Goodness of exact experimental designs with respect to a certain family of criteria

In the paper we assume to be given an approximate optimum exact design with respect to one optimality criterion. We investigate the goodness of this design in the sense of a family of criteria that includes those of A-E-, and .D-optimality.     

PERMUTATION TESTS AND OTHER TEST STATISTICS FOR ILL-BEHAVED DATA: EXPERIENCE OF THE NINDS t-PA STROKE TRIAL

Permutation tests are often used to analyze data since they may not require one to make assumptions regarding the form of the distribution to have a random and independent sample selection. We initially considered a permutation test to assess the treatment effect on computed tomography lesion volume in the National Institute of Neurological Disorders and Stroke (NINDS) t-PA Stroke Trial, which has highly skewed data. However, we encountered difficulties in summarizing the permutation test results on the lesion volume. In this paper, we discuss some aspects of permutation tests and illustrate our findings. This experience with the NINDS t-PA Stroke Trial data emphasizes that permutation tests are useful for clinical trials and can be used to validate assumptions of an observed test statistic. The permutation test places fewer restrictions on the underlying distribution but is not always distribution-free or an exact test, especially for ill-behaved data. Quasi-likelihood estimation using the generalized estimating equation (GEE) approach on transformed data seems to be a good choice for analyzing CT lesion data, based on both its corresponding permutation test and its clinical interpretation.     

Impact of surviving time on tests for carcinogenicity

In tumorigenicity experiments, each animal begins in a tumor-free state and then either develops a tumor or dies before developing a tumor. Animals that develop a tumor either die from the tumor or from other competing causes. All surviving animals are sacrificed at the end of the experiment, normally two years. The two most commonly used statistical tests are the logrank test for comparing hazards of death from rapidly lethal tumors and the Hoel-Walburg test for comparing prevalences of nonlethal tumors. However, the data obtained from a carcinogenicity experiment generally contains a mixture of fatal and incidental tumors. Peto et al.(1980)suggested combining the fatal and incidental tests for a comparison of tumor onset distributions.

Extensive simulations show that the trend test for tumor onset using the Peto procedure has the proper size, under the simulation constraints, when each group has identical mortality patterns, and the test with continuity correction tends to be conservative. When the animals n the dosed groups have reduced survival rates, the type I error rate is likely to exceed the nominal level. The continuity correction is recommended for a small reduction in survival time among the dosed groups to ensure the proper size. However, when there is a large reduction in survival times in the dosed groups, the onset test does not have the proper size.     

Maximum Average-Power (MAP) Tests

The objective of this article is to propose and study frequentist tests that have maximum average power, averaging with respect to some specified weight function. First, some relationships between these tests, called maximum average-power (MAP) tests, and most powerful or uniformly most powerful tests are presented. Second, the existence of a maximum average-power test for any hypothesis testing problem is shown. Third, an MAP test for any hypothesis testing problem with a simple null hypothesis is constructed, including some interesting classical examples. Fourth, an MAP test for a hypothesis testing problem with a composite null hypothesis is discussed. From any one-parameter exponential family, a commonly used UMPU test is shown to be also an MAP test with respect to a rich class of weight functions. Finally, some remarks are given to conclude the article.     

Small sample power of multivariate nonparametric tests for monotone trend

Bhattacharyya and Kioiz (1966) propose two multivariate nonparametric tests for monotone trend, one involving coordinate-wise Mann statistics and the other, coordinate-wise Spearman statistics. Dietz and Killeen (1981) propose a different test statistic based on coordinate-wise Mann statistics. The Pitman asymptotic relative efficiency of all three tests with respect to a normal theory competitor equals the cube root of the efficiency of a multivariate signed rank test with respect to Hotelling's T2. In this article, the small sample power of the nonparametric tests, the normal theory test, and a Bonferroni approach involving coordinate-wise univariate Mann or Spearman tests is examined in a simulation study. The Mann statistic of Dietz and Killeen and the Spearman statistic of Bhattacharyya and Klotz are found to perform well under both null and alternative hypotheses     

Rotation test with pairwise distance measures of sample vectors in a GLM

One way to cope with high-dimensional data even in small samples is the use of pairwise distance measures—such as the Euclidean distance—between the sample vectors. This is usually done with permutation tests. Here we propose the application of exact parametric rotation tests which are no longer restricted by the finite number of possible permutations of a sample. The method is presented in the framework of the general linear model.     

