Admissibility in quadratically regular problems and recurrence of symmetric Markov chains: Why the connection?

In the expository paper, a sufficient condition is discussed for the almost admissibility of formal Bayes rules in quadratically regular problems. This sufficient condition is equivalent to a recurrence property of a natural symmetric Markov chain constructed from the model and the improper prior. Some simple examples involving translation parameter models illustrate the results.     

Why is not design of experiments widely used by engineers in Europe?

An extensive literature review was carried out to detect why design of experiments (DoE) is not widely used among engineers in Europe. Once 16 main barriers were identified, a survey was carried out to obtain first-hand information about the significance of each. We obtained 101 responses from academics, consultants and practitioners interested in DoE. A statistical analysis of the survey is introduced, including: (a) a ranking of the barriers, (b) grouping of barriers using factorial analysis, (c) differences between characteristics of respondents. This exploratory analysis showed that the main barriers that hinder the widespread use of DoE are low managerial commitment and engineers’ general weakness in statistics. Once the barriers were classified, the most important resultant group was that related to business barriers.     

Wavelets and estimation of long memory in nonstationary models: Does anything beat the exact local whittle estimator?

In this article, we analyze the performance of five estimation methods for the long memory parameter d. The goal of our article is to construct a wavelet estimate for the fractional differencing parameter in nonstationary long memory processes that dominate the well-known estimate of Shimotsu and Phillips (2005) Shimotsu, K., Phillips, P. (2005). Exact local whittle estimation of fractional integration. Annals of statistics 20:87–127. [Google Scholar]. The simulation results show that the wavelet estimation method of Lee (2005) Lee, J. (2005). Estimating memory parameter in the US inflation rate. Economics Letters 87:207–210. [Google Scholar] with several tapering techniques performs better under most cases in nonstationary long memory. The comparison is based on the empirical root mean squared error of each estimate.     

Rejoinder: Why do we test multiple traits in genetic association studies?

This is a rejoinder to the discussions of “Why do we test multiple traits in genetic association studies”.     

The use of external controls: To what extent can it currently be recommended?

With more and better clinical data being captured outside of clinical studies and greater data sharing of clinical studies, external controls may become a more attractive alternative to randomized clinical trials (RCTs). Both industry and regulators recognize that in situations where a randomized study cannot be performed, external controls can provide the needed contextualization to allow a better interpretation of studies without a randomized control. It is also agreed that external controls will not fully replace RCTs as the gold standard for formal proof of efficacy in drug development and the yardstick of clinical research. However, it remains unclear in which situations conclusions about efficacy and a positive benefit/risk can reliably be based on the use of an external control. This paper will provide an overview on types of external control, their applications and the different sources of bias their use may incur, and discuss potential mitigation steps. It will also give recommendations on how the use of external controls can be justified.     

Deterministic Evolution of Strength in Multiple Comparisons Models: Who is the Greatest Golfer?

We present a statistical methodology for fitting time‐varying rankings, by estimating the strength parameters of the Plackett–Luce multiple comparisons model at regularly spaced times for each ranked item. We use the little‐known method of barycentric rational interpolation to interpolate between the strength parameters so that a competitor's strength can be evaluated at any time. We chose the time‐varying strengths to evolve deterministically rather than stochastically, a preference that we reason often has merit. There are many statistical and computational problems to overcome on fitting anything beyond ‘toy’ data sets. The methodological innovations here include a method for maximizing a likelihood function for many parameters, approximations for modelling tied data and an approach to the elimination of secular drift of the estimated ‘strengths’. The methodology has obvious applications to fields such as marketing, although we demonstrate our approach by analysing a large data set of golf tournament results, in search of an answer to the question ‘who is the greatest golfer of all time?’     

Estimates of subgroup treatment effects in overall nonsignificant trials: To what extent should we believe in them?

