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1.
Two-period crossover design is one of the commonly used designs in clinical trials. But, the estimation of treatment effect is complicated by the possible presence of carryover effect. It is known that ignoring the carryover effect when it exists can lead to poor estimates of the treatment effect. The classical approach by Grizzle (1965 Grizzle, J.E. (1965). The two-period change-over design and its use in clinical trials. Biometrics 21:467480. See Grizzle (1974) for corrections.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) consists of two stages. First, a preliminary test is conducted on carryover effect. If the carryover effect is significant, analysis is based only on data from period one; otherwise, analysis is based on data from both periods. A Bayesian approach with improper priors was proposed by Grieve (1985 Grieve, A.P. (1985). A Bayesian analysis of the two-period crossover design for clinical trials. Biometrics 41:979990.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) which uses a mixture of two models: a model with carryover effect and another without. The indeterminacy of the Bayes factor due to the arbitrary constant in the improper prior was addressed by assigning a minimally discriminatory value to the constant. In this article, we present an objective Bayesian estimation approach to the two-period crossover design which is also based on a mixture model, but using the commonly recommended Zellner–Siow g-prior. We provide simulation studies and a real data example and compare the numerical results with Grizzle (1965 Grizzle, J.E. (1965). The two-period change-over design and its use in clinical trials. Biometrics 21:467480. See Grizzle (1974) for corrections.[Crossref], [PubMed], [Web of Science ®] [Google Scholar])’s and Grieve (1985 Grieve, A.P. (1985). A Bayesian analysis of the two-period crossover design for clinical trials. Biometrics 41:979990.[Crossref], [PubMed], [Web of Science ®] [Google Scholar])’s approaches.  相似文献   

2.
Since the seminal paper of Ghirardato (1997 Ghirardato, P. 1997. On the independence for non-additive measures, with a Fubini theorem. Journal of Economic Theory 73:26191.[Crossref], [Web of Science ®] [Google Scholar]), it is known that Fubini theorem for non additive measures can be available only for functions as “slice-comonotonic” in the framework of product algebra. Later, inspired by Ghirardato (1997 Ghirardato, P. 1997. On the independence for non-additive measures, with a Fubini theorem. Journal of Economic Theory 73:26191.[Crossref], [Web of Science ®] [Google Scholar]), Chateauneuf and Lefort (2008 Chateauneuf, A., and J. P. Lefort. 2008. Some Fubini theorems on product σ-algebras for non-additive measures. International Journal of Approximate Reasoning 48:68696.[Crossref], [Web of Science ®] [Google Scholar]) obtained some Fubini theorems for non additive measures in the framework of product σ-algebra. In this article, we study Fubini theorem for non additive measures in the framework of g-expectation. We give some different assumptions that provide Fubini theorem in the framework of g-expectation.  相似文献   

3.
The objective of this paper is to study U-type designs for Bayesian non parametric response surface prediction under correlated errors. The asymptotic Bayes criterion is developed in terms of the asymptotic approach of Mitchell et al. (1994 Mitchell, T., Sacks, J., Ylvisaker, D. (1994). Asymptotic Bayes criteria for nonparametric response surface design. Ann. Stat. 22:634651.[Crossref], [Web of Science ®] [Google Scholar]) for a more general covariance kernel proposed by Chatterjee and Qin (2011 Chatterjee, K., Qin, H. (2011). Generalized discrete discrepancy and its applications in experimental designs. J. Stat. Plann. Inference 141:951960.[Crossref], [Web of Science ®] [Google Scholar]). A relationship between the asymptotic Bayes criterion and other criteria, such as orthogonality and aberration, is then developed. A lower bound for the criterion is also obtained, and numerical results show that this lower bound is tight. The established results generalize those of Yue et al. (2011 Yue, R.X., Qin, H., Chatterjee, K. (2011). Optimal U-type design for Bayesian nonparametric multiresponse prediction. J. Stat. Plann. Inference 141:24722479.[Crossref], [Web of Science ®] [Google Scholar]) from symmetrical case to asymmetrical U-type designs.  相似文献   

