Fundamentals of Health Risk Assessment. Use,Derivation, Validity and Limitations of Safety Indices

We investigated the way results of human health risk assessments are used, and the theory used to describe those methods, sometimes called the NAS paradigm. Contrary to a key tenet of that theory, current methods have strictly limited utility. The characterizations now considered standard, Safety Indices such as Acceptable Daily Intake, Reference Dose, and so on, usefully inform only decisions that require a choice between two policy alternatives (e.g., approve a food additive or not), decided solely on the basis of a finding of safety. Risk is characterized as the quotient of one of these Safety Indices divided by an estimate of exposure: a quotient greater than one implies that the situation may be considered safe. Such decisions are very widespread, both in the U. S. federal government and elsewhere. No current method is universal; different policies lead to different practices, for example, in California's Proposition 65, where statutory provisions specify some practices. Further, an important kind of human health risk assessment is not recognized by this theory: this kind characterizes risk as likelihood of harm, given estimates of exposure consequent to various decision choices. Likelihood estimates are necessary whenever decision makers have many possible decision choices and must weigh more than two societal values, such as in EPA's implementation of conventional air pollutants. These estimates can not be derived using current methods; different methods are needed. Our analysis suggests changes needed in both the theory and practice of human health risk assessment, and how what is done is depicted.     

A comparative study of U.S. and Iraqi students

This study uses a sample comprised of U.S. students and Iraqi students to determine if differences occur over ethical perceptions based on cultural/demographic issues. Irrespective of demographics, the results of this study indicate significant cultural differences between Iraqi students and American students with regard to selected ethical issues concerning graduate education. Specifically the differences occurred in the students' perceptions of winning is everything, selling one's soul, logic before emotion, and pander to professors. Iraqi students consistently viewed these beliefs as more necessary for success in their graduate education than did their American counterparts.     

A Further Improved Approximation Algorithm for Breakpoint Graph Decomposition

Breakpoint graph decomposition is a crucial step in all recent approximation algorithms for SORTING BY REVERSALS, which is one of the best-known algorithmic problems in computational molecular biology. Caprara and Rizzi recently improved the approximation ratio for breakpoint graph decomposition from to + 1.4348 + , for any positive . In this paper, we extend the techniques of Caprara and Rizzi and incorporate a balancing argument to further improve the approximation ratio to + 1.4193 + , for any positive . These improvements imply improved approximation results for SORTING BY REVERSALS for almost all random permutations.     

Human Interindividual Variability in Parameters Related to Health Risks

This paper reviews existing data on the variability in parameters relevant for health risk analyses. We cover both exposure-related parameters and parameters related to individual susceptibility to toxicity. The toxicity/susceptibility data base under construction is part of a longer term research effort to lay the groundwork for quantitative distributional analyses of non-cancer toxic risks. These data are broken down into a variety of parameter types that encompass different portions of the pathway from external exposure to the production of biological responses. The discrete steps in this pathway, as we now conceive them, are:Contact Rate (Breathing rates per body weight; fish consumption per body weight)Uptake or Absorption as a Fraction of Intake or Contact RateGeneral Systemic Availability Net of First Pass Elimination and Dilution via Distribution Volume (e.g., initial blood concentration per mg/kg of uptake)Systemic Elimination (half life or clearance)Active Site Concentration per Systemic Blood or Plasma ConcentrationPhysiological Parameter Change per Active Site Concentration (expressed as the dose required to make a given percentage change in different people, or the dose required to achieve some proportion of an individual's maximum response to the drug or toxicant)Functional Reserve Capacity–Change in Baseline Physiological Parameter Needed to Produce a Biological Response or Pass a Criterion of Abnormal FunctionComparison of the amounts of variability observed for the different parameter types suggests that appreciable variability is associated with the final step in the process–differences among people in functional reserve capacity. This has the implication that relevant information for estimating effective toxic susceptibility distributions may be gleaned by direct studies of the population distributions of key physiological parameters in people that are not exposed to the environmental and occupational toxicants that are thought to perturb those parameters. This is illustrated with some recent observations of the population distributions of Low Density Lipoprotein Cholesterol from the second and third National Health and Nutrition Examination Surveys.     

