Robust inference in an heteroscedastic measurement error model

In this paper we deal with robust inference in heteroscedastic measurement error models. Rather than the normal distribution, we postulate a Student t distribution for the observed variables. Maximum likelihood estimates are computed numerically. Consistent estimation of the asymptotic covariance matrices of the maximum likelihood and generalized least squares estimators is also discussed. Three test statistics are proposed for testing hypotheses of interest with the asymptotic chi-square distribution which guarantees correct asymptotic significance levels. Results of simulations and an application to a real data set are also reported.     

On the estimation of the extreme value and normal distribution parameters based on progressive type-II hybrid-censored data

A progressive hybrid censoring scheme is a mixture of type-I and type-II progressive censoring schemes. In this paper, we mainly consider the analysis of progressive type-II hybrid-censored data when the lifetime distribution of the individual item is the normal and extreme value distributions. Since the maximum likelihood estimators (MLEs) of these parameters cannot be obtained in the closed form, we propose to use the expectation and maximization (EM) algorithm to compute the MLEs. Also, the Newton–Raphson method is used to estimate the model parameters. The asymptotic variance–covariance matrix of the MLEs under EM framework is obtained by Fisher information matrix using the missing information and asymptotic confidence intervals for the parameters are then constructed. This study will end up with comparing the two methods of estimation and the asymptotic confidence intervals of coverage probabilities corresponding to the missing information principle and the observed information matrix through a simulation study, illustrated examples and real data analysis.     

含非随机缺失数据的面板数据参数估计方法

抽样调查领域常采用对多个受访者进行跟踪调查得到面板数据,进而对总体特性进行统计推断,在面板数据中常含缺失数据,大多数处理面板缺失数据的软件都是直接删去含缺失值的受访者以得到完全数据集,当数据缺失机制为非随机缺失时会导致总体参数估计结果有偏。本文针对数据缺失机制为非随机缺失情形下,如何对面板数据进行统计分析进行了阐述,主要采用的是基于模型的似然推断法,对目标变量、缺失指示变量和随机效应向量的联合分布建模,在已有选择模型和模式混合模型的基础上,引入随机效应,研究目标变量期望的计算方法,并研究随机效应杂合模型下参数的估计方法,在变量分布相对简单的情形下给出了用极大似然法推断总体参数的估计步骤,最后通过模拟分析比较方法的优劣。     

Methods of Statistical Inference for Median Regression Models with Doubly Censored Data

Recently, least absolute deviations (LAD) estimator for median regression models with doubly censored data was proposed and the asymptotic normality of the estimator was established. However, it is invalid to make inference on the regression parameter vectors, because the asymptotic covariance matrices are difficult to estimate reliably since they involve conditional densities of error terms. In this article, three methods, which are based on bootstrap, random weighting, and empirical likelihood, respectively, and do not require density estimation, are proposed for making inference for the doubly censored median regression models. Simulations are also done to assess the performance of the proposed methods.     

A tuning parameter free test for properties of space–time covariance functions

We propose a new nonparametric test to test for symmetry and separability of space–time covariance functions. Unlike the existing nonparametric tests, our test has the attractive convenience of being free of choosing any user-chosen number or smoothing parameter. The asymptotic null distributions of the test statistics are free of nuisance parameters and the critical values have been tabulated in the literature. From a practical point of view, our test is easy to implement and can be readily used by the practitioner. A Monte-Carlo experiment and real data analysis illustrate the finite sample performance of the new test.     

A Nonparametric Test Procedure Based on Quantiles for the Right Censored Data

In this study, we propose nonparametric tests using the several quantile statistics simultaneously for the right censored data. First of all, we consider statistics of the quadratic form with estimated covariance matrices. Then we derive the limiting distribution using the large sample approximation theory. Also we consider different forms of statistics such as the maximal and summing types with their limiting distributions. Then we illustrate our procedure with examples and compare performance among tests with empirical powers through a simulation study. Also we comment briefly on some interesting features including re-sampling methods as concluding remarks. Finally in Appendices, we provide proofs for the theoretic results needed for the derivation of the limiting distributions of the proposed test statistics.     

