Assessing the Precision of Turning Point Estimates in Polynomial Regression Functions

Researchers often report point estimates of turning point(s) obtained in polynomial regression models but rarely assess the precision of these estimates. We discuss three methods to assess the precision of such turning point estimates. The first is the delta method that leads to a normal approximation of the distribution of the turning point estimator. The second method uses the exact distribution of the turning point estimator of quadratic regression functions. The third method relies on Markov chain Monte Carlo methods to provide a finite sample approximation of the exact distribution of the turning point estimator. We argue that the delta method may lead to misleading inference and that the other two methods are more reliable. We compare the three methods using two data sets from the environmental Kuznets curve literature, where the presence and location of a turning point in the income-pollution relationship is the focus of much empirical work.     

Assessing Influence on the Liu Estimates in Linear Regression Models

The Liu estimator has been developed as an alternative to the ordinary least squares estimator in the presence of collinearity among the elements of regressors in linear regression models. We present the DFFITS and different versions of the Cook distance analogous to the ones given for the ordinary linear regression models of each individual observation on the Liu estimates. We suggest a version of the Cook distance based on one-step approximation. The mean shift outlier model for the Liu regression has also been investigated. Moreover, using the Sherman-Morrison-Woodbury theorem, we find approximate versions of the DFFITS and the Cook distance. The proposed diagnostics are evaluated on two data sets and yield promising results.     

On the construction of exact lower confidence bounds on the distance between any two ranked location parameters of K populations

In this paper, an exact lower confidence bound on the distance between any two ranked location parameters of k populations is derived. This confidence bound contains the confidence bounds of Kim (1986) and of Chen, Xiong and Lam (1993) as special cases.     

Polynomial Regression and Estimating Functions in the Presence of Multiplicative Measurement Error

We consider the polynomial regression model in the presence of multiplicative measurement error in the predictor. Two general methods are considered, with the methods differing in their assumptions about the distributions of the predictor and the measurement errors. Consistent parameter estimates and asymptotic standard errors are derived by using estimating equation theory. Diagnostics are presented for distinguishing additive and multiplicative measurement error. Data from a nutrition study are analysed by using the methods. The results from a simulation study are presented and the performances of the methods are compared.     

Lessons From Quantile Panel Estimation of the Environmental Kuznets Curve

We employ quantile regression fixed effects models to estimate the income-pollution relationship on NO _x (nitrogen oxide) and SO ₂ (sulfur dioxide) using U.S. data. Conditional median results suggest that conditional mean methods provide too optimistic estimates about emissions reduction for NO _x , while the opposite is found for SO ₂. Deleting outlier states reverses the absence of a turning point for SO ₂ in the conditional mean model, while the conditional median model is robust to them. We also document the relationship's sensitivity to including additional covariates for NO _x , and undertake simulations to shed light on some estimation issues of the methods employed.     

Performance of Confidence Intervals in Regression Models with Unbalanced One-Fold Nested Error Structures

Abstract

In this article we consider the problem of constructing confidence intervals for a linear regression model with unbalanced nested error structure. A popular approach is the likelihood-based method employed by PROC MIXED of SAS. In this article, we examine the ability of MIXED to produce confidence intervals that maintain the stated confidence coefficient. Our results suggest that intervals for the regression coefficients work well, but intervals for the variance component associated with the primary level cannot be recommended. Accordingly, we propose alternative methods for constructing confidence intervals on the primary level variance component. Computer simulation is used to compare the proposed methods. A numerical example and SAS code are provided to demonstrate the methods.     

中国区域经济增长对环境质量的影响——基于东、中、西部地区环境库兹涅茨曲线的实证研究

通过构建综合环境污染水平指标,运用1991--2009年省际面板数据,创新性地通过因子分析法,分析中国东、中、西部地区环境库兹涅茨曲线。结果表明：中国东、中、西部地区环境库兹涅茨曲线均呈“N型”,但地区之间正处于不同的阶段,东部地区的综合环境污染水平随经济增长呈下降趋势;中部和西部地区综合环境污染水平随经济增长呈上升趋势,造成这一差异的原因来自于规模效应、结构效应、技术效应、资源禀赋效应和环保规制效应。     

Regression Modelling of Disease Risk in Relation to Point Sources

We describe a class of models for the investigation of possible raised risk of disease around putative sources of environmental pollution. An adaptation of the point process method suggested by Diggle and Rowlingson is presented, allowing the use of routinely available aggregated data and incorporating the more general distance–risk model suggested by Elliott and co-workers. An application to data on cancers of the stomach around municipal solid waste incinerators is presented.     

