Generalized empirical likelihood inference in partial linear regression model for longitudinal data

In this paper, empirical likelihood inference for longitudinal data within the framework of partial linear regression models are investigated. The proposed procedures take into consideration the correlation within groups without involving direct estimation of nuisance parameters in the correlation matrix. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence intervals. A nonparametric version of Wilk's theorem for the limiting distribution of the empirical likelihood ratio is derived. Compared with methods based on normal approximations, the empirical likelihood does not require consistent estimators for the asymptotic variance and bias. The finite sample behaviour of the proposed method is evaluated with simulation and illustrated with an AIDS clinical trial data set.     

Empirical likelihood for the varying‐coefficient single‐index model

In this article the author investigates the application of the empirical‐likelihood‐based inference for the parameters of varying‐coefficient single‐index model (VCSIM). Unlike the usual cases, if there is no bias correction the asymptotic distribution of the empirical likelihood ratio cannot achieve the standard chi‐squared distribution. To this end, a bias‐corrected empirical likelihood method is employed to construct the confidence regions (intervals) of regression parameters, which have two advantages, compared with those based on normal approximation, that is, (1) they do not impose prior constraints on the shape of the regions; (2) they do not require the construction of a pivotal quantity and the regions are range preserving and transformation respecting. A simulation study is undertaken to compare the empirical likelihood with the normal approximation in terms of coverage accuracies and average areas/lengths of confidence regions/intervals. A real data example is given to illustrate the proposed approach. The Canadian Journal of Statistics 38: 434–452; 2010 © 2010 Statistical Society of Canada     

Empirical Likelihood Local Polynomial Regression Analysis of Clustered Data

Abstract. In this article, a naive empirical likelihood ratio is constructed for a non‐parametric regression model with clustered data, by combining the empirical likelihood method and local polynomial fitting. The maximum empirical likelihood estimates for the regression functions and their derivatives are obtained. The asymptotic distributions for the proposed ratio and estimators are established. A bias‐corrected empirical likelihood approach to inference for the parameters of interest is developed, and the residual‐adjusted empirical log‐likelihood ratio is shown to be asymptotically chi‐squared. These results can be used to construct a class of approximate pointwise confidence intervals and simultaneous bands for the regression functions and their derivatives. Owing to our bias correction for the empirical likelihood ratio, the accuracy of the obtained confidence region is not only improved, but also a data‐driven algorithm can be used for selecting an optimal bandwidth to estimate the regression functions and their derivatives. A simulation study is conducted to compare the empirical likelihood method with the normal approximation‐based method in terms of coverage accuracies and average widths of the confidence intervals/bands. An application of this method is illustrated using a real data set.     

Empirical likelihood for generalized linear models with fixed and adaptive designs

Empirical likelihood inference for generalized linear models with fixed and adaptive designs is considered. It is shown that the empirical log-likelihood ratio at the true parameters converges to the standard chi-square distribution. Furthermore, we obtain the maximum empirical likelihood estimate of the unknown parameter and the resulting estimator is shown to be asymptotically normal. Some simulations are conducted to illustrate the proposed method.     

Empirical likelihood for density-weighted average derivatives

In this paper, we investigate empirical likelihood (EL) inference for density-weighted average derivatives in nonparametric multiple regression models. A simply adjusted empirical log-likelihood ratio for the vector of density-weighted average derivatives is defined and its limiting distribution is shown to be a standard Chi-square distribution. To increase the accuracy and coverage probability of confidence regions, an EL inference procedure for the rescaled parameter vector is proposed by using a linear instrumental variables regression. The new method shares the same properties of the regular EL method with i.i.d. samples. For example, estimation of limiting variances and covariances is not needed. A Monte Carlo simulation study is presented to compare the new method with the normal approximation method and an existing EL method.     

Empirical Likelihood Based Synthetic Data Method for Censored Regression Analysis

In this article, we propose a new empirical likelihood method for linear regression analysis with a right censored response variable. The method is based on the synthetic data approach for censored linear regression analysis. A log-empirical likelihood ratio test statistic for the entire regression coefficients vector is developed and we show that it converges to a standard chi-squared distribution. The proposed method can also be used to make inferences about linear combinations of the regression coefficients. Moreover, the proposed empirical likelihood ratio provides a way to combine different normal equations derived from various synthetic response variables. Maximizing this empirical likelihood ratio yields a maximum empirical likelihood estimator which is asymptotically equivalent to the solution of the estimating equation that are optimal linear combination of the original normal equations. It improves the estimation efficiency. The method is illustrated by some Monte Carlo simulation studies as well as a real example.     

