Parkinson's disease: current scientific understanding,and John's story

1. Parkinson's disease is a progressive, neurological disease that has no cure, although medications may delay or relieve symptoms. Surgical treatments are appropriate for some patients. 2. Monitoring symptoms of Parkinson's disease is important because all medications deemed helpful for patients can also have serious side effects, including delusions and hallucinations. 3. Clients who have difficulty expressing themselves need a family member or friend to inform caregivers of their interests and sources of enjoyment. 4. Efforts can be made to forestall isolation in the client's home or long-term residence. Suggestions and answers to commonly asked questions can be found on the Internet.     

AIDS: implications for employee benefit plans and personnel policies.

Current projections indicate an inexorable increase in AIDS cases, with no cure in sight. The disease is affecting primarily those aged 21 to 44--those who have, in the past, been the main participants in employer-sponsored benefit plans and Social Security. Humane, economically viable benefit plan and personnel policy solutions to this public health catastrophe are described herein.     

Meeting summary--cell biology of Parkinson's disease and related neurodegenerative disorders

Parkinsonian disorders (idiopathic Parkinson's disease and clinically similar disorders) are characterized by impaired movements caused by the degeneration of brain centers involved in regulating normal and smooth movements of the body and its extremities. The mechanisms that cause such degeneration are unknown. This Perspective summarizes research described at a meeting held in June 2003, which was organized by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging to provide an update on recent advances in the cell biology of parkinsonian disorders.     

Why Digital Tools Have Not Yet Revolutionized Adolescent Health Research and What We Can Do

The promise of digital tools and devices for spurring new discoveries in adolescent health research is enticing. This special section draws attention to many of the advantages that mobile and wearable devices offer for ambulatory assessment research, which have now been realized. Despite such progress, digital tools have not yet delivered on their predicted revolution of adolescent health research. I offer four reasons for why digital devices have fallen short of this predicted promise. For each barrier, I suggest parallel strategies for ensuring adolescent research benefits from Ambulatory Assessment advances. To avoid missing out on opportunities to support young people, adolescence scholarship must develop in time with innovations in digital devices and platforms and move past what has, to date, been an overwhelming focus on fears about their usage.     

A GREAT DIVIDE?

Since 1980 most social scientists have found little evidence in support of popular and recurring commentaries that identify religion (and evangelical Protestants, in particular) as a major source of conservative political trends in the United States. But in the past several years a new line of research has reported results suggesting that earlier studies underestimated evidence that partisan change among specific religious groups has contributed to an emerging Republican electoral advantage. We assess this latter body of research, presenting the most comprehensive analysis to date of the effects of religious group memberships on political outcomes in national elections from 1972 through 2000. We address the limitations of past studies by incorporating advances in the measurement of religious denomination, adjudicating competing statistical models of the changing interrelationship of religion and voter alignments and extending previous investigations by simultaneously considering the impact of religion on (1) voting behavior, (2) partisanship, and (3) the representation of religious groups within the Democratic and Republican parties' electoral coalitions. Our results refine and extend past studies of religion and political change, providing evidence of limited changes in group-specific voting coupled with much larger changes in religion-based partisanship and party coalitions.     

Marriage in the New Millennium: A Decade in Review

This review focuses on broad themes characterizing marital research in the past decade. In addition to continuing themes, such as a focus on conflict, violence, and impact on physical and mental health outcomes, we also address the impact of the Healthy Marriage Initiative on marital research and recent advances in methodology. We highlight an overarching theme that characterizes much of the literature: the importance of context in understanding marital outcomes and the impact of positive marital transactions and marital strengths. Given the increasing diversity of married couples, the attention given to context over the past decade has been timely and appropriate, providing an increasingly solid foundation for future research.     