The Empirical Likelihood Inference of a Regression Parameter in Censored Partial Linear Models Based on a Piecewise Polynomial

This article aims at making an empirical likelihood inference of regression parameter in partial linear model when the response variable is right censored randomly. The present studies are mainly designed to use empirical likelihood (EL) method based on synthetic dependent data, and the result cannot be applied directly due to the unknown weights in it. In this paper, we introduce a censored empirical log-likelihood ratio and demonstrate that its limiting distribution is a standard chi-square distribution. The estimating procedure of β is developed based on piecewise polynomial method. As a result, the p-value of test and the confidence interval can be obtained without estimating other quantities. Some simulation studies are conducted to highlight the performance of the proposed EL method, and the results show a good performance. Finally, we apply our method into the real example of multiple myeloma data and show the proof of theorem.     

The ideas of conditional confidence in the simplest setting

A recently developed framework for comparing the properties of various conditional procedures is studied in detail in the setting of testing between two simple hypotheses, where the ideas are most transparent. In that setting, possible goodness criteria are considered, and illustrations are given. The conditional confidence methodology, unlike the Bayes, fiducial, and likelihood techniques, presents a measure of conclusiveness which has frequentist interpretability; and, unlike traditional Neyman-Pearson procedures, the measure is highly data-dependent.     

New Prediction Interval and Band in the Nonlinear Regression Model: Application to Predictive Modeling in Foods

This article is concerned with the proposal of a new prediction interval and band for the nonlinear regression model. The construction principle of this interval and band is based on an exact (the meaning of the term “exact” will be given later) confidence region for parameters of the nonlinear regression model. This region, fully described in Vila and Gauchi (2007 Vila , J.-P. , Gauchi , J.-P. ( 2007 ). Optimal designs based on exact confidence regions for parameter estimation of a nonlinear regression model . Journal of Statistical Planning and Inference 137 ( 9 ): 2935 – 2953 .[Crossref], [Web of Science ®] , [Google Scholar]), provides a rigorous justification for the new prediction interval and band that we propose. This new band is then compared to the classical bands (which are asymptotic and thus approximate for small n), and also to the band based on the bootstrap resampling method. The comparison of these bands is undertaken with simulated and real data from predictive modeling in food science.     

Contrasting the Gini and Zenga indices of economic inequality

The current financial turbulence in Europe inspires and perhaps requires researchers to rethink how to measure incomes, wealth, and other parameters of interest to policy-makers and others. The noticeable increase in disparities between less and more fortunate individuals suggests that measures based upon comparing the incomes of less fortunate with the mean of the entire population may not be adequate. The classical Gini and related indices of economic inequality, however, are based exactly on such comparisons. It is because of this reason that in this paper we explore and contrast the classical Gini index with a new Zenga index, the latter being based on comparisons of the means of less and more fortunate sub-populations, irrespectively of the threshold that might be used to delineate the two sub-populations. The empirical part of the paper is based on the 2001 wave of the European Community Household Panel data set provided by EuroStat. Even though sample sizes appear to be large, we supplement the estimated Gini and Zenga indices with measures of variability in the form of normal, t-bootstrap, and bootstrap bias-corrected and accelerated confidence intervals.     

Two new confidence intervals for the coefficient of variation in a normal distribution

In this article we introduce an approximately unbiased estimator for the population coefficient of variation, τ, in a normal distribution. The accuracy of this estimator is examined by several criteria. Using this estimator and its variance, two approximate confidence intervals for τ are introduced. The performance of the new confidence intervals is compared to those obtained by current methods.     