4.
Techniques used in variability assessment are subsequently used to draw conclusions regarding the “spread”/uniformity of data curves. Due to the limitations of these techniques, they are not adequate for circumstances where data manifest with multiple peaks. Examples of these manifestations (in three-dimensional space) include under-foot pressure distributions recorded for different types of footwear (Becerro-de-Bengoa-Vallejo et al., 2014 Biau, D.J. (2011). In brief: Standard deviation and standard error. Clinical Orthopaedics and Related Research 469(9):26612664.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]; Cibulka et al., 1994 Cibulka, M.T., Sinacore, D.R., Mueller, M.J. (1994). Shin splints and forefoot contact running: A case report. Journal of Orthopaedic &; Sports Physical Therapy 20(2):98102.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]; Davies et al., 2003 Davies, M.B., Betts, R.P., Scott, I.R. (2003). Optical plantar pressure analysis following internal fixation for displaced intra-articular os calcis fractures. Foot &; Ankle International 24(11):851856.[PubMed], [Web of Science ®] [Google Scholar]), surface textures and interfaces designed to impact friction, and and and molecular surface structures such as viral epitopes (Torras and Garcia-Valls, 2004 Torras, C., Garcia-Valls, R. (2004). Quantification of membrane morphology by interpretation of scanning electron microscopy images. Journal of Membrane Science 233(1–2):119127.[Crossref], [Web of Science ®] [Google Scholar]; Pacejka, 1997; Fustaffson, 1997). This article proposes a technique for generating a single variable – Λ that will quantify the uniformity of such surfaces. We define and validate this technique using several mathematical and graphical models.  相似文献   

5.
This paper aimed at providing an efficient new unbiased estimator for estimating the proportion of a potentially sensitive attribute in survey sampling. The suggested randomization device makes use of the means, variances of scrambling variables, and the two scalars lie between “zero” and “one.” Thus, the same amount of information has been used at the estimation stage. The variance formula of the suggested estimator has been obtained. We have compared the proposed unbiased estimator with that of Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436438.[Crossref], [Web of Science ®] [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489505.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]), and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) estimators. Relevant conditions are obtained in which the proposed estimator is more efficient than Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436438.[Crossref], [Web of Science ®] [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489505.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) estimators. The optimum estimator (OE) in the proposed class of estimators has been identified which finally depends on moments ratios of the scrambling variables. The variance of the optimum estimator has been obtained and compared with that of the Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436438.[Crossref], [Web of Science ®] [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489505.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) estimator and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) estimator. It is interesting to mention that the “optimum estimator” of the class of estimators due to Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) depends on the parameter π under investigation which limits the use of Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) OE in practice while the proposed OE in this paper is free from such a constraint. The proposed OE depends only on the moments ratios of scrambling variables. This is an advantage over the Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:33773380.[Crossref], [Web of Science ®] [Google Scholar]) estimator. Numerical illustrations are given in the support of the present study when the scrambling variables follow normal distribution. Theoretical and empirical results are very sound and quite illuminating in the favor of the present study.  相似文献   

6.
The t-distribution (univariate and multivariate) has many useful applications in robust statistical analysis. The parameter estimation of the t-distribution is carried out using maximum likelihood (ML) estimation method, and the ML estimates are obtained via the Expectation-Maximization (EM) algorithm. In this article, we will use the maximum Lq-likelihood (MLq) estimation method introduced by Ferrari and Yang (2010 Ferrari, D., and Y. Yang. 2010. Maximum lq-likelihood estimation. The Annals of Statistics 38 (2):75383.[Crossref], [Web of Science ®] [Google Scholar]) to estimate all the parameters of the multivariate t-distribution. We modify the EM algorithm to obtain the MLq estimates. We provide a simulation study and a real data example to illustrate the performance of the MLq estimators over the ML estimators.  相似文献   

7.
The problem of estimating of the vector β of the linear regression model y = Aβ + ? with ? ~ Np(0, σ2Ip) under quadratic loss function is considered when common variance σ2 is unknown. We first find a class of minimax estimators for this problem which extends a class given by Maruyama and Strawderman (2005 Maruyama, Y., and W. E. Strawderman. 2005. A new class of generalized Bayes minimax ridge regression estimators. Annals of Statistics 33:175370.[Crossref], [Web of Science ®] [Google Scholar]) and using these estimators, we obtain a large class of (proper and generalized) Bayes minimax estimators and show that the result of Maruyama and Strawderman (2005 Maruyama, Y., and W. E. Strawderman. 2005. A new class of generalized Bayes minimax ridge regression estimators. Annals of Statistics 33:175370.[Crossref], [Web of Science ®] [Google Scholar]) is a special case of our result. We also show that under certain conditions, these generalized Bayes minimax estimators have greater numerical stability (i.e., smaller condition number) than the least-squares estimator.  相似文献   

