Asymptotically efficient estimation in response adaptive trials

We examine the issue of asymptotic efficiency of estimation for response adaptive designs of clinical trials, from which the collected data set contains a dependency structure. We establish the asymptotic lower bound of exponential rates for consistent estimators. Under certain regularity conditions, we show that the maximum likelihood estimator achieves the asymptotic lower bound for response adaptive trials with dichotomous responses. Furthermore, it is shown that the maximum likelihood estimator of the treatment effect is asymptotically efficient in the Bahadur sense for response adaptive clinical trials.     

Nonparametric estimation of the conditional distribution function in a semiparametric censorship model

In this paper we propose a new nonparametric estimator of the conditional distribution function under a semiparametric censorship model. We establish an asymptotic representation of the estimator as a sum of iid random variables, balanced by some kernel weights. This representation is used for obtaining large sample results such as the rate of uniform convergence of the estimator, or its limit distributional law. We prove that the new estimator outperforms the conditional Kaplan–Meier estimator for censored data, in the sense that it exhibits lower asymptotic variance. Illustration through real data analysis is provided.     

Kernel regression estimation in a Banach space

In this paper, we study a nonparametric regression estimator when the response variable is in a separable Banach space and the explanatory variable takes values in a separable semi-metric space. Under general conditions, we establish some asymptotic results and give upper bounds for the p$p$-mean and almost sure (pointwise and integrated) estimation errors. Finally, we present the case where the explanatory variable is the Wiener process.     

Lifetesting and estimation with arbitrary distribution function

We consider the problem of estimating the life–distribution F from censored lifetimes. The observation scheme is renewal testing over a long time horizon although the results can apply to survival testing with repetitions. We exhibit a product–limit estimator of F which is shown to be consistent and to converge weakly to a GAUSsian process. To do this we first extend these properties of the NELSON-AALEN martingale estimator to the family of PoissoN–type counting processes. Our proof of weak convergence is based on the general functional central limit theorems for semimartingales as developed by .JACOB, SHIRYAYEV and others     

Robust Linear Calibration

We regard the simple linear calibration problem where only the response y of the regression line y = β₀ + β₁ t is observed with errors. The experimental conditions t are observed without error. For the errors of the observations y we assume that there may be some gross errors providing outlying observations. This situation can be modeled by a conditionally contaminated regression model. In this model the classical calibration estimator based on the least squares estimator has an unbounded asymptotic bias. Therefore we introduce calibration estimators based on robust one-step-M-estimators which have a bounded asymptotic bias. For this class of estimators we discuss two problems: The optimal estimators and their corresponding optimal designs. We derive the locally optimal solutions and show that the maximin efficient designs for non-robust estimation and robust estimation coincide.     

Statistical inference for a semiparametric measurement error regression model with heteroscedastic errors

Efficient inference for regression models requires that the heteroscedasticity be taken into account. We consider statistical inference under heteroscedasticity in a semiparametric measurement error regression model, in which some covariates are measured with errors. This paper has multiple components. First, we propose a new method for testing the heteroscedasticity. The advantages of the proposed method over the existing ones are that it does not need any nonparametric estimation and does not involve any mismeasured variables. Second, we propose a new two-step estimator for the error variances if there is heteroscedasticity. Finally, we propose a weighted estimating equation-based estimator (WEEBE) for the regression coefficients and establish its asymptotic properties. Compared with existing estimators, the proposed WEEBE is asymptotically more efficient, avoids undersmoothing the regressor functions and requires less restrictions on the observed regressors. Simulation studies show that the proposed test procedure and estimators have nice finite sample performance. A real data set is used to illustrate the utility of our proposed methods.     

