Linear sufficiency and completeness in the context of estimating the parametric function in the general Gauss–Markov model

In this paper we consider linear sufficiency and linear completeness in the context of estimating the estimable parametric function K^′β${\mathbf{K}}^{\prime }\mathit{\beta }$ under the general Gauss–Markov model {y,Xβ,σ²V}$\{\mathbf{y},\mathbf{X}\mathit{\beta },{\sigma }^2\mathbf{V}\}$. We give new characterizations for linear sufficiency, and define and characterize linear completeness in a case of estimation of K^′β${\mathbf{K}}^{\prime }\mathit{\beta }$. Also, we consider a predictive approach for obtaining the best linear unbiased estimator of K^′β${\mathbf{K}}^{\prime }\mathit{\beta }$, and subsequently, we give the linear analogues of the Rao–Blackwell and Lehmann–Scheffé Theorems in the context of estimating K^′β${\mathbf{K}}^{\prime }\mathit{\beta }$.     

A sequential design for a clinical trial with a linear prognostic factor

We study a randomized adaptive design to assign one of the L$L$ treatments to patients who arrive sequentially by means of an urn model. At each stage n$n$, a reward is distributed between treatments. The treatment applied is rewarded according to its response, 0?_Yn?1$0?Y_n?1$, and 1-_Yn$1-Y_n$ is distributed among the other treatments according to their performance until stage n-1$n-1$. Patients can be classified in K+1$K+1$ levels and we assume that the effect of this level in the response to the treatments is linear. We study the asymptotic behavior of the design when the ordinary least square estimators are used as a measure of performance until stage n-1$n-1$.     

Representations of moments using lower-order conditional moments

Moments and central moments of a random variable X   are expressed as integrals of functions of lower-order conditional moments and the cumulative distribution of X$X$. In particular, sample central moments of order 2k$2k$ are expressed as the sum of between groups variations, providing an analogue to the analysis of variance. Similar expressions are obtained for the expectations of real-valued and measurable functions of X$X$.     

Simulation-based sequential Bayesian design

We consider simulation-based methods for exploration and maximization of expected utility in sequential decision problems. We consider problems which require backward induction with analytically intractable expected utility integrals at each stage. We propose to use forward simulation to approximate the integral expressions, and a reduction of the allowable action space to avoid problems related to an increasing number of possible trajectories in the backward induction. The artificially reduced action space allows strategies to depend on the full history of earlier observations and decisions only indirectly through a low dimensional summary statistic. The proposed rule provides a finite-dimensional approximation to the unrestricted infinite-dimensional optimal decision rule. We illustrate the proposed approach with an application to an optimal stopping problem in a clinical trial.     

An alternative form of the Watson efficiency

Watson [1951. Serial correlation in regression analysis. Ph.D. Thesis, Department of Experimental Statistics, North Carolina State College, Raleigh] introduced a relative efficiency, which is often called the Watson efficiency in literatures, to measure the inefficiency of the least squares in linear regression models. The Watson efficiency is defined by determinant, but we shall show by two examples that such a criterion does not always work well in some cases. In this paper, an alternative form based on Euclidean norm of the Watson efficiency is proposed and some examples are given to illustrate superiority of the new relative efficiency.     

Non-rejective implementations of the Sampford sampling design

Sampford sampling is a method for unequal probability sampling. There exist several implementations of the Sampford sampling design which all are rejective methods, i.e. the sample is not always accepted. Thus the existing methods can be time consuming or even infeasible in some situations. In this paper, a fast and non-rejective list-sequential method, which works in all situations, is presented. The method is a modification of a previously existing rejective list-sequential method. Another list-sequential implementation of Sampford sampling is also presented.     

Estimation of the distribution function with calibration methods

The paper proposes a new calibration estimator for the distribution function of the study variable. This estimator is a distribution function unlike others estimators that use auxiliary information. Comparisons are made with existing estimators in two simulation studies.     

Optimal crossover designs when carryover effects are proportional to direct effects

Crossover designs are used for a variety of different applications. While these designs have a number of attractive features, they also induce a number of special problems and concerns. One of these is the possible presence of carryover effects. Even with the use of washout periods, which are for many applications widely accepted as an indispensable component, the effect of a treatment from a previous period may not be completely eliminated. A model that has recently received renewed attention in the literature is the model in which first-order carryover effects are assumed to be proportional to direct treatment effects. Under this model, assuming that the constant of proportionality is known, we identify optimal and efficient designs for the direct effects for different values of the constant of proportionality. We also consider the implication of these results for the case that the constant of proportionality is not known.     

Asymptotic properties of kernel estimates of a regression function

The consistency of the Parzen kernel-type as well as recursive kernel estimates of a regression function is shown. The rates of the convergence are studied and compared. Moreover, the problem of selecting asymptotically optimal kernels is discussed.     

Mean and sensitivity estimation in optional randomized response models

Optional randomized response models were introduced by Gupta et al. (2002). These models are based on the basic premise that a question may be sensitive for one respondent but may not be sensitive for another. In an optional RRT (randomized response technique) model, a respondent is asked to provide a scrambled response only if the respondent considers the question sensitive. Otherwise, the respondent provides a truthful response. The researcher does not know which type of response is provided. The proportion of respondents who provide a scrambled response is known as the sensitivity level of the question. In this paper, we estimate simultaneously the mean and the sensitivity level of a quantitative-response sensitive question using a two stage optional RRT model. The estimators are unbiased and asymptotically normally distributed. We discuss the advantages and disadvantages of using additive and multiplicative scrambling.     

