Construction of optimal designs in random coefficient regression models

We consider the problem of optimal experimental design in random coefficient regression models with respect to a quadratic loss function. By application of WHITTLE'S general equivalence theorem we obtain the structure of optimal designs. An alogrithm is given which allows, under certain assumptions, the construction of the information matrix of an optimal design. Moreover, we give conditions on the equivalence of optimal designs with respect to optimality criteria which are analogous to usual A-D- and _E/-optimality.     

Universal optimality of experimental designs: Definitions and a criterion

Several definitions of universal optimality of experimental designs are found in the Literature; we discuss the interrelations of these definitions using a recent characterization due to Friedland of convex functions of matrices. An easily checked criterion is given for a design to satisfy the main definition of universal optimality; this criterion says that a certain set of linear functions of the eigenvalues of the information matrix is maximized by the information matrix of a design if and only if that design is universally optimal. Examples are given; in particular we show that any universally optimal design is (M, S)-optimal in the sense of K. Shah.     

Robust designs for experiments with blocks

ABSTRACT

For experiments running in field plots or over time, the observations are often correlated due to spatial or serial correlation, which leads to correlated errors in a linear model analyzing the treatment means. Without knowing the exact correlation matrix of the errors, it is not possible to compute the generalized least-squares estimator for the treatment means and use it to construct optimal designs for the experiments. In this paper, we propose to use neighborhoods to model the covariance matrix of the errors, and apply a modified generalized least-squares estimator to construct robust designs for experiments with blocks. A minimax design criterion is investigated, and a simulated annealing algorithm is developed to find robust designs. We have derived several theoretical results, and representative examples are presented.     

On the analysis of unbalanced two-level supersaturated designs via generalized linear models

Supersaturated designs (SSDs) are factorial designs in which the number of experimental runs is smaller than the number of parameters to be estimated in the model. While most of the literature on SSDs has focused on balanced designs, the construction and analysis of unbalanced designs has not been developed to a great extent. Recent studies discuss the possible advantages of relaxing the balance requirement in construction or data analysis of SSDs, and that unbalanced designs compare favorably to balanced designs for several optimality criteria and for the way in which the data are analyzed. Moreover, the effect analysis framework of unbalanced SSDs until now is restricted to the central assumption that experimental data come from a linear model. In this article, we consider unbalanced SSDs for data analysis under the assumption of generalized linear models (GLMs), revealing that unbalanced SSDs perform well despite the unbalance property. The examination of Type I and Type II error rates through an extensive simulation study indicates that the proposed method works satisfactorily.     

Simple constructions for minimal neighbor and GN2 designs in linear blocks

Minimal neighbor designs and GN₂ designs in linear blocks are constructed for all admissible parameter sets. The method is straightforward and uses subsequences of the LWW terrace as initial blocks from which the remaining blocks are generated.     

Admissibility of Linear Predictors in the Superpopulation Model with Respect to Inequality Constraints under Matrix Loss Function

Admissibility of linear predictors for the linear quantity Qy is investigated in a superpopulation model with respect to some inequality constraints. Necessary and sufficient conditions for a linear predictor to be admissible in the class of homogeneous linear predictors and the class of inhomogeneous linear predictors are obtained, respectively, under matrix loss function.     

Interblock information in multidimensional block designs

In many experimental situations, d-way heterogeneity among experimental units may be controlled through use of multiple blocking criteria. In some cases it is reasonable to regard some or all of the block effects as random. Then the model is mixed and observations within blocks are correlated. Very general estimators of treatment effects and their dispersion matrix with recovery of interblock information are provided. They apply to designs with d > 1 blocking criteria that may be crossed, nested, or a combination thereof. These general results may be specialized to provide analyses of new classes of MBD's or used directly for numerical analyses of designs in the general class, perhaps through use as the basis for very general computer programs. Estimation of variance components is discussed, and an example is provided to illustrate adaptation of the general results.     

