Nonparametric hierarchical Bayes analysis of binomial data via Bernstein polynomial priors

For binomial data analysis, many methods based on empirical Bayes interpretations have been developed, in which a variance‐stabilizing transformation and a normality assumption are usually required. To achieve the greatest model flexibility, we conduct nonparametric Bayesian inference for binomial data and employ a special nonparametric Bayesian prior—the Bernstein–Dirichlet process (BDP)—in the hierarchical Bayes model for the data. The BDP is a special Dirichlet process (DP) mixture based on beta distributions, and the posterior distribution resulting from it has a smooth density defined on [0, 1]. We examine two Markov chain Monte Carlo procedures for simulating from the resulting posterior distribution, and compare their convergence rates and computational efficiency. In contrast to existing results for posterior consistency based on direct observations, the posterior consistency of the BDP, given indirect binomial data, is established. We study shrinkage effects and the robustness of the BDP‐based posterior estimators in comparison with several other empirical and hierarchical Bayes estimators, and we illustrate through examples that the BDP‐based nonparametric Bayesian estimate is more robust to the sample variation and tends to have a smaller estimation error than those based on the DP prior. In certain settings, the new estimator can also beat Stein's estimator, Efron and Morris's limited‐translation estimator, and many other existing empirical Bayes estimators. The Canadian Journal of Statistics 40: 328–344; 2012 © 2012 Statistical Society of Canada     

Bayesian estimation for first-order autoregressive model with explanatory variables

In this article, we develop a Bayesian analysis in autoregressive model with explanatory variables. When σ² is known, we consider a normal prior and give the Bayesian estimator for the regression coefficients of the model. For the case σ² is unknown, another Bayesian estimator is given for all unknown parameters under a conjugate prior. Bayesian model selection problem is also being considered under the double-exponential priors. By the convergence of ρ-mixing sequence, the consistency and asymptotic normality of the Bayesian estimators of the regression coefficients are proved. Simulation results indicate that our Bayesian estimators are not strongly dependent on the priors, and are robust.     

Bayes estimation for a bivariate survival model based on exponential distributions

Bayesian analysis of a bivariate survival model based on exponential distributions is discussed using both vague and conjugate prior distributions. Parameter and reliability estimators are given for the maximum likelihood technique and the Bayesian approach using both types of priors. A Monte Carlo study indicates the vague prior Bayes estimator of reliability performs better than its maximum likelihood counterpart.     

A Bayesian nonparametric estimator based on left censored data

Summary This paper introduces a Bayesian nonparametric estimator for an unknown distribution function based on left censored observations. Hjort (1990)/Lo (1993) introduced Bayesian nonparametric estimators derived from beta/beta-neutral processes which allow for right censoring. These processes are taken as priors from the class ofneutral to the right processes (Doksum, 1974). The Kaplan-Meier nonparametric product limit estimator can be obtained from these Bayesian nonparametric estimators in the limiting case of a vague prior. The present paper introduces what can be seen as the correspondingleft beta/beta-neutral process prior which allow for left censoring. The Bayesian nonparametyric estimator is obtained as in the corresponding product limit estimator based on left censored data.     

Objective Bayesian Analysis for Log-logistic Distribution

In this article, Bayesian approach is applied to estimate the parameters of Log-logistic distribution under reference prior and Jeffreys’ prior. The reference prior is derived and it is found that the reference prior is also a second-order matching priors as for the case of any parameter of interest. The Bayesian estimators cannot be obtained in explicit forms. Metropolis within Gibbs sampling algorithm is used to obtain the Bayesian estimators. The Bayesian estimates are compared with the maximum likelihood estimates via simulation study. A real dataset is considered for illustrative purposes.     

A matching prior for the product of normal means based on the modified profile likelihood

In this paper, we develop a matching prior for the product of means in several normal distributions with unrestricted means and unknown variances. For this problem, properly assigning priors for the product of normal means has been issued because of the presence of nuisance parameters. Matching priors, which are priors matching the posterior probabilities of certain regions with their frequentist coverage probabilities, are commonly used but difficult to derive in this problem. We developed the first order probability matching priors for this problem; however, the developed matching priors are unproper. Thus, we apply an alternative method and derive a matching prior based on a modification of the profile likelihood. Simulation studies show that the derived matching prior performs better than the uniform prior and Jeffreys’ prior in meeting the target coverage probabilities, and meets well the target coverage probabilities even for the small sample sizes. In addition, to evaluate the validity of the proposed matching prior, Bayesian credible interval for the product of normal means using the matching prior is compared to Bayesian credible intervals using the uniform prior and Jeffrey’s prior, and the confidence interval using the method of Yfantis and Flatman.     

