A multi-index model for quantile regression with ordinal data

In this paper, we propose a quantile approach to the multi-index semiparametric model for an ordinal response variable. Permitting non-parametric transformation of the response, the proposed method achieves a root-n rate of convergence and has attractive robustness properties. Further, the proposed model allows additional indices to model the remaining correlations between covariates and the residuals from the single-index, considerably reducing the error variance and thus leading to more efficient prediction intervals (PIs). The utility of the model is demonstrated by estimating PIs for functional status of the elderly based on data from the second longitudinal study of aging. It is shown that the proposed multi-index model provides significantly narrower PIs than competing models. Our approach can be applied to other areas in which the distribution of future observations must be predicted from ordinal response data.     

A Spline‐Based Semiparametric Maximum Likelihood Estimation Method for the Cox Model with Interval‐Censored Data

Abstract. We propose a spline‐based semiparametric maximum likelihood approach to analysing the Cox model with interval‐censored data. With this approach, the baseline cumulative hazard function is approximated by a monotone B‐spline function. We extend the generalized Rosen algorithm to compute the maximum likelihood estimate. We show that the estimator of the regression parameter is asymptotically normal and semiparametrically efficient, although the estimator of the baseline cumulative hazard function converges at a rate slower than root‐n. We also develop an easy‐to‐implement method for consistently estimating the standard error of the estimated regression parameter, which facilitates the proposed inference procedure for the Cox model with interval‐censored data. The proposed method is evaluated by simulation studies regarding its finite sample performance and is illustrated using data from a breast cosmesis study.     

Semiparametric median residual life model and inference

For randomly censored data, the authors propose a general class of semiparametric median residual life models. They incorporate covariates in a generalized linear form while leaving the baseline median residual life function completely unspecified. Despite the non‐identifiability of the survival function for a given median residual life function, a simple and natural procedure is proposed to estimate the regression parameters and the baseline median residual life function. The authors derive the asymptotic properties for the estimators, and demonstrate the numerical performance of the proposed method through simulation studies. The median residual life model can be easily generalized to model other quantiles, and the estimation method can also be applied to the mean residual life model. The Canadian Journal of Statistics 38: 665–679; 2010 © 2010 Statistical Society of Canada     

Variable selection in finite mixture of semi-parametric regression models

Abstract

In this paper we are concerned with variable selection in finite mixture of semiparametric regression models. This task consists of model selection for non parametric component and variable selection for parametric part. Thus, we encountered separate model selections for every non parametric component of each sub model. To overcome this computational burden, we introduced a class of variable selection procedures for finite mixture of semiparametric regression models using penalized approach for variable selection. It is shown that the new method is consistent for variable selection. Simulations show that the performance of proposed method is good, and it consequently improves pervious works in this area and also requires much less computing power than existing methods.     

A new test for high-dimensional regression coefficients in partially linear models

Partially linear regression models are semiparametric models that contain both linear and nonlinear components. They are extensively used in many scientific fields for their flexibility and convenient interpretability. In such analyses, testing the significance of the regression coefficients in the linear component is typically a key focus. Under the high-dimensional setting, i.e., “large p, small n,” the conventional F-test strategy does not apply because the coefficients need to be estimated through regularization techniques. In this article, we develop a new test using a U-statistic of order two, relying on a pseudo-estimate of the nonlinear component from the classical kernel method. Using the martingale central limit theorem, we prove the asymptotic normality of the proposed test statistic under some regularity conditions. We further demonstrate our proposed test's finite-sample performance by simulation studies and by analyzing some breast cancer gene expression data.     

Efficiency of the generalized difference-based Liu estimators in semiparametric regression models with correlated errors

In this paper, a generalized difference-based estimator is introduced for the vector parameter β in the semiparametric regression model when the errors are correlated. A generalized difference-based Liu estimator is defined for the vector parameter β in the semiparametric regression model. Under the linear nonstochastic constraint Rβ=r, the generalized restricted difference-based Liu estimator is given. The risk function for the β?_GRD(η) associated with weighted balanced loss function is presented. The performance of the proposed estimators is evaluated by a simulated data set.     

