Boosted coefficient models

Regression methods typically construct a mapping from the covariates into the real numbers. Here, however, we consider regression problems where the task is to form a mapping from the covariates into a set of (univariate) real-valued functions. Examples are given by conditional density estimation, hazard regression and regression with a functional response. Our approach starts by modeling the function of interest using a sum of B-spline basis functions. To model dependence on the covariates, the coefficients of this expansion are each modeled as functions of the covariates. We propose to estimate these coefficient functions using boosted tree models. Algorithms are provided for the above three situations, and real data sets are used to investigate their performance. The results indicate that the proposed methodology performs well. In addition, it is both straightforward, and capable of handling a large number of covariates.     

On multivariate quantile regression

To detect the dependence on the covariates in the lower and upper tails of the response distribution, regression quantiles are very useful tools in linear model problems with univariate response. We consider here a notion of regression quantiles for problems with multivariate responses. The approach is based on minimizing a loss function equivalent to that in the case of univariate response. To construct an affine equivariant notion of multivariate regression quantiles, we have considered a transformation retransformation procedure based on ‘data-driven coordinate systems’. We indicate some algorithm to compute the proposed estimates and establish asymptotic normality for them. We also, suggest an adaptive procedure to select the optimal data-driven coordinate system. We discuss the performance of our estimates with the help of a finite sample simulation study and to illustrate our methodology, we analyzed an interesting data-set on blood pressures of a group of women and another one on the dependence of sales performances on creative test scores.     

Multivariate-multiple circular regression

We introduce a fully model-based approach of studying functional relationships between a multivariate circular-dependent variable and several circular covariates, enabling inference regarding all model parameters and related prediction. Two multiple circular regression models are presented for this approach. First, for an univariate circular-dependent variable, we propose the least circular mean-square error (LCMSE) estimation method, and asymptotic properties of the LCMSE estimators and inferential methods are developed and illustrated. Second, using a simulation study, we provide some practical suggestions for model selection between the two models. An illustrative example is given using a real data set from protein structure prediction problem. Finally, a straightforward extension to the case with a multivariate-dependent circular variable is provided.     

Functional quasi-likelihood regression models with smooth random effects

Summary. We propose a class of semiparametric functional regression models to describe the influence of vector-valued covariates on a sample of response curves. Each observed curve is viewed as the realization of a random process, composed of an overall mean function and random components. The finite dimensional covariates influence the random components of the eigenfunction expansion through single-index models that include unknown smooth link and variance functions. The parametric components of the single-index models are estimated via quasi-score estimating equations with link and variance functions being estimated nonparametrically. We obtain several basic asymptotic results. The functional regression models proposed are illustrated with the analysis of a data set consisting of egg laying curves for 1000 female Mediterranean fruit-flies (medflies).     

Functional sliced inverse regression analysis

Most of the usual multivariate methods have been extended to the context of functional data analysis. Our contribution concerns the study of sliced inverse regression (SIR) when the response variable is real but the regressor is a function. In the first part, we show how the relevant properties of SIR remain essentially the same in the functional context under suitable conditions. Unfortunately, the estimation procedure used in the multivariate case cannot be directly transposed to the functional one. Then, we propose a solution that overcomes this difficulty and we show the consistency of the estimates of the parameters of the model.     

Curve prediction and clustering with mixtures of Gaussian process functional regression models

Shi, Wang, Murray-Smith and Titterington (Biometrics 63:714–723, 2007) proposed a Gaussian process functional regression (GPFR) model to model functional response curves with a set of functional covariates. Two main problems are addressed by their method: modelling nonlinear and nonparametric regression relationship and modelling covariance structure and mean structure simultaneously. The method gives very good results for curve fitting and prediction but side-steps the problem of heterogeneity. In this paper we present a new method for modelling functional data with ‘spatially’ indexed data, i.e., the heterogeneity is dependent on factors such as region and individual patient’s information. For data collected from different sources, we assume that the data corresponding to each curve (or batch) follows a Gaussian process functional regression model as a lower-level model, and introduce an allocation model for the latent indicator variables as a higher-level model. This higher-level model is dependent on the information related to each batch. This method takes advantage of both GPFR and mixture models and therefore improves the accuracy of predictions. The mixture model has also been used for curve clustering, but focusing on the problem of clustering functional relationships between response curve and covariates, i.e. the clustering is based on the surface shape of the functional response against the set of functional covariates. The model is examined on simulated data and real data.     

Robust Principal Component Functional Logistic Regression

In this article, we discuss the estimation of the parameter function for a functional logistic regression model in the presence of outliers. We consider ways that allow for the parameter estimator to be resistant to outliers, in addition to minimizing multicollinearity and reducing the high dimensionality, which is inherent with functional data. To achieve this, the functional covariates and functional parameter of the model are approximated in a finite-dimensional space generated by an appropriate basis. This approach reduces the functional model to a standard multiple logistic model with highly collinear covariates and potential high-dimensionality issues. The proposed estimator tackles these issues and also minimizes the effect of functional outliers. Results from a simulation study and a real world example are also presented to illustrate the performance of the proposed estimator.     

