Block designs for incomplete factorial treatment structures with two factors

Abstract

In this paper, the problem of obtaining efficient block designs for incomplete factorial treatment structure with two factors excluding one treatment combination for estimation of dual versus single treatment contrasts is considered. The designs have been obtained using the A-optimal completely randomized designs and modified strongest treatment interchange algorithm. A catalog of efficient block designs has been prepared for m₁?=?3, 4 and m₂?=?2, b?≤?10 and k?≤?9 and for m₁?=?3,4 and m₂?=?3, 4, b?≤?10 and k?≤?10.     

Likelihood ratio inference for mean residual life

One of the basic parameters in survival analysis is the mean residual life M ₀. For right censored observation, the usual empirical likelihood based log-likelihood ratio leads to a scaled c₁²{\chi_1^2} limit distribution and estimating the scaled parameter leads to lower coverage of the corresponding confidence interval. To solve the problem, we present a log-likelihood ratio l(M ₀) by methods of Murphy and van der Vaart (Ann Stat 1471–1509, 1997). The limit distribution of l(M ₀) is the standard c₁²{\chi_1^2} distribution. Based on the limit distribution of l(M ₀), the corresponding confidence interval of M ₀ is constructed. Since the proof of the limit distribution does not offer a computational method for the maximization of the log-likelihood ratio, an EM algorithm is proposed. Simulation studies support the theoretical result.     

Nonparametric Estimation of a Regression Function: Limiting Distribution2

Consider the regression model Y_i= g(x_i) + e_i, i = 1,…, n, where g is an unknown function defined on [0, 1], 0 = x₀ < x₁ < … < x_n≤ 1 are chosen so that max_1≤i≤n(x_i-x_{i- 1}) = 0(n^-1), and where {e_i} are i.i.d. with Ee₁= 0 and Var e₁ - s?². In a previous paper, Cheng & Lin (1979) study three estimators of g, namely, g_1n of Cheng & Lin (1979), g_2n of Clark (1977), and g_3n of Priestley & Chao (1972). Consistency results are established and rates of strong uniform convergence are obtained. In the current investigation the limiting distribution of &_in, i = 1, 2, 3, and that of the isotonic estimator g**_n are considered.     

Block Designs Robust Against the Presence of an Aberration in a Treatment-Control Setup

The author considers the problem of finding designs insensitive to the presence of an outlier in a treatment-control block design setup for estimating the set of elementary contrasts between the effects of each test treatment and a control treatment. The criterion of robustness suggested by Mandal (1989 Mandal , N. K. ( 1989 ). On robust designs . Cal. Stat. Assoc. Bull. 38 : 115 – 119 . [Google Scholar]) in block design setup for estimating a full set of orthonormal treatment contrasts is adapted. A new class viz. partially balanced treatment incomplete block designs (PBTIBD) is introduced and it is shown that balanced treatment incomplete block designs (BTIBD) and PBTIB designs, under certain conditions, are robust in the previous sense. Such designs are important in the sense that the inference on the treatment contrasts under consideration remain unaffected by the presence of an outlier.     

Estimation bayesienne des effets dans le modele a effets aleatoires de classification double avec interaction

The problem of estimating the effects in a balanced two-way classification with interaction \documentclass{article}\pagestyle{empty}\begin{document}$i = 1, \ldots ,I;j = 1, \ldots ,J;k = 1, \ldots ,K$\end{document} using a random effect model is considered from a Bayesian view point. Posterior distributions of r_i, c_j and t_ij are obtained under the assumptions that r_i, c_j, t_ij and e_ijk are all independently drawn from normal distributions with zero meansand variances \documentclass{article}\pagestyle{empty}\begin{document}$\sigma _r^2 ,\sigma _c^2 ,\sigma _t^2 ,\sigma _e^2$\end{document} respectively. A non informative reference prior is adopted for \documentclass{article}\pagestyle{empty}\begin{document}$\mu ,\sigma _r^2 ,\sigma _c^2 ,\sigma _t^2 ,\sigma _e^2$\end{document}. Various features of thisposterior distribution are obtained. The same features of the psoterior distribution for a fixed effect model are also obtained. A numerical example is given.     

Asymptotic Distributions of Unit-Root Tests When the Process Is Nearly Stationary

Several test criteria are available for testing the hypothesis that the autoregressive polynomial of an autoregressive moving average process has a single unit root. Schwert (1989), using a Monte Carlo study, investigated the performance of some of the available test criteria. He concluded that the actual levels of the test criteria considered in his study are far from the specified levels when the moving average polynomial also has a root close to 1. This article studies the asymptotic null distribution of the test statistics for testing p = 1 in the model Y_t = pY _t-1 + e _t – 0e _t-1 as 0 approaches 1. It is shown that the test statistics differ from one another in their asymptotic properties depending on the rate at which 0 converges to 1.     

On a problem of counting by weighing

Suppose it is desired to obtain a large number N_s of items for which individual counting is impractical, but one can demand a batch to weigh at least w units so that the number of items N in the batch may be close to the desired number N_s. If the items have mean weight ωTH, it is reasonable to have w equal to ωTHN_s when ωTH is known. When ωTH is unknown, one can take a sample of size n, not bigger than N_s, estimate ωTH by a good estimator ω_n, and set w equal to ω_nN_s. Let R_n = Kp²N²_s/n + K_sn be a measure of loss, where K_e and K_s are the coefficients representing the cost of the error in estimation and the cost of the sampling respectively, and p is the coefficient of variation for the weight of the items. If one determines the sample size to be the integer closest to pCN_s when p is known, where C is (K_e/K_s)^1/2, then R_n will be minimized. If p is unknown, a simple sequential procedure is proposed for which the average sample number is shown to be asymptotically equal to the optimal fixed sample size. When the weights are assumed to have a gamma distribution given ω and ω has a prior inverted gamma distribution, the optimal sample size can be found to be the nonnegative integer closest to pCN_s + p²A(pC – 1), where A is a known constant given in the prior distribution.     