Balanced treatment incomplete block designs through integer programming

An algorithm is presented to construct balanced treatment incomplete block (BTIB) designs using a linear integer programming approach. Construction of BTIB designs using the proposed approach is illustrated with an example. A list of efficient BTIB designs for 2 ? v ? 12, v + 1 ? b ? 50, 2 ? k ? min(10, v), r ? 10, r₀ ? 20 is provided. The proposed algorithm is implemented as part of an R package.     

C472. The expected value of a conditional variance: An upper bound

The article derives Bartlett corrections for improving the chi-square approximation to the likelihood ratio statistics in a class of symmetric nonlinear regression models. This is a wide class of models which encompasses the t model and several other symmetric distributions with longer-than normal tails. In this paper we present, in matrix notation, Bartlett corrections to likelihood ratio statistics in nonlinear regression models with errors that follow a symmetric distribution. We generalize the results obtained by Ferrari, S. L. P. and Arellano-Valle, R. B. (1996). Modified likelihood ratio and score tests in linear regression models using the t distribution. Braz. J. Prob. Statist., 10, 15–33, who considered a t distribution for the errors, and by Ferrari, S. L. P. and Uribe-Opazo, M. A. (2001). Corrected likelihood ratio tests in a class of symmetric linear regression models. Braz. J. Prob. Statist., 15, 49–67, who considered a symmetric linear regression model. The formulae derived are simple enough to be used analytically to obtain several Bartlett corrections in a variety of important models. We also present simulation results comparing the sizes and powers of the usual likelihood ratio tests and their Bartlett corrected versions.     

Optimal designs for estimating a choice hierarchy by a general nested multinomial logit model

Abstract

In choice experiments the process of decision-making can be more complex than the proposed by the Multinomial Logit Model (MNL). In these scenarios, models such as the Nested Multinomial Logit Model (NMNL) are often employed to model a more complex decision-making. Understanding the decision-making process is important in some fields such as marketing. Achieving a precise estimation of the models is crucial to the understanding of this process. To do this, optimal experimental designs are required. To construct an optimal design, information matrix is key. A previous research by others has developed the expression for the information matrix of the two-level NMNL model with two nests: Alternatives nest (J alternatives) and No-Choice nest (1 alternative). In this paper, we developed the likelihood function for a two-stage NMNL model for M nests and we present the expression for the information matrix for 2 nests with any amount of alternatives in them. We also show alternative D-optimal designs for No-Choice scenarios with similar relative efficiency but with less complex alternatives which can help to obtain more reliable answers and one application of these designs.     

Bayesian A- and D-optimal designs for gamma regression model with inverse link function

Bayesian optimal designs have received increasing attention in recent years, especially in biomedical and clinical trials. Bayesian design procedures can utilize the available prior information of the unknown parameters so that a better design can be achieved. With this in mind, this article considers the Bayesian A- and D-optimal designs of the two- and three-parameter Gamma regression model. In this regard, we first obtain the Fisher information matrix of the proposed model and then calculate the Bayesian A- and D-optimal designs assuming various prior distributions such as normal, half-normal, gamma, and uniform distribution for the unknown parameters. All of the numerical calculations are handled in R software. The results of this article are useful in medical and industrial researches.     

Optimizing the test power for a radiation retention model in the human body

The model that describes the retention in lungs of radioisotope particles is studied in this paper, considering the situation of an accident in facilities that handle radioactive materials. Optimal times to make the bioassays are computed for D‐ and c‐optimality, and efficiencies for the computed designs are provided and compared. Moreover, the test power is checked by means of simulations and replications. After that the inverse of the Fisher information matrix is compared to an estimation of the covariance matrix of the parameters. Finally, a study taking into consideration the randomness of the designs space is performed. Copyright © 2009 John Wiley & Sons, Ltd.     

Optimum Designs for Parameter Estimation in Linear Mixture Models with Synergistic Effects

In this article, we derive optimum designs for parameter estimation in a mixture experiment when the response function is linear in the mixing components with some synergistic effects. The D- and A-optimality criteria have been used for the purpose. The Equivalence Theorem has been used to check for the optimality of the proposed designs.     

