Comparing Survival Times for Treatments with Those for a Control Under Proportional Hazards

Inferences for survival curves based on right censored data are studied for situations in which it is believed that the treatments have survival times at least as large as the control or at least as small as the control. Testing homogeneity with the appropriate order restricted alternative and testing the order restriction as the null hypothesis are considered. Under a proportional hazards model, the ordering on the survival curves corresponds to an ordering on the regression coefficients. Approximate likelihood methods, which are obtained by applying order restricted procedures to the estimates of the regression coefficients, and ordered analogues to the log rank test, which are based on the score statistics, are considered. Mau's (1988) test, which does not require proportional hazards, is extended to this ordering on the survival curves. Using Monte Carlo techniques, the type I error rates are found to be close to the nominal level and the powers of these tests are compared. Other order restrictions on the survival curves are discussed briefly.     

Two-moment approximations to some null distributions in order-restricted inference: Unequal sample sizes

Bartholomew's statistics for testing homogeneity of normal means with ordered alternatives have null distributions which are mixtures of chi-squared or beta distributions according as the variances are known or not. If the sample sizes are not equal, the mixing coefficients can be difficult to compute. For a simple order and a simple tree ordering, approximations to the significance levels of these tests have been developed which are based on patterns in the weight sets. However, for a moderate or large number of means, these approximations can be tedious to implement. Employing the same approach that was used in the development of these approximations, two-moment chisquared and beta approximations are derived for these significance levels. Approximations are also developed for the testing situation in which the order restriction is the null hypothesis. Numerical studies show that in each of the cases the two-moment approximation is quite satisfactory for most practical purposes.     

On tail-ordering and comparison of failure rates

In this paper, we have studied some implications between tail-ordering (also known as dispersive ordering) and failure rate ordering (also called TP₂ ordering) of two probability distribution functions. Based on independent random samples from these distributions, a class of distribution-free tests has been proposed for testing the null hypothesis that the two life distributions are identical against the alternative that one failure rate is uniformly smaller than the other. The tests have good efficiencies as compared to their competitors.     

Weighted Mean Survival Test Statistics: a Class of Distance Tests for Censored Survival Data

A class of test statistics is introduced which is sensitive against the alternative of stochastic ordering in the two-sample censored data problem. The test statistics for evaluating a cumulative weighted difference in survival distributions are developed while taking into account the imbalances in base-line covariates between two groups. This procedure can be used to test the null hypothesis of no treatment effect, especially when base-line hazards cross and prognostic covariates need to be adjusted. The statistics are semiparametric, not rank based, and can be written as integrated weighted differences in estimated survival functions, where these survival estimates are adjusted for covariate imbalances. The asymptotic distribution theory of the tests is developed, yielding test procedures that are shown to be consistent under a fixed alternative. The choice of weight function is discussed and relies on stability and interpretability considerations. An example taken from a clinical trial for acquired immune deficiency syndrome is presented.     

Robust Tests in Semiparametric Partly Linear Models

Abstract.  This paper focuses on the problem of testing the null hypothesis that the regression parameter equals a fixed value under a semiparametric partly linear regression model by using a three-step robust estimate for the regression parameter and the regression function. Two families of tests statistics are considered and their asymptotic distributions are studied under the null hypothesis and under contiguous alternatives. A Monte Carlo study is performed to compare the finite sample behaviour of the proposed tests with the classical one.     

On similarity and independence properties of composite edf goodness-of-fit tests

Many test statistics for classical simple goodness-of-fit hypothesis testing problems are distancemeasures between the distribution function of the null hypothesis distributipn and the empirical distribution function sometimes called EDF tests. If a composite parametric null hypothesis is considered in place of the simple null hypothesis, then a test statistic can be obtained from each EDF test by replacing the known distribution function of the simple problem by the Rao-Blackwell estimating distribution function. In this note we use known results to show that these Rao-Blackwell-EDF test statistics have distributions that do not depend upon parameter values, and hence that these tests are independent of a complete sufficient statistic for the parameters.     

Hypotheses testing for generalized order statistics with simple order restrictions on model parameters under the alternative

In applications of generalized order statistics as, for instance, reliability analysis of engineering systems, prior knowledge about the order of the underlying model parameters is often available and may therefore be incorporated in inferential procedures. Taking this information into account, we establish the likelihood ratio test, Rao's score test, and Wald's test for test problems arising from the question of appropriate model selection for ordered data, where simple order restrictions are put on the parameters under the alternative hypothesis. For simple and composite null hypothesis, explicit representations of the corresponding test statistics are obtained along with some properties and their asymptotic distributions. A simulation study is carried out to compare the order restricted tests in terms of their power. In the set-up considered, the adapted tests significantly improve the power of the associated omnibus versions for small sample sizes, especially when testing a composite null hypothesis.     