Prion 2005: Between Fundamentals and Society's Needs

Prion diseases for the most part affect individuals older than 60 years of age and share features with other diseases characterized by protein deposits in the brain, such as Alzheimer's disease and Parkinson's disease. The international conference "Prion 2005: Between Fundamentals and Society's Needs," organized by the German Transmissible Spongiform Encephalopathies Research Platform, aimed to integrate and coordinate the research efforts of participants to better achieve prevention, treatment, control, and management of prion diseases, including Creutzfeldt-Jakob disease and fatal familial insomnia in humans. Several main topics were discussed, such as the molecular characteristics of prion strains, the cell biology of cellular and pathogenic forms of the prion proteins, the pathogenesis of the diseases they cause, emerging problems, and promising approaches for therapy and new diagnostic tools. The presentations at the Prion 2005 conference provided new insights in both basic and applied research, which will have broad implications for society's needs.     

Perspectives on the Biodemography of Longevity and Aging

Biodemography is a timely and exciting area of research that has been emerging over the past 15–20 years and might arguably be the most quickly growing area of demography. From the perspective of longevity and aging, questions arise that touch on the biological foundation of aging. With a focus on mortality, this article offers a perspective on recent developments in evolutionary biodemography. These include new theories, methods, and data that have resulted in striking new findings on the diversity of life courses (including the option of escape from aging for some species) that is licensed by nature across the tree of life. As the human life course is rapidly changing due to unimpeded population aging, advances in development of biodemographic theories, methods and databases may prove useful and inspire advances in sociology.     

Latin America and the Caribbean Revisited: Pathways for Research

This introductory article on Third sector research on Latin America and the Caribbean (LAC) was designed with two objectives in mind. The first, to present readers with a general up to date of the political, economic, and social overview as well as an actualized context of the region, intending to show the needs and trends that individuals and civil society organizations have experienced in the past 20 years by underlining some main advances and shortcomings for LAC. This was done with the intent and idea to provide the understanding of the issues that require attention to be approached in a scholarly and interdisciplinary fashion with a Third sector studies lens. The second was to present a series of pertinent original articles placed into three distinct axis or categories that correspond distinctively to major trends identified by the guest editors of this special issue as social inclusion and development, human rights and public policies and governance of Third sector organizations. The article clearly introduces original material by fourteen specialists in Third sector research who provide results on an ample and wide range of studies and theoretical analysis of this particular region of the world.     

Disabled People,Health Professionals and the Social Model of Disability: Can there be a research relationship?

The social model of disability is proposed as an alternative to models that have viewed disability as an individual, rather than a socio-political issue. The use of this model to guide both research theory and practice is proposed in order to equalise research power relationships, and involve and empower disabled people. Health professionals have traditionally reinforced the medical model of disability in both research and practice, and this has been seen as contributing to the oppression and marginalisation of disabled people. If the social model is to achieve wider dissemination, it would appear important to develop a dialogue between disabled people and health professionals. However, because of negative perceptions it can be difficult for health professionals to find an appropriate position in relation to disabled people, research and the social model of disability. While not denying the past, it appears essential to look at ways in which disabled people and health professionals can work together to overcome the oppression and marginalisation that has been linked to the provision of health services.     

Biosocial Influences on the Family: A Decade Review

The past decade brought a remarkable increase in the number and quality of biosocial studies of family processes. The current review summarizes recent advances in biosocial family research by providing key exemplars of emerging research paradigms. Research in the past decade has substantiated the claim in the previous Decade Review ( Booth, Carver, & Granger, 2000 ) that bidirectional influences between all levels of analysis are paramount. There is an emerging consensus that integrating factors at multiple biological and social levels is highly informative. Because ignoring biological factors often will underestimate mediating or moderating mechanisms, the review provides recommendations for biosocial family research. We also highlight the need for researchers who understand complex family environments to lend their expertise to biosocial studies.     

