Influence Diagnostics of Semiparametric Nonlinear Reproductive Dispersion Models

This article proposes a semiparametric nonlinear reproductive dispersion model (SNRDM) which is an extension of nonlinear reproductive dispersion model and semiparametric regression model. Maximum penalized likelihood estimators (MPLEs) of unknown parameters and nonparametric functions in SNRDMs are presented. Some novel diagnostic statistics such as Cook distance and difference deviance for parametric and nonparametric parts are developed to identify influence observations in SNRDMs on the basis of case-deletion method, and some formulae readily computed with the MPLEs algorithm for diagnostic measures are given. The equivalency of case-deletion models and mean-shift outlier models in SNRDM is investigated. A simulation study and a real example are used to illustrate the proposed diagnostic measures.     

Bayesian Analysis of Nonlinear Reproductive Dispersion Mixed Models for Longitudinal Data with Nonignorable Missing Covariates

This article proposes a Bayesian approach, which can simultaneously obtain the Bayesian estimates of unknown parameters and random effects, to analyze nonlinear reproductive dispersion mixed models (NRDMMs) for longitudinal data with nonignorable missing covariates and responses. The logistic regression model is employed to model the missing data mechanisms for missing covariates and responses. A hybrid sampling procedure combining the Gibber sampler and the Metropolis-Hastings algorithm is presented to draw observations from the conditional distributions. Because missing data mechanism is not testable, we develop the logarithm of the pseudo-marginal likelihood, deviance information criterion, the Bayes factor, and the pseudo-Bayes factor to compare several competing missing data mechanism models in the current considered NRDMMs with nonignorable missing covaraites and responses. Three simulation studies and a real example taken from the paediatric AIDS clinical trial group ACTG are used to illustrate the proposed methodologies. Empirical results show that our proposed methods are effective in selecting missing data mechanism models.     

Detection of influential observations in nonlinear reproductive dispersion models

A robust case-deletion diagnostic which could avoid masking is presented for nonlinear reproductive dispersion models (NRDM) (Jorgensen, 1997) that include generalized linear models and exponential family nonlinear models as special cases. Based on the second-order approximation of log-likelihood displacement and Poon & Poon's (1999) conformal normal curvature, a measure of local influence ranging from 0 to 1 is constructed. An example illustrates application of the techniques.     

Maximum-likelihood estimation and influence analysis in multivariate skew-normal reproductive dispersion mixed models for longitudinal data

Various mixed models were developed to capture the features of between- and within-individual variation for longitudinal data under the normality assumption of the random effect and the within-individual random error. However, the normality assumption may be violated in some applications. To this end, this article assumes that the random effect follows a skew-normal distribution and the within-individual error is distributed as a reproductive dispersion model. An expectation conditional maximization (ECME) algorithm together with the Metropolis-Hastings (MH) algorithm within the Gibbs sampler is presented to simultaneously obtain estimates of parameters and random effects. Several diagnostic measures are developed to identify the potentially influential cases and assess the effect of minor perturbation to model assumptions via the case-deletion method and local influence analysis. To reduce the computational burden, we derive the first-order approximations to case-deletion diagnostics. Several simulation studies and a real data example are presented to illustrate the newly developed methodologies.     

Assessing case influence on confidence intervals in nonlinear regression

Diagnostic techniques are proposed for assessing the influence of individual cases on confidence intervals in nonlinear regression. The technique proposed uses the method of profile t-plots applied to the case-deletion model. The effect of the geometry of the statistical model on the influence measures is assessed, and an algorithm for computing case-deleted confidence intervals is described. This algorithm provides a direct method for constructing a simple diagnostic measure based on the ratio of the lengths of confidence intervals. The generalization of these methods to multiresponse models is discussed.     

Diagnostics for generalized Poisson regression models with errors in variables

In this paper, we develop diagnostic methods for generalized Poisson regression (GPR) models with errors in variables based on the corrected likelihood. The one-step approximations of the estimates in the case-deletion model are given and case-deletion and local influence measures are presented. Meanwhile, based on a corrected score function, the testing statistics for the significance of dispersion parameters in GPR models with measurement errors are investigated. Finally, illustration of our methodology is given through numerical examples.     

