Truncated sequential change-point detection based on renewal counting processes II

The standard approach in change-point theory is to base the statistical analysis on a sample of fixed size. Alternatively, one observes some random phenomenon sequentially and takes action as soon as one observes some statistically significant deviation from the “normal” behaviour. The present paper is a continuation of Gut and Steinebach [2002. Truncated sequential change-point detection based on renewal counting processes. Scand. J. Statist. 29, 693–719] the main point being that here we look in more detail into the behaviour of the relevant stopping times, in particular the time it takes from the actual change-point until the change is detected, more precisely, we prove asymptotics for stopping times under alternatives.     

Bridging the Gap: A Generalized Stochastic Process for Count Data

The Bernoulli and Poisson processes are two popular discrete count processes; however, both rely on strict assumptions. We instead propose a generalized homogenous count process (which we name the Conway–Maxwell–Poisson or COM-Poisson process) that not only includes the Bernoulli and Poisson processes as special cases, but also serves as a flexible mechanism to describe count processes that approximate data with over- or under-dispersion. We introduce the process and an associated generalized waiting time distribution with several real-data applications to illustrate its flexibility for a variety of data structures. We consider model estimation under different scenarios of data availability, and assess performance through simulated and real datasets. This new generalized process will enable analysts to better model count processes where data dispersion exists in a more accommodating and flexible manner.     

Bayesian inference for a partially observed birth–death process using data on proportions

Stochastic kinetic models are often used to describe complex biological processes. Typically these models are analytically intractable and have unknown parameters which need to be estimated from observed data. Ideally we would have measurements on all interacting chemical species in the process, observed continuously in time. However, in practice, measurements are taken only at a relatively few time‐points. In some situations, only very limited observation of the process is available, for example settings in which experimenters can only observe noisy observations on the proportion of cells that are alive. This makes the inference task even more problematic. We consider a range of data‐poor scenarios and investigate the performance of various computationally intensive Bayesian algorithms in determining the posterior distribution using data on proportions from a simple birth‐death process.     

Modelling Aggregation on the Large Scale and Regularity on the Small Scale in Spatial Point Pattern Datasets

We consider a dependent thinning of a regular point process with the aim of obtaining aggregation on the large scale and regularity on the small scale in the resulting target point process of retained points. Various parametric models for the underlying processes are suggested and the properties of the target point process are studied. Simulation and inference procedures are discussed when a realization of the target point process is observed, depending on whether the thinned points are observed or not. The paper extends previous work by Dietrich Stoyan on interrupted point processes.     

Modeling of semi-competing risks by means of first passage times of a stochastic process

In semi-competing risks one considers a terminal event, such as death of a person, and a non-terminal event, such as disease recurrence. We present a model where the time to the terminal event is the first passage time to a fixed level c in a stochastic process, while the time to the non-terminal event is represented by the first passage time of the same process to a stochastic threshold S, assumed to be independent of the stochastic process. In order to be explicit, we let the stochastic process be a gamma process, but other processes with independent increments may alternatively be used. For semi-competing risks this appears to be a new modeling approach, being an alternative to traditional approaches based on illness-death models and copula models. In this paper we consider a fully parametric approach. The likelihood function is derived and statistical inference in the model is illustrated on both simulated and real data.     

Asymptotic robustness of least median of squares for autoregressions with additive outliers

This paper considers the robustness properties in the time series context of the least median of squares (LMS) estimator. The influence function of the LMS estimator is derived under additive outlier contamination. This influence function is redescending and bounded for fixed values of the AR parameters. The gross-error sensitivity, however, is an unbounded function of the AR parameters. In order to asses the global robustness behavior of the LMS estimator, we consider several notions of breakdown. The breakdown points of the LMS estimator depend on the value of the underlying AR parameter. Generally, the breakdown point is below one half for high values of the AR parameter. The bias curves of the LMS estimator reveal, however, that the magnitude of outliers has to be considerable in order to cause breakdown.     

Parameter Estimation for Inhomogeneous Space‐Time Shot‐Noise Cox Point Processes

We consider the problem of parameter estimation for inhomogeneous space‐time shot‐noise Cox point processes. We explore the possibility of using a stepwise estimation method and dimensionality‐reducing techniques to estimate different parts of the model separately. We discuss the estimation method using projection processes and propose a refined method that avoids projection to the temporal domain. This remedies the main flaw of the method using projection processes – possible overlapping in the projection process of clusters, which are clearly separated in the original space‐time process. This issue is more prominent in the temporal projection process where the amount of information lost by projection is higher than in the spatial projection process. For the refined method, we derive consistency and asymptotic normality results under the increasing domain asymptotics and appropriate moment and mixing assumptions. We also present a simulation study that suggests that cluster overlapping is successfully overcome by the refined method.     