Researching Health Communication Technology Intervention Projects: The Challenge of Achieving Utilization Levels Sufficient for Evaluation

ABSTRACT

The deployment of interactive communication technologies to deliver health services and education has grown significantly over the past decade. Telemedicine, the use of telecommunication technologies for health care, is one specific application that has enjoyed significant public and private funding for research projects. However, telemedicine project evaluators have run into a serious barrier in their research efforts, namely, the deployment of telemedicine is often tremendously time-consuming and often yields utilization levels inadequate for research purposes. This article seeks to overview this problem through a case analysis of a multidimensional telemedicine project in Michigan that enjoyed both success and failure. The article concludes with a discussion of five universal challenges that must be addressed for project evaluators to achieve utilization levels to allow for reliable research conclusions.     

Possible reasons for tax resistance in South Africa: A customised scale to measure and compare perceptions with previous research

Tax resistance takes two major forms, namely tax avoidance and tax evasion both of which diminish a government's tax receipts. Limited research on taxpayers’ perceptions has been conducted in South Africa. A study was undertaken in order to determine the perceptions of South African taxpayers about various aspects with regard to taxation. There are no standardised scales to measure taxpayers’ perceptions. The reasons for evading taxes, however, have been explored by both economists and psychologists. This article elaborates on the design of a measurement tool for determining taxpayers’ perceptions taking previous research into account. In addition, this article assesses whether findings from the current research substantiates earlier research. The results of the current study confirmed the majority of findings from past research. The significance of this study is emphasised, in that it builds on previous research, utilising insights from several disciplines and various theoretical perspectives.     

Social Work Education and the Neo-Liberal Challenge: The US Response to Increasing Global Inequality

During the past several decades, a ‘perfect storm’, resulting from the political–economic changes accompanying globalization, dramatic demographic and cultural transformations in US society and rapid technological advances, has created unprecedented challenges for the social work profession and social work education. These challenges include the widening gap in income and wealth both within the US and between the Global North and South; growing racial and class disparities in health and mental health care, education, employment and housing; a shift within policymaking circles towards fiscal austerity and policies that emphasize market-oriented and individually-focused solutions; and the changing nature of universities, student populations and the educational process itself. Although the formal documents of major social work organizations continue to emphasize social justice themes, the actual practice of social work and the preparation of students for practice, teaching and research have diverged considerably from this rhetorical mission. This is reflected in a variety of ways including, but not limited to, the uncritical adoption of ‘evidence-based practice’ as a cornerstone of social work education and research; the growing stratification of social work faculty; the increased reliance on untested online methods of education; and the emphasis on quantitative ‘outcomes’ as indicators of educational success. At the same time, social work education in the US has been unable to respond effectively to the implications of demographic and cultural diversity, despite the demands of its accrediting body, the Council on Social Work Education. This article will provide an overview of the changing environment of social work and social work education during the past several decades. This will be followed by a discussion of the impact of these changes on social work education and a critique of the response—to date—of social work educators. Finally, it will suggest some potential educational responses to these challenges.     

Genetic counseling: Implications for social work practice

Considerable advances have been made in recent years in medical genetics. These advances have led to a better understanding of the inheritance of disease. Social workers involved in schools, child welfare, medical, and other institutional settings often work with clients who have genetically inherited disorders. Consequently, there is a growing need for social workers to increase their knowledge of genetics and genetic counseling. In this article, the authors discuss the emerging field of genetic counseling and its implications for social work practice.     

Reflexive Research Ethics for Environmental Health and Justice: Academics and Movement-Building

Community-engaged research on environmental problems has reshaped researcher-participant relationships, academic-community interaction, and the role of community partners in human subjects protection and ethical oversight. We draw on our own and others' research collaborations with environmental health and justice social movement organizations to discuss the ethical concerns that emerge in community-engaged research. In this paper we introduce the concept of reflexive research ethics: ethical guidelines and decision-making principles that depend on continual reflexivity concerning the relationships between researchers and participants. Seeing ethics in this way can help scientists conduct research that simultaneously achieves a high level of professional conduct and protects the rights, well-being, and autonomy of both researchers and the multiple publics affected by research. We highlight our research with community-based organizations in Massachusetts, California, and Alaska, and discuss the potential impacts of the community or social movement on the research process and the potential impacts of research on community or social movement goals. We conclude by discussing ways in which the ethical concerns that surface in community-engaged research have led to advances in ethical research practices. This type of work raises ethical questions whose answers are broadly relevant for social movement, environmental, and public health scholars.     

