Semiparametric estimation of regression quantiles with application to standardizing weight for height and age in US children

The appropriate interpretation of measurements often requires standardization for concomitant factors. For example, standardization of weight for both height and age is important in obesity research and in failure-to-thrive research in children. Regression quantiles from a reference population afford one intuitive and popular approach to standardization. Current methods for the estimation of regression quantiles can be classified as nonparametric with respect to distributional assumptions or as fully parametric. We propose a semiparametric method where we model the mean and variance as flexible regression spline functions and allow the unspecified distribution to vary smoothly as a function of covariates. Similarly to Cole and Green, our approach provides separate estimates and summaries for location, scale and distribution. However, similarly to Koenker and Bassett, we do not assume any parametric form for the distribution. Estimation for either cross-sectional or longitudinal samples is obtained by using estimating equations for the location and scale functions and through local kernel smoothing of the empirical distribution function for standardized residuals. Using this technique with data on weight, height and age for females under 3 years of age, we find that there is a close relationship between quantiles of weight for height and age and quantiles of body mass index (BMI=weight/height²) for age in this cohort.     

Splines as a Useful and Convenient Statistical Tool

The framework for a unified statistical theory of spline regression assuming fixed knots using the truncated polynomial or “+” function representation is presented. In particular, a partial ordering of some spline models is introduced to clarify their relationship and to indicate the hypotheses that can be tested by using either standard multiple regression procedures or a little-used conditional test developed by Hotelling (1940). The construction of spline models with polynomial pieces of different degrees is illustrated. A numerical example from a chemical experiment is given by using the GLM procedure of the statistical software package SAS (Barr et al. 1976).     

Smoothing spline growth curves with covariates

We adapt the interactive spline model of Wahba. to growth curves o with covariates. The smoothing spline formulation permits a nonpara-metric representation of the growth curves. In the limit when the discretization error is small relative to the estimation error, the resulting growth curve estimates often depend only weakly on the number and locations of the knots. The smoothness parameter is determined from the data by minimizing an empirical estimate of the expected error. We show that the risk estimate of Craven and Wahba is a weighted goodness of fit estimate, A modified loss estimate is given, where a2 is replaced by its unbiased estimate.     

Monitoring and change-point estimation for spline-modeled non-linear profiles in phase II

In some applications of statistical quality control, quality of a process or a product is best characterized by a functional relationship between a response variable and one or more explanatory variables. This relationship is referred to as a profile. In certain cases, the quality of a process or a product is better described by a non-linear profile which does not follow a specific parametric model. In these circumstances, nonparametric approaches with greater flexibility in modeling the complicated profiles are adopted. In this research, the spline smoothing method is used to model a complicated non-linear profile and the Hotelling T² control chart based on the spline coefficients is used to monitor the process. After receiving an out-of-control signal, a maximum likelihood estimator is employed for change point estimation. The simulation studies, which include both global and local shifts, provide appropriate evaluation of the performance of the proposed estimation and monitoring procedure. The results indicate that the proposed method detects large global shifts while it is very sensitive in detecting local shifts.     

Identification of non-linear additive autoregressive models

Summary.  We propose a lag selection method for non-linear additive autoregressive models that is based on spline estimation and the Bayes information criterion. The additive structure of the autoregression function is used to overcome the 'curse of dimensionality', whereas the spline estimators effectively take into account such a structure in estimation. A stepwise procedure is suggested to implement the method proposed. A comprehensive Monte Carlo study demonstrates good performance of the method proposed and a substantial computational advantage over existing local-polynomial-based methods. Consistency of the lag selection method based on the Bayes information criterion is established under the assumption that the observations are from a stochastic process that is strictly stationary and strongly mixing, which provides the first theoretical result of this kind for spline smoothing of weakly dependent data.     

A plug-in the number of knots selector for polynomial spline regression

A plug-in the number of interior knots (NIKs) selector is proposed for polynomial spline estimation in nonparametric regression. The existence and properties of the optimal NIKs for spline regression are established by minimising the weighted mean integrated squared error. We obtain plug-in formulae for the optimal NIKs based on the theoretical results of asymptotic optimality, and develop strategies for choosing the NIKs of the spline estimator. The proposed NIKs selection method is tested on our simulated data with quite satisfactory performance, and is illustrated by analysing a fossil data set.     

Some asymptotic results on generalized penalized spline smoothing

Summary.  The paper discusses asymptotic properties of penalized spline smoothing if the spline basis increases with the sample size. The proof is provided in a generalized smoothing model allowing for non-normal responses. The results are extended in two ways. First, assuming the spline coefficients to be a priori normally distributed links the smoothing framework to generalized linear mixed models. We consider the asymptotic rates such that the Laplace approximation is justified and the resulting fits in the mixed model correspond to penalized spline estimates. Secondly, we make use of a fully Bayesian viewpoint by imposing an a priori distribution on all parameters and coefficients. We argue that with the postulated rates at which the spline basis dimension increases with the sample size the posterior distribution of the spline coefficients is approximately normal. The validity of this result is investigated in finite samples by comparing Markov chain Monte Carlo results with their asymptotic approximation in a simulation study.     