Time series analysis of categorical data using auto-odds ratio function

In this paper, we consider the auto-odds ratio function (AORF) as a measure of serial association for a stationary time series process of categorical data at two different time points. Numerical measures such as the autocorrelation function (ACF) have no meaningful interpretation, unless the time series data are numerical. Instead, we use the AORF as a measure of association to study the serial dependency of the categorical time series for both ordinal and nominal categories. Biswas and Song [Discrete-valued ARMA processes. Stat Probab Lett. 2009;79(17):1884–1889] provided some results on this measure for Pegram's operator-based AR(1) process with binary responses. Here, we extend this measure to more general set-ups, i.e. for AR(p) and MA(q) processes and for a general number of categories. We discuss how this method can effectively be used in parameter estimation and model selection. Following Weiß [Empirical measures of signed serial dependence in categorical time series. J Stat Comput Simul. 2011;81(4):411–429], we derive the large sample distribution of the estimator of the AORF under independent and identically distributed (iid) set-up. Some simulation results and two categorical data examples (one is ordinal and other nominal) are presented to illustrate the proposed method.     

Survival Models Based on the Ornstein-Uhlenbeck Process

When modelling survival data it may be of interest to imagine an underlying process leading up to the event in question. The Ornstein-Uhlenbeck process is a natural model to consider in a biological context because it stabilizes around some equilibrium point. This corresponds to the homeostasis often observed in biology, and also to some extent in the social sciences. First, we study the first-passage time distribution of an Ornstein-Uhlenbeck process, focussing especially on what is termed quasi-stationarity and the various shapes of the hazard rate. Next, we consider a model where the individual hazard rate is a squared function of an Ornstein-Uhlenbeck process. We extend known results on this model. The results on quasi-stationarity are relevant for recent discussions about mortality plateaus. In addition, we point out a connection to models for short-term interest rates in financial modeling.     

Irregularly observed time series – some asymptotics and the block bootstrap

We consider time series being observed at random time points. In addition to Parzen's classical modelling by amplitude modulating sequences, we state another modelling using an integer-valued sequence as the observation times. Limiting results are presented for the sample mean and are generalized to the class of functions of smooth means. Motivated by the complicated limiting behaviour, (moving) block bootstrap possibilities are investigated. Conditional on the used modelling for the irregular spacings, one is lead to different interpretations for the block length and hence bootstrap approaches. The block length either can be interpreted as the time (resulting in an observation string of fixed length containing a random number of observations) or as the number of observations (resulting in an observation string of variable length containing a fixed number of values). Both bootstrap approaches are shown to be asymptotically valid for the sample mean. Numerical examples and an application to real-world ozone data conclude the study.     

A note on non-negative continuous time processes

Summary.  Recently there has been much work on developing models that are suitable for analysing the volatility of a continuous time process. One general approach is to define a volatility process as the convolution of a kernel with a non-decreasing Lévy process, which is non-negative if the kernel is non-negative. Within the framework of time continuous autoregressive moving average (CARMA) processes, we derive a necessary and sufficient condition for the kernel to be non-negative. This condition is in terms of the Laplace transform of the CARMA kernel, which has a simple form. We discuss some useful consequences of this result and delineate the parametric region of stationarity and non-negative kernel for some lower order CARMA models.     

Analysis of longitudinal data with irregular, outcome-dependent follow-up

Summary.  A frequent problem in longitudinal studies is that subjects may miss scheduled visits or be assessed at self-selected points in time. As a result, observed outcome data may be highly unbalanced and the availability of the data may be directly related to the outcome measure and/or some auxiliary factors that are associated with the outcome. If the follow-up visit and outcome processes are correlated, then marginal regression analyses will produce biased estimates. Building on the work of Robins, Rotnitzky and Zhao, we propose a class of inverse intensity-of-visit process-weighted estimators in marginal regression models for longitudinal responses that may be observed in continuous time. This allows us to handle arbitrary patterns of missing data as embedded in a subject's visit process. We derive the large sample distribution for our inverse visit-intensity-weighted estimators and investigate their finite sample behaviour by simulation. Our approach is illustrated with a data set from a health services research study in which homeless people with mental illness were randomized to three different treatments and measures of homelessness (as percentage days homeless in the past 3 months) and other auxiliary factors were recorded at follow-up times that are not fixed by design.     

ROBUST ESTIMATION FOR EPIDEMIC MODELS

A robust approach to the analysis of epidemic data is suggested. This method is based on a natural extension of M-estimation for i.i.d. observations where the distribution may be asymmetric. It is discussed initially in the context of a general discrete time stochastic process before being applied to previously studied epidemic models. In particular we consider a class of chain binomial models and models based on time dependent branching processes. Robustness and efficiency properties are studied through simulation and some previously analysed data sets are considered.     