Efficient estimation in partially linear single‐index models for longitudinal data

In this paper, we consider the estimation of both the parameters and the nonparametric link function in partially linear single‐index models for longitudinal data that may be unbalanced. In particular, a new three‐stage approach is proposed to estimate the nonparametric link function using marginal kernel regression and the parametric components with generalized estimating equations. The resulting estimators properly account for the within‐subject correlation. We show that the parameter estimators are asymptotically semiparametrically efficient. We also show that the asymptotic variance of the link function estimator is minimized when the working error covariance matrices are correctly specified. The new estimators are more efficient than estimators in the existing literature. These asymptotic results are obtained without assuming normality. The finite‐sample performance of the proposed method is demonstrated by simulation studies. In addition, two real‐data examples are analyzed to illustrate the methodology.     

Bias-corrected estimations in varying-coefficient partially nonlinear models with measurement error in the nonparametric part

In this paper, we consider the statistical inference for the varying-coefficient partially nonlinear model with additive measurement errors in the nonparametric part. The local bias-corrected profile nonlinear least-squares estimation procedure for parameter in nonlinear function and nonparametric function is proposed. Then, the asymptotic normality properties of the resulting estimators are established. With the empirical likelihood method, a local bias-corrected empirical log-likelihood ratio statistic for the unknown parameter, and a corrected and residual adjusted empirical log-likelihood ratio for the nonparametric component are constructed. It is shown that the resulting statistics are asymptotically chi-square distribution under some suitable conditions. Some simulations are conducted to evaluate the performance of the proposed methods. The results indicate that the empirical likelihood method is superior to the profile nonlinear least-squares method in terms of the confidence regions of parameter and point-wise confidence intervals of nonparametric function.     

S–S method for stochastically ordered multinomial populations with missing data

Stochastic ordering is a useful concept in order restricted inferences. In this paper, we propose a new estimation technique for the parameters in two multinomial populations under stochastic orderings when missing data are present. In comparison with traditional maximum likelihood estimation method, our new method can guarantee the uniqueness of the maximum of the likelihood function. Furthermore, it does not depend on the choice of initial values for the parameters in contrast to the EM algorithm. Finally, we give the asymptotic distributions of the likelihood ratio statistics based on the new estimation method.     

A new heteroskedasticity-consistent covariance matrix estimator for the linear regression model

The assumption that all random errors in the linear regression model share the same variance (homoskedasticity) is often violated in practice. The ordinary least squares estimator of the vector of regression parameters remains unbiased, consistent and asymptotically normal under unequal error variances. Many practitioners then choose to base their inferences on such an estimator. The usual practice is to couple it with an asymptotically valid estimation of its covariance matrix, and then carry out hypothesis tests that are valid under heteroskedasticity of unknown form. We use numerical integration methods to compute the exact null distributions of some quasi-t test statistics, and propose a new covariance matrix estimator. The numerical results favor testing inference based on the estimator we propose.     

RANKED SET SAMPLING FROM LOCATION-SCALE FAMILIES OF SYMMETRIC DISTRIBUTIONS

Statistical inference based on ranked set sampling has primarily been motivated by nonparametric problems. However, the sampling procedure can provide an improved estimator of the population mean when the population is partially known. In this article, we consider estimation of the population mean and variance for the location-scale families of distributions. We derive and compare different unbiased estimators of these parameters based on rindependent replications of a ranked set sample of size n.Large sample properties, along with asymptotic relative efficiencies, help identify which estimators are best suited for different location-scale distributions.     

Rank Regression Analysis of Multivariate Failure Time Data Based on Marginal Linear Models

Abstract.  Multivariate failure time data arises when each study subject can potentially ex-perience several types of failures or recurrences of a certain phenomenon, or when failure times are sampled in clusters. We formulate the marginal distributions of such multivariate data with semiparametric accelerated failure time models (i.e. linear regression models for log-transformed failure times with arbitrary error distributions) while leaving the dependence structures for related failure times completely unspecified. We develop rank-based monotone estimating functions for the regression parameters of these marginal models based on right-censored observations. The estimating equations can be easily solved via linear programming. The resultant estimators are consistent and asymptotically normal. The limiting covariance matrices can be readily estimated by a novel resampling approach, which does not involve non-parametric density estimation or evaluation of numerical derivatives. The proposed estimators represent consistent roots to the potentially non-monotone estimating equations based on weighted log-rank statistics. Simulation studies show that the new inference procedures perform well in small samples. Illustrations with real medical data are provided.     