Non parametric multiple comparisons of non nested rival models

The practice for testing homogeneity of several rival models is of interest. In this article, we consider a non parametric multiple test for non nested distributions in the context of the model selection. Based on the linear sign rank test, and the known union–intersection principle, we let the magnitude of the data to give a better performance to the test statistic. We consider the sample and the non nested rival models as blocks and treatments, respectively, and introduce the extended Friedman test version to compare with the results of the test based on the linear sign rank test. A real dataset based on the waiting time to earthquake is considered to illustrate the results.     

Preliminary Test Estimators Induced by Three Large Sample Tests for Stochastic Constraints in a Regression Model with Multivariate Student-t Error

In this article, we consider the preliminary test approach to the estimation of the regression parameter in a multiple regression model with multivariate Student-t distribution. The preliminary test estimators (PTE) based on the Wald (W), Likelihood Ratio (LR), and Lagrangian Multiplier (LM) tests are given under the suspicion of stochastic constraints occurring. The bias, mean square error matr ix (MSEM), and weighted mean square error (WMSE) of the proposed estimators are derived and compared. The conditions of superiority of the proposed estimators are obtained. Finally, we conclude that the optimum choice of the level of significance becomes the traditional choice by using the W test.     

Locally minimax tests for multiple correlations

Let X be a normally distributed p-dimensional column vector with mean μ and positive definite covariance matrix σ. and let X α, α = 1,…, N, be a random sample of size N from this distribution. Partition X as ( X ₁, X ₍₂₎', X '₍₃₎)', where X₁ is one-dimension, X₍₂₎ is p₂- dimensional, and so 1 + p₁ + p₂ = p. Let ρ₁ and ρ be the multiple correlation coefficients of X₁ with X₍₂₎ and with ( X '₍₂₎, X '₍₃₎)', respectively. Write ρ2/2 = ρ² - ρ2/1. We shall cosider the following two problems     

Linear Signed Rank Test for Model Selection

In this article, we consider a linear signed rank test for non-nested distributions in the context of the model selection. Introducing a new test, we show that, it is asymptotically more efficient than the Vuong test and the test statistic based on B statistic introduced by Clarke. However, here, we let the magnitude of the data give a better performance to the test statistic. We have shown that this test is an unbiased one. The results of simulations show that the rank test has the greater statistical power than the Vuong test where the underline distributions is symmetric.     

The power of some tests of normality against weibull alternatives

The powers of the Kolmogorov-Smirnov, Weisberg-Bingham and Anderson-Darling tests of normality are determined by Monte Carlo sampling ror Weibull alternatives with 10 shape parameters ranging from 1.0 to 10.0 and seven sample sizes from 10 to 100. There is, in general, good agreement at the relatively few points for which power values have previously been published. The usefulness of examining the power as a function of the parameter(s) of an alternate distribution family is outlined.     

Local power properties of some asymptotic tests in symmetric linear regression models

In this paper we obtain asymptotic expansions, up to order n^−1/2 and under a sequence of Pitman alternatives, for the nonnull distribution functions of the likelihood ratio, Wald, score and gradient test statistics in the class of symmetric linear regression models. This is a wide class of models which encompasses the t model and several other symmetric distributions with longer-than normal tails. The asymptotic distributions of all four statistics are obtained for testing a subset of regression parameters. Furthermore, in order to compare the finite-sample performance of these tests in this class of models, Monte Carlo simulations are presented. An empirical application to a real data set is considered for illustrative purposes.     

Test for normality based on two new estimators of entropy

In this article, two new consistent estimators are introduced of Shannon's entropy that compares root of mean-square error with other estimators. Then we define new tests for normality based on these new estimators. Finally, by simulation, the powers of the proposed tests are compared under different alternatives with other entropy tests for normality.     

