A sequential design for a clinical trial with a linear prognostic factor

We study a randomized adaptive design to assign one of the L$L$ treatments to patients who arrive sequentially by means of an urn model. At each stage n$n$, a reward is distributed between treatments. The treatment applied is rewarded according to its response, 0?_Yn?1$0?Y_n?1$, and 1-_Yn$1-Y_n$ is distributed among the other treatments according to their performance until stage n-1$n-1$. Patients can be classified in K+1$K+1$ levels and we assume that the effect of this level in the response to the treatments is linear. We study the asymptotic behavior of the design when the ordinary least square estimators are used as a measure of performance until stage n-1$n-1$.     

The use of an identity in Anderson for multivariate multiple testing

Consider the model where there are I$I$ independent multivariate normal treatment populations with p×1$p\times 1$ mean vectors _μi${\mathit{\mu }}_i$, i=1,…,I$i=1,\dots ,I$, and covariance matrix Σ$\Sigma$. Independently the (I+1)$(I+1)$st population corresponds to a control and it too is multivariate normal with mean vector _μI+1${\mathit{\mu }}_{I+1}$ and covariance matrix Σ$\Sigma$. Now consider the following two multiple testing problems.     

Moderate deviations for LS estimator in simple linear EV regression model

In this paper, we consider the following simple linear Errors-in-Variables (EV) regression model _ηi=θ+β_xi+_?i${\eta }_i=\theta +\beta x_i+{?}_i$, _ξi=_xi+_δi${\xi }_i=x_i+{\delta }_i$, 1?i?n$1?i?n$. The moderate deviation principle for the least squares (LS) estimators of the unknown parameters θ$\theta$, β$\beta$ in the model are obtained.     

Distribution of concomitants of order statistics and their order statistics

For a random sample of size n$n$ from an absolutely continuous random vector (X,Y)$(X,Y)$, let _Yi:n$Y_{i:n}$ be i$i$th Y$Y$-order statistic and _Y[j:n]$Y_{[j:n]}$ be the Y$Y$-concomitant of _Xj:n$X_{j:n}$. We determine the joint pdf of _Yi:n$Y_{i:n}$ and _Y[j:n]$Y_{[j:n]}$ for all i,j=1$i,j=1$ to n$n$, and establish some symmetry properties of the joint distribution for symmetric populations. We discuss the uses of the joint distribution in the computation of moments and probabilities of various ranks for _Y[j:n]$Y_{[j:n]}$. We also show how our results can be used to determine the expected cost of mismatch in broken bivariate samples and approximate the first two moments of the ratios of linear functions of _Yi:n$Y_{i:n}$ and _Y[j:n]$Y_{[j:n]}$. For the bivariate normal case, we compute the expectations of the product of _Yi:n$Y_{i:n}$ and _Y[i:n]$Y_{[i:n]}$ for n=2$n=2$ to 8 for selected values of the correlation coefficient and illustrate their uses.     

Characterizations based on record values and order statistics

Consider a sequence of independent and identically distributed random variables {_Xi,i?1}$\{X_i,i?1\}$ with a common absolutely continuous distribution function F  . Let _X1:n?_X2:n???_Xn:n$X_{1:n}?X_{2:n}???X_{n:n}$ be the order statistics of {_X1,_X2,…,_Xn}$\{X_1,X_2,\dots ,X_n\}$ and {_Yl,l?1}$\{Y_l,l?1\}$ be the sequence of record values generated by {_Xi,i?1}$\{X_i,i?1\}$. In this work, the conditional distribution of _Yl$Y_l$ given _Xn:n$X_{n:n}$ is established. Some characterizations of F   based on record values and _Xn:n$X_{n:n}$ are then given.     

Nonparametric estimation of conditional expectation

Denote the integer lattice points in the N  -dimensional Euclidean space by Z^N${\mathbb{Z}}^N$ and assume that (_Xi,_Yi)$(X_{\mathbf{i}},Y_{\mathbf{i}})$, i∈Z^N$\mathbf{i}\in {\mathbb{Z}}^N$ is a mixing random field. Estimators of the conditional expectation r(x)=E[_Yi|_Xi=x]$r(\mathbf{x})=\mathrm{E}[Y_{\mathbf{i}}|X_{\mathbf{i}}=\mathbf{x}]$ by nearest neighbor methods are established and investigated. The main analytical result of this study is that, under general mixing assumptions, the estimators considered are asymptotically normal. Many difficulties arise since points in higher dimensional space N?2$N?2$ cannot be linearly ordered. Our result applies to many situations where parametric methods cannot be adopted with confidence.     

Improving density estimators of discretely observed processes by interpolation

We consider density estimation for a smooth stationary process _Xt$X_t$, t∈R$t\in \mathbf{R}$, based on a discrete sample _Yi=_XΔi$Y_i=X_{\mathrm{\Delta }i}$, i=0,…,n=T/Δ$i=0,\dots ,n=T/\Delta$. By a suitable interpolation scheme of order p  , we augment data to form an approximation _Xp,t$X_{p,t}$, t∈[0,T]$t\in [0,T]$, of the continuous-time process and base our density estimate on the augmented sample path. Our results show that this can improve the rate of convergence (measured in terms of n) of the density estimate. Among other things, this implies that recording n   observations using a small Δ$\Delta$ can be more efficient than recording n independent observations.     

On asymptotic properties of the parameter estimator for a type of SPDE

In this paper, we study a random field _U?(t,x)$U_{?}(t,x)$ governed by some type of stochastic partial differential equations with an unknown parameter θ$\theta$ and a small noise ?$?$. We construct an estimator of θ$\theta$ based on the continuous observation of N   Fourier coefficients of _U?(t,x)$U_{?}(t,x)$, and prove the strong convergence and asymptotic normality of the estimator when the noise ?$?$ tends to zero.     

Limit laws for the cumulative number of ties for the maximum in a random sequence

Let {_Xn,n?1}$\{X_n,n?1\}$ be a sequence of independent identically distributed random variables, taking nonnegative integer values. An observation _Xn$X_n$ is a tie for the maximum if _Xn=max{_X1,…,_Xn-1}$X_n=\max \{X_1,\dots ,X_{n-1}\}$. In this paper, we obtain weak and strong laws of large numbers and central limit theorems for the cumulative number of ties for the maximum among the first n$n$ observations.     

An identity for the Fisher information and Mahalanobis distance

Consider a mixture problem consisting of k classes. Suppose we observe an s-dimensional random vector X   whose distribution is specified by the relations P(X∈A|Y=i)=_Pi(A)$P(X\in A|Y=i)=P_i(A)$, where Y   is an unobserved class identifier defined on {1,…,k}$\{1,\dots ,k\}$, having distribution P(Y=i)=_pi$P(Y=i)=p_i$. Assuming the distributions _Pi$P_i$ having a common covariance matrix, elegant identities are presented that connect the matrix of Fisher information in Y   on the parameters _p1,…,_pk$p_1,\dots ,p_k$, the matrix of linear information in X, and the Mahalanobis distances between the pairs of P  's. Since the parameters are not free, the information matrices are singular and the technique of generalized inverses is used. A matrix extension of the Mahalanobis distance and its invariant forms are introduced that are of interest in their own right. In terms of parameter estimation, the results provide an independent of the parameter upper bound for the loss of accuracy by esimating _p1,…,_pk$p_1,\dots ,p_k$ from a sample of X^′$X^{\prime }$s, as compared with the ideal estimator based on a random sample of Y^′$Y^{\prime }$s.