Estimation and diagnostics for heteroscedastic nonlinear regression models based on scale mixtures of skew-normal distributions

An extension of some standard likelihood based procedures to heteroscedastic nonlinear regression models under scale mixtures of skew-normal (SMSN) distributions is developed. This novel class of models provides a useful generalization of the heteroscedastic symmetrical nonlinear regression models (Cysneiros et al., 2010), since the random term distributions cover both symmetric as well as asymmetric and heavy-tailed distributions such as skew-t, skew-slash, skew-contaminated normal, among others. A simple EM-type algorithm for iteratively computing maximum likelihood estimates of the parameters is presented and the observed information matrix is derived analytically. In order to examine the performance of the proposed methods, some simulation studies are presented to show the robust aspect of this flexible class against outlying and influential observations and that the maximum likelihood estimates based on the EM-type algorithm do provide good asymptotic properties. Furthermore, local influence measures and the one-step approximations of the estimates in the case-deletion model are obtained. Finally, an illustration of the methodology is given considering a data set previously analyzed under the homoscedastic skew-t nonlinear regression model.     

Diagnostics for quasi-likelihood nonlinear models

Quasi-likelihood nonlinear models (QLNMs) are an extension of generalized linear model and include a widen class of models as special cases. This article investigates some diagnostic methods in QLNMs. An equivalency between a case-deletion model and a mean-shift outlier model in QLNM is established. Two simulation study and a real dataset are used to illustrate the proposed diagnostic methods.     

Influence analysis of additive mixed-effects nonlinear regression models via EM algorithm

This paper presents a unified method for influence analysis to deal with random effects appeared in additive nonlinear regression models for repeated measurement data. The basic idea is to apply the Q-function, the conditional expectation of the complete-data log-likelihood function obtained from EM algorithm, instead of the observed-data log-likelihood function as used in standard influence analysis. Diagnostic measures are derived based on the case-deletion approach and the local influence approach. Two real examples and a simulation study are examined to illustrate our methodology.     

Influence Diagnostics for a Skew Extension of the Grubbs Measurement Error Model

Influence diagnostics methods are extended in this article to the Grubbs model when the unknown quantity x (latent variable) follows a skew-normal distribution. Diagnostic measures are derived from the case-deletion approach and the local influence approach under several perturbation schemes. The observed information matrix to the postulated model and Delta matrices to the corresponding perturbed models are derived. Results obtained for one real data set are reported, illustrating the usefulness of the proposed methodology.     

Influence on tests with focus on linear models

To assess the influence of single observations on the parameter estimates, case-deletion diagnostics are commonly used in linear regression models; one example is Cook's distance. For nested parametric models we consider a deletion diagnostic for evaluating the influence of a single observation on the likelihood ratio (LR) test. In order to have a common scale as reference, the asymptotic distribution of the diagnostic is derived and the values of the diagnostic are converted to percentiles. We focus on linear models and general linear models, and in these cases explicit results are derived. The performance of the diagnostic is explored in two small bench mark examples from linear regression and in a larger linear mixed model example.     

LOCAL INFLUENCE IN NONLINEAR REPRODUCTIVE DISPERSION MODELS

Nonlinear reproductive dispersion models (NRDM, Jorgensen 1997) include a wider range of distributions and nonlinear models such as the possibility of correlated errors and nonlinear hypotheses dropping the exponential family assumption. Based on the generalized Cook distance and the conformal normal curvature of Poon & Poon (1999), local influence of minor perturbations on the data set is investigated for NRDM. Two examples are used to illustrate our results.     

Statistical diagnostics for nonlinear regression models based on scale mixtures of skew-normal distributions

The purpose of this paper is to develop diagnostics analysis for nonlinear regression models (NLMs) under scale mixtures of skew-normal (SMSN) distributions introduced by Garay et al. [Nonlinear regression models based on SMSN distributions. J. Korean Statist. Soc. 2011;40:115–124]. This novel class of models provides a useful generalization of the symmetrical NLM [Vanegas LH, Cysneiros FJA. Assessment of diagnostic procedures in symmetrical nonlinear regression models. Comput. Statist. Data Anal. 2010;54:1002–1016] since the random terms distributions cover both symmetric as well as asymmetric and heavy-tailed distributions such as the skew-t, skew-slash, skew-contaminated normal distributions, among others. Motivated by the results given in Garay et al. [Nonlinear regression models based on SMSN distributions. J. Korean Statist. Soc. 2011;40:115–124], we presented a score test for testing the homogeneity of the scale parameter and its properties are investigated through Monte Carlo simulations studies. Furthermore, local influence measures and the one-step approximations of the estimates in the case-deletion model are obtained. The newly developed procedures are illustrated considering a real data set.     