Efficient Heuristics for Orientation Metric and Euclidean Steiner Tree Problems

We consider Steiner minimum trees (SMT) in the plane, where only orientations with angle , 0 i – 1 and an integer, are allowed. The orientations define a metric, called the orientation metric, , in a natural way. In particular, ₂ metric is the rectilinear metric and the Euclidean metric can beregarded as metric. In this paper, we provide a method to find an optimal SMT for 3 or 4 points by analyzing the topology of SMT's in great details. Utilizing these results and based on the idea of loop detection first proposed in Chao and Hsu, IEEE Trans. CAD, vol. 13, no. 3, pp. 303–309, 1994, we further develop an O(n²) time heuristic for the general SMT problem, including the Euclidean metric. Experiments performed on publicly available benchmark data for 12 different metrics, plus the Euclidean metric, demonstrate the efficiency of our algorithms and the quality of our results.     

Leadership styles,Machiavellianism, and needs of Saudi Arabian managers

The findings indicated that the economic environment and the cultural and religious orientations of managers in Saudi Arabia significantly influenced their scores on Machiavellianism and the relationships between their needs and leadership styles. In comparison to the U.S. norms the Saudi Arabian managers were found to be lower on Machiavellianism. Need for achievement was found to be positively related to need for power and structure dimension of leadership. The findings also showed Machiavellianism to be positively related to need for power and negatively related to consideration dimension of leadership. The findings are discussed in the context of a fast-growing economy and a highly religious and a traditional society.     

Codes of conduct in Hong Kong organisations

This paper first reviews the literature on the role of codes of conduct for organisations in Hong Kong in their attempts to manage increasingly complex ethical problems and issues. It shows that, although valuable foundations exist upon which to build, research and understanding of the subject is at it's embryonic stage. Social Psychology literature is examined to investigate what lessons those concerned with the study of ethics may learn and the work of Hofstede, as seminal in the area of work-related values, is emphasised in this context.Following Hofstede's proposals for strategies for operationalizing¹ constructs about human values, a content analysis² was conducted on a pilot sample of codes provided by Hong Kong organisations. The results show three clearly identified clusters of organisations with common formats. The first group, described as Foreign Legal, emphasises legal compliance, has criteria for invoking penalties and consists of foreign-owned, large multinational organisations. Companies in the second cluster have codes which, except in the case of a couple of larger organisations, mainly follow the Independent Commission Against Corruption's (ICAC) standard format. The third cluster, described as the Bank Network, also appear to largely conform to a format: the Hong Kong Banking Association's guidelines.Further analysis conducted here of the Hong Kong codes indicates the important role of emic teleological values³, such as trust and reputation, amongst indigenous organisations, rather than the amorality suggested by an earlier study (Dolecheck and Bethke, 1990). These results support the proposition that Hong Kong ethical perspectives are culture bound⁴, as there appear to be different emphases than revealed in an American study (Stevens, 1994), which identified an emphasis in the US codes upon introverted organisational issues and a failure to espouse deontological values⁵.The conclusion is that designing a research programme on business values in Hong Kong requires reference to studies of values in cross-cultural psychology generally and to Hofstede's work in particular. It also supports the need for indigenous research and models in this field which avoid the ethnocentrism inherent in much Western theory and research.     

Are g.p.a. and ethics related?

This article reports results of a study of some 200 college-aged students at California State University. Ethical values are measured using a subset of the well-known and frequently used Rokeach Value Survey. Using nonparametric statistical analysis, four value measures, and four different consistent tests of significance and probability, the research data, perhaps disappointedly for many observers including the authors, reveal that there is no relationship between college grade point average and student ethics. Statistical analysis was done on g.p.a. splits of less than 3.0 versus 3.0 or more and also on g.p.a. data for 2.5 or less versus 3.5 or more. In all cases, there are no significant relationships between high or low grade point averages and scores on ethical value rankings.     

Examining the link between social responsibility and decision styles

The paper examines the factors that influence socially responsible decision making by individuals. The study found four social responsibility styles: Playing it Safe, Weather The Storm, Problem to Solve, and Hope it Goes Away. These styles describe individuals on the basis of decision style, propensity for risk, and coping style. The styles explain why people with different values might come to the same decision in the same circumstances.     

Ethical Futures and Public-Private Partnerships: Peering Far Down the Track

This article employs an institutional perspective in formulating predictions about the ethical futures of privatization partnerships. Although this paper focuses on ethical concerns in the U.S. public sector, it incorporates a multinational dimension in (a) comparing the meaning of privatization among societies and (b) probing privatization financing in the global economy. Five assumptions that flow from institutional reasoning are made explicit as supports for subsequent predictions. The institutional logic shifts privatization conversation away from conventional debate about competition and efficiency toward centralizing forces in both sectors in response to globalization. In that regard, this study identifies the systemic erosion of (local) community integrity as the key privatization problem of the future.     

