An easy method of constructing latin square designs balanced for the immediate residual and other order effects

Bradley (1958) proposed a very simple procedure for constructing latin square designs to counterbalance the immediate sequential effect for an even number of treatments. When the number of treatments is odd, balance in a single latin square is not possible. In the present note we have developed an analogous method for the construction of such designs which may be used for an even or odd number of treatments. A proof has also been offered to assure the general validity of the procedure.     

Construction of incomplete Sudoku square and partially balanced incomplete block designs

Abstract

The present article deals with the study of association among the elements of a Sudoku square. In this direction, we have defined an association scheme and constructed incomplete Sudoku square designs which are capable of studying four explanatory variables and also happen to be the designs for two-way elimination of heterogeneity. Some series of Partially Balanced Incomplete Block (PBIB) designs have also been obtained.     

Deriving a lower bound for the proportion of perceivers in replicated difference tests by means of multiple test theory

Analyzing repeated difference tests aims in significance testing for differences as well as in estimating the mean discrimination ability of the consumers. In addition to the average success probability, the proportion of consumers that may detect the difference between two products and therefore account for any increase of this probability is of interest. While some authors address the first two goals, for the latter one only an estimator directly linked to the average probability seems to be used. However, this may lead to unreasonable results. Therefore we propose a new approach based on multiple test theory. We define a suitable set of hypotheses that is closed under intersection. From this, we derive a series of hypotheses that may be sequentially tested while the overall significance level will not be violated. By means of this procedure we may determine a minimal number of assessors that must have perceived the difference between the products at least once in a while. From this, we can find a conservative lower bound for the proportion of perceivers within the consumers. In several examples, we give some insight into the properties of this new method and show that the knowledge about this lower bound might indeed be valuable for the investigator. Finally, an adaption of this approach for similarity tests will be proposed.     

Testing a block exchangeable covariance matrix

Testing hypotheses about the structure of a covariance matrix for doubly multivariate data is often considered in the literature. In this paper the Rao's score test (RST) is derived to test the block exchangeable covariance matrix or block compound symmetry (BCS) covariance structure under the assumption of multivariate normality. It is shown that the empirical distribution of the RST statistic under the null hypothesis is independent of the true values of the mean and the matrix components of a BCS structure. A significant advantage of the RST is that it can be performed for small samples, even smaller than the dimension of the data, where the likelihood ratio test (LRT) cannot be used, and it outperforms the standard LRT in a number of contexts. Simulation studies are performed for the sample size consideration, and for the estimation of the empirical quantiles of the null distribution of the test statistic. The RST procedure is illustrated on a real data set from the medical studies.     

Adaptive choice of scale tests in flexible two-stage designs with applications in experimental ecology and clinical trials

In this paper, the two-sample scale problem is addressed within the rank framework which does not require to specify the underlying continuous distribution. However, since the power of a rank test depends on the underlying distribution, it would be very useful for the researcher to have some information on it in order to use the possibly most suitable test. A two-stage adaptive design is used with adaptive tests where the data from the first stage are used to compute a selector statistic to select the test statistic for stage 2. More precisely, an adaptive scale test due to Hall and Padmanabhan and its components are considered in one-stage and several adaptive and non-adaptive two-stage procedures. A simulation study shows that the two-stage test with the adaptive choice in the second stage and with Liptak combination, when it is not more powerful than the corresponding one-stage test, shows, however, a quite similar power behavior. The test procedures are illustrated using two ecological applications and a clinical trial.     

On the bias and mean square error of the least square estimator in a regression model with two inequality constraints and multivariate t error terms

We derive and numerically evaluate the bias and mean square error of the inequality constrained least squares estimator in a model with two inequality constraints and multivariate terror terms. Our results suggest that qualitatively, the estimator properties found for models with normal errors carry over to the case of multivariate terrors.     

Optimum Designs for Estimation of Parameters in a Quadratic Mixture-Amount Model

The authors propose a mixture-amount model, which is quadratic both in the proportions of mixing components and the amount of mixture. They attempt to find the A- and D-optimal designs for the estimation of the model parameters within a subclass of designs. The optimality of the derived designs in the entire class of competing designs has been investigated through equivalence theorem.     

Evaluation of the statistical power for multiple tests: a case study

It is challenging to estimate the statistical power when a complicated testing strategy is used to adjust for the type-I error for multiple comparisons in a clinical trial. In this paper, we use the Bonferroni Inequality to estimate the lower bound of the statistical power assuming that test statistics are approximately normally distributed and the correlation structure among test statistics is unknown or only partially known. The method was applied to the design of a clinical study for sample size and statistical power estimation.     

