Variable selection in the high-dimensional continuous generalized linear model with current status data

In survival studies, current status data are frequently encountered when some individuals in a study are not successively observed. This paper considers the problem of simultaneous variable selection and parameter estimation in the high-dimensional continuous generalized linear model with current status data. We apply the penalized likelihood procedure with the smoothly clipped absolute deviation penalty to select significant variables and estimate the corresponding regression coefficients. With a proper choice of tuning parameters, the resulting estimator is shown to be a root n/p_n-consistent estimator under some mild conditions. In addition, we show that the resulting estimator has the same asymptotic distribution as the estimator obtained when the true model is known. The finite sample behavior of the proposed estimator is evaluated through simulation studies and a real example.     

A Robust Variable Selection to t-type Joint Generalized Linear Models via Penalized t-type Pseudo-likelihood

Although the t-type estimator is a kind of M-estimator with scale optimization, it has some advantages over the M-estimator. In this article, we first propose a t-type joint generalized linear model as a robust extension to the classical joint generalized linear models for modeling data containing extreme or outlying observations. Next, we develop a t-type pseudo-likelihood (TPL) approach, which can be viewed as a robust version to the existing pseudo-likelihood (PL) approach. To determine which variables significantly affect the variance of the response variable, we then propose a unified penalized maximum TPL method to simultaneously select significant variables for the mean and dispersion models in t-type joint generalized linear models. Thus, the proposed variable selection method can simultaneously perform parameter estimation and variable selection in the mean and dispersion models. With appropriate selection of the tuning parameters, we establish the consistency and the oracle property of the regularized estimators. Simulation studies are conducted to illustrate the proposed methods.     

Application of shrinkage estimation in linear regression models with autoregressive errors

In this paper, we consider the shrinkage and penalty estimation procedures in the linear regression model with autoregressive errors of order p when it is conjectured that some of the regression parameters are inactive. We develop the statistical properties of the shrinkage estimation method including asymptotic distributional biases and risks. We show that the shrinkage estimators have a significantly higher relative efficiency than the classical estimator. Furthermore, we consider the two penalty estimators: least absolute shrinkage and selection operator (LASSO) and adaptive LASSO estimators, and numerically compare their relative performance with that of the shrinkage estimators. A Monte Carlo simulation experiment is conducted for different combinations of inactive predictors and the performance of each estimator is evaluated in terms of the simulated mean-squared error. This study shows that the shrinkage estimators are comparable to the penalty estimators when the number of inactive predictors in the model is relatively large. The shrinkage and penalty methods are applied to a real data set to illustrate the usefulness of the procedures in practice.     

Shrinkage estimation of location parameters in a multivariate skew-normal distribution

Abstract

This paper studies decision theoretic properties of Stein type shrinkage estimators in simultaneous estimation of location parameters in a multivariate skew-normal distribution with known skewness parameters under a quadratic loss. The benchmark estimator is the best location equivariant estimator which is minimax. A class of shrinkage estimators improving on the best location equivariant estimator is constructed when the dimension of the location parameters is larger than or equal to four. An empirical Bayes estimator is also derived, and motivated from the Bayesian procedure, we suggest a simple skew-adjusted shrinkage estimator and show its dominance property. The performances of these estimators are investigated by simulation.     

Sparse estimation and inference for censored median regression

Censored median regression has proved useful for analyzing survival data in complicated situations, say, when the variance is heteroscedastic or the data contain outliers. In this paper, we study the sparse estimation for censored median regression models, which is an important problem for high dimensional survival data analysis. In particular, a new procedure is proposed to minimize an inverse-censoring-probability weighted least absolute deviation loss subject to the adaptive LASSO penalty and result in a sparse and robust median estimator. We show that, with a proper choice of the tuning parameter, the procedure can identify the underlying sparse model consistently and has desired large-sample properties including root-n consistency and the asymptotic normality. The procedure also enjoys great advantages in computation, since its entire solution path can be obtained efficiently. Furthermore, we propose a resampling method to estimate the variance of the estimator. The performance of the procedure is illustrated by extensive simulations and two real data applications including one microarray gene expression survival data.     

