Bivariate zero-inflated negative binomial regression model with applications

Count data often display excessive number of zero outcomes than are expected in the Poisson regression model. The zero-inflated Poisson regression model has been suggested to handle zero-inflated data, whereas the zero-inflated negative binomial (ZINB) regression model has been fitted for zero-inflated data with additional overdispersion. For bivariate and zero-inflated cases, several regression models such as the bivariate zero-inflated Poisson (BZIP) and bivariate zero-inflated negative binomial (BZINB) have been considered. This paper introduces several forms of nested BZINB regression model which can be fitted to bivariate and zero-inflated count data. The mean–variance approach is used for comparing the BZIP and our forms of BZINB regression model in this study. A similar approach was also used by past researchers for defining several negative binomial and zero-inflated negative binomial regression models based on the appearance of linear and quadratic terms of the variance function. The nested BZINB regression models proposed in this study have several advantages; the likelihood ratio tests can be performed for choosing the best model, the models have flexible forms of marginal mean–variance relationship, the models can be fitted to bivariate zero-inflated count data with positive or negative correlations, and the models allow additional overdispersion of the two dependent variables.     

Random effect exponentiated-exponential geometric model for clustered/longitudinal zero-inflated count data

For count responses, there are situations in biomedical and sociological applications in which extra zeroes occur. Modeling correlated (e.g. repeated measures and clustered) zero-inflated count data includes special challenges because the correlation between measurements for a subject or a cluster needs to be taken into account. Moreover, zero-inflated count data are often faced with over/under dispersion problem. In this paper, we propose a random effect model for repeated measurements or clustered data with over/under dispersed response called random effect zero-inflated exponentiated-exponential geometric regression model. The proposed method was illustrated through real examples. The performance of the model and asymptotical properties of the estimations were investigated using simulation studies.KEYWORDS: Count model, under- and over-dispersion, zero-inflation, mixture model, zero-inflated poisson model     

Estimation of Median in Two-Phase Sampling Using Two Auxiliary Variables

In recent years, zero-inflated count data models, such as zero-inflated Poisson (ZIP) models, are widely used as the count data with extra zeros are very common in many practical problems. In order to model the correlated count data which are either clustered or repeated and to assess the effects of continuous covariates or of time scales in a flexible way, a class of semiparametric mixed-effects models for zero-inflated count data is considered. In this article, we propose a fully Bayesian inference for such models based on a data augmentation scheme that reflects both random effects of covariates and mixture of zero-inflated distribution. A computational efficient MCMC method which combines the Gibbs sampler and M-H algorithm is implemented to obtain the estimate of the model parameters. Finally, a simulation study and a real example are used to illustrate the proposed methodologies.     

GEE-based zero-inflated generalized Poisson model for clustered over or under-dispersed count data

The zero-inflated regression models such as zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB) or zero-inflated generalized Poisson (ZIGP) regression models can model the count data with excess zeros. The ZINB model can handle over-dispersed and the ZIGP model can handle the over or under-dispersed count data with excess zeros as well. Moreover, the count data may be correlated because of data collection procedure or special study design. The clustered sampling approach is one of the examples in which the correlation among subjects could be defined. In such situations, a marginal model using generalized estimating equation (GEE) approach can incorporate these correlations and lead up to the relationships at the population level. In this study, the GEE-based zero-inflated generalized Poisson regression model was proposed to fit over and under-dispersed clustered count data with excess zeros.     

Functional Form for the Zero-Inflated Generalized Poisson Regression Model

The generalized Poisson (GP) regression is an increasingly popular approach for modeling overdispersed as well as underdispersed count data. Several parameterizations have been performed for the GP regression, and the two well known models, the GP-1 and the GP-2, have been applied. The GP-P regression, which has been recently proposed, has the advantage of nesting the GP-1 and the GP-2 parametrically, besides allowing the statistical tests of the GP-1 and the GP-2 against a more general alternative. In several cases, count data often have excessive number of zero outcomes than are expected in the Poisson. This zero-inflation phenomenon is a specific cause of overdispersion, and the zero-inflated Poisson (ZIP) regression model has been proposed. However, if the data continue to suggest additional overdispersion, the zero-inflated negative binomial (ZINB-1 and ZINB-2) and the zero-inflated generalized Poisson (ZIGP-1 and ZIGP-2) regression models have been considered as alternatives. This article proposes a functional form of the ZIGP which mixes a distribution degenerate at zero with a GP-P distribution. The suggested model has the advantage of nesting the ZIP and the two well known ZIGP (ZIGP-1 and ZIGP-2) regression models, besides allowing the statistical tests of the ZIGP-1 and the ZIGP-2 against a more general alternative. The ZIP and the functional form of the ZIGP regression models are fitted, compared and tested on two sets of count data; the Malaysian insurance claim data and the German healthcare data.     