Designs for approximately linear regression: Maximizing the minimum coverage probability of confidence ellipsoids

The classical D-optimality principle in regression design may be motivated by a desire to maximize the coverage probability of a fixed-volume confidence ellipsoid on the regression parameters. When the fitted model is exactly correct, this amounts to minimizing the determinant of the covariance matrix of the estimators. We consider an analogue of this problem, under the approximately linear model E[y|x] = θ^Tz(x) + f(x). The nonlinear disturbance f(x) is essentially unknown, and the experimenter fits only to the linear part of the response. The resulting bias affects the coverage probability of the confidence ellipsoid on θ. We study the construction of designs which maximize the minimum coverage probability as f varies over a certain class. Explicit designs are given in the case that the fitted response surface is a plane.     

Feasible robust estimator in restricted semiparametric regression models based on the LTS approach

Under some nonstochastic linear restrictions based on either additional information or prior knowledge in a semiparametric regression model, a family of feasible generalized robust estimators for the regression parameter is proposed. The least trimmed squares (LTS) method proposed by Rousseeuw as a highly robust regression estimator is a statistical technique for fitting a regression model based on the subset of h observations (out of n) whose least-square fit possesses the smallest sum of squared residuals. The coverage h may be set between n/2 and n. The LTS estimator involves computing the hyperplane that minimizes the sum of the smallest h squared residuals. For practical purpose, it is assumed that the covariance matrix of the error term is unknown and thus feasible estimators are replaced. Then, we develop an algorithm for the LTS estimator based on feasible methods. Through the Monte Carlo simulation studies and a real data example, performance of the feasible type of robust estimators is compared with the classical ones in restricted semiparametric regression models.     

The generalized maximum Tsallis entropy estimators and applications to the Portland cement dataset

Tsallis entropy is a generalized form of entropy and tends to be Shannon entropy when q → 1. Using Tsallis entropy, an alternative estimation methodology (generalized maximum Tsallis entropy) is introduced and used to estimate the parameters in a linear regression model when the basic data are ill-conditioned. We describe the generalized maximum Tsallis entropy and for q = 2 we call that GMET2 estimator. We apply the GMET2 estimator for estimating the linear regression model Y = Xβ + e where the design matrix X is subject to severe multicollinearity. We compared the GMET2, generalized maximum entropy (GME), ordinary least-square (OLS), and inequality restricted least-square (IRLS) estimators on the analyzed dataset on Portland cement.     

Categorical information and the singular linear model

C. R. Rao (1978) discusses estimation for the common linear model in the case that the variance matrix σ² Q has known singular form Q . In the more general context of inference, this model exhibits certain special features and illustrates how information concerning unknowns can separate into a categorical component and a statistical component. The categorical component establishes that certain parameters are known in value and thus are not part of the statistical inference.     

D-optimal weighted paired comparison designs

As a generalization of the paired comparison designs, the experimental design which considers the weighted difference between responses is studied. D-optimal designs are constructed for a model with main effects and first-order interactions. The experimental region is a hypercube or a hypersphere.     

Some results on optimality in models with heteroscedastic errors from partial optimum designs

This paper studies optimum designs for linear models when the errors are heteroscedastic. Sufficient conditions are given in order to obtainD-, A- andE-optimum designs for a complete regression model from partial optimum designs for some sub-parameters. A result about optimality for a complete model from the optimality for the submodels is included. Supported by Junta de Andalucía, research group FQM244.     

Minimal Neighbor Designs in Linear Blocks

Neighbor designs are useful to neutralize the neighbor effects. In literature, most of the constructed neighbor designs are in circular blocks but linear blocks have more practical application in field experiments. In this article, some infinite series of minimal neighbor designs are constructed in proper linear blocks. There are many situations where minimal neighbor designs cannot be constructed in proper linear blocks. To overcome this problem neighbor designs in improper linear blocks and GN₂-designs in proper linear blocks are constructed.