Conditional estimation using prior information in 2‐stage group sequential designs assuming asymptotic normality when the trial terminated early

Two‐stage designs are widely used to determine whether a clinical trial should be terminated early. In such trials, a maximum likelihood estimate is often adopted to describe the difference in efficacy between the experimental and reference treatments; however, this method is known to display conditional bias. To reduce such bias, a conditional mean‐adjusted estimator (CMAE) has been proposed, although the remaining bias may be nonnegligible when a trial is stopped for efficacy at the interim analysis. We propose a new estimator for adjusting the conditional bias of the treatment effect by extending the idea of the CMAE. This estimator is calculated by weighting the maximum likelihood estimate obtained at the interim analysis and the effect size prespecified when calculating the sample size. We evaluate the performance of the proposed estimator through analytical and simulation studies in various settings in which a trial is stopped for efficacy or futility at the interim analysis. We find that the conditional bias of the proposed estimator is smaller than that of the CMAE when the information time at the interim analysis is small. In addition, the mean‐squared error of the proposed estimator is also smaller than that of the CMAE. In conclusion, we recommend the use of the proposed estimator for trials that are terminated early for efficacy or futility.     

Bias Adjustment Minimizing the Asymptotic Mean Square Error

A method of bias adjustment which minimizes the asymptotic mean square error is presented for an estimator typically given by maximum likelihood. Generally, this adjustment includes unknown population values. However, in some examples, the adjustment can be done without population values. In the case of a logit, a reasonable fixed value for the adjustment is found, which gives the asymptotic mean square error smaller than those of the asymptotically unbiased estimator and the maximum likelihood estimator. The weighted-score method, which yields directly the estimator with the minimized asymptotic mean square error, is also given.     

Bias‐reduced marginal Akaike information criteria based on a Monte Carlo method for linear mixed‐effects models

In linear mixed‐effects (LME) models, if a fitted model has more random‐effect terms than the true model, a regularity condition required in the asymptotic theory may not hold. In such cases, the marginal Akaike information criterion (AIC) is positively biased for (?2) times the expected log‐likelihood. The asymptotic bias of the maximum log‐likelihood as an estimator of the expected log‐likelihood is evaluated for LME models with balanced design in the context of parameter‐constrained models. Moreover, bias‐reduced marginal AICs for LME models based on a Monte Carlo method are proposed. The performance of the proposed criteria is compared with existing criteria by using example data and by a simulation study. It was found that the bias of the proposed criteria was smaller than that of the existing marginal AIC when a larger model was fitted and that the probability of choosing a smaller model incorrectly was decreased.     

A Spline‐Based Semiparametric Maximum Likelihood Estimation Method for the Cox Model with Interval‐Censored Data

Abstract. We propose a spline‐based semiparametric maximum likelihood approach to analysing the Cox model with interval‐censored data. With this approach, the baseline cumulative hazard function is approximated by a monotone B‐spline function. We extend the generalized Rosen algorithm to compute the maximum likelihood estimate. We show that the estimator of the regression parameter is asymptotically normal and semiparametrically efficient, although the estimator of the baseline cumulative hazard function converges at a rate slower than root‐n. We also develop an easy‐to‐implement method for consistently estimating the standard error of the estimated regression parameter, which facilitates the proposed inference procedure for the Cox model with interval‐censored data. The proposed method is evaluated by simulation studies regarding its finite sample performance and is illustrated using data from a breast cosmesis study.     

Ratio estimators based on a ranked set sample in a finite population setting

This paper considers the ratio estimator in a finite population setting in a ranked set sampling (RSS) design, where the sample is constructed either with or without replacement policies. It is shown that the proposed ratio estimator is slightly biased, but the amount of bias is smaller than the amount of bias of a simple random sample (SRS) ratio estimator. For the proposed ratio estimator, the paper provides explicit expressions for its mean square error and precision relative to the other competing estimators. It is shown that the new estimator has a substantial amount of improvement in efficiency with respect to SRS estimator. The proposed estimator is applied to two different finite population settings to estimate population mean.     

Estimating the correlation coefficient in the presence of correlated observations from a bivariate normal population

Estimation of the correlation coefficient between two variates (p) in the presence of correlated observations from a bivar iate normal population is considered The estimated maximum likelihood estimator (EMLE), an estimate based on the maximum likelihood estimator (MLE), is proposed and studied for the estimation of p For the large sample case , approximate expressions foi the variance and the bias of the Pearson estimate of the correlation coefficient are derived. These expressions suggests that the Pearson’s estimator possesses high mean square error (MSE) in estimating ρ in comparison to the MLE The MSE is particularly high when the observations within clusters aie highly correlated. The Pearson’s estimate, the MLE, and the EMLE aie evaluated in a simulation study This study shows that the proposed EMLE pefoims bettei than the Pearson’s correlation coefficient except when the number of clusters is small.     

