has some problematic points but the Bayesian approach does not have similar flaws. This work points out the reasons for using the Bayesian approach. It also lists advantages and disadvantages of the classical and Bayesian approaches. As an application, a zoological data set, including structural and sampling zeros, is used in the presence of extra zeros. In this work, it is observed that fitting a zero-inflated negative binomial regression model creates no problems at all, even though it is known that fitting a zero-inflated negative binomial regression model is the most problematic procedure in the classical approach. Additionally, it is found that the best fitting model is the log-linear model under the negative binomial regression model, which does not include three-way interactions of factors.     

Functional Form for the Zero-Inflated Generalized Poisson Regression Model

The generalized Poisson (GP) regression is an increasingly popular approach for modeling overdispersed as well as underdispersed count data. Several parameterizations have been performed for the GP regression, and the two well known models, the GP-1 and the GP-2, have been applied. The GP-P regression, which has been recently proposed, has the advantage of nesting the GP-1 and the GP-2 parametrically, besides allowing the statistical tests of the GP-1 and the GP-2 against a more general alternative. In several cases, count data often have excessive number of zero outcomes than are expected in the Poisson. This zero-inflation phenomenon is a specific cause of overdispersion, and the zero-inflated Poisson (ZIP) regression model has been proposed. However, if the data continue to suggest additional overdispersion, the zero-inflated negative binomial (ZINB-1 and ZINB-2) and the zero-inflated generalized Poisson (ZIGP-1 and ZIGP-2) regression models have been considered as alternatives. This article proposes a functional form of the ZIGP which mixes a distribution degenerate at zero with a GP-P distribution. The suggested model has the advantage of nesting the ZIP and the two well known ZIGP (ZIGP-1 and ZIGP-2) regression models, besides allowing the statistical tests of the ZIGP-1 and the ZIGP-2 against a more general alternative. The ZIP and the functional form of the ZIGP regression models are fitted, compared and tested on two sets of count data; the Malaysian insurance claim data and the German healthcare data.     

Comparisons of some bivariate regression models

The bivariate negative binomial regression (BNBR) and the bivariate Poisson log-normal regression (BPLR) models have been used to describe count data that are over-dispersed. In this paper, a new bivariate generalized Poisson regression (BGPR) model is defined. An advantage of the new regression model over the BNBR and BPLR models is that the BGPR can be used to model bivariate count data with either over-dispersion or under-dispersion. In this paper, we carry out a simulation study to compare the three regression models when the true data-generating process exhibits over-dispersion. In the simulation experiment, we observe that the bivariate generalized Poisson regression model performs better than the bivariate negative binomial regression model and the BPLR model.     

ESTIMATING A RATIO OF MEANS FROM BIVARIATE COUNTS WITH APPLICATIONS IN STEREOLOGY

In survey sampling and in stereology, it is often desirable to estimate the ratio of means θ= E(Y)/E(X) from bivariate count data (X, Y) with unknown joint distribution. We review methods that are available for this problem, with particular reference to stereological applications. We also develop new methods based on explicit statistical models for the data, and associated model diagnostics. The methods are tested on a stereological dataset. For point‐count data, binomial regression and bivariate binomial models are generally adequate. Intercept‐count data are often overdispersed relative to Poisson regression models, but adequately fitted by negative binomial regression.     

Zero-inflated sum of Conway-Maxwell-Poissons (ZISCMP) regression

While excess zeros are often thought to cause data over-dispersion (i.e. when the variance exceeds the mean), this implication is not absolute. One should instead consider a flexible class of distributions that can address data dispersion along with excess zeros. This work develops a zero-inflated sum-of-Conway-Maxwell-Poissons (ZISCMP) regression as a flexible analysis tool to model count data that express significant data dispersion and contain excess zeros. This class of models contains several special case zero-inflated regressions, including zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), zero-inflated binomial (ZIB), and the zero-inflated Conway-Maxwell-Poisson (ZICMP). Through simulated and real data examples, we demonstrate class flexibility and usefulness. We further utilize it to analyze shark species data from Australia's Great Barrier Reef to assess the environmental impact of human action on the number of various species of sharks.     

Marginalized zero-inflated generalized Poisson regression

The generalized Poisson (GP) regression model has been used to model count data that exhibit over-dispersion or under-dispersion. The zero-inflated GP (ZIGP) regression model can additionally handle count data characterized by many zeros. However, the parameters of ZIGP model cannot easily be used for inference on overall exposure effects. In order to address this problem, a marginalized ZIGP is proposed to directly model the population marginal mean count. The parameters of the marginalized zero-inflated GP model are estimated by the method of maximum likelihood. The regression model is illustrated by three real-life data sets.     

