Penalized optimal designs for dose-finding

Optimal design under a cost constraint is considered, with a scalar coefficient setting the compromise between information and cost. It is shown that for suitable cost functions, by increasing the value of the coefficient one can force the support points of an optimal design measure to concentrate around points of minimum cost. An example of adaptive design in a dose-finding problem with a bivariate binary model is presented, showing the effectiveness of the approach.     

Optimal design for classification of functional data

We study the design problem for the optimal classification of functional data. The goal is to select sampling time points so that functional data observed at these time points can be classified accurately. We propose optimal designs that are applicable to either dense or sparse functional data. Using linear discriminant analysis, we formulate our design objectives as explicit functions of the sampling points. We study the theoretical properties of the proposed design objectives and provide a practical implementation. The performance of the proposed design is evaluated through simulations and real data applications. The Canadian Journal of Statistics 48: 285–307; 2020 © 2019 Statistical Society of Canada     

Penalized contrast estimation in functional linear models with circular data

Our aim is to estimate the unknown slope function in the functional linear model when the response Y is real and the random function X is a second-order stationary and periodic process. We obtain our estimator by minimizing a standard (and very simple) mean-square contrast on linear finite dimensional spaces spanned by trigonometric bases. Our approach provides a penalization procedure which allows to automatically select the adequate dimension, in a non-asymptotic point of view. In fact, we can show that our penalized estimator reaches the optimal (minimax) rate of convergence in the sense of the prediction error. We complete the theoretical results by a simulation study and a real example that illustrates how the procedure works in practice.     

Penalized likelihood estimators for truncated data

We investigate the performance of linearly penalized likelihood estimators for estimating distributional parameters in the presence of data truncation. Truncation distorts the likelihood surface to create instabilities and high variance in the estimation of these parameters, and the penalty terms help in many cases to decrease estimation error and increase robustness. Approximate methods are provided for choosing a priori good penalty estimators, which are shown to perform well in a series of simulation experiments. The robustness of the methods is explored heuristically using both simulated and real data drawn from an operational risk context.     

Penalized quantile regression for dynamic panel data

This paper studies penalized quantile regression for dynamic panel data with fixed effects, where the penalty involves l₁ shrinkage of the fixed effects. Using extensive Monte Carlo simulations, we present evidence that the penalty term reduces the dynamic panel bias and increases the efficiency of the estimators. The underlying intuition is that there is no need to use instrumental variables for the lagged dependent variable in the dynamic panel data model without fixed effects. This provides an additional use for the shrinkage models, other than model selection and efficiency gains. We propose a Bayesian information criterion based estimator for the parameter that controls the degree of shrinkage. We illustrate the usefulness of the novel econometric technique by estimating a “target leverage” model that includes a speed of capital structure adjustment. Using the proposed penalized quantile regression model the estimates of the adjustment speeds lie between 3% and 44% across the quantiles, showing strong evidence that there is substantial heterogeneity in the speed of adjustment among firms.     

Penalized spline joint models for longitudinal and time-to-event data

The joint models for longitudinal data and time-to-event data have recently received numerous attention in clinical and epidemiologic studies. Our interest is in modeling the relationship between event time outcomes and internal time-dependent covariates. In practice, the longitudinal responses often show non linear and fluctuated curves. Therefore, the main aim of this paper is to use penalized splines with a truncated polynomial basis to parameterize the non linear longitudinal process. Then, the linear mixed-effects model is applied to subject-specific curves and to control the smoothing. The association between the dropout process and longitudinal outcomes is modeled through a proportional hazard model. Two types of baseline risk functions are considered, namely a Gompertz distribution and a piecewise constant model. The resulting models are referred to as penalized spline joint models; an extension of the standard joint models. The expectation conditional maximization (ECM) algorithm is applied to estimate the parameters in the proposed models. To validate the proposed algorithm, extensive simulation studies were implemented followed by a case study. In summary, the penalized spline joint models provide a new approach for joint models that have improved the existing standard joint models.     