SHRINKAGE, PRETEST AND ABSOLUTE PENALTY ESTIMATORS IN PARTIALLY LINEAR MODELS

We consider a partially linear model in which the vector of coefficients β in the linear part can be partitioned as ( β ₁, β ₂) , where β ₁ is the coefficient vector for main effects (e.g. treatment effect, genetic effects) and β ₂ is a vector for ‘nuisance’ effects (e.g. age, laboratory). In this situation, inference about β ₁ may benefit from moving the least squares estimate for the full model in the direction of the least squares estimate without the nuisance variables (Steinian shrinkage), or from dropping the nuisance variables if there is evidence that they do not provide useful information (pretesting). We investigate the asymptotic properties of Stein‐type and pretest semiparametric estimators under quadratic loss and show that, under general conditions, a Stein‐type semiparametric estimator improves on the full model conventional semiparametric least squares estimator. The relative performance of the estimators is examined using asymptotic analysis of quadratic risk functions and it is found that the Stein‐type estimator outperforms the full model estimator uniformly. By contrast, the pretest estimator dominates the least squares estimator only in a small part of the parameter space, which is consistent with the theory. We also consider an absolute penalty‐type estimator for partially linear models and give a Monte Carlo simulation comparison of shrinkage, pretest and the absolute penalty‐type estimators. The comparison shows that the shrinkage method performs better than the absolute penalty‐type estimation method when the dimension of the β ₂ parameter space is large.     

A note on bias reduction of maximum likelihood estimates for the scalar skew t distribution

The skew t distribution is a flexible parametric family to fit data, because it includes parameters that let us regulate skewness and kurtosis. A problem with this distribution is that, for moderate sample sizes, the maximum likelihood estimator of the shape parameter is infinite with positive probability. In order to try to solve this problem, Sartori (2006) has proposed using a modified score function as an estimating equation for the shape parameter. In this note we prove that the resulting modified maximum likelihood estimator is always finite, considering the degrees of freedom as known and greater than or equal to 2.     

Calculating the mvue of the fraction nonconforming for the bivariate normal

The minimum variance unbiased estimator of the proportion lying outside an m-dimensional rectangle for multivariate normal populations was derived by Baillie (1987a, b). The estimator is a natural extension of a univariate estimator widely used in acceptance sampling. Computation of the multivariate estimator is nontrivial; one must integrate a multivariate density over the intersection of an m-dimensional ellipsoid and an m-dimensional rectangle. We propose an algorithm for the bivariate case which involves a one-dimensional numerical integration and calls to routines for either an incomplete beta function or a Student's t cumulative distribution function     

Penalized quantile regression for dynamic panel data

This paper studies penalized quantile regression for dynamic panel data with fixed effects, where the penalty involves l₁ shrinkage of the fixed effects. Using extensive Monte Carlo simulations, we present evidence that the penalty term reduces the dynamic panel bias and increases the efficiency of the estimators. The underlying intuition is that there is no need to use instrumental variables for the lagged dependent variable in the dynamic panel data model without fixed effects. This provides an additional use for the shrinkage models, other than model selection and efficiency gains. We propose a Bayesian information criterion based estimator for the parameter that controls the degree of shrinkage. We illustrate the usefulness of the novel econometric technique by estimating a “target leverage” model that includes a speed of capital structure adjustment. Using the proposed penalized quantile regression model the estimates of the adjustment speeds lie between 3% and 44% across the quantiles, showing strong evidence that there is substantial heterogeneity in the speed of adjustment among firms.     

Penalized and Shrinkage Estimation in the Cox Proportional Hazards Model

This article considers the shrinkage estimation procedure in the Cox's proportional hazards regression model when it is suspected that some of the parameters may be restricted to a subspace. We have developed the statistical properties of the shrinkage estimators including asymptotic distributional biases and risks. The shrinkage estimators have much higher relative efficiency than the classical estimator, furthermore, we consider two penalty estimators—the LASSO and adaptive LASSO—and compare their relative performance with that of the shrinkage estimators numerically. A Monte Carlo simulation experiment is conducted for different combinations of irrelevant predictors and the performance of each estimator is evaluated in terms of simulated mean squared error. Simulation study shows that the shrinkage estimators are comparable to the penalty estimators when the number of irrelevant predictors in the model is relatively large. The shrinkage and penalty methods are applied to two real data sets to illustrate the usefulness of the procedures in practice.     

Regression with outlier shrinkage

We propose a robust regression method called regression with outlier shrinkage (ROS) for the traditional n>p$n>p$ cases. It improves over the other robust regression methods such as least trimmed squares (LTS) in the sense that it can achieve maximum breakdown value and full asymptotic efficiency simultaneously. Moreover, its computational complexity is no more than that of LTS. We also propose a sparse estimator, called sparse regression with outlier shrinkage (SROS), for robust variable selection and estimation. It is proven that SROS can not only give consistent selection but also estimate the nonzero coefficients with full asymptotic efficiency under the normal model. In addition, we introduce a concept of nearly regression equivariant estimator for understanding the breakdown properties of sparse estimators, and prove that SROS achieves the maximum breakdown value of nearly regression equivariant estimators. Numerical examples are presented to illustrate our methods.     