Local influence of nonlinear mixed effects model based on M-estimation

Abstract

In this work we mainly study the local influence in nonlinear mixed effects model with M-estimation. A robust method to obtain maximum likelihood estimates for parameters is presented, and the local influence of nonlinear mixed models based on robust estimation (M-estimation) by use of the curvature method is systematically discussed. The counting formulas of curvature for case weights perturbation, response variable perturbation and random error covariance perturbation are derived. Simulation studies are carried to access performance of the methods we proposed. We illustrate the diagnostics by an example presented in Davidian and Giltinan, which was analyzed under the non-robust situation.     

Influence diagnostics for Student-t censored linear regression models

In this paper, we extend the censored linear regression model with normal errors to Student-t errors. A simple EM-type algorithm for iteratively computing maximum-likelihood estimates of the parameters is presented. To examine the performance of the proposed model, case-deletion and local influence techniques are developed to show its robust aspect against outlying and influential observations. This is done by the analysis of the sensitivity of the EM estimates under some usual perturbation schemes in the model or data and by inspecting some proposed diagnostic graphics. The efficacy of the method is verified through the analysis of simulated data sets and modelling a real data set first analysed under normal errors. The proposed algorithm and methods are implemented in the R package CensRegMod.     

A semiparametric Bayesian approach to simplex regression model with heterogeneous dispersion

ABSTRACT

Simplex regression model is often employed to analyze continuous proportion data in many studies. In this paper, we extend the assumption of a constant dispersion parameter (homogeneity) to varying dispersion parameter (heterogeneity) in Simplex regression model, and present the B-spline to approximate the smoothing unknown function within the Bayesian framework. A hybrid algorithm combining the block Gibbs sampler and the Metropolis-Hastings algorithm is presented for sampling observations from the posterior distribution. The procedures for computing model comparison criteria such as conditional predictive ordinate statistic, deviance information criterion, and averaged mean squared error are presented. Also, we develop a computationally feasible Bayesian case-deletion influence measure based on the Kullback-Leibler divergence. Several simulation studies and a real example are employed to illustrate the proposed methodologies.     

INFLUENTIAL OBSERVATION IDENTIFICATION IN THE GROWTH CURVE MODEL WITH RAO'S SIMPLE COVARIANCE STRUCTURE

ABSTRACT

In this paper we discuss the identification of influential observations in a growth curve model with Rao's simple covariance structure. Based on the generalized Cook-type distance and the volume of a confidence ellipsoid, a variety of influence measures are proposed in terms of the case-deletion technique. Also, the influence of observations on a linear combination of regression coefficients is considered. For illustration, a practical example is analyzed using the proposed approach.     

Diagnostic Measures for Generalized Linear Models with Missing Covariates

Abstract.  In this paper, we carry out an in-depth investigation of diagnostic measures for assessing the influence of observations and model misspecification in the presence of missing covariate data for generalized linear models. Our diagnostic measures include case-deletion measures and conditional residuals. We use the conditional residuals to construct goodness-of-fit statistics for testing possible misspecifications in model assumptions, including the sampling distribution. We develop specific strategies for incorporating missing data into goodness-of-fit statistics in order to increase the power of detecting model misspecification. A resampling method is proposed to approximate the p -value of the goodness-of-fit statistics. Simulation studies are conducted to evaluate our methods and a real data set is analysed to illustrate the use of our various diagnostic measures.     

Bayesian semiparametric reproductive dispersion mixed models for non-normal longitudinal data: estimation and case influence analysis

Semiparametric reproductive dispersion mixed model (SPRDMM) is a natural extension of the reproductive dispersion model and the semiparametric mixed model. In this paper, we relax the normality assumption of random effects in SPRDMM and use a truncated and centred Dirichlet process prior to specify random effects, and present the Bayesian P-spline to approximate the smoothing unknown function. A hybrid algorithm combining the block Gibbs sampler and the Metropolis–Hastings algorithm is implemented to sample observations from the posterior distribution. Also, we develop Bayesian case deletion influence measure for SPRDMM based on the φ-divergence and present those computationally feasible formulas. Several simulation studies and a real example are presented to illustrate the proposed methodologies.     

CASE-DELETION DIAGNOSTICS FOR TEST STATISTICS IN MULTIVARIATE REGRESSION

Influence measures in multivariate regression analysis have been widely developed, especially through use of the case-deletion approach. However, there seem to be few accounts of the influence of observations on test statistics in hypothesis testing. This paper examines four common multivariate tests, namely the Wilks' ratio, Lawley-Hotelling trace, Pillai's trace and Roy's greatest root for testing a general linear hypothesis of the regression coefficients in multivariate regression. The influence of observations is measured using the case-deletion approach. The proposed diagnostic measures, except that of Roy's greatest root, can be expressed in terms of statistics without involving the actual deletion of observations. An illustrative example is given with satisfactory results.