Structured Modeling for Post-Mortem Brain Tissue Data

Structured means have been used in studying possible covariate effects on responses, whereas patterned covariances deal with random effects, missing data, and differing study designs. In this article, we develop new multivariate models with patterned means and covariance matrices to deal with special structures of the post-mortem brain tissue data collected in the Conte Center for the Neuroscience of Mental Disorders at the University of Pittsburgh. We obtain maximum likelihood estimates via the method of scoring for these new structured models. One-iteration estimators from a consistent starting point are used to derive the asymptotic distributions. The model fitting algorithms, as well as the asymptotic distributions, are examined using simulated data, and are applied to data from post-mortem tissue studies in schizophrenia.     

Improving the bandwidth-free inference methods by prewhitening

In this paper we consider inference of parameters in time series regression models. In the traditional inference approach, the heteroskedasticity and autocorrelation consistent (HAC) estimation is often involved to consistently estimate the asymptotic covariance matrix of regression parameter estimator. Since the bandwidth parameter in the HAC estimation is difficult to choose in practice, there has been a recent surge of interest in developing bandwidth-free inference methods. However, existing simulation studies show that these new methods suffer from severe size distortion in the presence of strong temporal dependence for a medium sample size. To remedy the problem, we propose to apply the prewhitening to the inconsistent long-run variance estimator in these methods to reduce the size distortion. The asymptotic distribution of the prewhitened Wald statistic is obtained and the general effectiveness of prewhitening is shown through simulations.     

Inference from PseudoLikelihoods with Plug‐In Estimates

Effective implementation of likelihood inference in models for high‐dimensional data often requires a simplified treatment of nuisance parameters, with these having to be replaced by handy estimates. In addition, the likelihood function may have been simplified by means of a partial specification of the model, as is the case when composite likelihood is used. In such circumstances tests and confidence regions for the parameter of interest may be constructed using Wald type and score type statistics, defined so as to account for nuisance parameter estimation or partial specification of the likelihood. In this paper a general analytical expression for the required asymptotic covariance matrices is derived, and suggestions for obtaining Monte Carlo approximations are presented. The same matrices are involved in a rescaling adjustment of the log likelihood ratio type statistic that we propose. This adjustment restores the usual chi‐squared asymptotic distribution, which is generally invalid after the simplifications considered. The practical implication is that, for a wide variety of likelihoods and nuisance parameter estimates, confidence regions for the parameters of interest are readily computable from the rescaled log likelihood ratio type statistic as well as from the Wald type and score type statistics. Two examples, a measurement error model with full likelihood and a spatial correlation model with pairwise likelihood, illustrate and compare the procedures. Wald type and score type statistics may give rise to confidence regions with unsatisfactory shape in small and moderate samples. In addition to having satisfactory shape, regions based on the rescaled log likelihood ratio type statistic show empirical coverage in reasonable agreement with nominal confidence levels.     

The Asymptotic Covariance Matrix of the Least Squares Estimator in the Stochastic Linear Regression Model: The Case of Elliptically Symmetric Distribution

This article considers the unconditional asymptotic covariance matrix of the least squares estimator in the linear regression model with stochastic explanatory variables. The asymptotic covariance matrix of the least squares estimator of regression parameters is evaluated relative to the standard asymptotic covariance matrix when the joint distribution of the dependent and explanatory variables is in the class of elliptically symmetric distributions. An empirical example using financial data is presented. Numerical examples and simulation experiments are given to illustrate the difference of the two asymptotic covariance matrices.     

Pattern–mixture and selection models for analysing longitudinal data with monotone missing patterns

Summary. We examine three pattern–mixture models for making inference about parameters of the distribution of an outcome of interest Y that is to be measured at the end of a longitudinal study when this outcome is missing in some subjects. We show that these pattern–mixture models also have an interpretation as selection models. Because these models make unverifiable assumptions, we recommend that inference about the distribution of Y be repeated under a range of plausible assumptions. We argue that, of the three models considered, only one admits a parameterization that facilitates the examination of departures from the assumption of sequential ignorability. The three models are nonparametric in the sense that they do not impose restrictions on the class of observed data distributions. Owing to the curse of dimensionality, the assumptions that are encoded in these models are sufficient for identification but not for inference. We describe additional flexible and easily interpretable assumptions under which it is possible to construct estimators that are well behaved with moderate sample sizes. These assumptions define semiparametric models for the distribution of the observed data. We describe a class of estimators which, up to asymptotic equivalence, comprise all the consistent and asymptotically normal estimators of the parameters of interest under the postulated semiparametric models. We illustrate our methods with the analysis of data from a randomized clinical trial of contracepting women.     