Calculating the power or sample size for the logistic and proportional hazards models

An algorithm is presented for calculating the power for the logistic and proportional hazards models in which some of the covariates are discrete and the remainders are multivariate normal. The mean and covariance matrix of the multivariate normal covariates may depend on the discrete covariates.

The algorithm, which finds the power of the Wald test, uses the result that the information matrix can be calculated using univariate numerical integration even when there are several continuous covariates. The algorithm is checked using simulation and in certain situations gives more accurate results than current methods which are based on simple formulae. The algorithm is used to explore properties of these models, in particular, the power gain from a prognostic covariate in the analysis of a clinical trial or observational study. The methods can be extended to determine power for other generalized linear models.     

Multivariate functional response low‐rank regression with an application to brain imaging data

We propose a multivariate functional response low‐rank regression model with possible high‐dimensional functional responses and scalar covariates. By expanding the slope functions on a set of sieve bases, we reconstruct the basis coefficients as a matrix. To estimate these coefficients, we propose an efficient procedure using nuclear norm regularization. We also derive error bounds for our estimates and evaluate our method using simulations. We further apply our method to the Human Connectome Project neuroimaging data to predict cortical surface motor task‐evoked functional magnetic resonance imaging signals using various clinical covariates to illustrate the usefulness of our results.     

Nonparametric covariate adjustment in estimating hazard ratios

In randomized clinical trials with time‐to‐event outcomes, the hazard ratio is commonly used to quantify the treatment effect relative to a control. The Cox regression model is commonly used to adjust for relevant covariates to obtain more accurate estimates of the hazard ratio between treatment groups. However, it is well known that the treatment hazard ratio based on a covariate‐adjusted Cox regression model is conditional on the specific covariates and differs from the unconditional hazard ratio that is an average across the population. Therefore, covariate‐adjusted Cox models cannot be used when the unconditional inference is desired. In addition, the covariate‐adjusted Cox model requires the relatively strong assumption of proportional hazards for each covariate. To overcome these challenges, a nonparametric randomization‐based analysis of covariance method was proposed to estimate the covariate‐adjusted hazard ratios for multivariate time‐to‐event outcomes. However, empirical evaluations of the performance (power and type I error rate) of the method have not been studied. Although the method is derived for multivariate situations, for most registration trials, the primary endpoint is a univariate outcome. Therefore, this approach is applied to univariate outcomes, and performance is evaluated through a simulation study in this paper. Stratified analysis is also investigated. As an illustration of the method, we also apply the covariate‐adjusted and unadjusted analyses to an oncology trial. Copyright © 2015 John Wiley & Sons, Ltd.     

An Application of U-Statistics to Nonparametric Functional Data Analysis

Functional regression functions, with explanatory variables taking values in some abstract function space, have been studied extensively. In this article, we aim to investigate the multivariate functional regression function, and propose a nonparametric estimator for the multivariate case. By applying some properties of U-statistics, some asymptotic distributions of such estimator are obtained under different cases.     

Bayesian density regression for discrete outcomes

We develop Bayesian models for density regression with emphasis on discrete outcomes. The problem of density regression is approached by considering methods for multivariate density estimation of mixed scale variables, and obtaining conditional densities from the multivariate ones. The approach to multivariate mixed scale outcome density estimation that we describe represents discrete variables, either responses or covariates, as discretised versions of continuous latent variables. We present and compare several models for obtaining these thresholds in the challenging context of count data analysis where the response may be over‐ and/or under‐dispersed in some of the regions of the covariate space. We utilise a nonparametric mixture of multivariate Gaussians to model the directly observed and the latent continuous variables. The paper presents a Markov chain Monte Carlo algorithm for posterior sampling, sufficient conditions for weak consistency, and illustrations on density, mean and quantile regression utilising simulated and real datasets.     

Estimating the error distribution function in semiparametric additive regression models

We consider semiparametric additive regression models with a linear parametric part and a nonparametric part, both involving multivariate covariates. For the nonparametric part we assume two models. In the first, the regression function is unspecified and smooth; in the second, the regression function is additive with smooth components. Depending on the model, the regression curve is estimated by suitable least squares methods. The resulting residual-based empirical distribution function is shown to differ from the error-based empirical distribution function by an additive expression, up to a uniformly negligible remainder term. This result implies a functional central limit theorem for the residual-based empirical distribution function. It is used to test for normal errors.     

Modeling association between multivariate correlated outcomes and high-dimensional sparse covariates: the adaptive SVS method

The problem of modeling the relationship between a set of covariates and a multivariate response with correlated components often arises in many areas of research such as genetics, psychometrics, signal processing. In the linear regression framework, such task can be addressed using a number of existing methods. In the high-dimensional sparse setting, most of these methods rely on the idea of penalization in order to efficiently estimate the regression matrix. Examples of such methods include the lasso, the group lasso, the adaptive group lasso or the simultaneous variable selection (SVS) method. Crucially, a suitably chosen penalty also allows for an efficient exploitation of the correlation structure within the multivariate response. In this paper we introduce a novel variant of such method called the adaptive SVS, which is closely linked with the adaptive group lasso. Via a simulation study we investigate its performance in the high-dimensional sparse regression setting. We provide a comparison with a number of other popular methods under different scenarios and show that the adaptive SVS is a powerful tool for efficient recovery of signal in such setting. The methods are applied to genetic data.     