On- and offline detection of structural breaks in thermal spraying processes

We investigate and develop methods for structural break detection, considering time series from thermal spraying process monitoring. Since engineers induce technical malfunctions during the processes, the time series exhibit structural breaks at known time points, giving us valuable information to conduct the investigations. First, we consider a recently developed robust online (also real-time) filtering (i.e. smoothing) procedure that comprises a test for local linearity. This test rejects when jumps and trend changes are present, so that it can also be useful to detect such structural breaks online. Second, based on the filtering procedure we develop a robust method for the online detection of ongoing trends. We investigate these two methods as to the online detection of structural breaks by simulations and applications to the time series from the manipulated spraying processes. Third, we consider a recently developed fluctuation test for constant variances that can be applied offline, i.e. after the whole time series has been observed, to control the spraying results. Since this test is not reliable when jumps are present in the time series, we suggest data transformation based on filtering and demonstrate that this transformation makes the test applicable.     

Bayesian Analysis of the Proportional Hazards Model with Time‐Varying Coefficients

We study a Bayesian analysis of the proportional hazards model with time‐varying coefficients. We consider two priors for time‐varying coefficients – one based on B‐spline basis functions and the other based on Gamma processes – and we use a beta process prior for the baseline hazard functions. We show that the two priors provide optimal posterior convergence rates (up to the term) and that the Bayes factor is consistent for testing the assumption of the proportional hazards when the two priors are used for an alternative hypothesis. In addition, adaptive priors are considered for theoretical investigation, in which the smoothness of the true function is assumed to be unknown, and prior distributions are assigned based on B‐splines.     

The discretely observed immigration-death process: Likelihood inference and spatiotemporal applications

ABSTRACT

We consider a stochastic process, the homogeneous spatial immigration-death (HSID) process, which is a spatial birth-death process with as building blocks (i) an immigration-death (ID) process (a continuous-time Markov chain) and (ii) a probability distribution assigning iid spatial locations to all events. For the ID process, we derive the likelihood function, reduce the likelihood estimation problem to one dimension, and prove consistency and asymptotic normality for the maximum likelihood estimators (MLEs) under a discrete sampling scheme. We additionally prove consistency for the MLEs of HSID processes. In connection to the growth-interaction process, which has a HSID process as basis, we also fit HSID processes to Scots pine data.     

State estimation for aoristic models

Aoristic data can be described by a marked point process in time in which the points cannot be observed directly but are known to lie in observable intervals, the marks. We consider Bayesian state estimation for the latent points when the marks are modeled in terms of an alternating renewal process in equilibrium and the prior is a Markov point process. We derive the posterior distribution, estimate its parameters and present some examples that illustrate the influence of the prior distribution. The model is then used to estimate times of occurrence of interval censored crimes.     

Parametric inference in a perturbed gamma degradation process

Abstract

We consider a degradation model which is the sum of two independent processes: an homogeneous gamma process and a Brownian motion. This model is called perturbed gamma process. Based on independent copies of the perturbed gamma process observed at irregular instants we propose to estimate the unknown parameters of the model using the moment method. Some general conditions allow to derive the asymptotic behavior of the estimators. We also show that these general conditions are fulfilled for some specific observation schemes. Finally, we illustrate our method by a numerical study and an application to a real data set.     

Nonparametric tests for stratified additive hazards model based on current status data

Stratified regression models are commonly employed when study subjects may come from possibly different strata such as different medical centers, and for the situation, one common question of interest is to test the existence of the stratum effect. To address this, there exists some literature on the testing of the stratum effects under the framework of the proportional hazards model when one observes right-censored data or interval-censored data. In this paper, we consider the situation under the additive hazards model when one faces current status data, for which there does not seem to exist an established test procedure. The asymptotic distributions of the proposed test procedure are provided. Also a simulation study is performed to evaluate the performance of the proposed method and indicates that it works well for practical situations. The approach is applied to a set of real current status data from a tumorigenicity study.     

Bayesian inference for dynamic social network data

We consider a continuous-time model for the evolution of social networks. A social network is here conceived as a (di-) graph on a set of vertices, representing actors, and the changes of interest are creation and disappearance over time of (arcs) edges in the graph. Hence we model a collection of random edge indicators that are not, in general, independent. We explicitly model the interdependencies between edge indicators that arise from interaction between social entities. A Markov chain is defined in terms of an embedded chain with holding times and transition probabilities. Data are observed at fixed points in time and hence we are not able to observe the embedded chain directly. Introducing a prior distribution for the parameters we may implement an MCMC algorithm for exploring the posterior distribution of the parameters by simulating the evolution of the embedded process between observations.