8.
Sanaullah et al. (2014 Sanaullah, A., Ali, H.M., Noor ul Amin, M., Hanif, M. (2014). Generalized exponential chain ratio estimators under stratified two-phase random sampling. Appl. Math. Comput. 226:541547.[Crossref], [Web of Science ®] [Google Scholar]) have suggested generalized exponential chain ratio estimators under stratified two-phase sampling scheme for estimating the finite population mean. However, the bias and mean square error (MSE) expressions presented in that work need some corrections, and consequently the study based on efficiency comparison also requires corrections. In this article, we revisit Sanaullah et al. (2014 Sanaullah, A., Ali, H.M., Noor ul Amin, M., Hanif, M. (2014). Generalized exponential chain ratio estimators under stratified two-phase random sampling. Appl. Math. Comput. 226:541547.[Crossref], [Web of Science ®] [Google Scholar]) estimator and provide the correct bias and MSE expressions of their estimator. We also propose an estimator which is more efficient than several competing estimators including the classes of estimators in Sanaullah et al. (2014 Sanaullah, A., Ali, H.M., Noor ul Amin, M., Hanif, M. (2014). Generalized exponential chain ratio estimators under stratified two-phase random sampling. Appl. Math. Comput. 226:541547.[Crossref], [Web of Science ®] [Google Scholar]). Three real datasets are used for efficiency comparisons.  相似文献   

9.
In this article, we discuss the method of linear kernel quantile estimator proposed by Parzen (1979 Parzen, E. (1979). Nonparametric statistical data modeling. J. Amer. Statist. Assoc. 74:105121.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]). We establish a Bahadur representation in sense of almost surely convergence with the rate log? αn under the case of S-mixing random variable sequence which was proposed by Berkes (2009 Berkes, I., Hörmann, S., (2009). Asymptotic results for the itpirical process of stationary sequences. Stoch. Process. Their Applic. 119:12981324.[Crossref], [Web of Science ®] [Google Scholar]). We also obtain the strong consistence of this estimator and its convergence rate.  相似文献   

10.
Consider the estimation of the regression parameters in the usual linear model. For design densities with infinite support, it has been shown by Faraldo Roca and González Manteiga [1] Faraldo Roca, P. and González Manteiga, W. 1987. “Efficiency of a new class of linear regression estimates obtained by preliminary nonparametric estimation”. In New Perspectives in Theoretical and Applied Statistics Edited by: Puri, M. L., Vilaplana, J. P. and Wertz, W. 229242. New York: John Wiley.  [Google Scholar] that it is possible to modify the classical least squares procedure and to obtain estimators for the regression parameters whose MSE's (mean squared errors) are smaller than those of the usual least squares estimators. The modification consists of presmoothing the response variables by a kernel estimator of the regression function. These authors also show that the gain in efficiency is not possible for a design density with compact support. We show that in this case local linear presmoothing does not fix this inefficiency problem, in spite of the well known fact that local linear fitting automatically corrects the bias in the endpoints of the (design density) support. We demonstrate on a theoretical basis how this inefficiency problem can be rectified in the compact design case: we prove that presmoothing with boundary kernels studied in Müller [2] Müller, H.-G. 1991. Smooth optimum kernel estimators near endpoints. Biometrika, 78: 521530. [Crossref], [Web of Science ®] [Google Scholar] and Müller and Wang [3] Müller, H.-G. and Wang, J.-L. 1994. Hazard rate estimation under random censoring with varying kernels and bandwidths. Biometrics, 50: 6176. [Crossref], [PubMed], [Web of Science ®] [Google Scholar] leads to regression estimators which are superior over the least squares estimators. A very careful analytic treatment is needed to arrive at these asymptotic results.  相似文献   