Analyzing clustered count data with a cluster-specific random effect zero-inflated Conway–Maxwell–Poisson distribution

Count data analysis techniques have been developed in biological and medical research areas. In particular, zero-inflated versions of parametric count distributions have been used to model excessive zeros that are often present in these assays. The most common count distributions for analyzing such data are Poisson and negative binomial. However, a Poisson distribution can only handle equidispersed data and a negative binomial distribution can only cope with overdispersion. However, a Conway–Maxwell–Poisson (CMP) distribution [4] can handle a wide range of dispersion. We show, with an illustrative data set on next-generation sequencing of maize hybrids, that both underdispersion and overdispersion can be present in genomic data. Furthermore, the maize data set consists of clustered observations and, therefore, we develop inference procedures for a zero-inflated CMP regression that incorporates a cluster-specific random effect term. Unlike the Gaussian models, the underlying likelihood is computationally challenging. We use a numerical approximation via a Gaussian quadrature to circumvent this issue. A test for checking zero-inflation has also been developed in our setting. Finite sample properties of our estimators and test have been investigated by extensive simulations. Finally, the statistical methodology has been applied to analyze the maize data mentioned before.     

Marginal zero-inflated regression models for count data

Data sets with excess zeroes are frequently analyzed in many disciplines. A common framework used to analyze such data is the zero-inflated (ZI) regression model. It mixes a degenerate distribution with point mass at zero with a non-degenerate distribution. The estimates from ZI models quantify the effects of covariates on the means of latent random variables, which are often not the quantities of primary interest. Recently, marginal zero-inflated Poisson (MZIP; Long et al. [A marginalized zero-inflated Poisson regression model with overall exposure effects. Stat. Med. 33 (2014), pp. 5151–5165]) and negative binomial (MZINB; Preisser et al., 2016) models have been introduced that model the mean response directly. These models yield covariate effects that have simple interpretations that are, for many applications, more appealing than those available from ZI regression. This paper outlines a general framework for marginal zero-inflated models where the latent distribution is a member of the exponential dispersion family, focusing on common distributions for count data. In particular, our discussion includes the marginal zero-inflated binomial (MZIB) model, which has not been discussed previously. The details of maximum likelihood estimation via the EM algorithm are presented and the properties of the estimators as well as Wald and likelihood ratio-based inference are examined via simulation. Two examples presented illustrate the advantages of MZIP, MZINB, and MZIB models for practical data analysis.     

Untangle the structural and random zeros in statistical modelings

Count data with structural zeros are common in public health applications. There are considerable researches focusing on zero-inflated models such as zero-inflated Poisson (ZIP) and zero-inflated Negative Binomial (ZINB) models for such zero-inflated count data when used as response variable. However, when such variables are used as predictors, the difference between structural and random zeros is often ignored and may result in biased estimates. One remedy is to include an indicator of the structural zero in the model as a predictor if observed. However, structural zeros are often not observed in practice, in which case no statistical method is available to address the bias issue. This paper is aimed to fill this methodological gap by developing parametric methods to model zero-inflated count data when used as predictors based on the maximum likelihood approach. The response variable can be any type of data including continuous, binary, count or even zero-inflated count responses. Simulation studies are performed to assess the numerical performance of this new approach when sample size is small to moderate. A real data example is also used to demonstrate the application of this method.     

