2 m 4 n designs with resolution III or IV containing clear two-factor interaction components

The orthogonal arrays with mixed levels have become widely used in fractional factorial designs. It is highly desirable to know when such designs with resolution III or IV have clear two-factor interaction components (2fic’s). In this paper, we give a complete classification of the existence of clear 2fic’s in regular 2 ^m 4 ⁿ designs with resolution III or IV. The necessary and sufficient conditions for a 2 ^m 4 ⁿ design to have clear 2fic’s are given. Also, 2 ^m 4 ⁿ designs of 32 runs with the most clear 2fic’s are given for n = 1,2.      

A method for obtaining randomized block designs in preclinical studies with multiple quantitative blocking variables

A method is proposed for block randomization of treatments to experimental units that can accommodate both multiple quantitative blocking variables and unbalanced designs. Hierarchical clustering in conjunction with leaf‐order optimization is used to block experimental units in multivariate space. The method is illustrated in the context of a diabetic mouse assay. A simulation study is presented to explore the utility of the proposed randomization method relative to that of a completely randomized approach, both in the presence and absence of covariate adjustment. An example R function is provided to illustrate the implementation of the method. Copyright © 2010 John Wiley & Sons, Ltd.     

Some results on constructing two-level block designs with general minimum lower order confounding

Block designs are widely used in experimental situations where the experimental units are heterogeneous. The blocked general minimum lower order confounding (B-GMC) criterion is suitable for selecting optimal block designs when the experimenters have some prior information on the importance of ordering of the treatment factors. This paper constructs B-GMC 2^{n ? m}: 2^r designs with 5 × 2^l/16 + 1 ? n ? (N ? 2^l) < 2^{l ? 1} for l(r + 1 ? l ? n ? m ? 1), where 2^{n ? m}: 2^r denotes a two-level regular block design with N = 2^{n ? m} runs, n treatment factors, and 2^r blocks. With suitable choice of the blocking factors, each B-GMC block design has a common specific structure. Some examples illustrate the simple and effective construction method.