11.
Recently, Koyuncu et al. (2013 Koyuncu, N., Gupta, S., Sousa, R. (2014). Exponential type estimators of the mean of a sensitive variable in the presence of non-sensitive auxiliary information. Communications in Statistics- Simulation and Computation[PubMed], [Web of Science ®] [Google Scholar]) proposed an exponential type estimator to improve the efficiency of mean estimator based on randomized response technique. In this article, we propose an improved exponential type estimator which is more efficient than the Koyuncu et al. (2013 Koyuncu, N., Gupta, S., Sousa, R. (2014). Exponential type estimators of the mean of a sensitive variable in the presence of non-sensitive auxiliary information. Communications in Statistics- Simulation and Computation[PubMed], [Web of Science ®] [Google Scholar]) estimator, which in turn was shown to be more efficient than the usual mean estimator, ratio estimator, regression estimator, and the Gupta et al. (2012 Gupta, S., Shabbir, J., Sousa, R., Corte-Real, P. (2012). Regression estimation of the mean of a sensitive variable in the presence of auxiliary information. Communications in Statistics – Theory and Methods 41:23942404.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) estimator. Under simple random sampling without replacement (SRSWOR) scheme, bias and mean square error expressions for the proposed estimator are obtained up to first order of approximation and comparisons are made with the Koyuncu et al. (2013 Koyuncu, N., Gupta, S., Sousa, R. (2014). Exponential type estimators of the mean of a sensitive variable in the presence of non-sensitive auxiliary information. Communications in Statistics- Simulation and Computation[PubMed], [Web of Science ®] [Google Scholar]) estimator. A simulation study is used to observe the performances of these two estimators. Theoretical findings are also supported by a numerical example with real data. We also show how to, extend the proposed estimator to the case when more than one auxiliary variable is available.  相似文献   

12.
Adaptive designs find an important application in the estimation of unknown percentiles for an underlying dose-response curve. A nonparametric adaptive design was suggested by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):21372150.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) to simultaneously estimate multiple percentiles of an unknown dose-response curve via generalized Polya urns. In this article, we examine the properties of the design proposed by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):21372150.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]) when delays in observing responses are encountered. Using simulations, we evaluate a modification of the design under varying group sizes. Our results demonstrate unbiased estimation with minimal loss in efficiency when compared to the original compound urn design.  相似文献   

13.
The aim of this article is the construction of the test statistic for the detection of changes in vector autoregressive (AR) models where both AR parameters and the variance matrix of the error term are the subjects of a change. The approximating distribution of the proposed statistic is the Gumbel distribution. The proof stands on the approximation of weakly dependent random vectors by independent ones and by application of Horváth’s extension of Darling-Erdös extremal result for random vectors, see Darling and Erdös (1956) Darling, D.A., Erdös, P. (1956). A limit theorem for the maximum of normalized sums of independent random variables. Duke Math. J. 23:143155.[Crossref], [Web of Science ®] [Google Scholar] and Horváth (1993) Horváth, L. (1993). The maximum likelihood method for testing changes in the parameters of normal observations. Ann. Stat. 21(2):671680.[Crossref], [Web of Science ®] [Google Scholar]. The test statistic is a modification of the likelihood ratio.  相似文献   

14.
This article addresses the problem of estimating the population mean in stratified random sampling using the information of an auxiliary variable. A class of estimators for population mean is defined with its properties under large sample approximation. In particular, various classes of estimators are identified as particular member of the suggested class. It has been shown that the proposed class of estimators is better than usual unbiased estimator, usual combined ratio estimator, usual product estimator, usual regression estimator and Koyuncu and Kadilar (2009 Koyuncu, N., Kadilar, C. (2009). Ratio and product estimators in stratified random sampling. J. Statist. Plan. Infere. 139:25522558.[Crossref], [Web of Science ®] [Google Scholar]) class of estimators. The results have been illustrated through an empirical study.  相似文献   

15.
Cooray and Ananda (2008 Cooray, K., Ananda, M.M.A. (2008). A Generalization of the half-normal distribution with applications to lifetime data. Commun. Stat. - Theory Methods 37:13231337.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) pioneered a lifetime model commonly used in reliability studies. Based on this distribution, we propose a new model called the odd log-logistic generalized half-normal distribution for describing fatigue lifetime data. Various of its structural properties are derived. We discuss the method of maximum likelihood to fit the model parameters. For different parameter settings and sample sizes, some simulation studies compare the performance of the new lifetime model. It can be very useful, and its superiority is illustrated by means of a real dataset.  相似文献   