Optimum designs for estimation of regression parameters in a balanced treatment incomplete block design set-up

The use of covariates in block designs is necessary when the experimental errors cannot be controlled using only the qualitative factors. The choice of values of the covariates for a given set-up attaining minimum variance for estimation of the regression parameters has attracted attention in recent times. In this paper, optimum covariate designs (OCD) have been considered for the set-up of the balanced treatment incomplete block (BTIB) designs, which form an important class of test-control designs. It is seen that the OCDs depend much on the methods of construction of the basic BTIB designs. The series of BTIB designs considered in this paper are mainly those as described by Bechhofer and Tamhane (1981) and Das et al. (2005). Different combinatorial arrangements and tools such as Hadamard matrices and different kinds of products of matrices viz Khatri-Rao product and Kronecker product have been conveniently used to construct OCDs with as many covariates as possible.     

An extension of the multivariate Chebyshev's inequality to a random vector with a singular covariance matrix

ABSTRACT

We extend Chebyshev's inequality to a random vector with a singular covariance matrix. Then we consider the case of a multivariate normal distribution for this generalization.     

The exact nonparametric analysis of a class of experimental designs

This article given an efficient computer algorithm for a certain nonparametric regression method based on Kendall's rank correlation statistics. The method applies to experimental designs for which the set of covariates exhibits certain orthogonality properties, and the dependent variables is continuous. Testing, point and interval estimation, and ties are discussed.     

Multiple testing using the posterior probabilities of directional alternatives,with application to genomic studies

This paper aims to connect Bayesian analysis and frequentist theory in the context of multiple comparisons. The authors show that when testing the equality of two sample means, the posterior probability of the one‐sided alternative hypothesis, defined as a half‐space, shares with the frequentist P‐value the property of uniformity under the null hypothesis. Ultimately, the posterior probability may thus be used in the same spirit as a P‐value in the Benjamini‐Hochberg procedure, or in any of its extensions.     

A discussion of the question: for what use are tests of hypotheses and tests of significance

The author believes that tests provide a poor model of most real problems, usually so poor that their objectivity is tangential and often too poor to be useful.     

Empirical bayes testing of a distribution function with d1richlet process priors

This paper considers the generalised empirical Bayes two-action (testing) and multiple action problems concerning a distribution function The Dirichiet process priors p of Ferguson have been used as the prior distributions on the space of distribution functions on the real line. The two-action component problem is considered in detail and when p is unknown partially empirical Bayes procedures {6 } which are asymptotically optimal with rates 0{jT1/2) and OCCmCn+l))     

Testing non-inferiority and superiority for two endpoints for several treatments with a control

Some multiple comparison procedures are described for multiple armed studies. The procedures are appropriate for testing all hypotheses for comparing two endpoints and multiple test arms to a single control group, for example three different fixed doses compared to a placebo. The procedure assumes that among the two endpoints, one is designated as a primary endpoint such that for a given treatment arm, no hypothesis for the secondary endpoint can be rejected unless the hypothesis for the primary endpoint was rejected. The procedures described control the family-wise error rate in the strong sense at a specified level α.     

Performance of some multiple testing procedures to compare three doses of a test drug and placebo

A study design with two or more doses of a test drug and placebo is frequently used in clinical drug development. Multiplicity issues arise when there are multiple comparisons between doses of test drug and placebo, and also when there are comparisons of doses with one another. An appropriate analysis strategy needs to be specified in advance to avoid spurious results through insufficient control of Type I error, as well as to avoid the loss of power due to excessively conservative adjustments for multiplicity. For evaluation of alternative strategies with possibly complex management of multiplicity, we compare the performance of several testing procedures through the simulated data that represent various patterns of treatment differences. The purpose is to identify which methods perform better or more robustly than the others and under what conditions. Copyright © 2005 John Wiley & Sons, Ltd.     

The use of conditional cutoffs in a forward selection procedure

Using a forward selection procedure for selecting the best subset of regression variables involves the calculation of critical values (cutoffs) for an F-ratio at each step of a multistep search process. On dropping the restrictive (unrealistic) assumptions used in previous works, the null distribution of the F-ratio depends on unknown regression parameters for the variables already included in the subset. For the case of known σ, by conditioning the F-ratio on the set of regressors included so far and also on the observed (estimated) values of their regression coefficients, we obtain a forward selection procedure whose stepwise type I error does not depend on the unknown (nuisance) parameters. A numerical example with an orthogonal design matrix illustrates the difference between conditional cutoffs, cutoffs for the centralF-distribution, and cutoffs suggested by Pope and Webster.     

On the asymptotic distribution of a class of aligned rank order test statistics in randomized block designs

In the present investigation, the unconditional asymptotic distribution of a class of aligned rank order test statistics for randomized block designs is derived under the null hypothesis and for nearby alternatives, as the number of blocks tends to infinity. The proofs of these results are based on the asymptotic equivalence in quadratic mean between aligned observations and their ranks and thus are quite similar to the Hájek and SKidák (1967) approach.     

Bayesian estimation of the dispersion matrix of a multivariate normal distribution

The estimation of the dispersion matrix of a multivariate normal distribution with zero mean on the basis of a random sample is discussed from a Bayesian view. An inverted-Wishart distribu- tion for the dispersion is taken, with its defining matrix of intraclass form. Some consistency properties are described. The posterior distribution is found and its mode investigated as a possible estimate in preference to that of maximum likelihood