Results concerning the generalized partially linear single-index model

The central topic of this article is the estimation of parameters of the generalized partially linear single-index model (GPLSIM). Two numerical optimization procedures are presented and an S-plus program based on these procedures is compared to a program by Wand in a simulation setting. The results from these simulations indicate that the estimates for the new procedures are as good, if not better, than Wand's. Also, this program is much more flexible than Wand's since it can handle more general models. Other simulations are also conducted. The first compares the effects of using linear interpolation versus spline interpolation in an optimization procedure. The results indicate that by using spline interpolation one gets more stable estimates at a cost of increased computational time. A second simulation was conducted to assess the performance of a method for estimating the variance of alpha. A third set of simulations is carried out to determine the best criterion for testing that one of the elements of alpha is equal to zero. The GPLSIM is applied to a water quality data set and the results indicate an interesting relationship between gastrointestinal illness and turbidity (cloudiness) of drinking water.     

A stepwise approach for the purely periodic interaction spline model

The basic idea of an interaction spline model was presented in Barry (1983). The general interaction spline models were proposed by Wahba (1986). The purely periodic spline model, a special case of the general interaction spline models, is considered in this paper. A stepwise approach using generalized cross validation (GCV) for fitting the model is proposed. Based on the nice orthogonality properties of the purely periodic functions, the stepwise approach is a promising method for the interaction spline model. The approach can also be generalized to the non-purely-periodic spline models. But this is no done here.     

Kernel spline regression

The authors propose «kernel spline regression,» a method of combining spline regression and kernel smoothing by replacing the polynomial approximation for local polynomial kernel regression with the spline basis. The new approach retains the local weighting scheme and the use of a bandwidth to control the size of local neighborhood. The authors compute the bias and variance of the kernel linear spline estimator, which they compare with local linear regression. They show that kernel spline estimators can succeed in capturing the main features of the underlying curve more effectively than local polynomial regression when the curvature changes rapidly. They also show through simulation that kernel spline regression often performs better than ordinary spline regression and local polynomial regression.     

ALL-BIAS DESIGNS FOR POLYNOMIAL SPLINE REGRESSION MODELS

Polynomial spline regression models of low degree have proved useful in modeling responses from designed experiments in science and engineering when simple polynomial models are inadequate. Where there is uncertainty in the number and location of the knots, or breakpoints, of the spline, then designs that minimize the systematic errors resulting from model misspecification may be appropriate. This paper gives a method for constructing such all‐bias designs for a single variable spline when the distinct knots in the assumed and true models come from some specified set. A class of designs is defined in terms of the inter‐knot intervals and sufficient conditions are obtained for a design within this class to be all‐bias under linear, quadratic and cubic spline models. An example of the construction of all‐bias designs is given.     

Multivariate partially linear single-index models: Bayesian analysis

Partially linear single-index models play important roles in advanced non-/semi-parametric statistics due to their generality and flexibility. We generalise these models from univariate response to multivariate responses. A Bayesian method with free-knot spline is used to analyse the proposed models, including the estimation and the prediction, and a Metropolis-within-Gibbs sampler is provided for posterior exploration. We also utilise the partially collapsed idea in our algorithm to speed up the convergence. The proposed models and methods of analysis are demonstrated by simulation studies and are applied to a real data set.     

Semiparametric Estimation with Profile Algorithm for Longitudinal Binary Data

This article considers analyzing longitudinal binary data semiparametrically and proposing GEE-Smoothing spline in the estimation of parametric and nonparametric components. The method is an extension of the parametric generalized estimating equation to semiparametric. The nonparametric component is estimated by smoothing spline approach, i.e., natural cubic spline. We use profile algorithm in the estimation of both parametric and nonparametric components. Properties of the estimators are evaluated by simulation.     

Estimating curves and derivatives with parametric penalized spline smoothing

Accurate estimation of an underlying function and its derivatives is one of the central problems in statistics. Parametric forms are often proposed based on the expert opinion or prior knowledge of the underlying function. However, these strict parametric assumptions may result in biased estimates when they are not completely accurate. Meanwhile, nonparametric smoothing methods, which do not impose any parametric form, are quite flexible. We propose a parametric penalized spline smoothing method, which has the same flexibility as the nonparametric smoothing methods. It also uses the prior knowledge of the underlying function by defining an additional penalty term using the distance of the fitted function to the assumed parametric function. Our simulation studies show that the parametric penalized spline smoothing method can obtain more accurate estimates of the function and its derivatives than the penalized spline smoothing method. The parametric penalized spline smoothing method is also demonstrated by estimating the human height function and its derivatives from the real data.     