Non Null Asymptotic Distributions of Some Criteria in Censored Exponential Regression

In this article, we consider the class of censored exponential regression models which is very useful for modeling lifetime data. Under a sequence of Pitman alternatives, the asymptotic expansions up to order n^{? 1/2} of the non null distribution functions of the likelihood ratio, Wald, Rao score, and gradient statistics are derive in this class of models. The non null asymptotic distribution functions of these statistics are obtained for testing a composite null hypothesis in the presence of nuisance parameters. The power of all four tests, which are equivalent to first order, are compared based on these non null asymptotic expansions. Furthermore, in order to compare the finite-sample performance of these tests in this class of models, we consider Monte Carlo simulations. We also present an empirical application for illustrative purposes.     

On asymptotic non-normality of null distributions of mrpp statistics

Severe departures from normality occur frequently for null distributions of statistics associated with applications of mulLi-response permutation procedures (MRPP) for either small or large finite populations. This paper describes the commonly encountered situation associated with asymptotic non-normality for null distributions of MRPP statistics which does not depend on the underlying multivariate distribution. In addition, this paper establishes the existence of a non-degenerate underlying distribution for which the null distributions of MRPP statistics are asymptotically non-normal for essentially all size structure configurations. It is known that MRPP statistics are symmetric versions of a broader class of statistics, most of which are asymmetric. Because of the non-normality associated with null distributions of MRPP statistics, this paper includes necessary results for inferences based on the exact first three moments of anv statistic in this broader class (analogous to existing results for MRPP statistics).     

空间动态面板模型的时间滞后效应检验

空间面板数据模型由于考虑了经济变量间的空间相关性,其优势日益凸显,已成为计量经济学的热点研究领域。将空间相关性与动态模式同时扩展到面板模型中的空间动态面板模型,不仅考虑了经济变量之间的空间相关性,还考虑了时间上的滞后性,是空间面板模型的发展,增强了模型的解释力。考虑一种带固定个体效应、因变量的时间滞后项、因变量与随机误差项均存在空间自相关性的空间动态面板回归模型,提出了在个体数n和时间数T都很大,且T相对地大于n的条件下空间动态面板模型中时间滞后效应存在性的LM和LR检验方法,其检验方法包括联合检验、一维及二维的边际和条件检验;推导出这些检验在零假设下的极限分布;其极限分布均服从卡方分布。通过模拟试验研究检验统计量的小样本性质,结果显示其具有优良的统计性质。     

A New Goodness-of-Fit Test for Censored Data with an Application in Monitoring Processes

In this article, we propose a new goodness-of-fit test for Type I or Type II censored samples from a completely specified distribution. This test is a generalization of Michael's test for censored data, which is based on the empirical distribution and a variance stabilizing transformation. Using Monte Carlo methods, the distributions of the test statistics are analyzed under the null hypothesis. Tables of quantiles of these statistics are also provided. The power of the proposed test is studied and compared to that of other well-known tests also using simulation. The proposed test is more powerful in most of the considered cases. Acceptance regions for the PP, QQ, and Michael's stabilized probability plots are derived, which enable one to visualize which data contribute to the decision of rejecting the null hypothesis. Finally, an application in quality control is presented as illustration.     

Second order asymptotic and non-asymptotic optimality properties of combined tests

Let p independent test statistics be available to test a null hypothesis concerned with the same parameter. The p are assumed to be similar tests. Asymptotic and non-asymptotic optimality properties of combined tests are studied. The asymptotic study centers around two notions. The first is Bahadur efficiency. The second is based on a notion of second order comparisons. The non-asymptotic study is concerned with admissibility questions. Most of the popular combining methods are considered along with a method not studied in the past. Among the results are the following: Assume each of the p statistics has the same Bahadur slope. Then the combined test based on the sum of normal transforms, is asymptotically best among all tests studied, by virtue of second order considerations. Most of the popular combined tests are inadmissible for testing the noncentrality parameter of chi-square, t, and F distributions. For chi-square a combined test is offered which is admissible, asymptotically optimal (first order), asymptotically optimal (second order) among all tests studied, and for which critical values are obtainable in special cases. Extensions of the basic model are given.     

Lorenz ranking of income distributions

Based on the stochastic comparison of the Lorenz curves of income distributions, five partial orderings of income distributions are obtained. Three of these orderings are the well known star shaped, stochastic and the Lorenz orderings. The other two are new and are studied in some detail. The weakest ordering which is called the Lorenz area ordering is of special importance since it enables us to compare interesting Lorenz curves. This latter ordering leads to a class of income inequality measures which are identical with the linear inequality measures considered by Mehran (1976). A discussion of these measures is presented together with an application to part of Kunzet's (1963) data.     

