Confidence Intervals in Regression That Utilize Uncertain Prior Information About a Vector Parameter

Consider a linear regression model with independent normally distributed errors. Suppose that the scalar parameter of interest is a specified linear combination of the components of the regression parameter vector. Also suppose that we have uncertain prior information that a parameter vector, consisting of specified distinct linear combinations of these components, takes a given value. Part of our evaluation of a frequentist confidence interval for the parameter of interest is the scaled expected length, defined to be the expected length of this confidence interval divided by the expected length of the standard confidence interval for this parameter, with the same confidence coefficient. We say that a confidence interval for the parameter of interest utilizes this uncertain prior information if (a) the scaled expected length of this interval is substantially less than one when the prior information is correct, (b) the maximum value of the scaled expected length is not too large and (c) this confidence interval reverts to the standard confidence interval, with the same confidence coefficient, when the data happen to strongly contradict the prior information. We present a new confidence interval for a scalar parameter of interest, with specified confidence coefficient, that utilizes this uncertain prior information. A factorial experiment with one replicate is used to illustrate the application of this new confidence interval.     

Approximate Bayesianity of Frequentist Confidence Intervals for a Binomial Proportion

The well-known Wilson and Agresti–Coull confidence intervals for a binomial proportion p are centered around a Bayesian estimator. Using this as a starting point, similarities between frequentist confidence intervals for proportions and Bayesian credible intervals based on low-informative priors are studied using asymptotic expansions. A Bayesian motivation for a large class of frequentist confidence intervals is provided. It is shown that the likelihood ratio interval for p approximates a Bayesian credible interval based on Kerman’s neutral noninformative conjugate prior up to O(n^{? 1}) in the confidence bounds. For the significance level α ? 0.317, the Bayesian interval based on the Jeffreys’ prior is then shown to be a compromise between the likelihood ratio and Wilson intervals. Supplementary materials for this article are available online.     

Bayes/frequentist compromise decision rules for Gaussian sampling

Bayesian methods have the potential to confer substantial advantages over frequentist when the assumed prior is approximately correct, but otherwise can perform poorly. Therefore, estimators and other inferences that strike a compromise between Bayes and frequentist optimality are attractive. To evaluate potential trade-offs, we study Bayes vs. frequentist risk under Gaussian sampling for families of point estimators and interval estimators. Bayes/frequentist compromises for interval estimation are more challenging than for point estimation, since performance involves an interplay between coverage and length. Each family allows ‘purchasing’ improved frequentist performance by allowing a small increase in Bayes risk over the Bayes rule. Any degree of increase can be specified, thus enabling greater or lesser trade-offs between Bayes and frequentist risk.     

A Modification for Bayesian Credible Intervals

In Bayesian analysis, people usually report the highest posterior density (HPD) credible interval as an interval estimate of an unknown parameter. However, when the unknown parameter is the nonnegative normal mean, the Bayesian HPD credible interval under the uniform prior has quite a low minimum frequentist coverage probability. To enhance the minimum frequentist coverage probability of a credible interval, I propose a new method of reporting the Bayesian credible interval. Numerical results show that the new reported credible interval has a much higher minimum frequentist coverage probability than the HPD credible interval.     

A matching prior for the product of normal means based on the modified profile likelihood

In this paper, we develop a matching prior for the product of means in several normal distributions with unrestricted means and unknown variances. For this problem, properly assigning priors for the product of normal means has been issued because of the presence of nuisance parameters. Matching priors, which are priors matching the posterior probabilities of certain regions with their frequentist coverage probabilities, are commonly used but difficult to derive in this problem. We developed the first order probability matching priors for this problem; however, the developed matching priors are unproper. Thus, we apply an alternative method and derive a matching prior based on a modification of the profile likelihood. Simulation studies show that the derived matching prior performs better than the uniform prior and Jeffreys’ prior in meeting the target coverage probabilities, and meets well the target coverage probabilities even for the small sample sizes. In addition, to evaluate the validity of the proposed matching prior, Bayesian credible interval for the product of normal means using the matching prior is compared to Bayesian credible intervals using the uniform prior and Jeffrey’s prior, and the confidence interval using the method of Yfantis and Flatman.     