Quantification of symmetry for functional data with application to equine lameness classification

This paper presents a study on symmetry of repeated bi-phased data signals, in particular, on quantification of the deviation between the two parts of the signal. Three symmetry scores are defined using functional data techniques such as smoothing and registration. One score is related to the L ₂-distance between the two parts of the signal, whereas the other two are constructed to specifically measure differences in amplitude and phase. Moreover, symmetry scores based on functional principal component analysis (PCA) are examined. The scores are applied to acceleration signals from a study on equine gait. The scores turn out to be highly associated with lameness, and their applicability for lameness quantification and detection is investigated. Four classification approaches turn out to give similar results. The scores describing amplitude and phase variation turn out to outperform the PCA scores when it comes to the classification of lameness.     

Robust optimal estimation of location from discretely sampled functional data

Estimating location is a central problem in functional data analysis, yet most current estimation procedures either unrealistically assume completely observed trajectories or lack robustness with respect to the many kinds of anomalies one can encounter in the functional setting. To remedy these deficiencies we introduce the first class of optimal robust location estimators based on discretely sampled functional data. The proposed method is based on M-type smoothing spline estimation with repeated measurements and is suitable for both commonly and independently observed trajectories that are subject to measurement error. We show that under suitable assumptions the proposed family of estimators is minimax rate optimal both for commonly and independently observed trajectories and we illustrate its highly competitive performance and practical usefulness in a Monte-Carlo study and a real-data example involving recent Covid-19 data.     

An augmented data scoring algorithm for maximum likelihood

The expectation-maximization (EM) method facilitates computation of max¬imum likelihood (ML) and maximum penalized likelihood (MPL) solutions. The procedure requires specification of unobservabie complete data which augment the measured or incomplete data. This specification defines a conditional expectation of the complete data log-likelihood function which is computed in the E-stcp. The EM algorithm is most effective when maximizing the iunction Q{0) denned in the F-stnp is easier than maximizing the likelihood function.

The Monte Carlo EM (MCEM) algorithm of Wei & Tanner (1990) was introduced for problems where computation of Q is difficult or intractable. However Monte Carlo can he computationally expensive, e.g. in signal processing applications involving large numbers of parameters. We provide another approach: a modification of thc standard EM algorithm avoiding computation of conditional expectations.     

Analysis of binary data for the balanced one-way classification

A test is proposed for testing the equality of proportions based on the data available from a one-way classification having t treatment conditions and n binary observations per treatment. The test statistic B is a constant multiple of the F-statistic which results when the analysis of variance procedure for the one-way classification is applied to the data and, hence, is computationally simple. The statistic B from this binary analysis of variance (BIANOVA) is distributed asymptotically as a chi-square random variable. The proposed test is uniformly more powerful than either the F-test indicated above or the Pearson chi-square test; however, the attained empirical level of significance is frequently higher than for either of these competitors and usually higher than the stated level of significance for smaller values of n (say n ≤ 20).     

Asymptotically optimal shrinkage estimates for non-normal data

Motivated by several practical issues, we consider the problem of estimating the mean of a p-variate population (not necessarily normal) with unknown finite covariance. A quadratic loss function is used. We give a number of estimators (for the mean) with their loss functions admitting expansions to the order of p ^?1/2 as p→∞. These estimators contain Stein's [Inadmissibility of the usual estimator for the mean of a multivariate normal population, in Proceedings of the Third Berkeley Symposium in Mathematical Statistics and Probability, Vol. 1, J. Neyman, ed., University of California Press, Berkeley, 1956, pp. 197–206] estimate as a particular case and also contain ‘multiple shrinkage’ estimates improving on Stein's estimate. Finally, we perform a simulation study to compare the different estimates.     

Homogeneity test for functional data

In the context of functional data analysis, we propose new sample tests for homogeneity. Based on some well-known depth measures, we construct four different statistics in order to measure distance between the two samples. A simulation study is performed to check the efficiency of the tests when confronted with shape and magnitude perturbation. Finally, we apply these tools to measure the homogeneity in some samples of real data, and we obtain good results using this new method.     

