Median regression model with left truncated and right censored data

We study the problem of fitting a heteroscedastic median regression model from left-truncated and right-censored data. It is demonstrated that the adapted Efron's self-consistency equation of McKeague et al. (2001) can be extended to analyze left-truncated and right-censored data. We evaluate the finite sample performance of the proposed estimators through simulation studies.     

Median regression model with left truncated and interval-censored data

We consider the problem of fitting a heteroscedastic median regression model from left-truncated and interval-censored data. It is demonstrated that the adapted Efron’s self-consistency equation of McKeague, Subramanian, and Sun (2001) can be extended to analyze left-truncated and interval-censored data. The asymptotic property of the proposed estimator is established. We evaluate the finite sample performance of the proposed estimators through simulation studies.     

Simultaneous estimation for non-crossing multiple quantile regression with right censored data

In this paper, we consider the estimation problem of multiple conditional quantile functions with right censored survival data. To account for censoring in estimating a quantile function, weighted quantile regression (WQR) has been developed by using inverse-censoring-probability weights. However, the estimated quantile functions from the WQR often cross each other and consequently violate the basic properties of quantiles. To avoid quantile crossing, we propose non-crossing weighted multiple quantile regression (NWQR), which estimates multiple conditional quantile functions simultaneously. We further propose the adaptive sup-norm regularized NWQR (ANWQR) to perform simultaneous estimation and variable selection. The large sample properties of the NWQR and ANWQR estimators are established under certain regularity conditions. The proposed methods are evaluated through simulation studies and analysis of a real data set.     

Semiparametric regression analysis of doubly censored failure time data from cohort studies

Lifetime Data Analysis - Doubly censored failure time data occur when the failure time of interest represents the elapsed time between two events, an initial event and a subsequent event, and the...     

Median regression model with doubly truncated data

We study the problem of fitting a heteroscedastic median regression model with doubly truncated data. A self-consistency equation is proposed to obtain an estimator. We set up a least absolute deviation estimating function. We establish the consistency and asymptotic normality for the case when covariates are discrete. The finite sample performance of the proposed estimators are investigated through simulation studies. The proposed method is illustrated using the AIDS Blood Transfusion Data.     

Deviance residuals in generalised log-gamma regression models with censored observations

In this article, we compare three residuals based on the deviance component in generalised log-gamma regression models with censored observations. For different parameter settings, sample sizes and censoring percentages, various simulation studies are performed and the empirical distribution of each residual is displayed and compared with the standard normal distribution. For all cases studied, the empirical distributions of the proposed residuals are in general symmetric around zero, but only a martingale-type residual presented negligible kurtosis for the majority of the cases studied. These studies suggest that the residual analysis usually performed in normal linear regression models can be straightforwardly extended for the martingale-type residual in generalised log-gamma regression models with censored data. A lifetime data set is analysed under log-gamma regression models and a model checking based on the martingale-type residual is performed.     

On estimation of frequency data with censored observations

The problem of the estimation of mean frequency of events in the presence of censoring is important in assessing the efficacy, safety and cost of therapies. The mean frequency is typically estimated by dividing the total number of events by the total number of patients under study. This method, referred to in this paper as the ‘naïve estimator’, ignores the censoring. Other approaches available for this problem require many assumptions that are rarely acceptable. These include the assumption of independence, constant hazard rate over time and other similar distributional assumptions. In this paper a simple non‐parametric estimator based on the sum of the products of Kaplan–Meier estimators is proposed as an estimator of mean frequency, and its approximate variance and standard error are derived. An illustration is provided to show the derivation of the proposed estimator. Although the clinical trial setting is used in this paper, the problem has applications in other areas where survival analysis is used and recurrent events are studied. Copyright © 2003 John Wiley & Sons, Ltd.     

Inverse regression estimation for censored data

An inverse regression methodology for assessing predictor performance in the censored data setup is developed along with inference procedures and a computational algorithm. The technique developed here allows for conditioning on the unobserved failure time along with a weighting mechanism that accounts for the censoring. The implementation is nonparametric and computationally fast. This provides an efficient methodological tool that can be used especially in cases where the usual modeling assumptions are not applicable to the data under consideration. It can also be a good diagnostic tool that can be used in the model selection process. We have provided theoretical justification of consistency and asymptotic normality of the methodology. Simulation studies and two data analyses are provided to illustrate the practical utility of the procedure.     

Quantile regression for interval censored data

As direct generalization of the quantile regression for complete observed data, an estimation method for quantile regression models with interval censored data is proposed, and the property of consistency is obtained. The property of asymptotic normality is also established with a bias converging to zero, and to reduce the bias, two bias correction methods are proposed. Methods proposed in this paper do not require the censoring vectors to be identically distributed, and can be applied to models with various covariates. Simulation results show that the proposed methods work well.     

Added variable plots for linear regression with censored data

In linear regression the structure of the hat matrix plays an important part in regression diagnostics. In this note we investigate the properties of the hat matrix for regression with censored responses in the presence of one or more explanatory variables observed without censoring. The censored points in the scatterplot are renovated to positions had they been observed without censoring in a renovation process based on Buckley-James censored regression estimators. This allows natural links to be established with the structure of ordinary least squares estimators. In particular, we show that the renovated hat matrix may be partitioned in a manner which assists in deciding whether further explanatory variables should be added to the linear model. The added variable plot for regression with censored data is developed as a diagnostic tool for this decision process.     