Adaptive robust estimation in joint mean–covariance regression model for bivariate longitudinal data

The estimation of the covariance matrix is important in the analysis of bivariate longitudinal data. A good estimator for the covariance matrix can improve the efficiency of the estimators of the mean regression coefficients. Furthermore, the covariance estimation itself is also of interest, but it is a challenging job to model the covariance matrix of bivariate longitudinal data due to the complex structure and positive definite constraint. In addition, most of existing approaches are based on the maximum likelihood, which is very sensitive to outliers or heavy-tail error distributions. In this article, an adaptive robust estimation method is proposed for bivariate longitudinal data. Unlike the existing likelihood-based methods, the proposed method can adapt to different error distributions. Specifically, at first, we utilize the modified Cholesky block decomposition to parameterize the covariance matrices. Secondly, we apply the bounded Huber's score function to develop a set of robust generalized estimating equations to estimate the parameters both in the mean and the covariance models simultaneously. A data-driven approach is presented to select the parameter c in the Huber's score function, which can ensure that the proposed method is robust and efficient. A simulation study and a real data analysis are conducted to illustrate the robustness and efficiency of the proposed approach.     

ASYMPTOTIC DISTRIBUTIONS OF SEMIPARAMETRIC MAXIMUM LIKELIHOOD ESTIMATORS WITH ESTIMATING EQUATIONS FOR GROUP-CENSORED DATA

Semiparametric maximum likelihood estimation with estimating equations (SMLE) is more flexible than traditional methods; it has fewer restrictions on distributions and regression models. The required information about distribution and regression structures is incorporated in estimating equations of the SMLE to improve the estimation quality of non‐parametric methods. The likelihood of SMLE for censored data involves complicated implicit functions without closed‐form expressions, and the first derivatives of the log‐profile‐likelihood cannot be expressed as summations of independent and identically distributed random variables; it is challenging to derive asymptotic properties of the SMLE for censored data. For group‐censored data, the paper shows that all the implicit functions are well defined and obtains the asymptotic distributions of the SMLE for model parameters and lifetime distributions. With several examples the paper compares the SMLE, the regular non‐parametric likelihood estimation method and the parametric MLEs in terms of their asymptotic efficiencies, and illustrates application of SMLE. Various asymptotic distributions of the likelihood ratio statistics are derived for testing the adequacy of estimating equations and a partial set of parameters equal to some known values.     

Estimated estimating equations: semiparametric inference for clustered and longitudinal data

Summary.  We introduce a flexible marginal modelling approach for statistical inference for clustered and longitudinal data under minimal assumptions. This estimated estimating equations approach is semiparametric and the proposed models are fitted by quasi-likelihood regression, where the unknown marginal means are a function of the fixed effects linear predictor with unknown smooth link, and variance–covariance is an unknown smooth function of the marginal means. We propose to estimate the nonparametric link and variance–covariance functions via smoothing methods, whereas the regression parameters are obtained via the estimated estimating equations. These are score equations that contain nonparametric function estimates. The proposed estimated estimating equations approach is motivated by its flexibility and easy implementation. Moreover, if data follow a generalized linear mixed model, with either a specified or an unspecified distribution of random effects and link function, the model proposed emerges as the corresponding marginal (population-average) version and can be used to obtain inference for the fixed effects in the underlying generalized linear mixed model, without the need to specify any other components of this generalized linear mixed model. Among marginal models, the estimated estimating equations approach provides a flexible alternative to modelling with generalized estimating equations. Applications of estimated estimating equations include diagnostics and link selection. The asymptotic distribution of the proposed estimators for the model parameters is derived, enabling statistical inference. Practical illustrations include Poisson modelling of repeated epileptic seizure counts and simulations for clustered binomial responses.