Permutation tests for homogeneity based on some characterizations

In this work, non parametric tests are proposed for testing the homogeneity of two or more populations. The tests are based on recently obtained characterizations. The test procedure is based on the permutation bootstrap technique. For the two-sample case the new tests are compared with permutation tests based on the empirical characteristic function and some other tests. The comparison is fulfilled via a Monte Carlo simulation.     

A Comparison of Permutation Hotelling's T 2 Test and Log-Ratio Test for Analyzing Compositional Data

An adding-back model is constructed for studying multiple outliers and influential observations. A logarithmic functional form for some influence measures having a better justification for plotting purposes is suggested. Two graphical methods with contours of constant measure values are proposed. They provide valuable information about the interrelationship of multiple influential observations and influence measures.     

Adaptive positive and negative runs test

As a nonparametric randomness test, the positive and negative runs test is widely used in practice due to the simplicity of its procedures. The test can lose efficiency if the alternative distribution is symmetrical at 0.5. In addition, the test can only be applied to test the randomness of a sequence from the uniform distribution. In this paper, we introduce an adaptive positive and negative runs test method to maximize the power function by choosing the optimal cut point. Also, the test is extended to check the randomness of a sequence generated from any other given distributions. Furthermore, we derive the exact distribution and obtain the asymptotical critical values of the proposed test statistics. Compared with the existed test, the efficiency of the proposed adaptive positive and negative runs test is competitive through simulation study.     

On gart's test for interaction of second order

Gart (1972) ottered a Statistic on testing the hypothesis of no second-order interaction in a 2×s×t contingency table. The statistic was tn be used as an asymptotic chi-square with (s-1) (t-1) degrees of freedom. We show that this statistic suiters from the drawback that unless certain side conditions hold, the statistic would reject the null hypothesis with probability approaching one asymptotically even in the null case. Hence the statistic is not strictly valid for the hypothesis for which it was intended.     

Multivariate generalizations of jonckheere's test for ordered alternatives

In many dose-response studies, each of several independent groups of animals is treated with a different dose of a substance. Many response variables are then measured on each animal. The distributions of the response variables may be nonnormal, and Jonckheere's (1954) test for ordered alternatives in the one-way layout is sometimes used to test whether the level of a single variable increases with increasing dose. In some applications, however, it is important to consider a set of response variables simultaneously. For instance, an increase in each of certain enzymes in the blood serum may suggest liver damage. To test whether these enzyme levels increase with increasing dose, it may be preferable to consider these enzymes as a group, rather than individually.

I propose two multivariate generalizations of Jonckheere's univariate test. Each multivariate test statistic is a function of coordinate-wise Jonckheere statistics—one a sum, the other a quadratic form. The sum statistic can be used to test the alternative hypothesis that each variable is stochastically increasing with increasing dose. The quadratic form statistic is designed for the more general alternative hypothesis that each variable is stochastically ordered with increasing dose.

For each of these two alternatives, I also propose a multivariate generalization of a normal theory test described by Puri (1965). I examine the asymptotic distributions of the four test statistics under the null hypothesis and under translation alternatives and compare each distribution-free test to the corresponding normal theory test in terms of asymptotic relative efficiency.

The multivariate Jonckheere tests are illustrated using does-response data from a subchronic toxicology study carried out by the National Toxicology Program. Four groups of ten male rats each were treated with increasing doses of vinylidene flouride, and the serum enzymes SDH, SGOT, and SGPT were measured. A comparison of univariate Jonckheere tests on each variable, bivariate tests on SDH and SGOT, and multivariate tests on all three variables gives insight into the behavior of the various procedures.     

Some exact tables for the squared ranks test

Since the squared ranks test was first proposed by Taha in 1964 it has been mentioned by several authors as a test that is easy to use, with good power in many situations. It is almost as easy to use as the Wilcoxon rank sum test, and has greater power when two populations differ in their scale parameters rather than in their location parameters. This paper discuss the versatility of the squared ranks test, introduces a test which uses squared ranks, and presents some exact tables