A gradient-based algorithm for semiparametric models with missing covariates

In the parametric regression model, the covariate missing problem under missing at random is considered. It is often desirable to use flexible parametric or semiparametric models for the covariate distribution, which can reduce a potential misspecification problem. Recently, a completely nonparametric approach was developed by [H.Y. Chen, Nonparametric and semiparametric models for missing covariates in parameter regression, J. Amer. Statist. Assoc. 99 (2004), pp. 1176–1189; Z. Zhang and H.E. Rockette, On maximum likelihood estimation in parametric regression with missing covariates, J. Statist. Plann. Inference 47 (2005), pp. 206–223]. Although it does not require a model for the covariate distribution or the missing data mechanism, the proposed method assumes that the covariate distribution is supported only by observed values. Consequently, their estimator is a restricted maximum likelihood estimator (MLE) rather than the global MLE. In this article, we show the restricted semiparametric MLE could be very misleading in some cases. We discuss why this problem occurs and suggest an algorithm to obtain the global MLE. Then, we assess the performance of the proposed method via some simulation experiments.     

Optimal experimental design criterion for discriminating semiparametric models

This paper studies the optimal experimental design problem to discriminate two regression models. Recently, López-Fidalgo et al. [2007. An optimal experimental design criterion for discriminating between non-normal models. J. Roy. Statist. Soc. B 69, 231–242] extended the conventional T-optimality criterion by Atkinson and Fedorov [1975a. The designs of experiments for discriminating between two rival models. Biometrika 62, 57–70; 1975b. Optimal design: experiments for discriminating between several models. Biometrika 62, 289–303] to deal with non-normal parametric regression models, and proposed a new optimal experimental design criterion based on the Kullback–Leibler information divergence. In this paper, we extend their parametric optimality criterion to a semiparametric setup, where we only need to specify some moment conditions for the null or alternative regression model. Our criteria, called the semiparametric Kullback–Leibler optimality criteria, can be implemented by applying a convex duality result of partially finite convex programming. The proposed method is illustrated by a simple numerical example.     

Analysing truncated data with semiparametric transformation models

Left-truncation often arises when patient information, such as time of diagnosis, is gathered retrospectively. In some cases, the distribution function, say G(x), of left-truncated variables can be parameterized as G(x; θ), where θ∈Θ?R^q and θ is a q-dimensional vector. Under semiparametric transformation models, we demonstrated that the approach of Chen et al. (Semiparametric analysis of transformation models with censored data. Biometrika. 2002;89:659–668) can be used to analyse this type of data. The asymptotic properties of the proposed estimators are derived. A simulation study is conducted to investigate the performance of the proposed estimators.     

Locally Efficient Semiparametric Estimators for Proportional Hazards Models with Measurement Error

We propose a new class of semiparametric estimators for proportional hazards models in the presence of measurement error in the covariates, where the baseline hazard function, the hazard function for the censoring time, and the distribution of the true covariates are considered as unknown infinite dimensional parameters. We estimate the model components by solving estimating equations based on the semiparametric efficient scores under a sequence of restricted models where the logarithm of the hazard functions are approximated by reduced rank regression splines. The proposed estimators are locally efficient in the sense that the estimators are semiparametrically efficient if the distribution of the error‐prone covariates is specified correctly and are still consistent and asymptotically normal if the distribution is misspecified. Our simulation studies show that the proposed estimators have smaller biases and variances than competing methods. We further illustrate the new method with a real application in an HIV clinical trial.     

Bayesian semiparametric models for nonignorable missing mechanisms in generalized linear models

Semiparametric models provide a more flexible form for modeling the relationship between the response and the explanatory variables. On the other hand in the literature of modeling for the missing variables, canonical form of the probability of the variable being missing (p) is modeled taking a fully parametric approach. Here we consider a regression spline based semiparametric approach to model the missingness mechanism of nonignorably missing covariates. In this model the relationship between the suitable canonical form of p (e.g. probit p) and the missing covariate is modeled through several splines. A Bayesian procedure is developed to efficiently estimate the parameters. A computationally advantageous prior construction is proposed for the parameters of the semiparametric part. A WinBUGS code is constructed to apply Gibbs sampling to obtain the posterior distributions. We show through an extensive Monte Carlo simulation experiment that response model coefficent estimators maintain better (when the true missingness mechanism is nonlinear) or equivalent (when the true missingness mechanism is linear) bias and efficiency properties with the use of proposed semiparametric missingness model compared to the conventional model.     

