Mixed Discrete and Continuous Cox Regression Model

The Cox (1972) regression model is extended to include discrete and mixed continuous/discrete failure time data by retaining the multiplicative hazard rate form of the absolutely continuous model. Application of martingale arguments to the regression parameter estimating function show the Breslow (1974) estimator to be consistent and asymptotically Gaussian under this model. A computationally convenient estimator of the variance of the score function can be developed, again using martingale arguments. This estimator reduces to the usual hypergeometric form in the special case of testing equality of several survival curves, and it leads more generally to a convenient consistent variance estimator for the regression parameter. A small simulation study is carried out to study the regression parameter estimator and its variance estimator under the discrete Cox model special case and an application to a bladder cancer recurrence dataset is provided.     

Nonparametric Estimation of Distribution Functions of Nonstandard Mixtures

ABSTRACT

Nonstandard mixtures are those that result from a mixture of a discrete and a continuous random variable. They arise in practice, for example, in medical studies of exposure. Here, a random variable that models exposure might have a discrete mass point at no exposure, but otherwise may be continuous. In this article we explore estimating the distribution function associated with such a random variable from a nonparametric viewpoint. We assume that the locations of the discrete mass points are known so that we will be able to apply a classical nonparametric smoothing approach to the problem. The proposed estimator is a mixture of an empirical distribution function and a kernel estimate of a distribution function. A simple theoretical argument reveals that existing bandwidth selection algorithms can be applied to the smooth component of this estimator as well. The proposed approach is applied to two example sets of data.     

A Semiparametric Model for Line Transect Sampling

This paper introduces an appealing semiparametric model for estimating wildlife abundance based on line transect data. The proposed method requires the existence of a parametric model and then improves the estimator using a kernel method. Properties of the resultant estimator are derived and an expression for the asymptotic mean square error (AMSE) of the estimator is given. Minimization of the AMSE leads to an explicit formula for an optimal choice of the smoothing parameter. Small-sample properties of the proposed estimator using the parametric half-normal model are investigated and compared with the classical kernel estimator using both simulations and real data. Numerical results show that improvements over the classical kernel estimator often can be realized even when the true density is far from the half-normal model.     

Parameter estimation in regression for long-term survival rate from censored data

In recent years, regression models have been shown to be useful for predicting the long-term survival probabilities of patients in clinical trials. The importance of a regression model is that once the regression parameters are estimated information about the regressed quantity is immediate. A simple estimator is proposed for the regression parameters in a model for the long-term survival rate. The proposed estimator is seen to arise from an estimating function that has the missing information principle underlying its construction. When the covariate takes values in a finite set, the proposed estimating function is equivalent to an ad hoc estimating function proposed in the literature. However, in general, the two estimating functions lead to different estimators of the regression parameter. For discrete covariates, the asymptotic covariance matrix of the proposed estimator is simple to calculate using standard techniques involving the predictable covariation process of martingale transforms. An ad hoc extension to the case of a one-dimensional continuous covariate is proposed. Simplicity and generalizability are two attractive features of the proposed approach. The last mentioned feature is not enjoyed by the other estimator.     

A minimum variance kernel estimator and a discrete frequency polygon estimator for ordinal contingency tables

This paper introduces two estimators, a boundary corrected minimum variance kernel estimator based on a uniform kernel and a discrete frequency polygon estimator, for the cell probabilities of ordinal contingency tables. Simulation results show that the minimum variance boundary kernel estimator has a smaller average sum of squared error than the existing boundary kernel estimators. The discrete frequency polygon estimator is simple and easy to interpret, and it is competitive with the minimum variance boundary kernel estimator. It is proved that both estimators have an optimal rate of convergence in terms of mean sum of squared error, The estimators are also defined for high-dimensional tables.     

GEE estimation of the covariance structure of a bivariate panel data model with an application to wage dynamics and the incidence of profit-sharing in West Germany

We propose a generalized estimating equations (GEE) approach to the estimation of the mean and covariance structure of bivariate time series processes of panel data. The one-step approach allows for mixed continuous and discrete dependent variables. A Monte Carlo Study is presented to compare our particular GEE estimator with more standard GEE-estimators. In the empirical illustration, we apply our estimator to the analysis of individual wage dynamics and the incidence of profit-sharing in West Germany. Our findings show that time-invariant unobserved individual ability jointly influences individual wages and participation in profit sharing schemes.     