Context in the Risk Assessment of Digital Systems

As the use of digital computers for instrumentation and control of safety-critical systems has increased, there has been a growing debate over the issue of whether probabilistic risk assessment techniques can be applied to these systems. This debate has centered on the issue of whether software failures can be modeled probabilistically. This paper describes a context-based approach to software risk assessment that explicitly recognizes the fact that the behavior of software is not probabilistic. The source of the perceived uncertainty in its behavior results from both the input to the software as well as the application and environment in which the software is operating. Failures occur as the result of encountering some context for which the software was not properly designed, as opposed to the software simply failing randomly. The paper elaborates on the concept of error-forcing context as it applies to software. It also illustrates a methodology which utilizes event trees, fault trees, and the Dynamic Flowgraph Methodology (DFM) to identify error-forcing contexts for software in the form of fault tree prime implicants.     

Politics,Public Opinion,and Privatization: A Test of Competing Theories in Great Britain

Reforms known collectively as the new public management (NPM) are sweeping governments worldwide. For a movement espousing customer-based service orientations, there is a curious paucity of research on citizens' attitudes toward these reforms. We know little about how citizens feel about them, how they arrive at their conclusions, and how durable their attitudes are likely to be. Using citizen attitudes culled from the 1987--1992 British General Election Panel Survey, we apply multiple regression analysis to begin exploring these issues in one critical area of NPM reform: privatization of state-owned enterprises. We find that the overall predictive power of the five theoretical perspectives culled from public opinion research and operationalized in our model is quite respectable, but that evaluations are too complex for any single explanation of public opinion formation to capture. We also find that British attitudes toward privatization were most associated with cue-taking from leaders and parties, ideological moorings associated with individualism, and income. From these findings we offer a set of hypotheses suitable for testing in future research—most especially, a disparate impact hypothesis—that have important implications for practice and theory-building regarding public opinion and market-based administrative reforms worldwide.     

Performance Assessments of Nuclear Waste Repositories: A Dialogue on Their Value and Limitations

Performance Assessment (PA) is the use of mathematical models to simulate the long-term behavior of engineered and geologic barriers in a nuclear waste repository; methods of uncertainty analysis are used to assess effects of parametric and conceptual uncertainties associated with the model system upon the uncertainty in outcomes of the simulation. PA is required by the U.S. Environmental Protection Agency as part of its certification process for geologic repositories for nuclear waste. This paper is a dialogue to explore the value and limitations of PA. Two skeptics acknowledge the utility of PA in organizing the scientific investigations that are necessary for confident siting and licensing of a repository; however, they maintain that the PA process, at least as it is currently implemented, is an essentially unscientific process with shortcomings that may provide results of limited use in evaluating actual effects on public health and safety. Conceptual uncertainties in a PA analysis can be so great that results can be confidently applied only over short time ranges, the antithesis of the purpose behind long-term, geologic disposal. Two proponents of PA agree that performance assessment is unscientific, but only in the sense that PA is an engineering analysis that uses existing scientific knowledge to support public policy decisions, rather than an investigation intended to increase fundamental knowledge of nature; PA has different goals and constraints than a typical scientific study. The proponents describe an ideal, six-step process for conducting generalized PA, here called probabilistic systems analysis (PSA); they note that virtually all scientific content of a PA is introduced during the model-building steps of a PSA; they contend that a PA based on simple but scientifically acceptable mathematical models can provide useful and objective input to regulatory decision makers. The value of the results of any PA must lie between these two views and will depend on the level of knowledge of the site, the degree to which models capture actual physical and chemical processes, the time over which extrapolations are made, and the proper evaluation of health risks attending implementation of the repository. The challenge is in evaluating whether the quality of the PA matches the needs of decision makers charged with protecting the health and safety of the public.     

On Shortest k-Edge-Connected Steiner Networks in Metric Spaces

Given a set of points P in a metric space, let l(P) denote the ratio of lengths between the shortest k-edge-connected Steiner network and the shortest k-edge-connected spanning network on P, and let r = inf l(P) P for k 1. In this paper, we show that in any metric space, r 3/4 for k 2, and there exists a polynomial-time -approximation for the shortest k-edge-connected Steiner network, where = 2 for even k and = 2 + 4/(3k) for odd k. In the Euclidean plane, and .     