A note on the asymptotic relative efficiency of estimators from the additive hazards model

In this note, the asymptotic variance formulas are explicitly derived and compared between the parametric and semiparametric estimators of a regression parameter and survival probability under the additive hazards model. To obtain explicit formulas, it is assumed that the covariate term including a regression coefficient follows a gamma distribution and the baseline hazard function is constant. The results show that the semiparametric estimator of the regression coefficient parameter is fully efficient relative to the parametric counterpart when the survival time and a covariate are independent, as in the proportional hazards model. Relative to a more realistic case of the parametric additive hazards model with a Weibull baseline, the loss of efficiency of the semiparametric estimator of survival probability is moderate.     

Marginal Likelihood Estimation for Proportional Odds Models with Right Censored Data

One majoraspect in medical research is to relate the survival times ofpatients with the relevant covariates or explanatory variables.The proportional hazards model has been used extensively in thepast decades with the assumption that the covariate effects actmultiplicatively on the hazard function, independent of time.If the patients become more homogeneous over time, say the treatmenteffects decrease with time or fade out eventually, then a proportionalodds model may be more appropriate. In the proportional oddsmodel, the odds ratio between patients can be expressed as afunction of their corresponding covariate vectors, in which,the hazard ratio between individuals converges to unity in thelong run. In this paper, we consider the estimation of the regressionparameter for a semiparametric proportional odds model at whichthe baseline odds function is an arbitrary, non-decreasing functionbut is left unspecified. Instead of using the exact survivaltimes, only the rank order information among patients is used.A Monte Carlo method is used to approximate the marginal likelihoodfunction of the rank invariant transformation of the survivaltimes which preserves the information about the regression parameter.The method can be applied to other transformation models withcensored data such as the proportional hazards model, the generalizedprobit model or others. The proposed method is applied to theVeteran's Administration lung cancer trial data.     

Feasible robust estimator in restricted semiparametric regression models based on the LTS approach

Under some nonstochastic linear restrictions based on either additional information or prior knowledge in a semiparametric regression model, a family of feasible generalized robust estimators for the regression parameter is proposed. The least trimmed squares (LTS) method proposed by Rousseeuw as a highly robust regression estimator is a statistical technique for fitting a regression model based on the subset of h observations (out of n) whose least-square fit possesses the smallest sum of squared residuals. The coverage h may be set between n/2 and n. The LTS estimator involves computing the hyperplane that minimizes the sum of the smallest h squared residuals. For practical purpose, it is assumed that the covariance matrix of the error term is unknown and thus feasible estimators are replaced. Then, we develop an algorithm for the LTS estimator based on feasible methods. Through the Monte Carlo simulation studies and a real data example, performance of the feasible type of robust estimators is compared with the classical ones in restricted semiparametric regression models.     

Assessing goodness-of-fit of categorical regression models based on case-control data

Demonstrated equivalence between a categorical regression model based on case‐control data and an I‐sample semiparametric selection bias model leads to a new goodness‐of‐fit test. The proposed test statistic is an extension of an existing Kolmogorov–Smirnov‐type statistic and is the weighted average of the absolute differences between two estimated distribution functions in each response category. The paper establishes an optimal property for the maximum semiparametric likelihood estimator of the parameters in the I‐sample semiparametric selection bias model. It also presents a bootstrap procedure, some simulation results and an analysis of two real datasets.     