Density Estimation by Total Variation Penalized Likelihood Driven by the Sparsity ℓ1 Information Criterion

Abstract. We propose a non‐linear density estimator, which is locally adaptive, like wavelet estimators, and positive everywhere, without a log‐ or root‐transform. This estimator is based on maximizing a non‐parametric log‐likelihood function regularized by a total variation penalty. The smoothness is driven by a single penalty parameter, and to avoid cross‐validation, we derive an information criterion based on the idea of universal penalty. The penalized log‐likelihood maximization is reformulated as an ?₁‐penalized strictly convex programme whose unique solution is the density estimate. A Newton‐type method cannot be applied to calculate the estimate because the ?₁‐penalty is non‐differentiable. Instead, we use a dual block coordinate relaxation method that exploits the problem structure. By comparing with kernel, spline and taut string estimators on a Monte Carlo simulation, and by investigating the sensitivity to ties on two real data sets, we observe that the new estimator achieves good L ₁ and L ₂ risk for densities with sharp features, and behaves well with ties.     

Flexible mixture modelling using the multivariate skew-t-normal distribution

This paper presents a robust probabilistic mixture model based on the multivariate skew-t-normal distribution, a skew extension of the multivariate Student’s t distribution with more powerful abilities in modelling data whose distribution seriously deviates from normality. The proposed model includes mixtures of normal, t and skew-normal distributions as special cases and provides a flexible alternative to recently proposed skew t mixtures. We develop two analytically tractable EM-type algorithms for computing maximum likelihood estimates of model parameters in which the skewness parameters and degrees of freedom are asymptotically uncorrelated. Standard errors for the parameter estimates can be obtained via a general information-based method. We also present a procedure of merging mixture components to automatically identify the number of clusters by fitting piecewise linear regression to the rescaled entropy plot. The effectiveness and performance of the proposed methodology are illustrated by two real-life examples.     

Ridge estimator in singulah oesiun with application to age-period-cohort analysis of disease rates

Ridge estimator of a singular design is considered for linear and gener¬alized linear models. Ridge penalty helps determine a unique estimator in singmar uesign. me tuning parameter o± tue penalty is seiecteu via gener¬alized cross-validation (GCV) method. It is proven that the ridge estimator lies in a special sub-parameter space and converges to the intrinsic estimator, an estimable function in singular design, as the shrinkage penalty diminishes. The expansion of the ridge estimator and its variance are also obtained. Thismethod is demonstrated through an application to age-period-cohort (APC) analysis of the incidence rates of cervical cancer in Ontario women 1980-1994     

A note on a modified double stage shrinkage estimator

A modified double stage shrinkage estimator has been proposed for the single parameter θ of a distribution function _Fθ. It is shown to be locally better in comparison to the usual double stage shrinkage estimator in the sense of smaller mean squared error in a certain neighbourhood of prior estimate θ_o of θ.     

Finite mixtures of multivariate skew t-distributions: some recent and new results

Finite mixtures of multivariate skew t (MST) distributions have proven to be useful in modelling heterogeneous data with asymmetric and heavy tail behaviour. Recently, they have been exploited as an effective tool for modelling flow cytometric data. A number of algorithms for the computation of the maximum likelihood (ML) estimates for the model parameters of mixtures of MST distributions have been put forward in recent years. These implementations use various characterizations of the MST distribution, which are similar but not identical. While exact implementation of the expectation-maximization (EM) algorithm can be achieved for ‘restricted’ characterizations of the component skew t-distributions, Monte Carlo (MC) methods have been used to fit the ‘unrestricted’ models. In this paper, we review several recent fitting algorithms for finite mixtures of multivariate skew t-distributions, at the same time clarifying some of the connections between the various existing proposals. In particular, recent results have shown that the EM algorithm can be implemented exactly for faster computation of ML estimates for mixtures with unrestricted MST components. The gain in computational time is effected by noting that the semi-infinite integrals on the E-step of the EM algorithm can be put in the form of moments of the truncated multivariate non-central t-distribution, similar to the restricted case, which subsequently can be expressed in terms of the non-truncated form of the central t-distribution function for which fast algorithms are available. We present comparisons to illustrate the relative performance of the restricted and unrestricted models, and demonstrate the usefulness of the recently proposed methodology for the unrestricted MST mixture, by some applications to three real datasets.     

Coverage accuracy for a mean without third moment

For constructing a confidence interval for the mean of a random variable with a known variance, one may prefer the sample mean standardized by the true standard deviation to the Student's t-statistic since the information of knowing the variance is used in the former way. In this paper, by comparing the leading error term in the expansion of the coverage probability, we show that the above statement is not true when the third moment is infinite. Our theory prefers the Student's t-statistic either when one-sided confidence intervals are considered for a heavier tail distribution or when two-sided confidence intervals are considered. Unlike other existing expansions for the Student's t-statistic, the derived explicit expansion for the case of infinite third moment can be used to estimate the coverage error so that bias correction becomes possible.