Nonparametric quasi-likelihood for right censored data

Quasi-likelihood was extended to right censored data to handle heteroscedasticity in the frame of the accelerated failure time (AFT) model. However, the assumption of known variance function in the quasi-likelihood for right censored data is usually unrealistic. In this paper, we propose a nonparametric quasi-likelihood by replacing the specified variance function with a nonparametric variance function estimator. This nonparametric variance function estimator is obtained by smoothing a function of squared residuals via local polynomial regression. The rate of convergence of the nonparametric variance function estimator and the asymptotic limiting distributions of the regression coefficient estimators are derived. It is demonstrated in simulations that for finite samples the proposed nonparametric quasi-likelihood method performs well. The new method is illustrated with one real dataset.     

Hazard function estimation from homogeneous right censored data with missing censoring indicators

The kernel smoothed Nelson–Aalen estimator has been well investigated, but is unsuitable when some of the censoring indicators are missing. A representation introduced by Dikta, however, facilitates hazard estimation when there are missing censoring indicators. In this article, we investigate (i) a kernel smoothed semiparametric hazard estimator and (ii) a kernel smoothed “pre-smoothed” Nelson–Aalen estimator. We derive the asymptotic normality of the proposed estimators and compare their asymptotic variances.     

A regression method for censored inverse-Gaussian data

Multiple regression methods are considered for progressively right-censored inverse-Gaussian data. Maximum-likelihood estimators are derived using the EM algorithm, and their asymptotic distributional properties are presented. The methodology is demonstrated using two case illustrations, one of which involves the defective feature of the inverse-Gaussian distribution. The relationship of the methodology to regression methods for complete inverse-Gaussian samples and to other regression methods for censored survival data is discussed.     

Bayesian regression analysis of data with censored initiating and terminating times: applications to aids

Data with censored initiating and terminating times arises quite frequently in acquired immunodeficiency syndrome (AIDS) epidemiologic studies. Analysis of such data involves a complicated bivariate likelihood, which is difficult to deal with computationally. Bayesian analysis, op the other hand, presents added complexities that have yet to be resolved. By exploiting the simple form of a complete data likelihood and utilizing the power of a Markov Chain Monte Carlo (MCMC) algorithm, this paper presents a methodology for fitting Bayesian regression models to such data. The proposed methods extend the work of Sinha (1997), who considered non-parametric Bayesian analysis of this type of data. The methodology is illustiated with an application to a cohort of HIV infected hemophiliac patients.     

Estimation in multiple linear regression model with doubly censored data

In this article, we propose three M-estimators for multiple regression model when response variable is subject to double censoring. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to construct interval estimators.     

Rank invariant tests with left truncated and interval censored data

Peto and Peto (1972) have studied rank invariant tests to compare two survival curves for right censored data. We apply their tests, including the logrank test and the generalized Wilcoxon test, to left truncated and interval censored data. The significance levels of the tests are approximated by Monte Carlo permutation tests. Simulation studies are conducted to show their size and power under different distributional differences. In particular, the logrank test works well under the Cox proportional hazards alternatives, as for the usual right censored data. The methods are illustrated by the analysis of the Massachusetts Health Care Panel Study dataset.     

Analysis of left censored data from the generalized exponential distribution

The generalized exponential distribution proposed by Gupta and Kundu [Gupta, R.D and Kundu, D., 1999, Generalized exponential distributions. Australian and New Zealand Journal of Statistics, 41(2), 173–188.] is an important lifetime distribution in survival analysis. In this paper, we consider the maximum likelihood estimation procedure of the parameters of the generalized exponential distribution when the data are left censored. We obtain the maximum likelihood estimators of the unknown para-meters and the Fisher information matrix. Simulation studies are carried out to observe the performance of the estimators in small sample.     

Parameter estimation in regression for long-term survival rate from censored data

In recent years, regression models have been shown to be useful for predicting the long-term survival probabilities of patients in clinical trials. The importance of a regression model is that once the regression parameters are estimated information about the regressed quantity is immediate. A simple estimator is proposed for the regression parameters in a model for the long-term survival rate. The proposed estimator is seen to arise from an estimating function that has the missing information principle underlying its construction. When the covariate takes values in a finite set, the proposed estimating function is equivalent to an ad hoc estimating function proposed in the literature. However, in general, the two estimating functions lead to different estimators of the regression parameter. For discrete covariates, the asymptotic covariance matrix of the proposed estimator is simple to calculate using standard techniques involving the predictable covariation process of martingale transforms. An ad hoc extension to the case of a one-dimensional continuous covariate is proposed. Simplicity and generalizability are two attractive features of the proposed approach. The last mentioned feature is not enjoyed by the other estimator.     

Bayes prediction based on right censored data

This paper is concerned with a Bayes prediction problem in the exponential distribution under random censorship. Using censored samples, we work out a prediction interval for a sum of interest which consists of some future samples. Differing from the general Bayes approach, we do not specify the prior distribution of the parameter, and only a first moment condition on the prior is assumed. Simulation studies are conducted to exhibit the coverage probabilities of the prediction interval. Financial support from the IAP research network (#P5/24) of the Belgian Government (Belgian Science Policy) is gratefully acknowledged.