Untangle the structural and random zeros in statistical modelings

Count data with structural zeros are common in public health applications. There are considerable researches focusing on zero-inflated models such as zero-inflated Poisson (ZIP) and zero-inflated Negative Binomial (ZINB) models for such zero-inflated count data when used as response variable. However, when such variables are used as predictors, the difference between structural and random zeros is often ignored and may result in biased estimates. One remedy is to include an indicator of the structural zero in the model as a predictor if observed. However, structural zeros are often not observed in practice, in which case no statistical method is available to address the bias issue. This paper is aimed to fill this methodological gap by developing parametric methods to model zero-inflated count data when used as predictors based on the maximum likelihood approach. The response variable can be any type of data including continuous, binary, count or even zero-inflated count responses. Simulation studies are performed to assess the numerical performance of this new approach when sample size is small to moderate. A real data example is also used to demonstrate the application of this method.     

Modeling road traffic crashes with zero-inflation and site-specific random effects

Zero-inflated count models are increasingly employed in many fields in case of “zero-inflation”. In modeling road traffic crashes, it has also shown to be useful in obtaining a better model-fitting when zero crash counts are over-presented. However, the general specification of zero-inflated model can not account for the multilevel data structure in crash data, which may be an important source of over-dispersion. This paper examines zero-inflated Poisson regression with site-specific random effects (REZIP) with comparison to random effect Poisson model and standard zero-inflated poison model. A practical and flexible procedure, using Bayesian inference with Markov Chain Monte Carlo algorithm and cross-validation predictive density techniques, is applied for model calibration and suitability assessment. Using crash data in Singapore (1998–2005), the illustrative results demonstrate that the REZIP model may significantly improve the model-fitting and predictive performance of crash prediction models. This improvement can contribute to traffic safety management and engineering practices such as countermeasure design and safety evaluation of traffic treatments.     

A doubly-inflated Poisson regression for correlated count data

Count data have emerged in many applied research areas. In recent years, there has been a considerable interest in models for count data. In modelling such data, it is common to face a large frequency of zeroes. The data are regarded as zero-inflated when the frequency of observed zeroes is larger than what is expected from a theoretical distribution such as Poisson distribution, as a standard model for analysing count data. Data analysis, using the simple Poisson model, may lead to over-dispersion. Several classes of different mixture models were proposed for handling zero-inflated data. But they do not apply to cases when inflated counts happen at some other points, in addition to zero. In these cases, a doubly-inflated Poisson model has been suggested which only be used for cross-sectional data and cannot consider correlations between observations. However, correlated count data have a large application, especially in the health and medical fields. The present study aims to introduce a Doubly-Inflated Poisson models with random effect for correlated doubly-inflated data. Then, the best performance of the proposed method is shown via different simulation scenarios. Finally, the proposed model is applied to a dental study.KEYWORDS: Count data, doubly-inflated, Poisson regression, zero-inflated, correlated data     

Estimation of Median in Two-Phase Sampling Using Two Auxiliary Variables

In recent years, zero-inflated count data models, such as zero-inflated Poisson (ZIP) models, are widely used as the count data with extra zeros are very common in many practical problems. In order to model the correlated count data which are either clustered or repeated and to assess the effects of continuous covariates or of time scales in a flexible way, a class of semiparametric mixed-effects models for zero-inflated count data is considered. In this article, we propose a fully Bayesian inference for such models based on a data augmentation scheme that reflects both random effects of covariates and mixture of zero-inflated distribution. A computational efficient MCMC method which combines the Gibbs sampler and M-H algorithm is implemented to obtain the estimate of the model parameters. Finally, a simulation study and a real example are used to illustrate the proposed methodologies.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

Random effect exponentiated-exponential geometric model for clustered/longitudinal zero-inflated count data

For count responses, there are situations in biomedical and sociological applications in which extra zeroes occur. Modeling correlated (e.g. repeated measures and clustered) zero-inflated count data includes special challenges because the correlation between measurements for a subject or a cluster needs to be taken into account. Moreover, zero-inflated count data are often faced with over/under dispersion problem. In this paper, we propose a random effect model for repeated measurements or clustered data with over/under dispersed response called random effect zero-inflated exponentiated-exponential geometric regression model. The proposed method was illustrated through real examples. The performance of the model and asymptotical properties of the estimations were investigated using simulation studies.KEYWORDS: Count model, under- and over-dispersion, zero-inflation, mixture model, zero-inflated poisson model     