随机效应零膨胀索赔次数回归模型

索赔频率预测是非寿险费率厘定的重要组成部分。最常使用的索赔频率预测模型是泊松回归和负二项回归,以及与它们相对应的零膨胀回归模型。但是,当索赔次数观察值既具有零膨胀特征,又存在组内相依结构时,上述模型都不能很好地拟合实际数据。为此,本文在泊松分布、负二项分布、广义泊松分布、P型负二项分布等条件下分别建立了随机效应零膨胀损失次数回归模型。为了改进模型的预测效果,对于连续型的解释变量,还引入了二次平滑项,并建立了结构性零比例与解释变量之间的回归关系。基于一组实际索赔次数数据的实证分析结果表明,该模型可以显著改进现有模型的拟合效果。     

Distribution-free inference of zero-inflated binomial data for longitudinal studies

Count responses with structural zeros are very common in medical and psychosocial research, especially in alcohol and HIV research, and the zero-inflated Poisson (ZIP) and zero-inflated negative binomial models are widely used for modeling such outcomes. However, as alcohol drinking outcomes such as days of drinkings are counts within a given period, their distributions are bounded above by an upper limit (total days in the period) and thus inherently follow a binomial or zero-inflated binomial (ZIB) distribution, rather than a Poisson or ZIP distribution, in the presence of structural zeros. In this paper, we develop a new semiparametric approach for modeling ZIB-like count responses for cross-sectional as well as longitudinal data. We illustrate this approach with both simulated and real study data.     

零膨胀泊松模型的改进在零次索赔建模中的应用

零膨胀是非寿险精算中的一种常见现象,国内外许多学者对此进行了研究分析,而最具影响力的方法是零膨胀泊松模型与Hurdle模型,但这两个方法在区分零之间的差别时存在不足。实际中,产生零次索赔的保单持有人并非全部同质,如何提取零中所包含的信息对保险公司来说是重要的。鉴此,基于零膨胀泊松模型与Hurdle模型的思想,提出修正的零膨胀泊松模型,并利用非寿险精算中的实际数据,对新模型进行了拟合分析。与零膨胀泊松模型拟合结果的比较说明,修正的零膨胀模型在零的处理上更符合实际情况,更能体现零中所包含的信息。     

零膨胀计数数据的联合建模及变量选择

零膨胀计数数据破坏了泊松分布的方差-均值关系，可由取值服从泊松分布的数据和取值为零(退化分布)的数据各占一定比例所构成的混合分布所解释。本文基于自适应弹性网技术， 研究了零膨胀计数数据的联合建模及变量选择问题.对于零膨胀泊松分布，引入潜变量，构造出零膨胀泊松模型的完全似然, 其中由零膨胀部分和泊松部分两项组成.考虑到协变量可能存在共线性和稀疏性，通过对似然函数加自适应弹性网惩罚得到目标函数,然后利用EM算法得到回归系数的稀疏估计量，并用贝叶斯信息准则BIC来确定最优调节参数.本文也给出了估计量的大样本性质的理论证明和模拟研究，最后把所提出的方法应用到实际问题中。     

Score test for testing zero-inflated Poisson regression against zero-inflated generalized Poisson alternatives

In several cases, count data often have excessive number of zero outcomes. This zero-inflated phenomenon is a specific cause of overdispersion, and zero-inflated Poisson regression model (ZIP) has been proposed for accommodating zero-inflated data. However, if the data continue to suggest additional overdispersion, zero-inflated negative binomial (ZINB) and zero-inflated generalized Poisson (ZIGP) regression models have been considered as alternatives. This study proposes the score test for testing ZIP regression model against ZIGP alternatives and proves that it is equal to the score test for testing ZIP regression model against ZINB alternatives. The advantage of using the score test over other alternative tests such as likelihood ratio and Wald is that the score test can be used to determine whether a more complex model is appropriate without fitting the more complex model. Applications of the proposed score test on several datasets are also illustrated.     

Multivariate models for correlated count data

In this study, we deal with the problem of overdispersion beyond extra zeros for a collection of counts that can be correlated. Poisson, negative binomial, zero-inflated Poisson and zero-inflated negative binomial distributions have been considered. First, we propose a multivariate count model in which all counts follow the same distribution and are correlated. Then we extend this model in a sense that correlated counts may follow different distributions. To accommodate correlation among counts, we have considered correlated random effects for each individual in the mean structure, thus inducing dependency among common observations to an individual. The method is applied to real data to investigate variation in food resources use in a species of marsupial in a locality of the Brazilian Cerrado biome.     