Restricted likelihood ratio lack-of-fit tests using mixed spline models

Summary.  Penalized regression spline models afford a simple mixed model representation in which variance components control the degree of non-linearity in the smooth function estimates. This motivates the study of lack-of-fit tests based on the restricted maximum likelihood ratio statistic which tests whether variance components are 0 against the alternative of taking on positive values. For this one-sided testing problem a further complication is that the variance component belongs to the boundary of the parameter space under the null hypothesis. Conditions are obtained on the design of the regression spline models under which asymptotic distribution theory applies, and finite sample approximations to the asymptotic distribution are provided. Test statistics are studied for simple as well as multiple-regression models.     

New tests for stochastic order with application to case control studies

It is shown that if a binary regression function is increasing then retrospective sampling induces a stochastic ordering of the covariate distributions among the responders, which we call cases, and the non-responders, which we call controls. We also show that if the covariate distributions are stochastically ordered then the regression function must be increasing. This means that testing whether the regression function is monotone is equivalent to testing whether the covariate distributions are stochastically ordered. Capitalizing on these new probabilistic observations we proceed to develop two new non-parametric tests for stochastic order. The new tests are based on either the maximally selected, or integrated, chi-bar statistic of order one. The tests are easy to compute and interpret and their large sampling distributions are easily found. Numerical comparisons show that they compare favorably with existing methods in both small and large samples. We emphasize that the new tests are applicable to any testing problem involving two stochastically ordered distributions.     

Permuiation tesis for k-sample binomial data with comparisons of exact and approximate P-levels

Exact ksample permutation tests for binary data for three commonly encountered hypotheses tests are presented,, The tests are derived both under the population and randomization models . The generating function for the number of cases in the null distribution is obtained, The asymptotic distributions of the test statistics are derived . Actual significance levels are computed for the asymptotic test versions , Random sampling of the null distribution is suggested as a superior alternative to the asymptotics and an efficient computer technique for implementing the random sampling is described., finally, some numerical examples are presented and sample size guidelines given for computer implementation of the exact tests.     

On optimal tests for separate hypotheses and conditional probability integral transformations

Consider the problem of testing the composite null hypothesis that a random sample X₁,…,X_n is from a parent which is a member of a particular continuous parametric family of distributions against an alternative that it is from a separate family of distributions. It is shown here that in many cases a uniformly most powerful similar (UMPS) test exists for this problem, and, moreover, that this test is equivalent to a uniformly most powerful invariant (UMPI) test. It is also seen in the method of proof used that the UMPS test statistic Is a function of the statistics U₁,…,U_n?k obtained by the conditional probability integral transformations (CPIT), and thus that no Information Is lost by these transformations, It is also shown that these optimal tests have power that is a nonotone function of the null hypothesis class of distributions, so that, for example, if one additional parameter for the distribution is assumed known, then the power of the test can not lecrease. It Is shown that the statistics U₁, …, U_n?k are independent of the complete sufficient statistic, and that these statistics have important invariance properties. Two examples at given. The UMPS tests for testing the two-parameter uniform family against the two-parameter exponential family, and for testing one truncation parameter distribution against another one are derived.     

Extensions of empirical likelihood and chi-squared-based tests for ordered alternatives

Several methods for comparing k populations have been proposed in the literature. These methods assess the same null hypothesis of equal distributions but differ in the alternative hypothesis they consider. We focus on two important alternative hypotheses: monotone and umbrella ordering. Two new families of test statistics are proposed, including two known tests, as well as two new powerful tests under monotone ordering. Furthermore, these families are adapted for testing umbrella ordering. We compare some members of the families with respect to power and Type I errors under different simulation scenarios. Finally, the methods are illustrated in several applications to real data.     

Distribution-free tests in randomized blocks

Classes of distribution-free tests are proposed for testing homogeneity against order restricted as well as unrestricted alternatives in randomized block designs with multiple observations per cell. Allowing for different interblock scoring schemes, these tests are constructed based on the method of within block rankings. Asymptotic distributions (cell sizes tending to infinity) of these tests are derived under the assumption of homogeneity. The Pitman asymptotic relative efficiencies relative to the least squares statistics are studied. It is shown that when blocks are governed by different distributions, adaptive choice of scores within each block results in asymptotically more efficient tests as compared with methods that ignore such information. Monte Carlo simulations of selected designs indicate that the method of within block rankings is more power robust with respect to differing block distributions.     

Comparisons of some tests for validation of stochastic simulation models

Properties of proposed parametric and nonparametric tests for the problem of validating stochastic simulation models are discussed. Asymptotic efficiencies for various types of alternatives are developed for some of the tests. Numerical procedures along with simulation methods are used to evaluate the adequacy of normal approximations to the null distributions of the statistics and the small-sample power of the tests.