Comparing more than one treatment to more than one control in incomplete blocks

The class of balanced treatment incomplete block designs is generalized to allow for comparison of v₁ test treatments and v₂ control treatments. The generalized class is equivalent to the class of balanced bipartite block designs considered by Jaggi, Gupta, and Parsad. Some results on design construction and A-optimality are given for small values of v₁ and v₂. Algorithms are developed for computing simultaneous confidence bounds for all test treatment versus control contrasts.     

Comparing several exponential populations with more than one control

Suppose there are k ₁ (k ₁ ≥ 1) test treatments that we wish to compare with k ₂ (k ₂ ≥ 1) control treatments. Assume that the observations from the ith test treatment and the jth control treatment follow a two-parameter exponential distribution and , where θ is a common scale parameter and and are the location parameters of the ith test and the jth control treatment, respectively, i = 1, . . . ,k ₁; j = 1, . . . ,k ₂. In this paper, simultaneous one-sided and two-sided confidence intervals are proposed for all k ₁ k ₂ differences between the test treatment location and control treatment location parameters, namely , and the required critical points are provided. Discussions of multiple comparisons of all test treatments with the best control treatment and an optimal sample size allocation are given. Finally, it is shown that the critical points obtained can be used to construct simultaneous confidence intervals for Pareto distribution location parameters.     

A Bayesian non‐inferiority test for two independent binomial proportions

In drug development, non‐inferiority tests are often employed to determine the difference between two independent binomial proportions. Many test statistics for non‐inferiority are based on the frequentist framework. However, research on non‐inferiority in the Bayesian framework is limited. In this paper, we suggest a new Bayesian index τ = P(π₁ > π₂ ? Δ₀ | X₁,X₂), where X₁ and X₂ denote binomial random variables for trials n₁ and n₂, and parameters π₁ and π₂, respectively, and the non‐inferiority margin is Δ₀ > 0. We show two calculation methods for τ, an approximate method that uses normal approximation and an exact method that uses an exact posterior PDF. We compare the approximate probability with the exact probability for τ. Finally, we present the results of actual clinical trials to show the utility of index τ. Copyright © 2013 John Wiley & Sons, Ltd.     

Dimension reduction boosting

L₂Boosting is an effective method for constructing model. In the case of high-dimensional setting, Bühlmann and Yu (2003 Bühlmann, P., Yu, B. (2003). Boosting with the L₂-loss: regression and classification. J. Amer. Stat. Assoc. 98:324–339.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) proposed the componentwise L₂Boosting, but componentwise L₂Boosting can only fit a special limited model. In this paper, by combining a boosting and sufficient dimension reduction method, e.g., sliced inverse regression (SIR), we propose a new method for regression, called dimension reduction boosting (DRBoosting). Compared with L₂Boosting, the computation of DRBoosting is less intensive and its prediction is better, especially for high-dimensional data. Simulations confirm the advantage of the new method.     

Asymptotic Inferences for an AR(1) Model with a Change Point and Possibly Infinite Variance

The basic model in this paper is an AR(1) model with a structural break in the AR parameter β at an unknown time k₀. That is, y_t = β₁y_{t ? 1}I{t ? k₀} + β₂y_{t ? 1}I{t > k₀} + ?_t, t = 1, 2, ???, T, where I{ · } denotes the indicator function. Suppose |β₁| < 1, |β₂| < 1, and {?_t, t ? 1} is a sequence of i.i.d. random variables which are in the domain of attraction of the normal law with zero mean and possibly infinite variance, then the limiting distributions for the least squares estimators of β₁ and β₂ are studied in the present paper, which extend some results in Chong (2001 Chong, T.L. (2001). Structural change in AR(1) models. Econometric Theory 17:87–155.[Crossref], [Web of Science ®] , [Google Scholar]).     

Berry–Esseen type bounds in heteroscedastic errors-in-variables model

ABSTRACT

Consider the heteroscedastic partially linear errors-in-variables (EV) model y_i = x_iβ + g(t_i) + ε_i, ξ_i = x_i + μ_i (1 ? i ? n), where ε_i = σ_ie_i are random errors with mean zero, σ²_i = f(u_i), (x_i, t_i, u_i) are non random design points, x_i are observed with measurement errors μ_i. When f( · ) is known, we derive the Berry–Esseen type bounds for estimators of β and g( · ) under {e_i,?1 ? i ? n} is a sequence of stationary α-mixing random variables, when f( · ) is unknown, the Berry–Esseen type bounds for estimators of β, g( · ), and f( · ) are discussed under independent errors.     

Asymptotic Properties of Quasi-Maximum Likelihood Estimates in Generalized Linear Models

This article introduces a novel method, named JC ₁, for obtaining G-efficient mixture design to fit quadratic models. The advantage of JC ₁ method over existing algorithms is that it gives G-efficient designs without need of generating all the extreme vertices, edge centroids and constraint plane centroids of the mixture experimental region. The performance of the new method is illustrated and its comparison is given with popularly used algorithms—Snee (1975) algorithm and Welch (1985 Welch , W. J. ( 1985 ). ACED: Algorithms for the construction of experimental designs . Amer. Statistician 39 : 146 .[Crossref] , [Google Scholar]) ACED algorithm for second-order (quadratic model) designs and it is observed that JC ₁ method performs as well as the existing methods or sometimes better than those with additional advantage of large savings in computational efforts.