Modeling road traffic crashes with zero-inflation and site-specific random effects

Zero-inflated count models are increasingly employed in many fields in case of “zero-inflation”. In modeling road traffic crashes, it has also shown to be useful in obtaining a better model-fitting when zero crash counts are over-presented. However, the general specification of zero-inflated model can not account for the multilevel data structure in crash data, which may be an important source of over-dispersion. This paper examines zero-inflated Poisson regression with site-specific random effects (REZIP) with comparison to random effect Poisson model and standard zero-inflated poison model. A practical and flexible procedure, using Bayesian inference with Markov Chain Monte Carlo algorithm and cross-validation predictive density techniques, is applied for model calibration and suitability assessment. Using crash data in Singapore (1998–2005), the illustrative results demonstrate that the REZIP model may significantly improve the model-fitting and predictive performance of crash prediction models. This improvement can contribute to traffic safety management and engineering practices such as countermeasure design and safety evaluation of traffic treatments.     

Zero-inflated Poisson and negative binomial integer-valued GARCH models

Zero inflation means that the proportion of 0's of a model is greater than the proportion of 0's of the corresponding Poisson model, which is a common phenomenon in count data. To model the zero-inflated characteristic of time series of counts, we propose zero-inflated Poisson and negative binomial INGARCH models, which are useful and flexible generalizations of the Poisson and negative binomial INGARCH models, respectively. The stationarity conditions and the autocorrelation function are given. Based on the EM algorithm, the estimating procedure is simple and easy to be implemented. A simulation study shows that the estimation method is accurate and reliable as long as the sample size is reasonably large. A real data example leads to superior performance of the proposed models compared with other competitive models in the literature.     

A Bayesian Approach for Zero-Inflated Count Regression Models by Using the Reversible Jump Markov Chain Monte Carlo Method and an Application

In this study, estimation of the parameters of the zero-inflated count regression models and computations of posterior model probabilities of the log-linear models defined for each zero-inflated count regression models are investigated from the Bayesian point of view. In addition, determinations of the most suitable log-linear and regression models are investigated. It is known that zero-inflated count regression models cover zero-inflated Poisson, zero-inflated negative binomial, and zero-inflated generalized Poisson regression models. The classical approach has some problematic points but the Bayesian approach does not have similar flaws. This work points out the reasons for using the Bayesian approach. It also lists advantages and disadvantages of the classical and Bayesian approaches. As an application, a zoological data set, including structural and sampling zeros, is used in the presence of extra zeros. In this work, it is observed that fitting a zero-inflated negative binomial regression model creates no problems at all, even though it is known that fitting a zero-inflated negative binomial regression model is the most problematic procedure in the classical approach. Additionally, it is found that the best fitting model is the log-linear model under the negative binomial regression model, which does not include three-way interactions of factors.     

Bayesian zero-inflated generalized Poisson regression model: estimation and case influence diagnostics

Count data with excess zeros arises in many contexts. Here our concern is to develop a Bayesian analysis for the zero-inflated generalized Poisson (ZIGP) regression model to address this problem. This model provides a useful generalization of zero-inflated Poisson model since the generalized Poisson distribution is overdispersed/underdispersed relative to Poisson. Due to the complexity of the ZIGP model, Markov chain Monte Carlo methods are used to develop a Bayesian procedure for the considered model. Additionally, some discussions on the model selection criteria are presented and a Bayesian case deletion influence diagnostics is investigated for the joint posterior distribution based on the Kullback–Leibler divergence. Finally, a simulation study and a psychological example are given to illustrate our methodology.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

Markov regression models for count time series with excess zeros: A partial likelihood approach

Count data with excess zeros are common in many biomedical and public health applications. The zero-inflated Poisson (ZIP) regression model has been widely used in practice to analyze such data. In this paper, we extend the classical ZIP regression framework to model count time series with excess zeros. A Markov regression model is presented and developed, and the partial likelihood is employed for statistical inference. Partial likelihood inference has been successfully applied in modeling time series where the conditional distribution of the response lies within the exponential family. Extending this approach to ZIP time series poses methodological and theoretical challenges, since the ZIP distribution is a mixture and therefore lies outside the exponential family. In the partial likelihood framework, we develop an EM algorithm to compute the maximum partial likelihood estimator (MPLE). We establish the asymptotic theory of the MPLE under mild regularity conditions and investigate its finite sample behavior in a simulation study. The performances of different partial-likelihood based model selection criteria are compared in the presence of model misspecification. Finally, we present an epidemiological application to illustrate the proposed methodology.