Systematic latin squares

In order to properly utilize restricted randomization in the selection of t × t Latin squares it is necessary to have some idea of the various types of systematic Latin squares that should be removed from the admissible sets. The best known systematic squares are the diagonal squares and the Knut Vik squares. When t is not a prime number there are various other types of diagonal and balanced Latin squares. Eleven types of 4 × 4 Latin squares, each of them being systematic, are identified, displayed, and their properties indicated. Eight types of systematic 6 × 6 Latin squares are also identified and displayed. The effect of removing systematic squares from the admissible sets of Latin squares is discussed. Recommendations are made on when a restricted randomization procedure is to be preferred to a full randomization procedure in the selection of a random t × t Latin square.     

An easy method of constructing latin square designs balanced for the immediate residual and other order effects

Bradley (1958) proposed a very simple procedure for constructing latin square designs to counterbalance the immediate sequential effect for an even number of treatments. When the number of treatments is odd, balance in a single latin square is not possible. In the present note we have developed an analogous method for the construction of such designs which may be used for an even or odd number of treatments. A proof has also been offered to assure the general validity of the procedure.     

Balanced incomplete Latin square designs

Latin squares have been widely used to design an experiment where the blocking factors and treatment factors have the same number of levels. For some experiments, the size of blocks may be less than the number of treatments. Since not all the treatments can be compared within each block, a new class of designs called balanced incomplete Latin squares (BILS) is proposed. A general method for constructing BILS is proposed by an intelligent selection of certain cells from a complete Latin square via orthogonal Latin squares. The optimality of the proposed BILS designs is investigated. It is shown that the proposed transversal BILS designs are asymptotically optimal for all the row, column and treatment effects. The relative efficiencies of a delete-one-transversal BILS design with respect to the optimal designs for both cases are also derived; it is shown to be close to 100%, as the order becomes large.     

EQUINEIGHBOURED XPERIMENTAL DESIGNS

This paper introduces a new class of designs called equi-neighboured designs. An equineighboured design has the property that every unordered pair of treatments occurs as nearest neighbours equally frequently at every level. These designs are defined in Section 4 and shown to be balanced when neighbouring observations are correlated. Some equineighboured designs are constructed using a complete set of orthogonal Latin squares. Cyclic equineighboured designs are also defined.     

Some new constructions of strength 3 mixed orthogonal arrays

Orthogonal arrays of strength 3 permit estimation of all the main effects of the experimental factors free from confounding or contamination with 2-factor interactions. We introduce methods of using arithmetic formulations and Latin squares to construct mixed orthogonal arrays of strength 3. Although the methods could be well extended to computing larger arrays, we confine computing to at most 100 run orthogonal arrays for practical uses. We find new arrays with run sizes 80 and 96, each has many distinct factor levels.     

Construction of incomplete Sudoku square and partially balanced incomplete block designs

Abstract

The present article deals with the study of association among the elements of a Sudoku square. In this direction, we have defined an association scheme and constructed incomplete Sudoku square designs which are capable of studying four explanatory variables and also happen to be the designs for two-way elimination of heterogeneity. Some series of Partially Balanced Incomplete Block (PBIB) designs have also been obtained.     

A theorem for selecting oa-based latin hypercubes using a distance criterion

The maximin distance criterion is used for the selection of an OA-based Latin hypercube. For the case in which the underlying orthogonal array is a full factorial design without replication, we construct an OA-based Latin hypercube that reaches the same distance as its parent array.     

Indivisible partitions of latin squares

In a latin square of order n, a k-plex is a selection of kn entries in which each row, column and symbol occurs k times. A 1-plex is also called a transversal. An indivisible k-plex is one that contains no c-plex for 0<c<k. For orders n∉{2,6}, existence of latin squares with a partition into 1-plexes was famously shown in 1960 by Bose, Shrikhande and Parker. A main result of this paper is that, if k divides n and 1<k<n then there exists a latin square of order n with a partition into indivisible k-plexes.Define κ(n) to be the largest integer k such that some latin square of order n contains an indivisible k-plex. We report on extensive computations of indivisible plexes and partitions in latin squares of order at most 9. We determine κ(n) exactly for n≤8 and find that κ(9)∈{6,7}. Up to order 8 we count all indivisible partitions in each species.For each group table of order n≤8 we report the number of indivisible plexes and indivisible partitions. For group tables of order 9 we give the number of indivisible plexes and identify which types of indivisible partitions occur. We will also report on computations which show that the latin squares of order 9 satisfy a conjecture that every latin square of order n has a set of ⌊n/2⌋ disjoint 2-plexes.By extending an argument used by Mann, we show that for all n≥5 there is some k∈{1,2,3,4} for which there exists a latin square of order n that has k disjoint transversals and a disjoint (n−k)-plex that contains no c-plex for any odd c.     