Variance Reduction in Smoothing Splines

Abstract.  We develop a variance reduction method for smoothing splines. For a given point of estimation, we define a variance-reduced spline estimate as a linear combination of classical spline estimates at three nearby points. We first develop a variance reduction method for spline estimators in univariate regression models. We then develop an analogous variance reduction method for spline estimators in clustered/longitudinal models. Simulation studies are performed which demonstrate the efficacy of our variance reduction methods in finite sample settings. Finally, a real data analysis with the motorcycle data set is performed. Here we consider variance estimation and generate 95% pointwise confidence intervals for the unknown regression function.     

A method for choosing the smoothing parameter in a semi-parametric model for detecting change-points in blood flow

In a smoothing spline model with unknown change-points, the choice of the smoothing parameter strongly influences the estimation of the change-point locations and the function at the change-points. In a tumor biology example, where change-points in blood flow in response to treatment were of interest, choosing the smoothing parameter based on minimizing generalized cross-validation (GCV) gave unsatisfactory estimates of the change-points. We propose a new method, aGCV, that re-weights the residual sum of squares and generalized degrees of freedom terms from GCV. The weight is chosen to maximize the decrease in the generalized degrees of freedom as a function of the weight value, while simultaneously minimizing aGCV as a function of the smoothing parameter and the change-points. Compared with GCV, simulation studies suggest that the aGCV method yields improved estimates of the change-point and the value of the function at the change-point.     

Penalized spline joint models for longitudinal and time-to-event data

The joint models for longitudinal data and time-to-event data have recently received numerous attention in clinical and epidemiologic studies. Our interest is in modeling the relationship between event time outcomes and internal time-dependent covariates. In practice, the longitudinal responses often show non linear and fluctuated curves. Therefore, the main aim of this paper is to use penalized splines with a truncated polynomial basis to parameterize the non linear longitudinal process. Then, the linear mixed-effects model is applied to subject-specific curves and to control the smoothing. The association between the dropout process and longitudinal outcomes is modeled through a proportional hazard model. Two types of baseline risk functions are considered, namely a Gompertz distribution and a piecewise constant model. The resulting models are referred to as penalized spline joint models; an extension of the standard joint models. The expectation conditional maximization (ECM) algorithm is applied to estimate the parameters in the proposed models. To validate the proposed algorithm, extensive simulation studies were implemented followed by a case study. In summary, the penalized spline joint models provide a new approach for joint models that have improved the existing standard joint models.     

A Spline‐Based Semiparametric Maximum Likelihood Estimation Method for the Cox Model with Interval‐Censored Data

Abstract. We propose a spline‐based semiparametric maximum likelihood approach to analysing the Cox model with interval‐censored data. With this approach, the baseline cumulative hazard function is approximated by a monotone B‐spline function. We extend the generalized Rosen algorithm to compute the maximum likelihood estimate. We show that the estimator of the regression parameter is asymptotically normal and semiparametrically efficient, although the estimator of the baseline cumulative hazard function converges at a rate slower than root‐n. We also develop an easy‐to‐implement method for consistently estimating the standard error of the estimated regression parameter, which facilitates the proposed inference procedure for the Cox model with interval‐censored data. The proposed method is evaluated by simulation studies regarding its finite sample performance and is illustrated using data from a breast cosmesis study.     

Component Selection in the Additive Regression Model

Abstract. Similar to variable selection in the linear model, selecting significant components in the additive model is of great interest. However, such components are unknown, unobservable functions of independent variables. Some approximation is needed. We suggest a combination of penalized regression spline approximation and group variable selection, called the group‐bridge‐type spline method (GBSM), to handle this component selection problem with a diverging number of correlated variables in each group. The proposed method can select significant components and estimate non‐parametric additive function components simultaneously. To make the GBSM stable in computation and adaptive to the level of smoothness of the component functions, weighted power spline bases and projected weighted power spline bases are proposed. Their performance is examined by simulation studies. The proposed method is extended to a partial linear regression model analysis with real data, and gives reliable results.     

Modified spline regression based on randomly right-censored data: A comparative study

ABSTRACT

In this paper, we propose modified spline estimators for nonparametric regression models with right-censored data, especially when the censored response observations are converted to synthetic data. Efficient implementation of these estimators depends on the set of knot points and an appropriate smoothing parameter. We use three algorithms, the default selection method (DSM), myopic algorithm (MA), and full search algorithm (FSA), to select the optimum set of knots in a penalized spline method based on a smoothing parameter, which is chosen based on different criteria, including the improved version of the Akaike information criterion (AICc), generalized cross validation (GCV), restricted maximum likelihood (REML), and Bayesian information criterion (BIC). We also consider the smoothing spline (SS), which uses all the data points as knots. The main goal of this study is to compare the performance of the algorithm and criteria combinations in the suggested penalized spline fits under censored data. A Monte Carlo simulation study is performed and a real data example is presented to illustrate the ideas in the paper. The results confirm that the FSA slightly outperforms the other methods, especially for high censoring levels.