Generalized Confidence Interval Estimation for the Difference in Paired Areas Under the ROC Curves in the Absence of a Gold Standard

Receiver operating characteristic (ROC) curves can be used to assess the accuracy of tests measured on ordinal or continuous scales. The most commonly used measure for the overall diagnostic accuracy of diagnostic tests is the area under the ROC curve (AUC). A gold standard (GS) test on the true disease status is required to estimate the AUC. However, a GS test may be too expensive or infeasible. In many medical researches, the true disease status of the subjects may remain unknown. Under the normality assumption on test results from each disease group of subjects, we propose a heuristic method of estimating confidence intervals for the difference in paired AUCs of two diagnostic tests in the absence of a GS reference. This heuristic method is a three-stage method by combining the expectation-maximization (EM) algorithm, bootstrap method, and an estimation based on asymptotic generalized pivotal quantities (GPQs) to construct generalized confidence intervals for the difference in paired AUCs in the absence of a GS. Simulation results show that the proposed interval estimation procedure yields satisfactory coverage probabilities and expected interval lengths. The numerical example using a published dataset illustrates the proposed method.     

Sample Sizes in the Interval Estimation of the Correlation Coefficient

An expression is derived for the maximum length of the interval estimator of the correlation coefficient, p, under bivariate normal assumptions. The prespecification of this minimum attainable precision and the confidence level results in an expression for the sample size required. An approximate expression for the sample size is proposed and is numerically shown to be as good as or better than that based on the Fisher's Z transformation.     

The impact of missing values in the concentration–time curve on the assessment of bioequivalence

A complication that may arise in some bioequivalence studies is that of ‘incomplete subject profiles’, caused by missing values that occur at one or more sampling points in the concentration–time curve for some study subjects. We assess the impact of incomplete subject profiles on the assessment of bioequivalence in a standard two‐period crossover design. The specific aim of the investigation is to assess the impact of four different patterns of missing concentration values on the coverage level of a 90% nominal two‐sided confidence interval for the ratio of geometric means and then to consider the impact on the probability of concluding bioequivalence. An overall conclusion from the results is that random missingness – that is, missingness for reasons unrelated to the bioavailability of the formulation involved or, more generally, to any aspect of the study design and conduct – has a damaging effect on the study conclusions only when the number of missing values is fairly large. On the other hand, a missingness pattern that potentially has a very damaging effect on the study conclusions is that which arises when values are missing ‘late’ in the concentration–time curve. Copyright © 2005 John Wiley & Sons, Ltd     

Regression analysis of case-cohort studies in the presence of dependent interval censoring

The case-cohort design is widely used as a means of reducing the cost in large cohort studies, especially when the disease rate is low and covariate measurements may be expensive, and has been discussed by many authors. In this paper, we discuss regression analysis of case-cohort studies that produce interval-censored failure time with dependent censoring, a situation for which there does not seem to exist an established approach. For inference, a sieve inverse probability weighting estimation procedure is developed with the use of Bernstein polynomials to approximate the unknown baseline cumulative hazard functions. The proposed estimators are shown to be consistent and the asymptotic normality of the resulting regression parameter estimators is established. A simulation study is conducted to assess the finite sample properties of the proposed approach and indicates that it works well in practical situations. The proposed method is applied to an HIV/AIDS case-cohort study that motivated this investigation.     

Controlling type I error in the reference‐scaled bioequivalence evaluation of highly variable drugs

Reference‐scaled average bioequivalence (RSABE) approaches for highly variable drugs are based on linearly scaling the bioequivalence limits according to the reference formulation within‐subject variability. RSABE methods have type I error control problems around the value where the limits change from constant to scaled. In all these methods, the probability of type I error has only one absolute maximum at this switching variability value. This allows adjusting the significance level to obtain statistically correct procedures (that is, those in which the probability of type I error remains below the nominal significance level), at the expense of some potential power loss. In this paper, we explore adjustments to the EMA and FDA regulatory RSABE approaches, and to a possible improvement of the original EMA method, designated as HoweEMA. The resulting adjusted methods are completely correct with respect to type I error probability. The power loss is generally small and tends to become irrelevant for moderately large (affordable in real studies) sample sizes.     

On testing and estimating the interaction between treatments and environmental conditions in binomial experiments: The case of two stations

Estimating confidence intervals for the interaction between treatments and environmental conditions in binomial experiments is analyzed. Testing the interaction is studied also. The problem is reduced to that of estimating or testing the interaction parameter in 2 × 2 × 2 contingency tables with given marginals. Programs for determining the exact conditional tests and their power functions are provided for sample of size not exceeding 100. Large sample approximations based on maximum likelihood (ML) and on the arcsin transformation for proportions are studied.