Crossover designs in the presence of carry-over effects from two factors

Experiments, used in the telecommunications industry and elsewhere, are considered that involve the simultaneous application of levels of two unrelated factors, treatments and stimuli, to each of several subjects in a succession of time periods. The existence is suspected of carry-over effects of treatments and stimuli, in the period immediately following the period of their application. Methods are given for the construction of separate sequences of treatments and of stimuli; these methods are based on the Latin squares of Williams and of Russell. In the resulting designs, the treatments and stimuli are either orthogonal or nearly orthogonal, and the coincidence of the direct and carry-over effects of each factor is either balanced or nearly balanced. The efficiencies of the designs are assessed by comparing the average variances of elementary contrasts in the levels of each factor with appropriate lower bounds.     

Small orthogonal main effect plans with four factors

In this paper we study orthogonal main effect plans with four factors, A table of such designs, where each factor has at most 10 levels, and there are at most 40 runs, is generated. We determine the spectrum of the degrees of freedom of pure error for these designs.     

Low-order spatially-distinct latin squares

The order three to five spatially-distinct Latin squares, and the order three to six spatially-distinct Latin square treatment designs are listed. Some statistical results are given. Designs for 4, 5 and 6 treatments that were found previously to be robust to a linear by linear interacrion are shown to be optimal. Designs with good neighbour balanced are also considered.     

Inference Based on General Linear Models for Order Restricted Randomization

This article develops statistical inference for the general linear models in order restricted randomized (ORR) designs. The ORR designs use the heterogeneity among experimental units to induce a negative correlation structure among responses obtained from different treatment regimes. This negative correlation structure acts as a variance reduction technique for treatment contrast. The parameters of the general linear models are estimated and a generalized F-test is constructed for its components. It is shown that the null distribution of the test statistic can be approximated reasonably well with an F-distribution for moderate sample sizes. It is also shown that the empirical power of the proposed test is substantially higher than the powers of its competitors in the literature. The proposed test and estimator are applied to a data set from a clinical trial to illustrate how one can improve such an experiment.     

Experimental designs and their efficiencies for spatially correlated observations in two dimensions

Optimality of experimental designs for spatially correlated observations is investigated.come two dimensional correlation structures are discussed and an attempt has been made to find optimal or nearly optimal design for each sitution.The solution lend to designs similar to that used for repeated measurements.The relative efficiency of the proposed designs in comparison to randomized latin square designs is tabulated for some cases.     

Optimal and efficient semi-Latin squares

An (n×n)/k$(n\times n)/k$semi-Latin square is an n×n square array in which nk distinct symbols (representing treatments) are placed in such a way that there are exactly k   symbols in each cell (row–column intersection) and each symbol occurs once in each row and once in each column. Semi-Latin squares form a class of row–column designs generalising Latin squares, and have applications in areas including the design of agricultural experiments, consumer testing, and via their duals, human–machine interaction. In the present paper, new theoretical and computational methods are developed to determine optimal or efficient (n×n)/k$(n\times n)/k$ semi-Latin squares for values of n and k for which such semi-Latin squares were previously unknown. The concept of subsquares of uniform semi-Latin squares is studied, new applications of the DESIGN package for GAP are developed, and exact algebraic computational techniques for comparing efficiency measures of binary equireplicate block designs are described. Applications include the complete enumeration of the (4×4)/k$(4\times 4)/k$ semi-Latin squares for k=2,…,10$k=2,\dots ,10$, and the determination of those that are A-, D-, and E-optimal, the construction of efficient (6×6)/k$(6\times 6)/k$ semi-Latin squares for k=4,5,6$k=4,5,6$, and counterexamples to a long-standing conjecture of R.A. Bailey and to a similar conjecture of D. Bedford and R.M. Whitaker.     

On d- and e- minimax optimal designs for estimating the axial slopes of a second-order response surface over hypercubic regions

Design of experiments for estimating the slopes of a response surface is considered. Design criteria analogous to the traditional ones but based upon the variance-covariance matrix of the estimated slopes along factor axes are proposed. Optimal designs under the proposed criteria are derived for second-order polynomial regression over hypercubic regions. Best de¬signs within some commonly used classes of designs are also obtained and their efficiencies are investigated.     

Statistical Inference of Adaptive Designs with Binary Responses

Adaptive designs of clinical trials are ethical alternatives when the traditional randomization becomes ethically infeasible in desperate medical situations. However, such a design creates a dependency among trial data and its statistical analysis becomes more complex than the analysis for traditional randomized clinical trials. In this article, we examine adaptive designs with dichotomous responses from two treatments and extend some commonly used statistical methods for independent data. Under a regularity condition, the estimated odds ratio and its logarithm are shown to follow asymptotically normal distributions. Moreover, the ordinary goodness-of-fit test statistic for two-by-two contingency tables with dependent data is shown to be asymptotically chi-square distributed. We also discuss the consistency of maximum likelihood estimators of the unknown parameters for a wide class of adaptive designs.     

The interplay of optimality and combinatorics in experimental design

The design of statistical experiments, as developed by R. A. Fisher and his followers, often used combinatorial structures that yielded simple calculation of estimates and/or symmetric variances and covariances. Examples are block designs with balance, regression experiments with equally spaced observations, etc. More recently, considerations of optimality (choosing a design that achieves most accurate inference in some sense) have sometimes justified the traditional designs, but have sometimes led to new combinatorial investigations. Illustrations are given.