Orthogonally blocked mixture component–amount designs via projections of F-squares

Orthogonal block designs for Scheffé’s quadratic model have been considered previously by Draper et al. (1993), John (1984), Lewis et al. (1994) and Prescott, Draper, Dean, and Lewis (1993). Prescott and Draper (2004) obtained mixture component–amount designs via projections of standard mixture designs, viz., the simplex-lattice, the simplex-centroid and the orthogonally blocked mixture designs based on latin squares. Aggarwal, Singh, Sarin, and Husain (2009) considered the case of components assuming equal volume fractions and obtained mixture designs in orthogonal blocks using F-squares. In this paper, we construct orthogonal blocks of two and three mixture component–amount blends by projecting the class of four component mixture designs presented by Aggarwal et al. (2009).     

Mixture designs for five components in orthogonal blocks

The methods developed by John and Draper et al. of partitioning the blends (runs) of four mixture components into two or more orthogonal blocks when fitting quadratic models are extended to mixtures of five components. The characteristics of Latin squares of side five are used to derive rules for reliably and quickly obtaining designs with specific properties. The designs also produce orthogonal blocks when higher order models are fitted.     

Orthogonally Blocked Mixture Experiments in Ellipsoidal Restricted Regions

In practical situations involving mixtures formed from several ingredients, interest is sometimes centered on the response in an ellipsoidal neighborhood around a standard formulation. We show that standard, orthogonally blocked, response surface designs, defined on a q ? 1 dimensional unit sphere, may be transformed into similarly orthogonally blocked q-ingredient mixture designs defined within an ellipsoid centered at the standard formulation. The method is illustrated using several examples of mixture experiments with three, four, and five ingredients, arranged in two, three, or four orthogonal blocks, obtained by projecting standard central composite designs and Box–Behnken designs into the ellipsoidal mixture region. Rotations of the resulting designs within the ellipsoidal regions are also considered.     

A variable selection proposal for multiple linear regression analysis

Variable selection in multiple linear regression models is considered. It is shown that for the special case of orthogonal predictor variables, an adaptive pre-test-type procedure proposed by Venter and Steel [Simultaneous selection and estimation for the some zeros family of normal models, J. Statist. Comput. Simul. 45 (1993), pp. 129–146] is almost equivalent to least angle regression, proposed by Efron et al. [Least angle regression, Ann. Stat. 32 (2004), pp. 407–499]. A new adaptive pre-test-type procedure is proposed, which extends the procedure of Venter and Steel to the general non-orthogonal case in a multiple linear regression analysis. This new procedure is based on a likelihood ratio test where the critical value is determined data-dependently. A practical illustration and results from a simulation study are presented.     

Using orthogonal array for constructing three-level search designs

We consider the problem of constructing search designs for 3^m factorial designs. By using projection properties of some three-level orthogonal arrays, some search designs are obtained for 3 ? m ? 11. The new obtained orthogonal search designs are capable of searching and identifying up to four two-factor interactions and estimating them along with the general mean and main effects. The resulted designs have very high searching probabilities; it means that besides the well-known orthogonal structure, they have high ability in searching the true effects.     

Optimal Bayesian sampling plans for exponential distributions based on hybrid censored samples

We study variable sampling plans for exponential distributions based on type-I hybrid censored samples. For this problem, two sampling plans based on the non-failure sample proportion and the conditional maximum likelihood estimator are proposed by Chen et al. [J. Chen, W. Chou, H. Wu, and H. Zhou, Designing acceptance sampling schemes for life testing with mixed censoring, Naval Res. Logist. 51 (2004), pp. 597–612] and Lin et al. [C.-T. Lin, Y.-L. Huang, and N. Balakrishnan, Exact Bayesian variable sampling plans for the exponential distribution based on type-I and type-II censored samples, Commun. Statist. Simul. Comput. 37 (2008), pp. 1101–1116], respectively. From the theoretic decision point of view, the preceding two sampling plans are not optimal due to their decision functions not being the Bayes decision functions. In this article, we consider the decision theoretic approach, and the optimal Bayesian sampling plan based on sufficient statistics is derived under a general loss function. Furthermore, for the conjugate prior distribution, the closed-form formula of the Bayes decision rule can be obtained under either the linear or quadratic decision loss. The resulting Bayesian sampling plan has the minimum Bayes risk, and hence it is better than the sampling plans proposed by Chen et al. (2004) and Lin et al. (2008). Numerical comparisons are given and demonstrate that the performance of the proposed Bayesian sampling plan is superior to that of Chen et al. (2004) and Lin et al. (2008).     

Nearly optimal orthogonally blocked desings for a quadratic mixture model with q components

In experiments with mixtures involving process variables, orthogonal block designs may be used to allow estimation of the parameters of the mixture components independently of estimation of the parameters of the process variables. In the class of orthogonally blocked designs based on pairs of suitably chosen Latin squares, the optimal designs consist primarily of binary blends of the mixture components, regardless of how many ingredients are available for the mixture. This paper considers ways of modifying these optimal designs so that some or all of the runs used in the experiment include a minimum proportion of each mixture ingredient. The designs considered are nearly optimal in the sense that the experimental points are chosen to follow ridges of maxima in the optimality criteria. Specific designs are discussed for mixtures involving three and four components and distinctions are identified for different designs with the same optimality properties. The ideas presented for these specific designs are readily extended to mixtures with q>4 components.     

