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The discussion on the use and misuse of p-values in 2016 by the American Statistician Association was a timely assertion that statistical concept should be properly used in science. Some researchers, especially the economists, who adopt significance testing and p-values to report their results, may felt confused by the statement, leading to misinterpretations of the statement. In this study, we aim to re-examine the accuracy of the p-value and introduce an alternative way for testing the hypothesis. We conduct a simulation study to investigate the reliability of the p-value. Apart from investigating the performance of p-value, we also introduce some existing approaches, Minimum Bayes Factors and Belief functions, for replacing p-value. Results from the simulation study confirm unreliable p-value in some cases and that our proposed approaches seem to be useful as the substituted tool in the statistical inference. Moreover, our results show that the plausibility approach is more accurate for making decisions about the null hypothesis than the traditionally used p-values when the null hypothesis is true. However, the MBFs of Edwards et al. [Bayesian statistical inference for psychological research. Psychol. Rev. 70(3) (1963), pp. 193–242]; Vovk [A logic of probability, with application to the foundations of statistics. J. Royal Statistical Soc. Series B (Methodological) 55 (1993), pp. 317–351] and Sellke et al. [Calibration of p values for testing precise null hypotheses. Am. Stat. 55(1) (2001), pp. 62–71] provide more reliable results compared to all other methods when the null hypothesis is false.KEYWORDS: Ban of P-value, Minimum Bayes Factors, belief functions 相似文献
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This paper deals with the derivation of (i) the MLE (ii) the MVUE (iii) a Bayes estimator of the probability in the title, for the case p = 2. Simulation studies are carried out to compare these estimators. The results suggest that the MLE and the Bayes estimator are biased and the Bayes estimator have the smallest MSE. In the general case, explicit expression for the probability in the title is derived and the MLE and Bayes estimator are obtained. A general method of deriving the MVUE is pointed out. Because of the simulation studies for p = 2 it is recommended that the Bayes or predictive estimator should be used. 相似文献
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Carroll KJ 《Pharmaceutical statistics》2006,5(4):283-293
In oncology, it may not always be possible to evaluate the efficacy of new medicines in placebo-controlled trials. Furthermore, while some newer, biologically targeted anti-cancer treatments may be expected to deliver therapeutic benefit in terms of better tolerability or improved symptom control, they may not always be expected to provide increased efficacy relative to existing therapies. This naturally leads to the use of active-control, non-inferiority trials to evaluate such treatments. In recent evaluations of anti-cancer treatments, the non-inferiority margin has often been defined in terms of demonstrating that at least 50% of the active control effect has been retained by the new drug using methods such as those described by Rothmann et al., Statistics in Medicine 2003; 22:239-264 and Wang and Hung Controlled Clinical Trials 2003; 24:147-155. However, this approach can lead to prohibitively large clinical trials and results in a tendency to dichotomize trial outcome as either 'success' or 'failure' and thus oversimplifies interpretation. With relatively modest modification, these methods can be used to define a stepwise approach to design and analysis. In the first design step, the trial is sized to show indirectly that the new drug would have beaten placebo; in the second analysis step, the probability that the new drug is superior to placebo is assessed and, if sufficiently high in the third and final step, the relative efficacy of the new drug to control is assessed on a continuum of effect retention via an 'effect retention likelihood plot'. This stepwise approach is likely to provide a more complete assessment of relative efficacy so that the value of new treatments can be better judged. 相似文献
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Continuous populations are grouped in many social, economic, medical, or technical fields of research. However, by grouping
them, a lot of information provided by the continuous population is lost. Especially the median split, which is still adopted
by many researchers, and its generalization to an equiprobable k-group split lead to a high efficiency loss. Here, this loss of information is investigated by analytical and numerical analyses
for some typical symmetric and skew population distributions often found in applications. Various distribution parameters,
numbers of groups, and split methods are taken from theoretical considerations and real data sets. Losses sometimes in excess
of 50% can be reduced by optimal grouping. 相似文献
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编辑推荐：与《货币战争》相比,《货币战争2：金权天下》更系统、更完善、更严密,更趋向于现实。以三百年的历史纵深,全面阐述欧美主要金融势力集团的历史沿革,系统解析当今世界幕后主宰力量的运作和决策机制,清晰地勾勒出了错综复杂的国际金融势力集团的人脉关系图谱,并预言：世界单一货币将在2024年成为现实。 相似文献
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