Log‐rank permutation tests for trend: saddlepoint p‐values and survival rate confidence intervals

Suppose p + 1 experimental groups correspond to increasing dose levels of a treatment and all groups are subject to right censoring. In such instances, permutation tests for trend can be performed based on statistics derived from the weighted log‐rank class. This article uses saddlepoint methods to determine the mid‐P‐values for such permutation tests for any test statistic in the weighted log‐rank class. Permutation simulations are replaced by analytical saddlepoint computations which provide extremely accurate mid‐P‐values that are exact for most practical purposes and almost always more accurate than normal approximations. The speed of mid‐P‐value computation allows for the inversion of such tests to determine confidence intervals for the percentage increase in mean (or median) survival time per unit increase in dosage. The Canadian Journal of Statistics 37: 5‐16; 2009 © 2009 Statistical Society of Canada     

A generalized Fleming and Harrington's class of tests for interval‐censored data

The class $G^{\rho,\lambda }$ of weighted log‐rank tests proposed by Fleming & Harrington [Fleming & Harrington (1991) Counting Processes and Survival Analysis, Wiley, New York] has been widely used in survival analysis and is nowadays, unquestionably, the established method to compare, nonparametrically, k different survival functions based on right‐censored survival data. This paper extends the $G^{\rho,\lambda }$ class to interval‐censored data. First we introduce a new general class of rank based tests, then we show the analogy to the above proposal of Fleming & Harrington. The asymptotic behaviour of the proposed tests is derived using an observed Fisher information approach and a permutation approach. Aiming to make this family of tests interpretable and useful for practitioners, we explain how to interpret different choices of weights and we apply it to data from a cohort of intravenous drug users at risk for HIV infection. The Canadian Journal of Statistics 40: 501–516; 2012 © 2012 Statistical Society of Canada     

Smoothed empirical likelihood confidence intervals for the relative distribution with left‐truncated and right‐censored data

The study of differences among groups is an interesting statistical topic in many applied fields. It is very common in this context to have data that are subject to mechanisms of loss of information, such as censoring and truncation. In the setting of a two‐sample problem with data subject to left truncation and right censoring, we develop an empirical likelihood method to do inference for the relative distribution. We obtain a nonparametric generalization of Wilks' theorem and construct nonparametric pointwise confidence intervals for the relative distribution. Finally, we analyse the coverage probability and length of these confidence intervals through a simulation study and illustrate their use with a real data set on gastric cancer. The Canadian Journal of Statistics 38: 453–473; 2010 © 2010 Statistical Society of Canada     

Discrete‐time survival trees

Tree‐based methods are frequently used in studies with censored survival time. Their structure and ease of interpretability make them useful to identify prognostic factors and to predict conditional survival probabilities given an individual's covariates. The existing methods are tailor‐made to deal with a survival time variable that is measured continuously. However, survival variables measured on a discrete scale are often encountered in practice. The authors propose a new tree construction method specifically adapted to such discrete‐time survival variables. The splitting procedure can be seen as an extension, to the case of right‐censored data, of the entropy criterion for a categorical outcome. The selection of the final tree is made through a pruning algorithm combined with a bootstrap correction. The authors also present a simple way of potentially improving the predictive performance of a single tree through bagging. A simulation study shows that single trees and bagged‐trees perform well compared to a parametric model. A real data example investigating the usefulness of personality dimensions in predicting early onset of cigarette smoking is presented. The Canadian Journal of Statistics 37: 17‐32; 2009 © 2009 Statistical Society of Canada     

Least squares estimation of varying‐coefficient hazard regression with application to breast cancer dose‐intensity data

To enhance modeling flexibility, the authors propose a nonparametric hazard regression model, for which the ordinary and weighted least squares estimation and inference procedures are studied. The proposed model does not assume any parametric specifications on the covariate effects, which is suitable for exploring the nonlinear interactions between covariates, time and some exposure variable. The authors propose the local ordinary and weighted least squares estimators for the varying‐coefficient functions and establish the corresponding asymptotic normality properties. Simulation studies are conducted to empirically examine the finite‐sample performance of the new methods, and a real data example from a recent breast cancer study is used as an illustration. The Canadian Journal of Statistics 37: 659–674; 2009 © 2009 Statistical Society of Canada     

Large‐sample tests of extreme‐value dependence for multivariate copulas

Starting from the characterization of extreme‐value copulas based on max‐stability, large‐sample tests of extreme‐value dependence for multivariate copulas are studied. The two key ingredients of the proposed tests are the empirical copula of the data and a multiplier technique for obtaining approximate p‐values for the derived statistics. The asymptotic validity of the multiplier approach is established, and the finite‐sample performance of a large number of candidate test statistics is studied through extensive Monte Carlo experiments for data sets of dimension two to five. In the bivariate case, the rejection rates of the best versions of the tests are compared with those of the test of Ghoudi et al. (1998) recently revisited by Ben Ghorbal et al. (2009). The proposed procedures are illustrated on bivariate financial data and trivariate geological data. The Canadian Journal of Statistics 39: 703–720; 2011. © 2011 Statistical Society of Canada     