General upper bound for the number of blocks having a given number of treatments common with a given block

The purpose of this paper is systematically to derive the general upper bound for the number of blocks having a given number of treatments common with a given block of certain incomplete block designs. The approach adopted here is based on the spectral decomposition of N′N for the incidence matrix N of a design, where N' is the transpose of the matrix N. This approach will lead us to upper bounds for incomplete block designs, in particular for a large number of partially balanced incomplete block (PBIB) designs, which are not covered with the standard approach (Shah 1964, 1966), Kapadia (1966)) of using well known relations between blocks of the designs and their association schemes. Several results concerning block structure of block designs are also derived from the main theorem. Finally, further generalizations of the main theorem are discussed with some illustrations.     

Experimentation order with good properties for 2 k factorial designs

Randomizing the order of experimentation in a factorial design does not always achieve the desired effect of neutralizing the influence of unknown factors. In fact, with some very reasonable assumptions, an important proportion of random orders achieve the same degree of protection as that obtained by experimenting in the design matrix standard order. In addition, randomization can induce a large number of changes in factor levels and thus make experimentation expensive and difficult. De Leon et al. [Experimentation order in factorial designs with 8 or 16 runs, J. Appl. Stat. 32 (2005), pp. 297–313] proposed experimentation orders for designs with eight or 16 runs that combine an excellent level of protection against the influence of unknown factors, with the minimum number of changes in factor levels. This article presents a new methodology to obtain experimentation orders with the desired properties for designs with any number of runs.     

On confidence regions of semiparametric nonlinear reproductive dispersion models

This article investigates the confidence regions for semiparametric nonlinear reproductive dispersion models (SNRDMs), which is an extension of nonlinear regression models. Based on local linear estimate of nonparametric component and generalized profile likelihood estimate of parameter in SNRDMs, a modified geometric framework of Bates and Wattes is proposed. Within this geometric framework, we present three kinds of improved approximate confidence regions for the parameters and parameter subsets in terms of curvatures. The work extends the previous results of Hamilton et al. [in Accounting for intrinsic nonlinearity in nonlinear regression parameter inference regions, Ann. Statist. 10, pp. 386–393, 1982], Hamilton [in Confidence regions for parameter subset in nonlinear regression, Biometrika, 73, pp. 57–64, 1986], Wei [in On confidence regions of embedded models in regular parameter families (a geometric approch), Austral. J. Statist. 36, pp. 327–338, 1994], Tang et al. [in Confidence regions in quasi-likelihood nonlinear models: a geometric approach, J. Biomath. 15, pp. 55–64, 2000b] and Zhu et al. [in On confidence regions of semiparametric nonlinear regression models, Acta. Math. Scient. 20, pp. 68–75, 2000].     

Block designs for incomplete factorial treatment structures with two factors

Abstract

In this paper, the problem of obtaining efficient block designs for incomplete factorial treatment structure with two factors excluding one treatment combination for estimation of dual versus single treatment contrasts is considered. The designs have been obtained using the A-optimal completely randomized designs and modified strongest treatment interchange algorithm. A catalog of efficient block designs has been prepared for m₁?=?3, 4 and m₂?=?2, b?≤?10 and k?≤?9 and for m₁?=?3,4 and m₂?=?3, 4, b?≤?10 and k?≤?10.     

Balanced and partially balanced incomplete block designs with autocorrelation errors

The paper aims to find variance balanced and variance partially balanced incomplete block designs when observations within blocks are autocorrelated and we call them BIBAC and PBIBAC designs. Orthogonal arrays of type I and type II when used as BIBAC designs have smaller average variance of elementary contrasts of treatment effects compared to the corresponding Balanced Incomplete Block (BIB) designs with homoscedastic, uncorrelated errors. The relative efficiency of BIB designs compared to BIBAC designs depends on the block size k and the autocorrelation ρ and is independent of the number of treatments. Further this relative efficiency increases with increasing k. Partially balanced incomplete block designs with autocorrelated errors are introduced using partially balanced incomplete block designs and orthogonal arrays of type I and type II.     

Extensions of D-optimal minimal designs for symmetric mixture models

The purpose of mixture experiments is to explore the optimum blends of mixture components, which will provide the desirable response characteristics in finished products. D-optimal minimal designs have been considered for a variety of mixture models, including Scheffé's linear, quadratic, and cubic models. Usually, these D-optimal designs are minimally supported since they have just as many design points as the number of parameters. Thus, they lack the degrees of freedom to perform the lack-of-fit (LOF) tests. Also, the majority of the design points in D-optimal minimal designs are on the boundary: vertices, edges, or faces of the design simplex. In this article, extensions of the D-optimal minimal designs are developed for a general mixture model to allow additional interior points in the design space to enable prediction of the entire response surface. Also a new strategy for adding multiple interior points for symmetric mixture models is proposed. We compare the proposed designs with Cornell (1986 Cornell, J.A. (1986). A comparison between two ten-point designs for studying three-component mixture systems. J. Qual. Technol. 18(1):1–15.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) two 10-point designs for the LOF test by simulations.     