Some results on maximum likelihood estimators of parameters of exponential distribution under type I progressive censoring with changing failure rates

In this paper the study of relative bias (RB), exact variance and mean square error (MSE) of the maximum likelihood estimators of the exponential distribution under type I progressive censoring with changing failure rates is considered. A minimum mean square error (MMSE) estimator for the parameter at each stage is proposed. The numerical evalution of their relative performance is made for selected values of n and p. Further results concerning group-censoring, total expected waiting time and optimal spacings of the times of censoring are derived and results obtained by Kendell and Anderson (1971) are deduced as special cases.     

Bayes and Empirical Bayes Inference in Changepoint Problems

ABSTRACT

In the case of the random design nonparametric regression, the double smoothing technique is applied to estimate the multivariate regression function. The proposed estimator has desirable properties in both the finite sample and the asymptotic cases. In the finite sample case, it has bounded conditional (and unconditional) bias and variance. On the other hand, in the asymptotic case, it has the same mean square error as the local linear estimator in Fan (Design-Adaptive Nonparametric Regression. Journal of the American Statistical Association 1992, 87, 998–1004; Local Linear Regression Smoothers and Their Minimax Efficiencies. Annals of Statistics 1993, 21, 196–216). Simulation studies demonstrate that the proposed estimator is better than the local linear estimator, because it has a smaller sample mean integrated square error and gives smoother estimates.     

Combined estimators for the correlation coefficient

Three combined estimators for the bivariate normal correlation parameter are considered. The data consist of k independent sample correlation coefficients and it is assumed that the underlying correlation parameters are all equal to ρ. Based upon the joint density function of the sample correlations a combined estimator of ρ is obtained as an approximation to the maximum likelihood solution. Two linearly combined estimators are also considered. One of them is based on Fisher's z-transformation of the sample correlations and the other on an unbiased estimator of ρ. The comparison of these three estimators indicates that the combined (approximate) MLE has a slightly smaller estimated mean squared error relative to the other two combined methods of estimation, but it does so at the expense of a relatively larger bias.     

Finite-sample properties of the maximum likelihood estimator for the binary logit model with random covariates

We examine the finite sample properties of the maximum likelihood estimator for the binary logit model with random covariates. Previous studies have either relied on large-sample asymptotics or have assumed non-random covariates. Analytic expressions for the first-order bias and second-order mean squared error function for the maximum likelihood estimator in this model are derived, and we undertake numerical evaluations to illustrate these analytic results for the single covariate case. For various data distributions, the bias of the estimator is signed the same as the covariate’s coefficient, and both the absolute bias and the mean squared errors increase symmetrically with the absolute value of that parameter. The behaviour of a bias-adjusted maximum likelihood estimator, constructed by subtracting the (maximum likelihood) estimator of the first-order bias from the original estimator, is examined in a Monte Carlo experiment. This bias-correction is effective in all of the cases considered, and is recommended for use when this logit model is estimated by maximum likelihood using small samples.     

A Convolution Estimator for the Density of Nonlinear Regression Observations

Abstract. The problem of estimating an unknown density function has been widely studied. In this article, we present a convolution estimator for the density of the responses in a nonlinear heterogenous regression model. The rate of convergence for the mean square error of the convolution estimator is of order n ^?1 under certain regularity conditions. This is faster than the rate for the kernel density method. We derive explicit expressions for the asymptotic variance and the bias of the new estimator, and further a data‐driven bandwidth selector is proposed. We conduct simulation experiments to check the finite sample properties, and the convolution estimator performs substantially better than the kernel density estimator for well‐behaved noise densities.     

A new perspective in functional EIV linear model: Part I

Simple linear regression in the functional errors-in-variables (EIV) model is revisited from a different perspective, where the problem is addressed by using the small-sigma model instead of large sample theory. A general analysis is developed to study the slope’s estimator that minimizes a family of objective functions, of which the least-squares fit and the maximum likelihood estimator are minimizers of such special functions. General formulas for the higher-order terms of the bias, the variance, and the mean square error are derived. Accordingly, two efficient estimators are proposed after implementing the pre- and the post-bias elimination techniques. Numerical tests confirm the superiority of the proposed estimators over others.     