Noninformative priors for linear combinations of normal means with unequal variances

For normal populations with unequal variances, we develop matching priors and reference priors for a linear combination of the means. Here, we find three second-order matching priors: a highest posterior density (HPD) matching prior, a cumulative distribution function (CDF) matching prior, and a likelihood ratio (LR) matching prior. Furthermore, we show that the reference priors are all first-order matching priors, but that they do not satisfy the second-order matching criterion that establishes the symmetry and the unimodality of the posterior under the developed priors. The results of a simulation indicate that the second-order matching prior outperforms the reference priors in terms of matching the target coverage probabilities, in a frequentist sense. Finally, we compare the Bayesian credible intervals based on the developed priors with the confidence intervals derived from real data.     

Bayesian Estimation of the Parameters of Bivariate Exponential Distributions

In this article, we develop an empirical Bayesian approach for the Bayesian estimation of parameters in four bivariate exponential (BVE) distributions. We have opted for gamma distribution as a prior for the parameters of the model in which the hyper parameters have been estimated based on the method of moments and maximum likelihood estimates (MLEs). A simulation study was conducted to compute empirical Bayesian estimates of the parameters and their standard errors. We use moment estimators or MLEs to estimate the hyper parameters of the prior distributions. Furthermore, we compare the posterior mode of parameters obtained by different prior distributions and the Bayesian estimates based on gamma priors are very close to the true values as compared to improper priors. We use MCMC method to obtain the posterior mean and compared the same using the improper priors and the classical estimates, MLEs.     

Bayesian multivariate normal analysis under the extended reflected normal loss function

This paper considers the Bayesian analysis of the multivariate normal distribution under a new and bounded loss function, based on a reflection of the multivariate normal density function. The Bayes estimators of the mean vector can be derived for an arbitrary prior distribution of [d]. When the covariance matrix has an inverted Wishart prior density, a Bayes estimator of[d] is obtained under a bounded loss function, based on the entropy loss. Finally the admissibility of all linear estimators c[d]+ d for the mean vector is considered     

Bayesian sample size determination for phase IIA clinical trials using historical data and semi‐parametric prior's elicitation

The Simon's two‐stage design is the most commonly applied among multi‐stage designs in phase IIA clinical trials. It combines the sample sizes at the two stages in order to minimize either the expected or the maximum sample size. When the uncertainty about pre‐trial beliefs on the expected or desired response rate is high, a Bayesian alternative should be considered since it allows to deal with the entire distribution of the parameter of interest in a more natural way. In this setting, a crucial issue is how to construct a distribution from the available summaries to use as a clinical prior in a Bayesian design. In this work, we explore the Bayesian counterparts of the Simon's two‐stage design based on the predictive version of the single threshold design. This design requires specifying two prior distributions: the analysis prior, which is used to compute the posterior probabilities, and the design prior, which is employed to obtain the prior predictive distribution. While the usual approach is to build beta priors for carrying out a conjugate analysis, we derived both the analysis and the design distributions through linear combinations of B‐splines. The motivating example is the planning of the phase IIA two‐stage trial on anti‐HER2 DNA vaccine in breast cancer, where initial beliefs formed from elicited experts' opinions and historical data showed a high level of uncertainty. In a sample size determination problem, the impact of different priors is evaluated.     

Reference Priors for Poisson Processes Involving Nuisance Parameters

A Bayesian reference analysis for determining the posterior distribution of the strength of a radiation source is performed. The only pieces of information available are the numbers of counts gathered in a gross and a background measurement along with the respective counting times and a state-of-knowledge distribution for the efficiency. This situation is addressed by combining the calculations of a “one-at-a-time” reference prior and a reference prior with partial information. The posterior distribution of the source strength obtained with the reference prior leads to credible intervals that have better frequentist coverage than corresponding intervals founded on uniform or Jeffreys’ priors.     

A novel weighted likelihood estimation with empirical Bayes flavor

We propose a novel approach to estimation, where a set of estimators of a parameter is combined into a weighted average to produce the final estimator. The weights are chosen to be proportional to the likelihood evaluated at the estimators. We investigate the method for a set of estimators obtained by using the maximum likelihood principle applied to each individual observation. The method can be viewed as a Bayesian approach with a data-driven prior distribution. We provide several examples illustrating the new method and argue for its consistency, asymptotic normality, and efficiency. We also conduct simulation studies to assess the performance of the estimators. This straightforward methodology produces consistent estimators comparable with those obtained by the maximum likelihood method. The method also approximates the distribution of the estimator through the “posterior” distribution.     

Bayesian analysis of the generalized gamma distribution using non-informative priors

The Generalized gamma (GG) distribution plays an important role in statistical analysis. For this distribution, we derive non-informative priors using formal rules, such as Jeffreys prior, maximal data information prior and reference priors. We have shown that these most popular formal rules with natural ordering of parameters, lead to priors with improper posteriors. This problem is overcome by considering a prior averaging approach discussed in Berger et al. [Overall objective priors. Bayesian Analysis. 2015;10(1):189–221]. The obtained hybrid Jeffreys-reference prior is invariant under one-to-one transformations and yields a proper posterior distribution. We obtained good frequentist properties of the proposed prior using a detailed simulation study. Finally, an analysis of the maximum annual discharge of the river Rhine at Lobith is presented.     