A Simple Analysis of the Exact Probability Matching Prior in the Location-Scale Model

It has long been asserted that in univariate location-scale models, when concerned with inference for either the location or scale parameter, the use of the inverse of the scale parameter as a Bayesian prior yields posterior credible sets that have exactly the correct frequentist confidence set interpretation. This claim dates to at least Peers, and has subsequently been noted by various authors, with varying degrees of justification. We present a simple, direct demonstration of the exact matching property of the posterior credible sets derived under use of this prior in the univariate location-scale model. This is done by establishing an equivalence between the conditional frequentist and posterior densities of the pivotal quantities on which conditional frequentist inferences are based.     

Bayesian Recovery of the Initial Condition for the Heat Equation

We study a Bayesian approach to recovering the initial condition for the heat equation from noisy observations of the solution at a later time. We consider a class of prior distributions indexed by a parameter quantifying “smoothness” and show that the corresponding posterior distributions contract around the true parameter at a rate that depends on the smoothness of the true initial condition and the smoothness and scale of the prior. Correct combinations of these characteristics lead to the optimal minimax rate. One type of priors leads to a rate-adaptive Bayesian procedure. The frequentist coverage of credible sets is shown to depend on the combination of the prior and true parameter as well, with smoother priors leading to zero coverage and rougher priors to (extremely) conservative results. In the latter case, credible sets are much larger than frequentist confidence sets, in that the ratio of diameters diverges to infinity. The results are numerically illustrated by a simulated data example.     

Bayesian Confidence Interval for the Ratio of Marginal Probabilities in the Matched-Pair Design

This article studies the construction of a Bayesian confidence interval for the ratio of marginal probabilities in matched-pair designs. Under a Dirichlet prior distribution, the exact posterior distribution of the ratio is derived. The tail confidence interval and the highest posterior density (HPD) interval are studied, and their frequentist performances are investigated by simulation in terms of mean coverage probability and mean expected length of the interval. An advantage of Bayesian confidence interval is that it is always well defined for any data structure and has shorter mean expected width. We also find that the Bayesian tail interval at Jeffreys prior performs as well as or better than the frequentist confidence intervals.     

Objective Bayesian Analysis for Log-logistic Distribution

In this article, Bayesian approach is applied to estimate the parameters of Log-logistic distribution under reference prior and Jeffreys’ prior. The reference prior is derived and it is found that the reference prior is also a second-order matching priors as for the case of any parameter of interest. The Bayesian estimators cannot be obtained in explicit forms. Metropolis within Gibbs sampling algorithm is used to obtain the Bayesian estimators. The Bayesian estimates are compared with the maximum likelihood estimates via simulation study. A real dataset is considered for illustrative purposes.     

Bayesian confidence interval for the risk ratio in a correlated 2 × 2 table with structural zero

This paper studies the construction of a Bayesian confidence interval for the risk ratio (RR) in a 2 × 2 table with structural zero. Under a Dirichlet prior distribution, the exact posterior distribution of the RR is derived, and tail-based interval is suggested for constructing Bayesian confidence interval. The frequentist performance of this confidence interval is investigated by simulation and compared with the score-based interval in terms of the mean coverage probability and mean expected width of the interval. An advantage of the Bayesian confidence interval is that it is well defined for all data structure and has shorter expected width. Our simulation shows that the Bayesian tail-based interval under Jeffreys’ prior performs as well as or better than the score-based confidence interval.     

The Bernstein–von Mises theorem in semiparametric competing risks models

Semiparametric Bayesian models are nowadays a popular tool in event history analysis. An important area of research concerns the investigation of frequentist properties of posterior inference. In this paper, we propose novel semiparametric Bayesian models for the analysis of competing risks data and investigate the Bernstein–von Mises theorem for differentiable functionals of model parameters. The model is specified by expressing the cause-specific hazard as the product of the conditional probability of a failure type and the overall hazard rate. We take the conditional probability as a smooth function of time and leave the cumulative overall hazard unspecified. A prior distribution is defined on the joint parameter space, which includes a beta process prior for the cumulative overall hazard. We first develop the large-sample properties of maximum likelihood estimators by giving simple sufficient conditions for them to hold. Then, we show that, under the chosen priors, the posterior distribution for any differentiable functional of interest is asymptotically equivalent to the sampling distribution derived from maximum likelihood estimation. A simulation study is provided to illustrate the coverage properties of credible intervals on cumulative incidence functions.     