Bernstein conditional density estimation with application to conditional distribution and regression functions

In this paper we propose a smooth nonparametric estimation for the conditional probability density function based on a Bernstein polynomial representation. Our estimator can be written as a finite mixture of beta densities with data-driven weights. Using the Bernstein estimator of the conditional density function, we derive new estimators for the distribution function and conditional mean. We establish the asymptotic properties of the proposed estimators, by proving their asymptotic normality and by providing their asymptotic bias and variance. Simulation results suggest that the proposed estimators can outperform the Nadaraya–Watson estimator and, in some specific setups, the local linear kernel estimators. Finally, we use our estimators for modeling the income in Italy, conditional on year from 1951 to 1998, and have another look at the well known Old Faithful Geyser data.     

Bounded influence nonlinear signed‐rank regression

In this paper we consider weighted generalized‐signed‐rank estimators of nonlinear regression coefficients. The generalization allows us to include popular estimators such as the least squares and least absolute deviations estimators but by itself does not give bounded influence estimators. Adding weights results in estimators with bounded influence function. We establish conditions needed for the consistency and asymptotic normality of the proposed estimator and discuss how weight functions can be chosen to achieve bounded influence function of the estimator. Real life examples and Monte Carlo simulation experiments demonstrate the robustness and efficiency of the proposed estimator. An example shows that the weighted signed‐rank estimator can be useful to detect outliers in nonlinear regression. The Canadian Journal of Statistics 40: 172–189; 2012 © 2012 Statistical Society of Canada     

Partially linear models and polynomial spline approximations for the analysis of unbalanced panel data

In this paper, we study the estimation of the unbalanced panel data partially linear models with a one-way error components structure. A weighted semiparametric least squares estimator (WSLSE) is developed using polynomial spline approximation and least squares. We show that the WSLSE is asymptotically more efficient than the corresponding unweighted estimator for both parametric and nonparametric components of the model. This is a significant improvement over previous results in the literature which showed that the simply weighting technique can only improve the estimation of the parametric component. The asymptotic normalities of the proposed WSLSE are also established.     

Asymptotical improvement of maximum likelihood estimators on Kullback–Leibler loss

We discuss the general form of a first-order correction to the maximum likelihood estimator which is expressed in terms of the gradient of a function, which could for example be the logarithm of a prior density function. In terms of Kullback–Leibler divergence, the correction gives an asymptotic improvement over maximum likelihood under rather general conditions. The theory is illustrated for Bayes estimators with conjugate priors. The optimal choice of hyper-parameter to improve the maximum likelihood estimator is discussed. The results based on Kullback–Leibler risk are extended to a wide class of risk functions.     

Semiparametric inference of proportional odds model based on randomly truncated data

This paper studies the estimation in the proportional odds model based on randomly truncated data. The proposed estimators for the regression coefficients include a class of minimum distance estimators defined through weighted empirical odds function. We have investigated the asymptotic properties like the consistency and the limiting distribution of the proposed estimators under mild conditions. The finite sample properties were investigated through simulation study making comparison of some of the estimators in the class. We conclude with an illustration of our proposed method to a well-known AIDS data.     

Minimum Hellinger distance estimation in a nonparametric mixture model

In this paper, we investigate the estimation problem of the mixture proportion λ$\lambda$ in a nonparametric mixture model of the form λF(x)+(1-λ)G(x)$\lambda F(x)+(1-\lambda )G(x)$ using the minimum Hellinger distance approach, where F and G are two unknown distributions. We assume that data from the distributions F and G   as well as from the mixture distribution λF+(1-λ)G$\lambda F+(1-\lambda )G$ are available. We construct a minimum Hellinger distance estimator of λ$\lambda$ and study its asymptotic properties. The proposed estimator is chosen to minimize the Hellinger distance between a parametric mixture model and a nonparametric density estimator. We also develop a maximum likelihood estimator of λ$\lambda$. Theoretical properties such as the existence, strong consistency, asymptotic normality and asymptotic efficiency of the proposed estimators are investigated. Robustness properties of the proposed estimator are studied using a Monte Carlo study. Two real data examples are also analyzed.     

