Uniqueness of permuted treatment estimator distributions in the proportional hazards model

We discuss findings regarding the permutation distributions of treatment effect estimators in the proportional hazards model. For fixed sample size n, we will prove that all uncensored and untied event times yield the same permutation distribution of treatment effect estimators in the proportional hazards model. In other words this distribution is irrelevant with respect to the actual event times. We will show several uniqueness properties under different conditions. These properties are useful for small sample permutation tests and also helpful to large sample cases.     

Inferences on partial linear models with right censored data by empirical likelihood

ABSTRACT

This article considers inference for partial linear models with right censored data. We use empirical likelihood based on the Buckley and James (1979 Buckley, J., James, I. (1979). Linear regression with censored data. Biometrika 66:429–436.[Crossref], [Web of Science ®] , [Google Scholar]) estimating equation to derive the confidence region for the regression parameter. We introduce an adjusted empirical likelihood ratio statistic for the parameter of interest and show that its limiting distribution is standard chi-square. A simulation is carried out to compare our method with the synthetic data approach in Wang and Li (2002 Wang, Q.-H., Li, G. (2002). Empirical Likelihood Semiparametric Regression Analysis under Random Censorship. J. Multivariate Anal. 83:469–486.[Crossref], [Web of Science ®] , [Google Scholar]).     

Comparison of goodness of fit tests for the cox proportional hazards model

The proportional hazards regression model of Cox(1972) is widely used in analyzing survival data. We examine several goodness of fit tests for checking the proportionality of hazards in the Cox model with two-sample censored data, and compare the performance of these tests by a simulation study. The strengths and weaknesses of the tests are pointed out. The effects of the extent of random censoring on the size and power are also examined. Results of a simulation study demonstrate that Gill and Schumacher's test is most powerful against a broad range of monotone departures from the proportional hazards assumption, but it may not perform as well fail for alternatives of nonmonotone hazard ratio. For the latter kind of alternatives, Andersen's test may detect patterns of irregular changes in hazards.     

Estimation of reliability for a multicomponent survival stress-strength model based on exponential distributions

Uniformly minimum variance unbiased estimator (UMVUE) of reliability in stress-strength model (known stress) is obtained for a multicomponent survival model based on exponential distributions for parallel system. The variance of this estimator is compared with Cramer-Rao lower bound (CRB) for the variance of unbiased estimator of reliability, and the mean square error (MSE) of maximum likelihood estimator of reliability in case of two component system.