Objective Bayesian Analysis of Skew‐t Distributions

Abstract. We study the Jeffreys prior and its properties for the shape parameter of univariate skew‐t distributions with linear and nonlinear Student's t skewing functions. In both cases, we show that the resulting priors for the shape parameter are symmetric around zero and proper. Moreover, we propose a Student's t approximation of the Jeffreys prior that makes an objective Bayesian analysis easy to perform. We carry out a Monte Carlo simulation study that demonstrates an overall better behaviour of the maximum a posteriori estimator compared with the maximum likelihood estimator. We also compare the frequentist coverage of the credible intervals based on the Jeffreys prior and its approximation and show that they are similar. We further discuss location‐scale models under scale mixtures of skew‐normal distributions and show some conditions for the existence of the posterior distribution and its moments. Finally, we present three numerical examples to illustrate the implications of our results on inference for skew‐t distributions.     

Calibrating the prior distribution for a normal model with conjugate prior

For a normal model with a conjugate prior, we provide an in-depth examination of the effects of the hyperparameters on the long-run frequentist properties of posterior point and interval estimates. Under an assumed sampling model for the data-generating mechanism, we examine how hyperparameter values affect the mean-squared error (MSE) of posterior means and the true coverage of credible intervals. We develop two types of hyperparameter optimality. MSE optimal hyperparameters minimize the MSE of posterior point estimates. Credible interval optimal hyperparameters result in credible intervals that have a minimum length while still retaining nominal coverage. A poor choice of hyperparameters has a worse consequence on the credible interval coverage than on the MSE of posterior point estimates. We give an example to demonstrate how our results can be used to evaluate the potential consequences of hyperparameter choices.     

Frequentist and Bayesian Interval Estimators for the Normal Mean

It is well known that a Bayesian credible interval for a parameter of interest is derived from a prior distribution that appropriately describes the prior information. However, it is less well known that there exists a frequentist approach developed by Pratt (1961 Pratt , J. W. ( 1961 ). Length of confidence intervals . J. Amer. Statist. Assoc. 56 : 549 – 657 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) that also utilizes prior information in the construction of frequentist confidence intervals. This frequentist approach produces confidence intervals that have minimum weighted average expected length, averaged according to some weight function that appropriately describes the prior information. We begin with a simple model as a starting point in comparing these two distinct procedures in interval estimation. Consider X ₁,…, X _n that are independent and identically N(μ, σ²) distributed random variables, where σ² is known, and the parameter of interest is μ. Suppose also that previous experience with similar data sets and/or specific background and expert opinion suggest that μ = 0. Our aim is to: (a) develop two types of Bayesian 1 ? α credible intervals for μ, derived from an appropriate prior cumulative distribution function F(μ) more importantly; (b) compare these Bayesian 1 ? α credible intervals for μ to the frequentist 1 ? α confidence interval for μ derived from Pratt's frequentist approach, in which the weight function corresponds to the prior cumulative distribution function F(μ). We show that the endpoints of the Bayesian 1 ? α credible intervals for μ are very different to the endpoints of the frequentist 1 ? α confidence interval for μ, when the prior information strongly suggests that μ = 0 and the data supports the uncertain prior information about μ. In addition, we assess the performance of these intervals by analyzing their coverage probability properties and expected lengths.     

Flexible objective Bayesian linear regression with applications in survival analysis

We study objective Bayesian inference for linear regression models with residual errors distributed according to the class of two-piece scale mixtures of normal distributions. These models allow for capturing departures from the usual assumption of normality of the errors in terms of heavy tails, asymmetry, and certain types of heteroscedasticity. We propose a general non-informative, scale-invariant, prior structure and provide sufficient conditions for the propriety of the posterior distribution of the model parameters, which cover cases when the response variables are censored. These results allow us to apply the proposed models in the context of survival analysis. This paper represents an extension to the Bayesian framework of the models proposed in [16]. We present a simulation study that shows good frequentist properties of the posterior credible intervals as well as point estimators associated to the proposed priors. We illustrate the performance of these models with real data in the context of survival analysis of cancer patients.     