Bayesian and frequentist prediction limits for the Poisson distribution

Prediction limits for Poisson distribution are useful in real life when predicting the occurrences of some phenomena, for example, the number of infections from a disease per year among school children, or the number of hospitalizations per year among patients with cardiovascular disease. In order to allocate the right resources and to estimate the associated cost, one would want to know the worst (i.e., an upper limit) and the best (i.e., the lower limit) scenarios. Under the Poisson distribution, we construct the optimal frequentist and Bayesian prediction limits, and assess frequentist properties of the Bayesian prediction limits. We show that Bayesian upper prediction limit derived from uniform prior distribution and Bayesian lower prediction limit derived from modified Jeffreys non informative prior coincide with their respective frequentist limits. This is not the case for the Bayesian lower prediction limit derived from a uniform prior and the Bayesian upper prediction limit derived from a modified Jeffreys prior distribution. Furthermore, it is shown that not all Bayesian prediction limits derived from a proper prior can be interpreted in a frequentist context. Using a counterexample, we state a sufficient condition and show that Bayesian prediction limits derived from proper priors satisfying our condition cannot be interpreted in a frequentist context. Analysis of simulated data and data on Atlantic tropical storm occurrences are presented.     

A note on Bayesian nonparametric regression function estimation

In this note the problem of nonparametric regression function estimation in a random design regression model with Gaussian errors is considered from the Bayesian perspective. It is assumed that the regression function belongs to a class of functions with a known degree of smoothness. A prior distribution on the given class can be induced by a prior on the coefficients in a series expansion of the regression function through an orthonormal system. The rate of convergence of the resulting posterior distribution is employed to provide a measure of the accuracy of the Bayesian estimation procedure defined by the posterior expected regression function. We show that the Bayes’ estimator achieves the optimal minimax rate of convergence under mean integrated squared error over the involved class of regression functions, thus being comparable to other popular frequentist regression estimators.     

Estimation of covariance matrices based on hierarchical inverse-Wishart priors

This paper focuses on Bayesian shrinkage methods for covariance matrix estimation. We examine posterior properties and frequentist risks of Bayesian estimators based on new hierarchical inverse-Wishart priors. More precisely, we give the conditions for the existence of the posterior distributions. Advantages in terms of numerical simulations of posteriors are shown. A simulation study illustrates the performance of the estimation procedures under three loss functions for relevant sample sizes and various covariance structures.     

A prior for the variance in hierarchical models

The choice of prior distributions for the variances can be important and quite difficult in Bayesian hierarchical and variance component models. For situations where little prior information is available, a ‘nonin-formative’ type prior is usually chosen. ‘Noninformative’ priors have been discussed by many authors and used in many contexts. However, care must be taken using these prior distributions as many are improper and thus, can lead to improper posterior distributions. Additionally, in small samples, these priors can be ‘informative’. In this paper, we investigate a proper ‘vague’ prior, the uniform shrinkage prior (Strawder-man 1971; Christiansen & Morris 1997). We discuss its properties and show how posterior distributions for common hierarchical models using this prior lead to proper posterior distributions. We also illustrate the attractive frequentist properties of this prior for a normal hierarchical model including testing and estimation. To conclude, we generalize this prior to the multivariate situation of a covariance matrix.     

Bayesian analysis of elapsed times in continuous‐time Markov chains

The authors consider Bayesian analysis for continuous‐time Markov chain models based on a conditional reference prior. For such models, inference of the elapsed time between chain observations depends heavily on the rate of decay of the prior as the elapsed time increases. Moreover, improper priors on the elapsed time may lead to improper posterior distributions. In addition, an infinitesimal rate matrix also characterizes this class of models. Experts often have good prior knowledge about the parameters of this matrix. The authors show that the use of a proper prior for the rate matrix parameters together with the conditional reference prior for the elapsed time yields a proper posterior distribution. The authors also demonstrate that, when compared to analyses based on priors previously proposed in the literature, a Bayesian analysis on the elapsed time based on the conditional reference prior possesses better frequentist properties. The type of prior thus represents a better default prior choice for estimation software.     

Empirical bayes estimation of binomial parameter with symmetric priors

This paper deals with the problem of estimating the binomial parameter via the nonparametric empirical Bayes approach. This estimation problem has the feature that estimators which are asymptotically optimal in the usual empirical Bayes sense do not exist (Robbins (1958, 1964)), However, as pointed out by Liang (1934) and Gupta and Liang (1988), it is possible to construct asymptotically optimal empirical Bayes estimators if the unknown prior is symmetric about the point 1/2, In this paper, assuming symmetric priors a monotone empirical Bayes estimator is constructed by using the isotonic regression method. This estimator is asymptotically optimal in the usual empirical Bayes sense. The corresponding rate of convergence is investigated and shown to be of order n^-1, where n is the number of past observations at hand.