再生核Hilbert空间展开的函数型回归模型变量选择

针对协变量是函数型、响应变量是标量的多元函数型回归模型,文章提出了函数系数基于再生核Hilbert空间展开的变量选择方法。首先,利用带积分余项的泰勒展开式和再生核Hilbert空间内积性质将模型转化为结构化形式,其次,通过自适应弹性网惩罚对结构化模型中的组间和组内系数同时进行压缩。结果证明了这种压缩估计具有Oracle性质,蒙特卡罗模拟结果也显示新方法在不同样本量、不同噪声和变量相关性干扰下均优于基于普通基函数展开的变量选择方法,且尤其适用于原始协变量高度相关的情形。最后,通过分析一个商品房平均销售价格影响因素数据演示了新方法的应用。     

Asymptotic theory for maximum likelihood estimates in reduced-rank multivariate generalized linear models

Reduced-rank regression is a dimensionality reduction method with many applications. The asymptotic theory for reduced rank estimators of parameter matrices in multivariate linear models has been studied extensively. In contrast, few theoretical results are available for reduced-rank multivariate generalized linear models. We develop M-estimation theory for concave criterion functions that are maximized over parameter spaces that are neither convex nor closed. These results are used to derive the consistency and asymptotic distribution of maximum likelihood estimators in reduced-rank multivariate generalized linear models, when the response and predictor vectors have a joint distribution. We illustrate our results in a real data classification problem with binary covariates.     

Residual Kriging for Functional Spatial Prediction of Salinity Curves

Recently, several methodologies to perform geostatistical analysis of functional data have been proposed. All of them assume that the spatial functional process considered is stationary. However, in practice, we often have nonstationary functional data because there exists an explicit spatial trend in the mean. Here, we propose a methodology to extend kriging predictors for functional data to the case where the mean function is not constant through the region of interest. We consider an approach based on the classical residual kriging method used in univariate geostatistics. We propose a three steps procedure. Initially, a functional regression model is used to detrend the mean. Then we apply kriging methods for functional data to the regression residuals to predict a residual curve at a non-data location. Finally, the prediction curve is obtained as the sum of the trend and the residual prediction. We apply the methodology to salinity data corresponding to 21 salinity curves recorded at the Ciénaga Grande de Santa Marta estuary, located in the Caribbean coast of Colombia. A cross-validation analysis was carried out to track the performance of the proposed methodology.     

Functional logistic regression: a comparison of three methods

Functional logistic regression is becoming more popular as there are many situations where we are interested in the relation between functional covariates (as input) and a binary response (as output). Several approaches have been advocated, and this paper goes into detail about three of them: dimension reduction via functional principal component analysis, penalized functional regression, and wavelet expansions in combination with Least Absolute Shrinking and Selection Operator penalization. We discuss the performance of the three methods on simulated data and also apply the methods to data regarding lameness detection for horses. Emphasis is on classification performance, but we also discuss estimation of the unknown parameter function.     

Multivariate meta-analysis for data consortia,individual patient meta-analysis,and pooling projects

We discuss maximum likelihood and estimating equations methods for combining results from multiple studies in pooling projects and data consortia using a meta-analysis model, when the multivariate estimates with their covariance matrices are available. The estimates to be combined are typically regression slopes, often from relative risk models in biomedical and epidemiologic applications. We generalize the existing univariate meta-analysis model and investigate the efficiency advantages of the multivariate methods, relative to the univariate ones. We generalize a popular univariate test for between-studies homogeneity to a multivariate test. The methods are applied to a pooled analysis of type of carotenoids in relation to lung cancer incidence from seven prospective studies. In these data, the expected gain in efficiency was evident, sometimes to a large extent. Finally, we study the finite sample properties of the estimators and compare the multivariate ones to their univariate counterparts.     

Simultaneous estimation and inference for multiple response variables

Multivariate data arise frequently in biomedical and health studies where multiple response variables are collected across subjects. Unlike a univariate procedure fitting each response separately, a multivariate regression model provides a unique opportunity in studying the joint evolution of various response variables. In this paper, we propose two estimation procedures that improve estimation efficiency for the regression parameter by accommodating correlations among the response variables. The proposed procedures do not require knowledge of the true correlation structure nor does it estimate the parameters associated with the correlation. Theoretical and simulation results confirm that the proposed estimators are more efficient than the one obtained from the univariate approach. We further propose simple and powerful inference procedures for a goodness-of-fit test that possess the chi-squared asymptotic properties. Extensive simulation studies suggest that the proposed tests are more powerful than the Wald test based on the univariate procedure. The proposed methods are also illustrated through the mother’s stress and children’s morbidity study.