Solving unobserved heterogeneity with latent class inflated Poisson regression model

Inflated data and over-dispersion are two common problems when modeling count data with traditional Poisson regression models. In this study, we propose a latent class inflated Poisson (LCIP) regression model to solve the unobserved heterogeneity that leads to inflations and over-dispersion. The performance of the model estimation is evaluated through simulation studies. We illustrate the usefulness of introducing a latent class variable by analyzing the Behavioral Risk Factor Surveillance System (BRFSS) data, which contain several excessive values and characterized by over-dispersion. As a result, the new model we proposed displays a better fit than the standard Poisson regression and zero-inflated Poisson regression models for the inflated counts.KEYWORDS: Inflated data, latent class, heterogeneity, Poisson regression, over-dispersion     

Marginal zero-inflated regression models for count data

Data sets with excess zeroes are frequently analyzed in many disciplines. A common framework used to analyze such data is the zero-inflated (ZI) regression model. It mixes a degenerate distribution with point mass at zero with a non-degenerate distribution. The estimates from ZI models quantify the effects of covariates on the means of latent random variables, which are often not the quantities of primary interest. Recently, marginal zero-inflated Poisson (MZIP; Long et al. [A marginalized zero-inflated Poisson regression model with overall exposure effects. Stat. Med. 33 (2014), pp. 5151–5165]) and negative binomial (MZINB; Preisser et al., 2016) models have been introduced that model the mean response directly. These models yield covariate effects that have simple interpretations that are, for many applications, more appealing than those available from ZI regression. This paper outlines a general framework for marginal zero-inflated models where the latent distribution is a member of the exponential dispersion family, focusing on common distributions for count data. In particular, our discussion includes the marginal zero-inflated binomial (MZIB) model, which has not been discussed previously. The details of maximum likelihood estimation via the EM algorithm are presented and the properties of the estimators as well as Wald and likelihood ratio-based inference are examined via simulation. Two examples presented illustrate the advantages of MZIP, MZINB, and MZIB models for practical data analysis.     

A comparison of count data models with an application to daily cigarette consumption of young persons

The objective of this study is providing a comparative assessment for researchers to deal with the challenges of analyzing count data and examining the factors associated with daily cigarette consumption among the young people in Turkey. We fitted Poisson (P), negative binomial (NB), zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), Poisson hurdle (PH) and negative binomial hurdle (NBH) regressions to cigarette consumption count data by using the 2014 Turkey Health Survey. Our results showed that the ZINB and NBH models should be preferred. We also found that, gender, employment and tobacco use at home are more effective factors for smokers and nonsmokers in the 15–24 age group in Turkey.     

Non nested model selection for spatial count regression models with application to health insurance

In this paper we consider spatial regression models for count data. We examine not only the Poisson distribution but also the generalized Poisson capable of modeling over-dispersion, the negative Binomial as well as the zero-inflated Poisson distribution which allows for excess zeros as possible response distribution. We add random spatial effects for modeling spatial dependency and develop and implement MCMC algorithms in $R$ for Bayesian estimation. The corresponding R library ‘spatcounts’ is available on CRAN. In an application the presented models are used to analyze the number of benefits received per patient in a German private health insurance company. Since the deviance information criterion is only appropriate for exponential family models, we use in addition the Vuong and Clarke test with a Schwarz correction to compare possibly non nested models. We illustrate how they can be used in a Bayesian context.     

A test for lack-of-fit of zero-inflated negative binomial models

When a count data set has excessive zero counts, nonzero counts are overdispersed, and the effect of a continuous covariate might be nonlinear, for analysis a semiparametric zero-inflated negative binomial (ZINB) regression model is proposed. The unspecified smooth functional form for the continuous covariate effect is approximated by a cubic spline. The semiparametric ZINB regression model is fitted by maximizing the likelihood function. The likelihood ratio procedure is used to evaluate the adequacy of a postulated parametric functional form for the continuous covariate effect. An extensive simulation study is conducted to assess the finite-sample performance of the proposed test. The practicality of the proposed methodology is demonstrated with data of a motorcycle survey of traffic regulations conducted in 2007 in Taiwan by the Ministry of Transportation and Communication.