Interval-wise testing for functional data

In the framework of null hypothesis significance testing for functional data, we propose a procedure able to select intervals of the domain imputable for the rejection of a null hypothesis. An unadjusted p-value function and an adjusted one are the output of the procedure, namely interval-wise testing. Depending on the sort and level α of type-I error control, significant intervals can be selected by thresholding the two p-value functions at level α. We prove that the unadjusted (adjusted) p-value function point-wise (interval-wise) controls the probability of type-I error and it is point-wise (interval-wise) consistent. To enlighten the gain in terms of interpretation of the phenomenon under study, we applied the interval-wise testing to the analysis of a benchmark functional data set, i.e. Canadian daily temperatures. The new procedure provides insights that current state-of-the-art procedures do not, supporting similar advantages in the analysis of functional data with less prior knowledge.     

Penalized likelihood approach for the four-parameter kappa distribution

The four-parameter kappa distribution (K4D) is a generalized form of some commonly used distributions such as generalized logistic, generalized Pareto, generalized Gumbel, and generalized extreme value (GEV) distributions. Owing to its flexibility, the K4D is widely applied in modeling in several fields such as hydrology and climatic change. For the estimation of the four parameters, the maximum likelihood approach and the method of L-moments are usually employed. The L-moment estimator (LME) method works well for some parameter spaces, with up to a moderate sample size, but it is sometimes not feasible in terms of computing the appropriate estimates. Meanwhile, using the maximum likelihood estimator (MLE) with small sample sizes shows substantially poor performance in terms of a large variance of the estimator. We therefore propose a maximum penalized likelihood estimation (MPLE) of K4D by adjusting the existing penalty functions that restrict the parameter space. Eighteen combinations of penalties for two shape parameters are considered and compared. The MPLE retains modeling flexibility and large sample optimality while also improving on small sample properties. The properties of the proposed estimator are verified through a Monte Carlo simulation, and an application case is demonstrated taking Thailand’s annual maximum temperature data.     

A zero-inflated non default rate regression model for credit scoring data

The aim of this paper is to propose a survival credit risk model that jointly accommodates three types of time-to-default found in bank loan portfolios. It leads to a new framework that extends the standard cure rate model introduced by Berkson and Gage (1952 Berkson, J., and R. P. Gage. 1952. Survival curve for cancer patients following treatment. Journal of the American Statistical Association 47 (259):501–15.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) regarding the accommodation of zero-inflations. In other words, we propose a new survival model that takes into account three different types of individuals which have so far not been jointly accounted for: (i) an individual with an event at the starting time (zero time); (ii) non susceptible for the event, or (iii) susceptible for the event. Considering this, the zero-inflated Weibull non default rate regression models, which include a multinomial logistic link for the three classes, are presented using an application for credit scoring data. The parameter estimation is reached by the maximum-likelihood estimation procedure and Monte Carlo simulations are carried out to assess its finite sample performance.     

Review of ODA 1.0 optimal data analysis for DOSTM

Statistics and Computing -     

Interpretable sparse SIR for functional data

We propose a semiparametric framework based on sliced inverse regression (SIR) to address the issue of variable selection in functional regression. SIR is an effective method for dimension reduction which computes a linear projection of the predictors in a low-dimensional space, without loss of information on the regression. In order to deal with the high dimensionality of the predictors, we consider penalized versions of SIR: ridge and sparse. We extend the approaches of variable selection developed for multidimensional SIR to select intervals that form a partition of the definition domain of the functional predictors. Selecting entire intervals rather than separated evaluation points improves the interpretability of the estimated coefficients in the functional framework. A fully automated iterative procedure is proposed to find the critical (interpretable) intervals. The approach is proved efficient on simulated and real data. The method is implemented in the R package SISIR available on CRAN at https://cran.r-project.org/package=SISIR.

     

Mantel test for spatial functional data

Statistics for spatial functional data is an emerging field in statistics which combines methods of spatial statistics and functional data analysis to model spatially correlated functional data. Checking for spatial autocorrelation is an important step in the statistical analysis of spatial data. Several statistics to achieve this goal have been proposed. The test based on the Mantel statistic is widely known and used in this context. This paper proposes an application of this test to the case of spatial functional data. Although we focus particularly on geostatistical functional data, that is functional data observed in a region with spatial continuity, the test proposed can also be applied with functional data which can be measured on a discrete set of areas of a region (areal functional data) by defining properly the distance between the areas. Based on two simulation studies, we show that the proposed test has a good performance. We illustrate the methodology by applying it to an agronomic data set.