Probability density estimation with data missing at random when covariables are present

This paper addresses the problem of the probability density estimation in the presence of covariates when data are missing at random (MAR). The inverse probability weighted method is used to define a nonparametric and a semiparametric weighted probability density estimators. A regression calibration technique is also used to define an imputed estimator. It is shown that all the estimators are asymptotically normal with the same asymptotic variance as that of the inverse probability weighted estimator with known selection probability function and weights. Also, we establish the mean squared error (MSE) bounds and obtain the MSE convergence rates. A simulation is carried out to assess the proposed estimators in terms of the bias and standard error.     

Additive Transformation Models for Multivariate Interval-Censored Data

ABSTRACT

We present a new estimator of extreme quantiles dedicated to Weibull tail distributions. This estimate is based on a consistent estimator of the Weibull tail coefficient. This parameter is defined as the regular variation coefficient of the inverse cumulative hazard function. We give conditions in order to obtain the weak consistency and the asymptotic distribution of the extreme quantiles estimator. Its asymptotic as well as its finite sample performances are compared to classical ones.     

Periodograms asymptotic distributions in periodically correlated processes and multivariate stationary processes: An alternative approach

Discrete time periodically correlated (PC) processes are viewed as the processes with time-dependent spectra. This, together with an auxiliary operator which is defined here is employed to apply classical results on the asymptotic distribution of the periodogram of the univariate white noise (innovations) to derive the asymptotic distributions of the periodograms for the PC processes and also for the multivariate stationary processes. We assume only the continuity and positive definiteness of the spectral densities together with the independence of the innovations.     

Asymptotic normality for plug-in estimators of diversity indices on countable alphabets

The plug-in estimator is one of the most popular approaches to the estimation of diversity indices. In this paper, we study its asymptotic distribution for a large class of diversity indices on countable alphabets. In particular, we give conditions for the plug-in estimator to be asymptotically normal, and in the case of uniform distributions, where asymptotic normality fails, we give conditions for the asymptotic distribution to be chi-squared. Our results cover some of the most commonly used indices, including Simpson's index, Reńyi's entropy and Shannon's entropy.     

A note on asymptotic parametric prediction

This paper is devoted to asymptotic behaviour of plug-in statistical predictors obtained by replacing the unknown parameter in a conditional expectation by a suitable estimator. We derive the L²$L^2$-convergence rate and limit in distribution for the predictors. Applications to ARMA processes and diffusion processes are considered.     

Trace of the Variance-Covariance Matrix in Natural Exponential Families

In this article, we introduce the notion of trace variance function which is the trace of the variance-covariance matrix. Under some conditions, we prove that this trace variance function characterizes the Natural Exponential Family (NEF). We apply this characterization in order to estimate the distribution which belongs to some NEFs. Therefore, we introduce the estimator of this trace variance function. We give the asymptotic properties of this estimator. Finally, we illustrate our results using a simulation study.     

Estimation of the scale parameter of the half-logistic distribution with multiply type II censored sample

In this paper, we consider the maximum likelihood and Bayes estimation of the scale parameter of the half-logistic distribution based on a multiply type II censored sample. However, the maximum likelihood estimator(MLE) and Bayes estimator do not exist in an explicit form for the scale parameter. We consider a simple method of deriving an explicit estimator by approximating the likelihood function and discuss the asymptotic variances of MLE and approximate MLE. Also, an approximation based on the Laplace approximation (Tierney & Kadane, 1986) is used to obtain the Bayes estimator. In order to compare the MLE, approximate MLE and Bayes estimates of the scale parameter, Monte Carlo simulation is used.     

Bias-reduced extreme quantile estimators of Weibull tail-distributions

In this paper, we consider the problem of estimating an extreme quantile of a Weibull tail-distribution. The new extreme quantile estimator has a reduced bias compared to the more classical ones proposed in the literature. It is based on an exponential regression model that was introduced in Diebolt et al. [2007. Bias-reduced estimators of the Weibull-tail coefficient. Test, to appear]. The asymptotic normality of the extreme quantile estimator is established. We also introduce an adaptive selection procedure to determine the number of upper order statistics to be used. A simulation study as well as an application to a real data set is provided in order to prove the efficiency of the above-mentioned methods.