Nonparametric Bayes estimation of gap-time distribution with recurrent event data

Nonparametric Bayes (NPB) estimation of the gap-time survivor function governing the time to occurrence of a recurrent event in the presence of censoring is considered. In our Bayesian approach, the gap-time distribution, denoted by F, has a Dirichlet process prior with parameter α. We derive NPB and nonparametric empirical Bayes (NPEB) estimators of the survivor function F?=1?F and construct point-wise credible intervals. The resulting Bayes estimator of F? extends that based on single-event right-censored data, and the PL-type estimator is a limiting case of this Bayes estimator. Through simulation studies, we demonstrate that the PL-type estimator has smaller biases but higher root-mean-squared errors (RMSEs) than those of the NPB and the NPEB estimators. Even in the case of a mis-specified prior measure parameter α, the NPB and the NPEB estimators have smaller RMSEs than the PL-type estimator, indicating robustness of the NPB and NPEB estimators. In addition, the NPB and NPEB estimators are smoother (in some sense) than the PL-type estimator.     

A prior for the variance in hierarchical models

The choice of prior distributions for the variances can be important and quite difficult in Bayesian hierarchical and variance component models. For situations where little prior information is available, a ‘nonin-formative’ type prior is usually chosen. ‘Noninformative’ priors have been discussed by many authors and used in many contexts. However, care must be taken using these prior distributions as many are improper and thus, can lead to improper posterior distributions. Additionally, in small samples, these priors can be ‘informative’. In this paper, we investigate a proper ‘vague’ prior, the uniform shrinkage prior (Strawder-man 1971; Christiansen & Morris 1997). We discuss its properties and show how posterior distributions for common hierarchical models using this prior lead to proper posterior distributions. We also illustrate the attractive frequentist properties of this prior for a normal hierarchical model including testing and estimation. To conclude, we generalize this prior to the multivariate situation of a covariance matrix.     

The behrens‐fisher problem revisited: A bayes‐frequentist synthesis

The Behrens‐Fisher problem concerns the inference for the difference between the means of two normal populations whose ratio of variances is unknown. In this situation, Fisher's fiducial interval differs markedly from the Neyman‐Pearson confidence interval. A prior proposed by Jeffreys leads to a credible interval that is equivalent to Fisher's solution but it carries a different interpretation. The authors propose an alternative prior leading to a credible interval whose asymptotic coverage probability matches the frequentist coverage probability more accurately than the interval of Jeffreys. Their simulation results indicate excellent matching even in small samples.     

A Note on Confidence Intervals for a Linear Function of Poisson Rates

We consider three interval estimators for linear functions of Poisson rates: a Wald interval, a t interval with Satterthwaite's degrees of freedom, and a Bayes interval using noninformative priors. The differences in these intervals are illustrated using data from the Crash Records Bureau of the Texas Department of Public Safety. We then investigate the relative performance of these intervals via a simulation study. This study demonstrates that the Wald interval performs poorly when expected counts are less than 5, while the interval based on the noninformative prior performs best. It also shows that the Bayes interval and the interval based on the t distribution perform comparably well for more moderate expected counts.     

Bayesian and frequentist confidence intervals via adjusted likelihoods under prior specification on the interest parameter

Suppose a prior is specified only on the interest parameter and a posterior distribution, free from nuisance parameters, is considered on the basis of the profile likelihood or an adjusted version thereof. In this setup, we derive higher order asymptotic results on the construction of confidence intervals that have approximately correct posterior as well as frequentist coverage. Apart from meeting both Bayesian and frequentist objectives under prior specification on the interest parameter alone, these results allow a comparison with their counterpart arising when the nuisance parameters are known, and hence provide additional justification for the Cox and Reid adjustment from a Bayesian-cum-frequentist perspective, with regard to neutralization of unknown nuisance parameters.