Mixture designs with orthogonal blocks

Constructions of blocked mixture designs are considered in situations where BLUEs of the block effect contrasts are orthogonal to the BLUEs of the regression coefficients. Orthogonal arrays (OA), Balanced Arrays (BAs), incidence matrices of balanced incomplete block designs (BIBDs), and partially balanced incomplete block designs (PBIBDs) are used. Designs with equal and unequal block sizes are considered. Also both cases where the constants involved in the orthogonality conditions depend and do not depend on the factors have been taken into account. Some standard (already available) designs can be obtained as particular cases of the designs proposed here.     

Tables of Cyclic Incomplete Block Designs: r=k

Initial blocks and efficiencies are given for cyclic incomplete block designs in the range t= 10(1)60 and r=k= 3(1)10. The designs have been selected by search procedures using optimality criteria which maximize the efficiency factor.     

Mixture experiments with process variables: d-optimal orthogonal experimental designs

Blending experiments with mixture in the presence of process variables are considered. We present an experimental design for quadratic (or linear) blending. The design in two orthogonal blocks is D-optimized in the case where there are no restrictions on the blending in two orthogonal blocks is presented when there are arbitrary restrictions on the blending components. The pair of orthogonal blocks can be used with and arbitrary number of process variables. The number of design points needed when different orthogonal blocks are used is usually smaller than when a single block is repeated at the various process variables levels.     

A new unrelated question randomized response model

In this paper, we extend the work of Gjestvang and Singh [A new randomized response model, J. R. Statist. Soc. Ser. B (Methodological) 68 (2006), pp. 523–530] to propose a new unrelated question randomized response model that can be used for any sampling scheme. The interesting thing is that the estimator based on one sample is free from the use of known proportion of an unrelated character, unlike Horvitz et al. [The unrelated question randomized response model, Social Statistics Section, Proceedings of the American Statistical Association, 1967, pp. 65–72], Greenberg et al. [The unrelated question randomized response model: Theoretical framework, J. Amer. Statist. Assoc. 64 (1969), pp. 520–539] and Mangat et al. [An improved unrelated question randomized response strategy, Calcutta Statist. Assoc. Bull. 42 (1992), pp. 167–168] models. The relative efficiency of the proposed model with respect to the existing competitors has been studied.     

Alternative modeling techniques for the quantal response data in mixture experiments

Mixture experiments are commonly encountered in many fields including chemical, pharmaceutical and consumer product industries. Due to their wide applications, mixture experiments, a special study of response surface methodology, have been given greater attention in both model building and determination of designs compared with other experimental studies. In this paper, some new approaches are suggested on model building and selection for the analysis of the data in mixture experiments by using a special generalized linear models, logistic regression model, proposed by Chen et al. [7]. Generally, the special mixture models, which do not have a constant term, are highly affected by collinearity in modeling the mixture experiments. For this reason, in order to alleviate the undesired effects of collinearity in the analysis of mixture experiments with logistic regression, a new mixture model is defined with an alternative ratio variable. The deviance analysis table is given for standard mixture polynomial models defined by transformations and special mixture models used as linear predictors. The effects of components on the response in the restricted experimental region are given by using an alternative representation of Cox's direction approach. In addition, odds ratio and the confidence intervals of odds ratio are identified according to the chosen reference and control groups. To compare the suggested models, some model selection criteria, graphical odds ratio and the confidence intervals of the odds ratio are used. The advantage of the suggested approaches is illustrated on tumor incidence data set.     

A new method for estimating finite-population quantiles using auxiliary information

A computationally simple method for estimating finite-population quantiles in the presence of auxiliary information is proposed. An algorithm is also found for implementing related approaches for estimating quantiles, including that of Rao et al. (1990), obtained from inverting difference-type estimators of the distribution function. The proposed estimation procedure can be seen as a one-step iteration of the suggested algorithm and is asymptotically equivalent to the limiting estimator. In particular, the proposed method yields a simple and efficient way of approximating Rao et al.'s estimator. Simulation studies based on two real populations show that the approximation can be very satisfactory even for small to moderate samples.     

MULTI-FACTOR BALANCED BLOCK DESIGNS WITH COMPLETE ADJUSTED ORTHOGONALITY FOR ALL PAIRS OF TREATMENT FACTORS

A new series of multi-factor balanced block designs is introduced. Each of these designs has the following properties: (i) each of its k– 1 treatment factors is disposed in a cyclic or multi-cyclic balanced incomplete block design with parameters (v,b,r,k,Λ) = (a(k-l) + 1,a²(k-1) +a, ak, k, k) (a > 1); (ii) the incidence of any one of the treatment factors on any other is balanced; and (iii) after adjustment for blocks only, the relationship between any two of the treatment factors is that of adjusted orthogonality. The treatment factors are thus orthogonal to one another in the within-blocks stratum of the analysis of variance. The designs provide a benchmark with which other designs may be compared.