Model‐based linear clustering

The authors propose a profile likelihood approach to linear clustering which explores potential linear clusters in a data set. For each linear cluster, an errors‐in‐variables model is assumed. The optimization of the derived profile likelihood can be achieved by an EM algorithm. Its asymptotic properties and its relationships with several existing clustering methods are discussed. Methods to determine the number of components in a data set are adapted to this linear clustering setting. Several simulated and real data sets are analyzed for comparison and illustration purposes. The Canadian Journal of Statistics 38: 716–737; 2010 © 2010 Statistical Society of Canada     

Testing for intercept‐scale switch in linear autoregression

Autoregressive models with switching regime are a frequently used class of nonlinear time series models, which are popular in finance, engineering, and other fields. We consider linear switching autoregressions in which the intercept and variance possibly switch simultaneously, while the autoregressive parameters are structural and hence the same in all states, and we propose quasi‐likelihood‐based tests for a regime switch in this class of models. Our motivation is from financial time series, where one expects states with high volatility and low mean together with states with low volatility and higher mean. We investigate the performance of our tests in a simulation study, and give an application to a series of IBM monthly stock returns. The Canadian Journal of Statistics 40: 427–446; 2012 © 2012 Statistical Society of Canada     

Non‐parametric interval estimation for the partial area under the ROC curve

Accurate diagnosis of disease is a critical part of health care. New diagnostic and screening tests must be evaluated based on their abilities to discriminate diseased conditions from non‐diseased conditions. For a continuous‐scale diagnostic test, a popular summary index of the receiver operating characteristic (ROC) curve is the area under the curve (AUC). However, when our focus is on a certain region of false positive rates, we often use the partial AUC instead. In this paper we have derived the asymptotic normal distribution for the non‐parametric estimator of the partial AUC with an explicit variance formula. The empirical likelihood (EL) ratio for the partial AUC is defined and it is shown that its limiting distribution is a scaled chi‐square distribution. Hybrid bootstrap and EL confidence intervals for the partial AUC are proposed by using the newly developed EL theory. We also conduct extensive simulation studies to compare the relative performance of the proposed intervals and existing intervals for the partial AUC. A real example is used to illustrate the application of the recommended intervals. The Canadian Journal of Statistics 39: 17–33; 2011 © 2011 Statistical Society of Canada     

Data depth‐based nonparametric scale tests

Liu and Singh (1993, 2006) introduced a depth‐based d‐variate extension of the nonparametric two sample scale test of Siegel and Tukey (1960). Liu and Singh (2006) generalized this depth‐based test for scale homogeneity of k ≥ 2 multivariate populations. Motivated by the work of Gastwirth (1965), we propose k sample percentile modifications of Liu and Singh's proposals. The test statistic is shown to be asymptotically normal when k = 2, and compares favorably with Liu and Singh (2006) if the underlying distributions are either symmetric with light tails or asymmetric. In the case of skewed distributions considered in this paper the power of the proposed tests can attain twice the power of the Liu‐Singh test for d ≥ 1. Finally, in the k‐sample case, it is shown that the asymptotic distribution of the proposed percentile modified Kruskal‐Wallis type test is χ² with k ? 1 degrees of freedom. Power properties of this k‐sample test are similar to those for the proposed two sample one. The Canadian Journal of Statistics 39: 356–369; 2011 © 2011 Statistical Society of Canada     

D‐optimal minimax fractional factorial designs

The D‐optimal minimax criterion is proposed to construct fractional factorial designs. The resulting designs are very efficient, and robust against misspecification of the effects in the linear model. The criterion was first proposed by Wilmut & Zhou (2011); their work is limited to two‐level factorial designs, however. In this paper we extend this criterion to designs with factors having any levels (including mixed levels) and explore several important properties of this criterion. Theoretical results are obtained for construction of fractional factorial designs in general. This minimax criterion is not only scale invariant, but also invariant under level permutations. Moreover, it can be applied to any run size. This is an advantage over some other existing criteria. The Canadian Journal of Statistics 41: 325–340; 2013 © 2013 Statistical Society of Canada     

The CLT under right censorship and reporting delays

We extend the central limit theorem (CLT) under right censorship to the case when at the time of analysis we may have reporting delays. Under weak moment assumptions we derive an i.i.d. representation of the estimator, from which asymptotic normality easily follows.