Acccounting and Volksgeist – Teritorial Claims on Accounting Regulation

In this paper, it is argued that international diversityin the rules governing corporate accountability is afunction of the desire to preserve local jurisdictionsby maintaining national distinctiveness. Successiveattempts at regulatory harmonisation in Europe havemet considerable resistance, starting with Savignysappeal to the spirit of the people (Volksgeist)and ending with the notion of subsidiarity. In thispaper, territorial claims on regulation are exploredin the context of the rules governing asset revaluation,where there are still almost as many required methodsof accounting in the European Union as there aremember states. The paper rejects the conventionalexplanation that such differences are culture-bound,and instead suggests that the continued existence ofnational rules in accounting reflects the pursuit ofautonomy by individual states and the self-interestof national regulators.     

Nanshin: Budget-Maximizing Behavior,the Imperial Japanese Navy and the Origins of the Pacific War

Inter-service rivalry over budget allocations between the Japanese Imperial Navy and the Imperial Army played a crucial role in the genesis of World War Two in the Pacific. The adoption of a nanshin (southward advance) strategy by the Navy may be explained as an attempt to maximize its budget leading directly to the attack on Pearl Harbor in 1941. To date, this argument has been presented in the form of historical narrative without any explanatory theoretical framework. The present paper seeks to place inter-service budgetary rivalry within the context of public choice theory to enhance understanding of this historical perspective.     

Democratizing Risk Management: Successful Public Involvement in Local Water Management Decisions

This paper discusses a successful public involvement effort that addressed and resolved several highly controversial water management issues involving environmental and flood risks associated with an electrical generation facility in British Columbia. It begins with a discussion of concepts for designing public involvement, summarizing research that indicates why individuals and groups may find it difficult to make complex choices. Reasons for public involvement, and the range of current practices are discussed. Next, four principles for designing group decision process are outlined, emphasizing decision-aiding concepts that include value-focused thinking and adaptive management. The next sections discuss the Alouette River Stakeholder Committee process in terms of objectives, participation, process, methods for structuring values and creating alternatives, information sources, and results. Discussion and conclusions complete the paper.     

Approximation Algorithms for Quadratic Programming

We consider the problem of approximating the global minimum of a general quadratic program (QP) with n variables subject to m ellipsoidal constraints. For m=1, we rigorously show that an -minimizer, where error (0, 1), can be obtained in polynomial time, meaning that the number of arithmetic operations is a polynomial in n, m, and log(1/). For m 2, we present a polynomial-time (1- )-approximation algorithm as well as a semidefinite programming relaxation for this problem. In addition, we present approximation algorithms for solving QP under the box constraints and the assignment polytope constraints.     

Business student ethical values anew in the 1990s

This paper uses a Rokeach Value Survey methodology to again ask the question, now in the mid 1990s, whether business student ethics are different from non-business student ethics. Additionally, the paper addresses the question of whether a course can alter or change student ethics and values during a semester. Thirdly, this paper attempts to operationalize and empirically test and measure the new ethical concepts of moral management and moral maximization.     

On Integrality, Stability and Composition of Dicycle Packings and Covers

Given a digraph D, the minimum integral dicycle cover problem (known also as the minimum feedback arc set problem) is to find a minimum set of arcs that intersects every dicycle; the maximum integral dicycle packing problem is to find a maximum set of pairwise arc disjoint dicycles. These two problems are NP-complete.Assume D has a 2-vertex cut. We show how to derive a minimum dicycle cover (a maximum dicycle packing) for D, by composing certain covers (packings) of the corresponding pieces. The composition of the covers is simple and was partially considered in the literature before. The main contribution of this paper is to the packing problem. Let be the value of a minimum integral dicycle cover, and * () the value of a maximum (integral) dicycle packing. We show that if = then a simple composition, similar to that of the covers, is valid for the packing problem. We use these compositions to extend an O(n³) (resp., O(n⁴)) algorithm for finding a minimum integral dicycle cover (resp., packing) from planar digraphs to K_3,3-free digraphs (i.e., digraphs not containing any subdivision of K_3,3).However, if , then such a simple composition for the packing problem is not valid. We show, that if the pieces satisfy, what we call, the stability property, then a simple composition does work. We prove that if = * holds for each piece, then the stability property holds as well. Further, we use the stability property to show that if = * holds for each piece, then = * holds for D as well.