Reliable error estimation for Sobol’ indices

In the field of sensitivity analysis, Sobol’ indices are sensitivity measures widely used to assess the importance of inputs of a model to its output. The estimation of these indices is often performed through Monte Carlo or quasi-Monte Carlo methods. A notable method is the replication procedure that estimates first-order indices at a reduced cost in terms of number of model evaluations. An inherent practical problem of this estimation is how to quantify the number of model evaluations needed to ensure that estimates satisfy a desired error tolerance. This article addresses this challenge by proposing a reliable error bound for first-order and total effect Sobol’ indices. Starting from the integral formula of the indices, the error bound is defined in terms of the discrete Walsh coefficients of the different integrands. We propose a sequential estimation procedure of Sobol’ indices using the error bound as a stopping criterion. The sequential procedure combines Sobol’ sequences with either Saltelli’s strategy to estimate both first-order and total effect indices, or the replication procedure to estimate only first-order indices.     

Discrete Nonparametric Kernel and Parametric Methods for the Modeling of Pavement Deterioration

This article is concerned with one discrete nonparametric kernel and two parametric regression approaches for providing the evolution law of pavement deterioration. The first parametric approach is a survival data analysis method; and the second is a nonlinear mixed-effects model. The nonparametric approach consists of a regression estimator using the discrete associated kernels. Some asymptotic properties of the discrete nonparametric kernel estimator are shown as, in particular, its almost sure consistency. Moreover, two data-driven bandwidth selection methods are also given, with a new theoretical explicit expression of optimal bandwidth provided for this nonparametric estimator. A comparative simulation study is realized with an application of bootstrap methods to a measure of statistical accuracy.     

Nonparametric estimation of regression models with mixed discrete and continuous covariates by the K-nn method

In this article we consider the problem of estimating a nonparametric conditional mean function with mixed discrete and continuous covariates by the nonparametric k-nearest-neighbor (k-nn) method. We derive the asymptotic normality result of the proposed estimator and use Monte Carlo simulations to demonstrate its finite sample performance. We also provide an illustrative empirical example of our method.     

An empirical saddlepoint approximation based method for smoothing survival functions under right censoring

The Kaplan–Meier (KM) estimator is ubiquitously used for estimating survival functions, but it provides only a discrete approximation at the observation times and does not deliver a proper distribution if the largest observation is censored. Using KM as a starting point, we devise an empirical saddlepoint approximation‐based method for producing a smooth survival function that is unencumbered by choice of tuning parameters. The procedure inverts the moment generating function (MGF) defined through a Riemann–Stieltjes integral with respect to an underlying mixed probability measure consisting of the discrete KM mass function weights and an absolutely continuous exponential right‐tail completion. Uniform consistency, and weak and strong convergence results are established for the resulting MGF and its derivatives, thus validating their usage as inputs into the saddlepoint routines. Relevant asymptotic results are also derived for the density and distribution function estimates. The performance of the resulting survival approximations is examined in simulation studies, which demonstrate a favourable comparison with the log spline method (Kooperberg & Stone, 1992) in small sample settings. For smoothing survival functions we argue that the methodology has no immediate competitors in its class, and we illustrate its application on several real data sets. The Canadian Journal of Statistics 47: 238–261; 2019 © 2019 Statistical Society of Canada     

Nonparametric estimation of response coefficients

In this paper we propose a nonparametric kernel method of estimating response coefficients in the stochastic regressors model. The method is straightforward, and the estimator is easy to calculate. The asymptotic normality of the proposed estimator is established, and an illustrative example is presented.     

Mixed-spectra analysis for stationary random fields

We consider a, discrete time, weakly stationary bidimensional process, for which the spectral measure is the sum of an absolutely continuous measure, a discrete measure of finite order and a finite number of absolutely continuous measures on several lines. In this paper we are interested in estimating the spectral density of the absolutely continuous measure and of the density on the lines. For this aim, by using the double kernel method, we construct consistent estimators of these densities and we study their asymptotic behaviors in term of the mean squared error with rate.     

Discrete triangular associated kernel and bandwidth choices in semiparametric estimation for count data

This work deals with semiparametric kernel estimator of probability mass functions which are assumed to be modified Poisson distributions. This semiparametric approach is based on discrete associated kernel method appropriated for modelling count data; in particular, the famous discrete symmetric triangular kernels are used. Two data-driven bandwidth selection procedures are investigated and an explicit expression of optimal bandwidth not available until now is provided. Moreover, some asymptotic properties of the cross-validation criterion adapted for discrete semiparametric kernel estimation are studied. Finally, to measure the performance of semiparametric estimator according to each type of bandwidth parameter, some applications are realized on three real count data-sets from sociology and biology.     