Approximate and exact optimal designs for paired comparisons of partial profiles when there are two groups of factors

For paired comparison experiments involving pairs of multifactor options differing in a specified number of factors the problem of finding optimal designs is considered, when only main effects are to be estimated. It is presumed that the set of factors can be partitioned into two groups such that the number of levels is constant within each group. The optimal designs for this frequently encountered case are also optimal for the corresponding choice experiments under the hypothesis that the parameters in the multinomial logit model are equal to zero.     

Utilization of higher order moments of scrambling variables in randomized response sampling

In this paper, a new estimator for estimating the proportion of a potentially sensitive attribute in survey sampling has been introduced. The proposed estimator makes use of higher order moments of the scrambling variable at the estimation stage. The proposed estimator has been found to be more efficient than the estimator due to Kuk [1990. Asking sensitive questions indirectly. Biomerika 77(2), 436–438] and Franklin [1989. A comparison of estimators for randomized response sampling with continuous distributions from a dichotomous population. Comm. Statist. Theory Methods 18, 489–505] type estimators in randomized response sampling. Recently, Guerriero and Sandri [2007. A note on the comparison of some randomized response procedures. J. Statist. Plann. Inference 137, 2184–2190] have shown that the family of randomized response models proposed by Kuk [1990. Asking sensitive questions indirectly. Biomerika 77(2), 436–438] is better than the Simmons’ family in terms of efficiency and protection.     

Hypotheses testing: Poisson versus stress-release

We consider the problem of hypotheses testing with the basic simple hypothesis: observed sequence of points corresponds to stationary Poisson process with known intensity against a composite one-sided parametric alternative that this is a stress-release point process. The underlying family of measures is locally asymptotically quadratic and we describe the behavior of score-function, likelihood ratio and Wald tests in the asymptotics of large samples. The results of numerical simulations are presented.     

A comparison of conditional Poisson sampling versus unequal probability sampling with replacement

The variance of the Horvitz–Thompson estimator for a fixed size Conditional Poisson sampling scheme without replacement and with unequal inclusion probabilities is compared to the variance of the Hansen–Hurwitz estimator for a sampling scheme with replacement. We show, using a theorem by Gabler, that the sampling design without replacement is more efficient than the sampling design with replacement.     

Equivalence theorem for Schur optimality of experimental designs

An experimental design is said to be Schur optimal, if it is optimal with respect to the class of all Schur isotonic criteria, which includes Kiefer's criteria of _Φp${\Phi }_p$-optimality, distance optimality criteria and many others. In the paper we formulate an easily verifiable necessary and sufficient condition for Schur optimality in the set of all approximate designs of a linear regression experiment with uncorrelated errors. We also show that several common models admit a Schur optimal design, for example the trigonometric model, the first-degree model on the Euclidean ball, and the Berman's model.     

On the simple linear regression model with correlated measurement errors

The simple linear regression model with measurement error has been subject to much research. In this work we will focus on this model when the error in the explanatory variable is correlated with the error in the regression equation. Specifically, we are interested in the comparison between the ordinary errors-in-variables estimator of the regression coefficient β$\beta$ and the estimator that takes account of the correlation between the errors. Based on large sample approximations, we compare the estimators and find that the estimator that takes account of the correlation should be preferred in most situations. We also compare the estimators in small sample situations. This is done by stochastic simulation. The results show that the estimators behave quite similarly in most of the simulated situations, but that the ordinary errors-in-variables estimator performs considerably worse than the estimator that takes account of the correlation for certain parameter combinations. In addition, we look briefly into the bias introduced by ignoring correlated errors when computing sample correlations, and in predictions.     

Uniform coverage designs for mixture experiments

We investigate an optimization problem for mixture experiments. We consider the case when a large number of ingredients are available but mixtures can contain only a few number of ingredients. These conditions are held in experiments for self assembling molecular systems. First, we introduce a concept of uniform coverage design specialized for the situation. Next, we propose to use the stepwise technique for estimating coefficients of third-order Scheffe model which describes a response surface. After that, we propose a method of adding new mixtures for a movement to an extremum region. By this method, additional mixtures of experiments are extremum points of current estimated model and points which lead to more accurate estimation of current model prediction. This methodology is studied numerically for a model constructed from real data.     

MV-optimality standardized through the coefficient of variation

Many of the usual criteria for optimal experimental designs do not take into account the different scale of the variance of the parameters. Dette [1997. Designing experiments with respect to “standardized” optimality criteria. J. Roy. Statist. Soc. Ser. B Stat. Methodol. 59(1), 97–110] provided a standardization based on the efficiencies for estimating each of the parameters. This approach provides designs with similar efficiencies for all of the parameters.     

Exact Designs Minimising the Integrated Variance in Quadratic Regression

Exact designs are given which minimise the average variance of a quadratic regression polynomial fitted by the method of least squares.