16.
Repeated measurement designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this paper the works of Iqbal and Tahir (2009 Iqbal, I., and M. H. Tahir. 2009. Circular strongly balanced repeated measurements designs. Communications in Statistics—Theory and Methods 38:368696.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) and Iqbal, Tahir, and Ghazali (2010 Iqbal, I., M. H. Tahir, and S. S. A. Ghazali. 2010. Circular first- and second-order balanced repeated measurements designs. Communications in Statistics—Theory and Methods 39:22840.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) are generalized for the construction of circular-balanced and circular strongly balanced repeated measurements designs through the method of cyclic shifts for three periods.  相似文献   

17.
Filipiak and Markiewicz (2012 Filipiak, K., Markiewicz, A. (2012). On universal optimality of circular weakly neighbor balanced designs under an interference model. Comm. Stat. Theor Methods 41: 23562366.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]) proved the universal optimality of circular weakly neighbor balanced designs (CWNBDs) under the interference model with fixed neighbor effects among the class of complete block designs. In two special cases where a CWNBD cannot exist, Filipiak et al. (2012 Filipiak, K., Markiewicz, A., Ró?ański, R. (2012). Maximal determinant over a certain class of matrices and its application to D-optimality of designs. Linear Algebra Appl. 436(4): 874887.[Crossref], [Web of Science ®] [Google Scholar]) characterized D-optimal designs. The aim of this paper is to show the universal optimality of CWNBDs and to characterize D-optimal designs under the interference model with random neighbor effects.  相似文献   

18.
Cossette et al. (2010 Cossette, H., Marceau, E., Maume-Deschamps, V. (2010). Discerte-time risk models based on time series for count random variables. ASTIN Bull. 40:123150.[Crossref], [Web of Science ®] [Google Scholar], 2011 Cossette, H., Marceau, E., Toureille, F. (2011). risk models based on time series for count random variables. Insur. Math. Econ. 48:1928.[Crossref], [Web of Science ®] [Google Scholar]) gave a novel collective risk model where the total numbers of claims satisfy the first-order integer-valued autoregressive process. For a risk model, it is interesting to investigate the upper bound of ruin probability. However, the loss increments of the above model are dependent; it is difficult to derive the upper bound of ruin probability. In this article, we propose an approximation model with stationary independent increments. The upper bound of ruin probability and the adjustment coefficient are derived. The approximation model is illustrated via four simulated examples. Results show that the gap of the approximation model and dependent model can be ignored by adjusting values of parameters.  相似文献   

19.
In this article, assuming that the error terms follow a multivariate t distribution,we derive the exact formulae forthe moments of the heterogeneous preliminary test (HPT) estimator proposed by Xu (2012b Xu, H. (2012b). MSE performance and minimax regret significance points for a HPT estimator when each individual regression coefficient is estimated. Commun. Stat. Theory Methods 42:21522164.[Taylor &; Francis Online], [Web of Science ®] [Google Scholar]). We also execute the numerical evaluation to investigate the mean squared error (MSE) performance of the HPT estimator and compare it with those of the feasible ridge regression (FRR) estimator and the usual ordinary least squared (OLS) estimator. Further, we derive the optimal critical values of the preliminary F test for the HPT estimator, using the minimax regret function proposed by Sawa and Hiromatsu (1973 Sawa, T., Hiromatsu, T. (1973). Minimax regret significance points for a preliminary test in regression analysis. Econometrica 41:10931101.[Crossref], [Web of Science ®] [Google Scholar]). Our results show that (1) the optimal significance level (α*) increases as the degrees of freedom of multivariate t distribution (ν0) increases; (2) when ν0 ? 10, the value of α* is close to that in the normal error case.  相似文献   

20.
This paper proposes a bivariate version of the univariate discrete generalized geometric distribution considered by Gómez–Déniz (2010 Gómez–Déniz, E. (2010). Another generalization of the geometric distribution. Test 19:399415.[Crossref], [Web of Science ®] [Google Scholar]). The proposed bivariate distribution can have a positive or negative correlation coefficient which can be used for modeling bivariate-dependent count data. After discussing some of its properties, maximum likelihood estimation is discussed. Two illustrative examples are given for fitting and demonstrating the usefulness of the new bivariate distribution proposed here.  相似文献   

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