Alternative moment approximations for berkson's minimum logit chi-squared estimator

Expressions are derived for the bias to order J^-1 , the variance to order J^-2 and the mean squared error to order J^-2 of Berkson's minimum logit chi-squared estimator where J is the number of distinct design points. These moment approximations are numerically compared to Monte Carlo estimates of the true moments and the moment approximations of Amemiya (1980) which are appropriate when the “average” number of observations per design point is large. They are used to compare the mean squared error of the minimum logit chi-squared estimator to that of the maximum likelihood estimator and to investigate the effect of bias on confidence intenrals constructed using the minimum logit chi-squared estimator.     

On parameter estimation in Bernoulli trials with dependence

A simple estimator is proposed for the dependence parameter for the Klotz model of Bernoulli trials with Markov dependence and it is compared with the ratio estimator given by Price and the approximate maximum likelihood estimator given by Klotz. The proposed estimator is shown to have considerably smaller bias than the other two estimators with comparable mean squared errors, and has all the large sample optimal properties that the other two estimators have.     

Design considerations for small experiments and simple logistic regression

Inference for a generalized linear model is generally performed using asymptotic approximations for the bias and the covariance matrix of the parameter estimators. For small experiments, these approximations can be poor and result in estimators with considerable bias. We investigate the properties of designs for small experiments when the response is described by a simple logistic regression model and parameter estimators are to be obtained by the maximum penalized likelihood method of Firth [Firth, D., 1993, Bias reduction of maximum likelihood estimates. Biometrika, 80, 27–38]. Although this method achieves a reduction in bias, we illustrate that the remaining bias may be substantial for small experiments, and propose minimization of the integrated mean square error, based on Firth's estimates, as a suitable criterion for design selection. This approach is used to find locally optimal designs for two support points.     

A New Estimator for a Population Proportion Using Group Testing

The maximum likelihood estimator is widely used in estimating the population proportion using group testing. However, it is positive biased and some alternatives have been raised in literatures. In this study, we propose a new estimator by weighted combination of order statistics. Two rules are supplied to determine the unknown weight. Using the rule of minimizing the absolute bias, our estimator is almost unbiased in most cases shown by simulations. Using the rule of minimizing the mean square error, a simple estimator with weight 1 is recommended for its good performance.     

A new estimator of entropy

Vasicek (1976) proposed an estimator of entropy based on spacings. A new estimator of entropy is proposed. This new estimator is based on local linear regression. Comparisons between this new estimator and Vasicek's estimator are made. The mean square error (MSE) of the new estimator is consistently smaller than the MSE of Vasicek's estimator.     

A Sample Selection Model with Skew‐normal Distribution

Non‐random sampling is a source of bias in empirical research. It is common for the outcomes of interest (e.g. wage distribution) to be skewed in the source population. Sometimes, the outcomes are further subjected to sample selection, which is a type of missing data, resulting in partial observability. Thus, methods based on complete cases for skew data are inadequate for the analysis of such data and a general sample selection model is required. Heckman proposed a full maximum likelihood estimation method under the normality assumption for sample selection problems, and parametric and non‐parametric extensions have been proposed. We generalize Heckman selection model to allow for underlying skew‐normal distributions. Finite‐sample performance of the maximum likelihood estimator of the model is studied via simulation. Applications illustrate the strength of the model in capturing spurious skewness in bounded scores, and in modelling data where logarithm transformation could not mitigate the effect of inherent skewness in the outcome variable.     

A pseudo‐empirical best linear unbiased prediction approach to small area estimation using survey weights

The authors develop a small area estimation method using a nested error linear regression model and survey weights. In particular, they propose a pseudo‐empirical best linear unbiased prediction (pseudo‐EBLUP) estimator to estimate small area means. This estimator borrows strength across areas through the model and makes use of the survey weights to preserve the design consistency as the area sample size increases. The proposed estimator also has a nice self‐benchmarking property. The authors also obtain an approximation to the model mean squared error (MSE) of the proposed estimator and a nearly unbiased estimator of MSE. Finally, they compare the proposed estimator with the EBLUP estimator and the pseudo‐EBLUP estimator proposed by Prasad & Rao (1999), using data analyzed earlier by Battese, Harter & Fuller (1988).     

On bias reduction estimators of skew-normal and skew-t distributions

A particular concerns of researchers in statistical inference is bias in parameters estimation. Maximum likelihood estimators are often biased and for small sample size, the first order bias of them can be large and so it may influence the efficiency of the estimator. There are different methods for reduction of this bias. In this paper, we proposed a modified maximum likelihood estimator for the shape parameter of two popular skew distributions, namely skew-normal and skew-t, by offering a new method. We show that this estimator has lower asymptotic bias than the maximum likelihood estimator and is more efficient than those based on the existing methods.