Semiparametric regression methods for temporal processes subject to multiple sources of censoring

Process regression methodology is underdeveloped relative to the frequency with which pertinent data arise. In this article, the response-190 is a binary indicator process representing the joint event of being alive and remaining in a specific state. The process is indexed by time (e.g., time since diagnosis) and observed continuously. Data of this sort occur frequently in the study of chronic disease. A general area of application involves a recurrent event with non-negligible duration (e.g., hospitalization and associated length of hospital stay) and subject to a terminating event (e.g., death). We propose a semiparametric multiplicative model for the process version of the probability of being alive and in the (transient) state of interest. Under the proposed methods, the regression parameter is estimated through a procedure that does not require estimating the baseline probability. Unlike the majority of process regression methods, the proposed methods accommodate multiple sources of censoring. In particular, we derive a computationally convenient variant of inverse probability of censoring weighting based on the additive hazards model. We show that the regression parameter estimator is asymptotically normal, and that the baseline probability function estimator converges to a Gaussian process. Simulations demonstrate that our estimators have good finite sample performance. We apply our method to national end-stage liver disease data. The Canadian Journal of Statistics 48: 222–237; 2020 © 2019 Statistical Society of Canada     

Estimation of partially linear single-index additive hazards model with current status data

In this paper, we introduce a partially linear single-index additive hazards model with current status data. Both the unknown link function of the single-index term and the cumulative baseline hazard function are approximated by B-splines under a monotonicity constraint on the latter. The sieve method is applied to estimate the nonparametric and parametric components simultaneously. We show that, when the nonparametric link function is an exact B-spline, the resultant estimator of regression parameter vector is asymptotically normal and achieves the semiparametric information bound and the rate of convergence of the estimator for the cumulative baseline hazard function is optimal. Simulation studies are presented to examine the finite sample performance of the proposed estimation method. For illustration, we apply the method to a clinical dataset with current status outcome.     

NEW EFFICIENT ESTIMATION AND VARIABLE SELECTION METHODS FOR SEMIPARAMETRIC VARYING-COEFFICIENT PARTIALLY LINEAR MODELS

The complexity of semiparametric models poses new challenges to statistical inference and model selection that frequently arise from real applications. In this work, we propose new estimation and variable selection procedures for the semiparametric varying-coefficient partially linear model. We first study quantile regression estimates for the nonparametric varying-coefficient functions and the parametric regression coefficients. To achieve nice efficiency properties, we further develop a semiparametric composite quantile regression procedure. We establish the asymptotic normality of proposed estimators for both the parametric and nonparametric parts and show that the estimators achieve the best convergence rate. Moreover, we show that the proposed method is much more efficient than the least-squares-based method for many non-normal errors and that it only loses a small amount of efficiency for normal errors. In addition, it is shown that the loss in efficiency is at most 11.1% for estimating varying coefficient functions and is no greater than 13.6% for estimating parametric components. To achieve sparsity with high-dimensional covariates, we propose adaptive penalization methods for variable selection in the semiparametric varying-coefficient partially linear model and prove that the methods possess the oracle property. Extensive Monte Carlo simulation studies are conducted to examine the finite-sample performance of the proposed procedures. Finally, we apply the new methods to analyze the plasma beta-carotene level data.     

Finite Mixture of Generalized Semiparametric Models: Variable Selection via Penalized Estimation

Selection of the important variables is one of the most important model selection problems in statistical applications. In this article, we address variable selection in finite mixture of generalized semiparametric models. To overcome computational burden, we introduce a class of variable selection procedures for finite mixture of generalized semiparametric models using penalized approach for variable selection. Estimation of nonparametric component will be done via multivariate kernel regression. It is shown that the new method is consistent for variable selection and the performance of proposed method will be assessed via simulation.     

Empirical likelihood-based serial correlation testing in partially varying coefficient single-index models

ABSTRACT

Partially varying coefficient single-index models (PVCSIM) are a class of semiparametric regression models. One important assumption is that the model error is independently and identically distributed, which may contradict with the reality in many applications. For example, in the economical and financial applications, the observations may be serially correlated over time. Based on the empirical likelihood technique, we propose a procedure for testing the serial correlation of random error in PVCSIM. Under some regular conditions, we show that the proposed empirical likelihood ratio statistic asymptotically follows a standard χ² distribution. We also present some numerical studies to illustrate the performance of our proposed testing procedure.