A Convolution Estimator for the Density of Nonlinear Regression Observations

Abstract. The problem of estimating an unknown density function has been widely studied. In this article, we present a convolution estimator for the density of the responses in a nonlinear heterogenous regression model. The rate of convergence for the mean square error of the convolution estimator is of order n ^?1 under certain regularity conditions. This is faster than the rate for the kernel density method. We derive explicit expressions for the asymptotic variance and the bias of the new estimator, and further a data‐driven bandwidth selector is proposed. We conduct simulation experiments to check the finite sample properties, and the convolution estimator performs substantially better than the kernel density estimator for well‐behaved noise densities.     

Frontier estimation using kernel smoothing estimators with data transformation

In economics, a production frontier function is a graph that shows the maximum output of production units such as firms, industries, or economies, as a function of their inputs. Practically, estimating production frontiers often requires imposition of constraints such as monotonicity or monotone concavity. However, few constrained estimators of production frontier have been proposed in the literature. They are based on simple envelopment techniques which often suffer from lack of precision and smoothness. Motivated by this observation, we propose a smooth constrained nonparametric frontier estimator respecting constraints by considering kernel smoothing estimators from a transformed data. It is particularly appealing to practitioners who would like to use smooth estimates that, in addition, satisfy theoretical axioms of production. The utility of this method is illustrated through application to one real dataset and simulation evidences are also presented to show its superiority over the most known methods.     

Classification with discrete and continuous variables via general mixed-data models

We study the problem of classifying an individual into one of several populations based on mixed nominal, continuous, and ordinal data. Specifically, we obtain a classification procedure as an extension to the so-called location linear discriminant function, by specifying a general mixed-data model for the joint distribution of the mixed discrete and continuous variables. We outline methods for estimating misclassification error rates. Results of simulations of the performance of proposed classification rules in various settings vis-à-vis a robust mixed-data discrimination method are reported as well. We give an example utilizing data on croup in children.     

Discrete associated kernels method and extensions

Discrete kernel estimation of a probability mass function (p.m.f.), often mentioned in the literature, has been far less investigated in comparison with continuous kernel estimation of a probability density function (p.d.f.). In this paper, we are concerned with a general methodology of discrete kernels for smoothing a p.m.f. f. We give a basic of mathematical tools for further investigations. First, we point out a generalizable notion of discrete associated kernel which is defined at each point of the support of f and built from any parametric discrete probability distribution. Then, some properties of the corresponding estimators are shown, in particular pointwise and global (asymptotical) properties. Other discrete kernels are constructed from usual discrete probability distributions such as Poisson, binomial and negative binomial. For small samples sizes, underdispersed discrete kernel estimators are more interesting than the empirical estimator; thus, an importance of discrete kernels is illustrated. The choice of smoothing bandwidth is classically investigated according to cross-validation and, novelly, to excess of zeros methods. Finally, a unification way of this method concerning the general probability function is discussed.     

Deficiency of the mle of a smooth survival function under the proportional hazard model

The problem of estimating a smooth distribution function F at a point t is treated under the proportional hazard model of random censorship. It is shown that a certain class of properly chosen kernel type estimator of F asymptotically perform better than the maximum likelihood estimator. It is shown that the relative deficiency of the maximum likelihood estimator of F under the proportional hazard model with respect to the properly chosen kernel type estimator tends to infinity as the sample size tends to infinity.     

Weighted Poisson and Semiparametric Kernel Models Applied to Parasite Growth

This work deals with some parametric and semiparametric modeling approaches for count data distributions related to development of spiraling whitefly which is an insect pest collected in Brazzaville, Republic of Congo. In this study, the count data distributions are assumed to be modified Poisson probability mass functions. For the discrete semiparametric associated kernel estimator investigated, its almost sure consistency and asymptotic normality are shown under some asumptions. Some weighted Poisson models (WPD) are applied in comparison with the semiparametric approach for finite samples characterizing the growth of spiraling whitefly. Finally, the discrete semiparametric estimation is simple and effective for estimating any count distribution while WPD are practically more meaningful.     

Fast Censored Linear Regression

Weighted log‐rank estimating function has become a standard estimation method for the censored linear regression model, or the accelerated failure time model. Well established statistically, the estimator defined as a consistent root has, however, rather poor computational properties because the estimating function is neither continuous nor, in general, monotone. We propose a computationally efficient estimator through an asymptotics‐guided Newton algorithm, in which censored quantile regression methods are tailored to yield an initial consistent estimate and a consistent derivative estimate of the limiting estimating function. We also develop fast interval estimation with a new proposal for sandwich variance estimation. The proposed estimator is asymptotically equivalent to the consistent root estimator and barely distinguishable in samples of practical size. However, computation time is typically reduced by two to three orders of magnitude for point estimation alone. Illustrations with clinical applications are provided.