Generalized Empirical Likelihood Inference in Generalized Linear Models for Longitudinal Data

In this article, the generalized linear model for longitudinal data is studied. A generalized empirical likelihood method is proposed by combining generalized estimating equations and quadratic inference functions based on the working correlation matrix. It is proved that the proposed generalized empirical likelihood ratios are asymptotically chi-squared under some suitable conditions, and hence it can be used to construct the confidence regions of the parameters. In addition, the maximum empirical likelihood estimates of parameters are obtained, and their asymptotic normalities are proved. Some simulations are undertaken to compare the generalized empirical likelihood and normal approximation-based method in terms of coverage accuracies and average areas/lengths of confidence regions/intervals. An example of a real data is used for illustrating our methods.     

Generalized empirical likelihood inference in partially linear model for longitudinal data with missing response variables and error-prone covariates

In this article, we consider statistical inference for longitudinal partial linear models when the response variable is sometimes missing with missingness probability depending on the covariate that is measured with error. A generalized empirical likelihood (GEL) method is proposed by combining correction attenuation and quadratic inference functions. The method that takes into consideration the correlation within groups is used to estimate the regression coefficients. Furthermore, residual-adjusted empirical likelihood (EL) is employed for estimating the baseline function so that undersmoothing is avoided. The empirical log-likelihood ratios are proven to be asymptotically Chi-squared, and the corresponding confidence regions for the parameters of interest are then constructed. Compared with methods based on NAs, the GEL does not require consistent estimators for the asymptotic variance and bias. The numerical study is conducted to compare the performance of the EL and the normal approximation-based method, and a real example is analysed.     

The Bayesian elastic net regression

A Bayesian elastic net approach is presented for variable selection and coefficient estimation in linear regression models. A simple Gibbs sampling algorithm was developed for posterior inference using a location-scale mixture representation of the Bayesian elastic net prior for the regression coefficients. The penalty parameters are chosen through an empirical method that maximizes the data marginal likelihood. Both simulated and real data examples show that the proposed method performs well in comparison to the other approaches.     

Censored median regression and profile empirical likelihood

We implement profile empirical likelihood-based inference for censored median regression models. Inference for any specified subvector is carried out by profiling out the nuisance parameters from the “plug-in” empirical likelihood ratio function proposed by Qin and Tsao. To obtain the critical value of the profile empirical likelihood ratio statistic, we first investigate its asymptotic distribution. The limiting distribution is a sum of weighted chi square distributions. Unlike for the full empirical likelihood, however, the derived asymptotic distribution has intractable covariance structure. Therefore, we employ the bootstrap to obtain the critical value, and compare the resulting confidence intervals with the ones obtained through Basawa and Koul’s minimum dispersion statistic. Furthermore, we obtain confidence intervals for the age and treatment effects in a lung cancer data set.     

Weighted empirical likelihood for generalized linear models with longitudinal data

In this paper, we introduce the empirical likelihood (EL) method to longitudinal studies. By considering the dependence within subjects in the auxiliary random vectors, we propose a new weighted empirical likelihood (WEL) inference for generalized linear models with longitudinal data. We show that the weighted empirical likelihood ratio always follows an asymptotically standard chi-squared distribution no matter which working weight matrix that we have chosen, but a well chosen working weight matrix can improve the efficiency of statistical inference. Simulations are conducted to demonstrate the accuracy and efficiency of our proposed WEL method, and a real data set is used to illustrate the proposed method.     

Empirical Likelihood Based Rank Regression Inference

Rank regression procedures have been proposed and studied for numerous research applications that do not satisfy the underlying assumptions of the more common linear regression models. This article develops confidence regions for the slope parameter of rank regression using an empirical likelihood (EL) ratio method. It has the advantage of not requiring variance estimation which is required for the normal approximation method. The EL method is also range respecting and results in asymmetric confidence intervals. Simulation studies are used to compare and evaluate normal approximation versus EL inference methods for various conditions such as different sample size or error distribution. The simulation study demonstrates our proposed EL method almost outperforms the traditional method in terms of coverage probability, lower-tail side error, and upper-tail side error. An application of stability analysis also shows the EL method results in shorter confidence intervals for real life data.     

Empirical Likelihood Inference of the Partial Linear Isotonic Errors-in-variables Regression Models with Missing Data

This article is concerned with statistical inference of the partial linear isotonic regression model missing response and measurement errors in covariates. We proposed an empirical likelihood ratio test statistics and show that it has a limiting weighted chi-square distribution. An adjusted empirical likelihood ratio statistic, which is shown to have a limiting standard central chi-square distribution, is then proposed further. A maximum empirical likelihood estimator is also developed. A simulation study is conducted to examine the finite-sample property of proposed procedure.     

Empirical likelihood inference for the regression model of mean quality‐adjusted lifetime with censored data

The authors consider the empirical likelihood method for the regression model of mean quality‐adjusted lifetime with right censoring. They show that an empirical log‐likelihood ratio for the vector of the regression parameters is asymptotically a weighted sum of independent chi‐squared random variables. They adjust this empirical log‐likelihood ratio so that the limiting distribution is a standard chi‐square and construct corresponding confidence regions. Simulation studies lead them to conclude that empirical likelihood methods outperform the normal approximation methods in terms of coverage probability. They illustrate their methods with a data example from a breast cancer clinical trial study.     