In drug development, it sometimes occurs that a new drug does not demonstrate effectiveness for the full study population but appears to be beneficial in a relevant subgroup. In case the subgroup of interest was not part of a confirmatory testing strategy, the inflation of the overall type I error is substantial and therefore such a subgroup analysis finding can only be seen as exploratory at best. To support such exploratory findings, an appropriate replication of the subgroup finding should be undertaken in a new trial. We should, however, be reasonably confident in the observed treatment effect size to be able to use this estimate in a replication trial in the subpopulation of interest. We were therefore interested in evaluating the bias of the estimate of the subgroup treatment effect, after selection based on significance for the subgroup in an overall “failed” trial. Different scenarios, involving continuous as well as dichotomous outcomes, were investigated via simulation studies. It is shown that the bias associated with subgroup findings in overall nonsignificant clinical trials is on average large and varies substantially across plausible scenarios. This renders the subgroup treatment estimate from the original trial of limited value to design the replication trial. An empirical Bayesian shrinkage method is suggested to minimize this overestimation. The proposed estimator appears to offer either a good or a conservative correction to the observed subgroup treatment effect hence provides a more reliable subgroup treatment effect estimate for adequate planning of future studies.     

Gender and income inequality in the UK 1968–90: the feminization of earnings or of poverty?

This paper uses data from the Family Expenditure Survey for five selected years between 1968 and 1990 to examine trends in the income distribution in the UK, highlighting the role of women's labour force participation and earnings. The increased labour force participation of married women (especially mothers of young children in the 1980s) made a greater contribution to the decline of the 'traditional' male breadwinner family than the increased number of lone parents. The lower half of the distribution of weekly earnings became increasingly dominated by women. Though women's weekly earnings remained low relative to men's, the increase in their participation meant that, over the period, an increased share of family income came from women's labour market income: in 1990 nearly a quarter of the income of families with children came from women's earnings. Women's earnings were an important factor in keeping families out of poverty. There was no trend towards increasing feminization of poverty over the sample period. Adult women were somewhat more likely to be poor than adult men were, but female-headed families were very much more likely to be in poverty, and much more dependent on state benefits, than male-headed families were. Women's increased role in the labour market affected those in male-headed families more than those in female-headed families. Alongside a broad tendency for women's earnings to reduce poverty and inequality, there is evidence that the female population has become more economically polarized.     

Active‐controlled,non‐inferiority trials in oncology: arbitrary limits,infeasible sample sizes and uninformative data analysis. Is there another way?

In oncology, it may not always be possible to evaluate the efficacy of new medicines in placebo-controlled trials. Furthermore, while some newer, biologically targeted anti-cancer treatments may be expected to deliver therapeutic benefit in terms of better tolerability or improved symptom control, they may not always be expected to provide increased efficacy relative to existing therapies. This naturally leads to the use of active-control, non-inferiority trials to evaluate such treatments. In recent evaluations of anti-cancer treatments, the non-inferiority margin has often been defined in terms of demonstrating that at least 50% of the active control effect has been retained by the new drug using methods such as those described by Rothmann et al., Statistics in Medicine 2003; 22:239-264 and Wang and Hung Controlled Clinical Trials 2003; 24:147-155. However, this approach can lead to prohibitively large clinical trials and results in a tendency to dichotomize trial outcome as either 'success' or 'failure' and thus oversimplifies interpretation. With relatively modest modification, these methods can be used to define a stepwise approach to design and analysis. In the first design step, the trial is sized to show indirectly that the new drug would have beaten placebo; in the second analysis step, the probability that the new drug is superior to placebo is assessed and, if sufficiently high in the third and final step, the relative efficacy of the new drug to control is assessed on a continuum of effect retention via an 'effect retention likelihood plot'. This stepwise approach is likely to provide a more complete assessment of relative efficacy so that the value of new treatments can be better judged.     

Number of predictors and multicollinearity: What are their effects on error and bias in regression?

The present Monte Carlo simulation study adds to the literature by analyzing parameter bias, rates of Type I and Type II error, and variance inflation factor (VIF) values produced under various multicollinearity conditions by multiple regressions with two, four, and six predictors. Findings indicate multicollinearity is unrelated to Type I error, but increases Type II error. Investigation of bias suggests that multicollinearity increases the variability in parameter bias, while leading to overall underestimation of parameters. Collinearity also increases VIF. In the case of all diagnostics however, increasing the number of predictors interacts with multicollinearity to compound observed problems.     

Comment on: On the role of data,statistics and decisions in a pandemic statistics for climate protection and health—dare (more) progress!

AStA Advances in Statistical Analysis - In the Corona pandemic, it became clear with burning clarity how much good quality statistics are needed, and at the same time how unsuccessful we are at...