Curative fictions: The ‘narrative cure’ in Judith Herman's trauma and recovery and Chantal Chawaf's Le Manteau noir

Abstract

The possibility of a so‐called ‘narrative cure’, whereby a survivor of traumatic experience can begin to deal with her past through integrating it into narrative, has become central both to psychotherapy and to literary criticism on writings of trauma as a means of ethical, ‘truthful’ testimony and of healing. This article seeks to question the correlation between testimony and ‘cure’ through analysing the function of the ‘narrative cure’ in a psychotherapeutic text and in a literary text. This highlights how any notion of ‘truthful’ testimony is always underwritten by fiction, which raises crucial ethical questions about the relation between fiction and ‘truth’, testimony and ‘cure’ and psychotherapy and literature. I argue that the ‘narrative cure’ is not a privileged space of curative ‘truth’, but a point of tension between memory and amnesia and between ‘truth’ and fiction; it is precisely this tension, I suggest, which should characterize and structure interdisciplinary responses to trauma.     

Critical issues on informed consent in Africa

Biomedical research has made tremendous advances during the last decade in improving human health and well being. In spite of these advances, research has encountered serious emerging challenges as it moves across boarders and confronts different societies with different cultural practices, beliefs, moral thoughts and different values. A pervasive and perplexing issue affecting the current advances in research is the perception that research might end up exploiting populations unless it is conducted in the context of a strong ethical framework. Furthermore, informed consent has increasingly become a thorny area for researchers when considering what should be done when introducing the process into a community, especially if the process might destroy the traditional value system and customs of the community. In this paper, I argue that community consent is an unethical process which should be subverted for community dialogue and community education in research in Africa.     

Family Processes and Children's and Adolescents' Well-Being

The primary purpose of this review was to examine theory and research published during the past decade that focused on family processes and children's and adolescents' well-being. Scholarship focused on family processes and child and adolescent well-being made significant and exciting advances during this decade based on several key advancements. In addition to a brief introduction and a conclusion, this decade in review is organized into four sections. In the first section, advances made in the literature because of increased attention to complexity and specificity are illustrated. The second section describes advances that were made because of increased attention to family processes in diverse families. Diversity in the samples of families studied, extensions in family process models, and the revisioning of grand theories using a diversity lens that were used to conceptualize family processes are detailed. In the third section, the importance of time in the study of family processes and child and adolescent well-being is described. The emphasis on families' daily lives is noted. In addition, prospective considerations and studies of change over time are highlighted. Strengths in family functioning are detailed in the fourth section of this article: positivity, regulatory processes, and family organization. These three areas were selected to elaborate the idea that one of the major advancements in the family process literature during the past decade was an emphasis on family strengths. This review concludes with a commentary regarding how conceptual and methodological advancements during the past decade can guide future scholarship.     

Monitoring proteins in intact cells

In the past decade, tremendous progress has been made in understanding the molecular mechanisms that underlie many neurodegenerative disorders, and common aspects of the pathological processes that lead to neuronal cell death have emerged. Nearly all of these advances have come from genetic, molecular, and biochemical studies that point to alterations in protein folding or protein-protein interactions as the fundamental mechanism behind these disorders. New microscopy/imaging technologies for detecting protein-protein interactions are now poised to contribute to progress in this field. Here we describe a novel technique based on fluorescence resonance energy transfer, called fluorescence lifetime imaging microscopy (FLIM), which allows monitoring of protein conformation and protein-protein interactions in intact cells. For example, using FLIM, we have studied the interaction of two proteins related to Alzheimer's disease: amyloid precursor protein (APP) and presenilin (PS-1). By measuring the lifetime of a donor fluorophore linked to PS-1, we show, with high subcellular resolution, localization of the PS-1-APP interaction within neurons. This approach may have widespread applicability in studies of neurodegenerative disease mechanisms.