Linear regression analysis with inequality constraints on the regression parameters via empirical likelihood

An empirical likelihood ratio test is developed for testing for or against inequality constraints on regression parameters in linear regression analysis. The proposed approach imposes no parametric model nor identically distributing assumption on the random errors. The asymptotic distribution of the proposed test statistic under null hypothesis is shown to be of chi-bar-squared type. The asymptotic power under contiguous alternatives is also briefly discussed. Moreover, an adjusted empirical likelihood method is adopted to improve the small sample size behaviour of the proposed test. Several simulation studies are carried out to assess the finite sample performance of the proposed tests. The results reveal that the proposed tests could be valuable for improving inference efficiency. A real-life example is discussed to illustrate the theoretical results.     

Empirical Likelihood for Censored Linear Regression

In this paper we investigate the empirical likelihood method in a linear regression model when the observations are subject to random censoring. An empirical likelihood ratio for the slope parameter vector is defined and it is shown that its limiting distribution is a weighted sum of independent chi-square distributions. This reduces to the empirical likelihood to the linear regression model first studied by Owen (1991) if there is no censoring present. Some simulation studies are presented to compare the empirical likelihood method with the normal approximation based method proposed in Lai et al. (1995). It was found that the empirical likelihood method performs much better than the normal approximation method.     

Weighted composite quantile regression analysis for nonignorable missing data using nonresponse instrument

Efficient statistical inference on nonignorable missing data is a challenging problem. This paper proposes a new estimation procedure based on composite quantile regression (CQR) for linear regression models with nonignorable missing data, that is applicable even with high-dimensional covariates. A parametric model is assumed for modelling response probability, which is estimated by the empirical likelihood approach. Local identifiability of the proposed strategy is guaranteed on the basis of an instrumental variable approach. A set of data-based adaptive weights constructed via an empirical likelihood method is used to weight CQR functions. The proposed method is resistant to heavy-tailed errors or outliers in the response. An adaptive penalisation method for variable selection is proposed to achieve sparsity with high-dimensional covariates. Limiting distributions of the proposed estimators are derived. Simulation studies are conducted to investigate the finite sample performance of the proposed methodologies. An application to the ACTG 175 data is analysed.     

The Empirical Likelihood Inference of a Regression Parameter in Censored Partial Linear Models Based on a Piecewise Polynomial

This article aims at making an empirical likelihood inference of regression parameter in partial linear model when the response variable is right censored randomly. The present studies are mainly designed to use empirical likelihood (EL) method based on synthetic dependent data, and the result cannot be applied directly due to the unknown weights in it. In this paper, we introduce a censored empirical log-likelihood ratio and demonstrate that its limiting distribution is a standard chi-square distribution. The estimating procedure of β is developed based on piecewise polynomial method. As a result, the p-value of test and the confidence interval can be obtained without estimating other quantities. Some simulation studies are conducted to highlight the performance of the proposed EL method, and the results show a good performance. Finally, we apply our method into the real example of multiple myeloma data and show the proof of theorem.     

Bayesian Analysis in Regression Models Using Pseudo-Likelihoods

This article deals with the issue of using a suitable pseudo-likelihood, instead of an integrated likelihood, when performing Bayesian inference about a scalar parameter of interest in the presence of nuisance parameters. The proposed approach has the advantages of avoiding the elicitation on the nuisance parameters and the computation of multidimensional integrals. Moreover, it is particularly useful when it is difficult, or even impractical, to write the full likelihood function.

We focus on Bayesian inference about a scalar regression coefficient in various regression models. First, in the context of non-normal regression-scale models, we give a theroetical result showing that there is no loss of information about the parameter of interest when using a posterior distribution derived from a pseudo-likelihood instead of the correct posterior distribution. Second, we present non trivial applications with high-dimensional, or even infinite-dimensional, nuisance parameters in the context of nonlinear normal heteroscedastic regression models, and of models for binary outcomes and count data, accounting also for possibile overdispersion. In all these situtations, we show that non Bayesian methods for eliminating nuisance parameters can be usefully incorporated into a one-parameter Bayesian analysis.     

Empirical likelihood for parameters in an additive partially linear errors-in-variables model with longitudinal data

Empirical likelihood inferences for the parameter component in an additive partially linear errors-in-variables model with longitudinal data are investigated in this article. A corrected-attenuation block empirical likelihood procedure is used to estimate the regression coefficients, a corrected-attenuation block empirical log-likelihood ratio statistic is suggested and its asymptotic distribution is obtained. Compared with the method based on normal approximations, our proposed method does not require any consistent estimator for the asymptotic variance and bias. Simulation studies indicate that our proposed method performs better than the method based on normal approximations in terms of relatively higher coverage probabilities and smaller confidence regions. Furthermore, an example of an air pollution and health data set is used to illustrate the performance of the proposed method.